CHRISTOPHER MARK NORRIS
Affiliation: University of Kentucky
- Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementiaDana M Niedowicz
Sanders Brown Center on Aging, University of Kentucky, 800 S, Limestone, Sanders Brown 211, Lexington, KY 40536 0230, USA
Acta Neuropathol Commun 2:64. 2014....
- Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged ratsDiana M Sama
Graduate Center for Gerontology, University of Kentucky, Lexington, Kentucky, United States of America
PLoS ONE 7:e38170. 2012..The results suggest that diverse functional changes associated with brain aging may arise, in part, from selective alterations in TNF signaling...
- Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's modelsChristopher M Norris
Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
J Neurosci 25:4649-58. 2005..Thus, the data identify calcineurin upregulation in astrocytes as a novel candidate for an intracellular trigger of astrogliosis, particularly in aging and AD brain...
- Recovery of afferent function and synaptic strength in hippocampal CA1 following traumatic brain injuryChristopher M Norris
Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, Kentucky, USA
J Neurotrauma 26:2269-78. 2009..Although plasticity mechanisms appear to remain intact, synaptic strength deficits in CA1 could limit information throughput in the hippocampus, leading to persistent memory dysfunction...
- Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with agingChristopher M Norris
Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536, USA
Neurobiol Aging 31:328-38. 2010..Thus, these studies point to altered CN function as a novel and potentially key factor in aging-dependent neuronal Ca(2+) dysregulation...
- Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neuronsJohn C Gant
Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
J Neurosci 31:1693-703. 2011..Thus, disruption of FKBP1b recapitulated much of the Ca(2+)-dysregulation aging phenotype in young rat hippocampus, supporting a novel hypothesis that declining FKBP function plays a major role in unhealthy brain aging...
- Interleukin-1beta-dependent signaling between astrocytes and neurons depends critically on astrocytic calcineurin/NFAT activityMichelle A Sama
Department of Molecular and Biomedical Pharmacology, Graduate Center for Gerontology, University of Kentucky, Lexington, Kentucky 40536, USA
J Biol Chem 283:21953-64. 2008..Taken together, the results have potentially important implications for the propagation and maintenance of neuroinflammatory signaling processes associated with many neurodegenerative conditions and diseases...
- Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signalingHafiz Mohmmad Abdul
The Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536, USA
J Neurosci 29:12957-69. 2009..The results suggest that NFAT signaling is selectively altered in AD and may play an important role in driving Abeta-mediated neurodegeneration...
- Disparate effects of serum on basal and evoked NFAT activity in primary astrocyte culturesJennifer L Furman
Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY 40536, USA
Neurosci Lett 469:365-9. 2010..Together, the results demonstrate that the presence of serum and cell confluency have a major impact on CN/NFAT signaling in primary astrocyte cultures and therefore must be taken into consideration when using this model system...
- The Ca(V) 1.2 Ca(2+) channel is expressed in sarcolemma of type I and IIa myofibers of adult skeletal muscleDusan M Jeftinija
Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY 40536, USA
Muscle Nerve 36:482-90. 2007..2 and type IIa-positive fibers. Taken together, these data suggest that the Ca(V) 1.2 Ca(2+) channel is expressed in adult skeletal muscle in a fiber type-specific manner, which may help to maintain oxidative muscle phenotype...