Research Topics
Species | Anthony NormanSummaryAffiliation: University of California Country: USA Publications
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Publications
13th Workshop consensus for vitamin D nutritional guidelinesAnthony W Norman
Department of Biochemistry and Division of Biomedical Sciences, 5456 Boyce Hall, University of California-Riverside, Riverside, CA 92521, USA
J Steroid Biochem Mol Biol 103:204-5. 2007
Steroid-hormone rapid actions, membrane receptors and a conformational ensemble modelAnthony W Norman
Department of Biochemistry, University of California, Riverside, California 92521, USA
Nat Rev Drug Discov 3:27-41. 2004- From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good healthAnthony W Norman
Department of Biochemistry and Division of Biomedical Sciences, University of California, Riverside, CA, USA
Am J Clin Nutr 88:491S-499S. 2008.... - Ligand structure-function relationships in the vitamin D endocrine system from the perspective of drug development (including cancer treatment)Anthony W Norman
Department of Biochemistry, Biomedical Sciences, University of California, Riverside, CA 92521, USA
Recent Results Cancer Res 164:55-82. 2003.... - Update on biological actions of 1alpha,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3Anthony W Norman
Department of Biochemistry, University of California, Riverside, CA 92521, USA
Mol Cell Endocrinol 197:1-13. 2002..This report summarizes the status of several current research frontiers in this arena of the vitamin D endocrine system... - A specific binding protein/receptor for 1alpha,25-dihydroxyvitamin D(3) is present in an intestinal caveolae membrane fractionAnthony W Norman
Department of Biochemistry, University of California, Riverside, CA 92521, USA
Biochem Biophys Res Commun 298:414-9. 2002..Therefore, chick CMF may represent a good source for isolation and characterization of the putative VDR(mem) for 1alpha,25(OH)(2)D(3)... 
Vitamin D nutritional policy needs a vision for the futureAnthony W Norman
Department of Biochemistry and Division of Biomedical Sciences, University of California, Riverside, CA 92521, USA
Exp Biol Med (Maywood) 235:1034-45. 2010....- Minireview: vitamin D receptor: new assignments for an already busy receptorAnthony W Norman
Department of Biochemistry and Biomedical Sciences, University of California, Riverside, California 92506, USA
Endocrinology 147:5542-8. 2006.... - Applications of the Vitamin D sterol-Vitamin D receptor (VDR) conformational ensemble modelMathew T Mizwicki
Department of Biochemistry, University of California, Riverside, CA 92521, USA
Steroids 70:464-71. 2005..In addition, evidence that the model is consistent with the pH requirement for Vitamin D sterol-VDR crystallization will be presented... - The vitamin D receptor is present in caveolae-enriched plasma membranes and binds 1 alpha,25(OH)2-vitamin D3 in vivo and in vitroJohanna A Huhtakangas
Department of Biochemistry, University of California, Riverside, California 92521, USA
Mol Endocrinol 18:2660-71. 2004..This study supports the presence of VDR as the 1,25D-binding protein associated with plasma membrane caveolae... - A perspective on how the Vitamin D sterol/Vitamin D receptor (VDR) conformational ensemble model can potentially be used to understand the structure-function results of A-ring modified Vitamin D sterolsMathew T Mizwicki
Department of Biochemistry, University of California, Riverside, CA 92521, USA
J Steroid Biochem Mol Biol 97:69-82. 2005.... - 1alpha,25(OH)2 vitamin D3 actions on ion channels in osteoblastsLaura P Zanello
Department of Biochemistry, University of California, Riverside, 92521, USA
Steroids 71:291-7. 2006..Rapid 1,25D actions on Cl(-) and Ca(2+) currents seem to couple to secretory activities in osteoblasts, thus contributing to bone mass formation... - The vitamin D sterol-vitamin D receptor ensemble model offers unique insights into both genomic and rapid-response signalingMathew T Mizwicki
Department of Biochemistry, University of California, Riverside, CA 92521, USA
Sci Signal 2:re4. 2009..We also discuss how these three factors collectively provide a rational explanation for the complexities of VDS regulation of cell biology and highlight the current limitations of the model... - On the mechanism underlying (23S)-25-dehydro-1alpha(OH)-vitamin D3-26,23-lactone antagonism of hVDRwt gene activation and its switch to a superagonistMathew T Mizwicki
Department of Biochemistry, University of California, Riverside, California 92521, USA
J Biol Chem 284:36292-301. 2009..Finally, the results/model generated, coupled with application of a VDR ensemble allosterics model, provide an understanding for the species specificity of MK... - 1alpha,25(OH)2-Vitamin D3 stimulation of secretion via chloride channel activation in Sertoli cellsDanusa Menegaz
Department of Biochemistry, University of California, 900 University Ave, Riverside, CA 92521, USA
J Steroid Biochem Mol Biol 119:127-34. 2010..We conclude that 1,25(OH)2-D3 appears to be a modulator of male reproductive functions at least in part by stimulating Sertoli cell secretory functions... - Rapid modulation of osteoblast ion channel responses by 1alpha,25(OH)2-vitamin D3 requires the presence of a functional vitamin D nuclear receptorLaura P Zanello
Department of Biochemistry, University of California, Riverside, CA 92521
Proc Natl Acad Sci U S A 101:1589-94. 2004..This is a demonstration of the requirement of a functional classic steroid receptor for the rapid hormonal modulation of electric currents linked to secretory activities in a target cell... - Synthesis and NMR studies of (13)C-labeled vitamin D metabolitesWilliam H Okamura
Department of Chemistry, University of California, Riverside, California 92521, USA
J Org Chem 67:1637-50. 2002.... - Electrical responses to 1alpha,25(OH)2-Vitamin D3 and their physiological significance in osteoblastsLaura P Zanello
Department of Biochemistry, University of California, Riverside, CA 92521, USA
Steroids 69:561-5. 2004..The absence of both 1,25D3 membrane and nuclear effects in VDR KO osteoblasts may explain bone abnormalities typically found in VDR KO mice... - A molecular description of ligand binding to the two overlapping binding pockets of the nuclear vitamin D receptor (VDR): structure-function implicationsMathew T Mizwicki
Department of Biochemistry, University of California, 5470 Boyce Hall, Riverside, CA 92521, USA
J Steroid Biochem Mol Biol 121:98-105. 2010.... - Presence of a truncated form of the vitamin D receptor (VDR) in a strain of VDR-knockout miceCraig M Bula
Department of Biochemistry, University of California Riverside, 92521, USA
Endocrinology 146:5581-6. 2005..Thus, we have determined that this widely used strain of the VDR-KO mouse can express a form of the VDR that can bind ligand but not activate gene transcription... - Multiple molecular mechanisms of 1 alpha,25(OH)2-vitamin D3 rapid modulation of three ion channel activities in osteoblastsLaura P Zanello
Department of Biochemistry, University of California, Riverside, CA 92521, USA
Bone 33:71-9. 2003..8 cells occur through multiple mechanisms that, on the one hand, involve a possible direct interaction with the L-type Ca(2+) channel molecule and, on the other hand, molecular pathways that may include a putative membrane receptor... - Molecular tools for study of genomic and rapid signal transduction responses initiated by 1 alpha,25(OH)(2)-vitamin D(3)Anthony W Norman
Department of Biochemistry, University of California, Riverside, CA 92521, USA
Steroids 67:457-66. 2002..In conclusion, we have presented evidence that 1 alpha,25(OH)(2)D(3) mediated rapid response and genomic response signal transduction pathways utilize differing shapes of ligand, both as agonists and antagonists... - Two key proteins of the vitamin D endocrine system come into crystal clear focus: comparison of the X-ray structures of the nuclear receptor for 1alpha,25(OH)2 vitamin D3, the plasma vitamin D binding protein, and their ligandsMathew T Mizwicki
Department of Biochemistry, University of California, Riverside, California 92521, USA
J Bone Miner Res 18:795-806. 2003 - Evidence that annexin II is not a putative membrane receptor for 1alpha,25(OH)2-vitamin D3Mathew T Mizwicki
Department of Biochemistry, University of California, Riverside California 92521, USA
J Cell Biochem 91:852-63. 2004.... - Characterization of five 19-nor-analogs of 1alpha,25(OH)2-Vitamin D3 with 20-cyclopropyl-modified side-chains: implications for ligand binding and calcemic propertiesChristopher J Olivera
Department of Biochemistry, University of California, Riverside, CA 92521, USA
J Steroid Biochem Mol Biol 89:99-106. 2004.... - Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signalingMathew T Mizwicki
Department of Biochemistry, University of California, Riverside, CA 92521, USA
Proc Natl Acad Sci U S A 101:12876-81. 2004.... - New insights into Vitamin D sterol-VDR proteolysis, allostery, structure-function from the perspective of a conformational ensemble modelMathew T Mizwicki
Department of Biochemistry, University of California Riverside, Riverside, CA 92521, USA
J Steroid Biochem Mol Biol 103:243-62. 2007.... - Conservative mutageneic perturbations of amino acids connecting helix 12 in the 1alpha,25(OH)2-D3 receptor (VDR) to the ligand cause significant transactivational effectsCraig M Bula
Department of Biochemistry, University of California Riverside, Riverside, CA 92521, USA
J Steroid Biochem Mol Biol 103:286-92. 2007..Importantly, the V418 location may accommodate larger sidechains and may even enhance the interaction with specific nuclear coactivators... - Molecular mechanism of the vitamin D antagonistic actions of (23S)-25-dehydro-1alpha-hydroxyvitamin D3-26,23-lactone depends on the primary structure of the carboxyl-terminal region of the vitamin d receptorEiji Ochiai
Department of Biochemistry, University of California-Riverside, Riverside, CA 92521, USA
Mol Endocrinol 19:1147-57. 2005.... - Prolactin blocks nuclear translocation of VDR by regulating its interaction with BRCA1 in osteosarcoma cellsChanghui Deng
Division of Biomedical Sciences, University of California, Riverside, California 92521, USA
Mol Endocrinol 23:226-36. 2009..This, to our knowledge, is the first demonstration of a role for BRCA1 in nuclear accumulation of a steroid hormone and the first demonstration that PRL has the potential to affect the cell cycle through effects on BRCA1... - Vitamin D receptor (VDR) regulation of voltage-gated chloride channels by ligands preferring a VDR-alternative pocket (VDR-AP)Danusa Menegaz
Department of Biochemistry, University of California, Riverside, California 92521, USA
Mol Endocrinol 25:1289-300. 2011..The fact that 25D3 is equipotent to 1,25D3 in opening ORCC suggests that reconsideration of the ability of 25D3 to generate biological responses in vivo may be in order... - The urgent need to recommend an intake of vitamin D that is effectiveReinhold Vieth
Am J Clin Nutr 85:649-50. 2007 - Evidence for distinct membrane receptors for 1 alpha,25-(OH)(2)D(3) and 24R,25-(OH)(2)D(3) in osteoblastsBarbara D Boyan
Department of Orthopaedics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Steroids 67:235-46. 2002..These results demonstrate that response to 1 alpha,25-(OH)(2)D(3) and 24R,25-(OH)(2)D(3) depends on osteoblast maturation state and suggest that specific and distinct membrane receptors are involved... - 1alpha,25-dihydroxyvitamin D3 inhibits uncoupling protein 2 expression in human adipocytesHang Shi
University of Tennessee, Knoxville, Tennessee 37996, USA
FASEB J 16:1808-10. 2002..Thus, suppression of 1alpha,25-(OH)2-D3 and consequent up-regulation of UCP2 may contribute to our previous observation of increased thermogenesis in mice fed with high calcium diets... - Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinasesAnthony M Vertino
Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
J Biol Chem 280:14130-7. 2005.... - Effect of 25-hydroxyl group orientation on biological activity and binding to the 1alpha,25-dihydroxy vitamin D3 receptorElaine D Collins
Department of Chemistry, San Jose State University, San Jose, CA 95192, USA
J Steroid Biochem Mol Biol 94:279-88. 2005..The 25-hydroxyl orientation combined with the 16,17-ene functionality of analog LA enhances its ability to interact with VDR and induce biological actions... - The antagonism between 2-methyl-1,25-dihydroxyvitamin D3 and 2-methyl-20-epi-1,25-dihydroxyvitamin D3 in non-genomic pathway-mediated biological responses induced by 1alpha,25-dihydroxyvitamin D3 assessed by NB4 cell differentiationDaishiro Miura
Teijin Institute for Bio-Medical Research, Teijin Pharma Ltd, 4-3-2 Asahigaoka, Hino, Tokyo 191-8512, Japan
J Steroid Biochem Mol Biol 94:469-79. 2005..Further examination to elucidate the relationship between the altered ligand shape and receptors interaction will be important for molecular level understanding of the mechanism of antagonism of the non-genomic pathway... - NIH deltanoids meeting on Vitamin D and cancer. Conclusion and strategic optionsRoger Bouillon
Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
J Steroid Biochem Mol Biol 97:3-5. 2005..In the mean time, the public should be informed about the risks of vitamin D deficiency and insufficiency and appropriate steps should be taken to improve the vitamin D nutritional status of large parts of the world population... - Proceedings of the Fifth International Meeting on Rapid Responses to Steroid HormonesBrian Harvey
Royal College of Surgeons, Ireland
Steroids 73:851-2. 2008 - Vitamin D deficiencyRoger Bouillon
N Engl J Med 357:1980-1; author reply 1981-2. 2007 - Novel Gemini analogs of 1alpha,25-dihydroxyvitamin D(3) with enhanced transcriptional activityFranci A Weyts
Department of Biochemistry and Molecular Biology UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA
Biochem Pharmacol 67:1327-36. 2004..We conclude that enhanced potency of the novel Gemini analogs is at least partly due to increased metabolic stability of the analogs, resulting in more cofactor binding and elevated levels of transcription... - 1alpha,25-dihydroxyvitamin D3 induces vascular smooth muscle cell migration via activation of phosphatidylinositol 3-kinaseMichela C Rebsamen
Vascular Medicine Research, Brigham and Women's Hospital and Harvard Medical School, Cambridge, Mass 02139, USA
Circ Res 91:17-24. 2002.... - Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in breast cancer cellsIda Stenfeldt Mathiasen
Apoptosis Laboratory, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
J Biol Chem 277:30738-45. 2002..Thus, these compounds may prove useful in the treatment of tumors resistant to therapeutic agents dependent on the classical caspase cascade... - IFN-gamma- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37Adrian R Martineau
Wellcome Trust Center for Research in Clinical Tropical Medicine, Division of Medicine, Wright Fleming Institute, Imperial College London, United Kingdom
J Immunol 178:7190-8. 2007..7%. These findings suggest that vitamin D contributes to protection against TB by "nonclassical" mechanisms that include the induction of antimicrobial peptides...
Research Grants
- STUDIES ON VITAMIN D AND CALCIUM METABOLISMAnthony Norman; Fiscal Year: 2007....
- STUDIES ON VITAMIN D AND CALCIUM METABOLISMAnthony Norman; Fiscal Year: 2005..This may allow specific therapeutic intervention (e.g. type 1 diabetes, leukemia cancer control, psoriasis, immune disorders or osteoporosis) without hypercalcemia. ..