Andrew J Norris

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint A novel mass spectrometric assay for the cerebroside sulfate activator protein (saposin B) and arylsulfatase A
    Andrew J Norris
    Pasarow Mass Spectrometry Laboratory, Department of Psychiatry, and Neuropsychiatric Institute, University of California Los Angeles, Los Angeles, CA 90024, USA
    J Lipid Res 46:2254-64. 2005
  2. ncbi request reprint Nitroxyl inhibits breast tumor growth and angiogenesis
    Andrew J Norris
    Surgical Oncology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Int J Cancer 122:1905-10. 2008
  3. ncbi request reprint Targeted inhibition of EG-1 blocks breast tumor growth
    Ming Lu
    University of California, Los Angeles School of Medicine, Department of Surgery, Division of Oncology, Los Angeles, California, USA
    Cancer Biol Ther 6:936-41. 2007
  4. ncbi request reprint Boric acid inhibits adenosine diphosphate-ribosyl cyclase non-competitively
    Danny H Kim
    Department of Environmental Health Sciences, Box 951772, University of California, 650 Charles E Young Dr South, Los Angeles, CA 90095 1772, USA
    J Chromatogr A 1115:246-52. 2006
  5. ncbi request reprint Inhibition kinetics of carba- and C-fucosyl analogues of GDP-fucose against fucosyltransferase V: implication for the reaction mechanism
    Andrew J Norris
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Bioorg Med Chem Lett 14:571-3. 2004
  6. ncbi request reprint Borate-nucleotide complex formation depends on charge and phosphorylation state
    Danny H Kim
    Department of Environmental Health Sciences, University of California, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    J Mass Spectrom 39:743-51. 2004
  7. ncbi request reprint EG-1 interacts with c-Src and activates its signaling pathway
    Ming Lu
    Department of Surgery, Division of Oncology, UCLA School of Medicine, Los Angeles, CA, USA
    Int J Oncol 29:1013-8. 2006
  8. pmc Ionizing radiation activates the Nrf2 antioxidant response
    J Tyson McDonald
    Division of Molecular and Cellular Oncology, Department of Radiation Oncology, and Pasarow Mass Spectrometry Laboratory, David Geffen School of Medicine at University of California, Los Angeles, California 90095 1714, USA
    Cancer Res 70:8886-95. 2010
  9. pmc High throughput screening of small molecule libraries for modifiers of radiation responses
    Kwanghee Kim
    Department of Radiation Oncology, University of California at Los Angeles UCLA, Los Angeles, California 90095 1714, USA
    Int J Radiat Biol 87:839-45. 2011

Collaborators

Detail Information

Publications9

  1. ncbi request reprint A novel mass spectrometric assay for the cerebroside sulfate activator protein (saposin B) and arylsulfatase A
    Andrew J Norris
    Pasarow Mass Spectrometry Laboratory, Department of Psychiatry, and Neuropsychiatric Institute, University of California Los Angeles, Los Angeles, CA 90024, USA
    J Lipid Res 46:2254-64. 2005
    ..The modified assay for the coupled ASA/CSAct reaction could find applicability in settings in which the assay could not be performed previously because of the need for radiolabeled substrate, which is now not required...
  2. ncbi request reprint Nitroxyl inhibits breast tumor growth and angiogenesis
    Andrew J Norris
    Surgical Oncology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Int J Cancer 122:1905-10. 2008
    ..Therefore, HNO appears to act via mechanism(s) different from those of existing breast cancer drugs, making it a potential candidate to overcome known and emerging drug resistance pathways...
  3. ncbi request reprint Targeted inhibition of EG-1 blocks breast tumor growth
    Ming Lu
    University of California, Los Angeles School of Medicine, Department of Surgery, Division of Oncology, Los Angeles, California, USA
    Cancer Biol Ther 6:936-41. 2007
    ..These observations demonstrate that EG-1 is relevant to human breast cancer, and is a molecular target worthy of translational efforts into effective breast cancer therapy...
  4. ncbi request reprint Boric acid inhibits adenosine diphosphate-ribosyl cyclase non-competitively
    Danny H Kim
    Department of Environmental Health Sciences, Box 951772, University of California, 650 Charles E Young Dr South, Los Angeles, CA 90095 1772, USA
    J Chromatogr A 1115:246-52. 2006
    ..5+/-0.5 mM. Boric acid binding to cADPR, determined by electrospray ionization mass spectrometry, was characterized by an apparent binding constant, KA, of 655+/-99 L/mol at pH 10.3...
  5. ncbi request reprint Inhibition kinetics of carba- and C-fucosyl analogues of GDP-fucose against fucosyltransferase V: implication for the reaction mechanism
    Andrew J Norris
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Bioorg Med Chem Lett 14:571-3. 2004
    ..1+/-9.8 microM, similar to the K(m) value for GDP-Fuc (50.4+/-5.5 microM), while the C-Fuc analogue exhibited significantly weak competitive inhibition with a K(i) value of 889+/-93 microM...
  6. ncbi request reprint Borate-nucleotide complex formation depends on charge and phosphorylation state
    Danny H Kim
    Department of Environmental Health Sciences, University of California, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    J Mass Spectrom 39:743-51. 2004
    ..At pH 7.4, using ammonium bicarbonate buffer, only borate-NAD(+) complex was observed. This indicates that the borate-NAD(+) complex may be the most physiologically relevant of those studied...
  7. ncbi request reprint EG-1 interacts with c-Src and activates its signaling pathway
    Ming Lu
    Department of Surgery, Division of Oncology, UCLA School of Medicine, Los Angeles, CA, USA
    Int J Oncol 29:1013-8. 2006
    ..Furthermore, EG-1 shows interaction with multiple other SH3- and WW-containing molecules involved in various signaling pathways. These observations suggest that EG-1 may be involved in signaling pathways including c-Src activation...
  8. pmc Ionizing radiation activates the Nrf2 antioxidant response
    J Tyson McDonald
    Division of Molecular and Cellular Oncology, Department of Radiation Oncology, and Pasarow Mass Spectrometry Laboratory, David Geffen School of Medicine at University of California, Los Angeles, California 90095 1714, USA
    Cancer Res 70:8886-95. 2010
    ....
  9. pmc High throughput screening of small molecule libraries for modifiers of radiation responses
    Kwanghee Kim
    Department of Radiation Oncology, University of California at Los Angeles UCLA, Los Angeles, California 90095 1714, USA
    Int J Radiat Biol 87:839-45. 2011
    ..Selected compounds within these initial verified hits from both types of libraries identified potent mitigators of lethal whole body irradiation (WBI) in mice...