CHRISTOPHER MARK NORRIS

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats
    Diana M Sama
    Graduate Center for Gerontology, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 7:e38170. 2012
  2. pmc Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models
    Christopher M Norris
    Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 25:4649-58. 2005
  3. pmc Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging
    Christopher M Norris
    Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Neurobiol Aging 31:328-38. 2010
  4. pmc Recovery of afferent function and synaptic strength in hippocampal CA1 following traumatic brain injury
    Christopher M Norris
    Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    J Neurotrauma 26:2269-78. 2009
  5. pmc Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons
    John C Gant
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    J Neurosci 31:1693-703. 2011
  6. pmc Interleukin-1beta-dependent signaling between astrocytes and neurons depends critically on astrocytic calcineurin/NFAT activity
    Michelle A Sama
    Department of Molecular and Biomedical Pharmacology, Graduate Center for Gerontology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 283:21953-64. 2008
  7. pmc Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling
    Hafiz Mohmmad Abdul
    The Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 29:12957-69. 2009
  8. pmc The Ca(V) 1.2 Ca(2+) channel is expressed in sarcolemma of type I and IIa myofibers of adult skeletal muscle
    Dusan M Jeftinija
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Muscle Nerve 36:482-90. 2007
  9. pmc Disparate effects of serum on basal and evoked NFAT activity in primary astrocyte cultures
    Jennifer L Furman
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY 40536, USA
    Neurosci Lett 469:365-9. 2010

Collaborators

Detail Information

Publications9

  1. pmc Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats
    Diana M Sama
    Graduate Center for Gerontology, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 7:e38170. 2012
    ..The results suggest that diverse functional changes associated with brain aging may arise, in part, from selective alterations in TNF signaling...
  2. pmc Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models
    Christopher M Norris
    Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 25:4649-58. 2005
    ..Thus, the data identify calcineurin upregulation in astrocytes as a novel candidate for an intracellular trigger of astrogliosis, particularly in aging and AD brain...
  3. pmc Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging
    Christopher M Norris
    Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Neurobiol Aging 31:328-38. 2010
    ..Thus, these studies point to altered CN function as a novel and potentially key factor in aging-dependent neuronal Ca(2+) dysregulation...
  4. pmc Recovery of afferent function and synaptic strength in hippocampal CA1 following traumatic brain injury
    Christopher M Norris
    Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    J Neurotrauma 26:2269-78. 2009
    ..Although plasticity mechanisms appear to remain intact, synaptic strength deficits in CA1 could limit information throughput in the hippocampus, leading to persistent memory dysfunction...
  5. pmc Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons
    John C Gant
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    J Neurosci 31:1693-703. 2011
    ..Thus, disruption of FKBP1b recapitulated much of the Ca(2+)-dysregulation aging phenotype in young rat hippocampus, supporting a novel hypothesis that declining FKBP function plays a major role in unhealthy brain aging...
  6. pmc Interleukin-1beta-dependent signaling between astrocytes and neurons depends critically on astrocytic calcineurin/NFAT activity
    Michelle A Sama
    Department of Molecular and Biomedical Pharmacology, Graduate Center for Gerontology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 283:21953-64. 2008
    ..Taken together, the results have potentially important implications for the propagation and maintenance of neuroinflammatory signaling processes associated with many neurodegenerative conditions and diseases...
  7. pmc Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling
    Hafiz Mohmmad Abdul
    The Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 29:12957-69. 2009
    ..The results suggest that NFAT signaling is selectively altered in AD and may play an important role in driving Abeta-mediated neurodegeneration...
  8. pmc The Ca(V) 1.2 Ca(2+) channel is expressed in sarcolemma of type I and IIa myofibers of adult skeletal muscle
    Dusan M Jeftinija
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Muscle Nerve 36:482-90. 2007
    ..2 and type IIa-positive fibers. Taken together, these data suggest that the Ca(V) 1.2 Ca(2+) channel is expressed in adult skeletal muscle in a fiber type-specific manner, which may help to maintain oxidative muscle phenotype...
  9. pmc Disparate effects of serum on basal and evoked NFAT activity in primary astrocyte cultures
    Jennifer L Furman
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY 40536, USA
    Neurosci Lett 469:365-9. 2010
    ..Together, the results demonstrate that the presence of serum and cell confluency have a major impact on CN/NFAT signaling in primary astrocyte cultures and therefore must be taken into consideration when using this model system...

Research Grants7

  1. Calcineurin and inflammatory signaling processes in aging and Alzheimer's Disease
    CHRISTOPHER MARK NORRIS; Fiscal Year: 2010
    ....
  2. Calcineurin and inflammatory signaling processes in aging and Alzheimer's Disease
    Christopher Norris; Fiscal Year: 2006
    ....
  3. Calcineurin and Biobehavioral Markers of Brain Aging
    Christopher Norris; Fiscal Year: 2007
    ..Furthermore, individual neurons and glia will be harvested from zipper slices to examine single cell gene expression profiles using gene microarray technology. ..
  4. Calcineurin and inflammatory signaling processes in aging and Alzheimer's Disease
    Christopher Norris; Fiscal Year: 2007
    ....
  5. Calcineurin and inflammatory signaling processes in aging and Alzheimer's Disease
    Christopher Norris; Fiscal Year: 2009
    ....