Genomes and Genes
Andrew J Norris
Affiliation: University of California
- A novel mass spectrometric assay for the cerebroside sulfate activator protein (saposin B) and arylsulfatase AAndrew J Norris
Pasarow Mass Spectrometry Laboratory, Department of Psychiatry, and Neuropsychiatric Institute, University of California Los Angeles, Los Angeles, CA 90024, USA
J Lipid Res 46:2254-64. 2005..The modified assay for the coupled ASA/CSAct reaction could find applicability in settings in which the assay could not be performed previously because of the need for radiolabeled substrate, which is now not required...
- Nitroxyl inhibits breast tumor growth and angiogenesisAndrew J Norris
Surgical Oncology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Int J Cancer 122:1905-10. 2008..Therefore, HNO appears to act via mechanism(s) different from those of existing breast cancer drugs, making it a potential candidate to overcome known and emerging drug resistance pathways...
- Targeted inhibition of EG-1 blocks breast tumor growthMing Lu
University of California, Los Angeles School of Medicine, Department of Surgery, Division of Oncology, Los Angeles, California, USA
Cancer Biol Ther 6:936-41. 2007..These observations demonstrate that EG-1 is relevant to human breast cancer, and is a molecular target worthy of translational efforts into effective breast cancer therapy...
- Boric acid inhibits adenosine diphosphate-ribosyl cyclase non-competitivelyDanny H Kim
Department of Environmental Health Sciences, Box 951772, University of California, 650 Charles E Young Dr South, Los Angeles, CA 90095 1772, USA
J Chromatogr A 1115:246-52. 2006..5+/-0.5 mM. Boric acid binding to cADPR, determined by electrospray ionization mass spectrometry, was characterized by an apparent binding constant, KA, of 655+/-99 L/mol at pH 10.3...
- Inhibition kinetics of carba- and C-fucosyl analogues of GDP-fucose against fucosyltransferase V: implication for the reaction mechanismAndrew J Norris
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
Bioorg Med Chem Lett 14:571-3. 2004..1+/-9.8 microM, similar to the K(m) value for GDP-Fuc (50.4+/-5.5 microM), while the C-Fuc analogue exhibited significantly weak competitive inhibition with a K(i) value of 889+/-93 microM...
- Borate-nucleotide complex formation depends on charge and phosphorylation stateDanny H Kim
Department of Environmental Health Sciences, University of California, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
J Mass Spectrom 39:743-51. 2004..At pH 7.4, using ammonium bicarbonate buffer, only borate-NAD(+) complex was observed. This indicates that the borate-NAD(+) complex may be the most physiologically relevant of those studied...
- EG-1 interacts with c-Src and activates its signaling pathwayMing Lu
Department of Surgery, Division of Oncology, UCLA School of Medicine, Los Angeles, CA, USA
Int J Oncol 29:1013-8. 2006..Furthermore, EG-1 shows interaction with multiple other SH3- and WW-containing molecules involved in various signaling pathways. These observations suggest that EG-1 may be involved in signaling pathways including c-Src activation...
- Ionizing radiation activates the Nrf2 antioxidant responseJ Tyson McDonald
Division of Molecular and Cellular Oncology, Department of Radiation Oncology, and Pasarow Mass Spectrometry Laboratory, David Geffen School of Medicine at University of California, Los Angeles, California 90095 1714, USA
Cancer Res 70:8886-95. 2010....
- High throughput screening of small molecule libraries for modifiers of radiation responsesKwanghee Kim
Department of Radiation Oncology, University of California at Los Angeles UCLA, Los Angeles, California 90095 1714, USA
Int J Radiat Biol 87:839-45. 2011..Selected compounds within these initial verified hits from both types of libraries identified potent mitigators of lethal whole body irradiation (WBI) in mice...