Anthony Norman

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc 13th Workshop consensus for vitamin D nutritional guidelines
    Anthony W Norman
    Department of Biochemistry and Division of Biomedical Sciences, 5456 Boyce Hall, University of California Riverside, Riverside, CA 92521, USA
    J Steroid Biochem Mol Biol 103:204-5. 2007
  2. ncbi request reprint Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model
    Anthony W Norman
    Department of Biochemistry, University of California, Riverside, California 92521, USA
    Nat Rev Drug Discov 3:27-41. 2004
  3. ncbi request reprint From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health
    Anthony W Norman
    Department of Biochemistry and Division of Biomedical Sciences, University of California, Riverside, CA, USA
    Am J Clin Nutr 88:491S-499S. 2008
  4. ncbi request reprint Ligand structure-function relationships in the vitamin D endocrine system from the perspective of drug development (including cancer treatment)
    Anthony W Norman
    Department of Biochemistry, Biomedical Sciences, University of California, Riverside, CA 92521, USA
    Recent Results Cancer Res 164:55-82. 2003
  5. ncbi request reprint Update on biological actions of 1alpha,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3
    Anthony W Norman
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Mol Cell Endocrinol 197:1-13. 2002
  6. ncbi request reprint A specific binding protein/receptor for 1alpha,25-dihydroxyvitamin D(3) is present in an intestinal caveolae membrane fraction
    Anthony W Norman
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Biochem Biophys Res Commun 298:414-9. 2002
  7. doi request reprint Vitamin D nutritional policy needs a vision for the future
    Anthony W Norman
    Department of Biochemistry and Division of Biomedical Sciences, University of California, Riverside, CA 92521, USA
    Exp Biol Med (Maywood) 235:1034-45. 2010
  8. ncbi request reprint Minireview: vitamin D receptor: new assignments for an already busy receptor
    Anthony W Norman
    Department of Biochemistry and Biomedical Sciences, University of California, Riverside, California 92506, USA
    Endocrinology 147:5542-8. 2006
  9. ncbi request reprint Applications of the Vitamin D sterol-Vitamin D receptor (VDR) conformational ensemble model
    Mathew T Mizwicki
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Steroids 70:464-71. 2005
  10. ncbi request reprint The vitamin D receptor is present in caveolae-enriched plasma membranes and binds 1 alpha,25(OH)2-vitamin D3 in vivo and in vitro
    Johanna A Huhtakangas
    Department of Biochemistry, University of California, Riverside, California 92521, USA
    Mol Endocrinol 18:2660-71. 2004

Research Grants

  1. STUDIES ON VITAMIN D AND CALCIUM METABOLISM
    Anthony Norman; Fiscal Year: 2007
  2. STUDIES ON VITAMIN D AND CALCIUM METABOLISM
    Anthony Norman; Fiscal Year: 2005

Collaborators

Detail Information

Publications44

  1. pmc 13th Workshop consensus for vitamin D nutritional guidelines
    Anthony W Norman
    Department of Biochemistry and Division of Biomedical Sciences, 5456 Boyce Hall, University of California Riverside, Riverside, CA 92521, USA
    J Steroid Biochem Mol Biol 103:204-5. 2007
  2. ncbi request reprint Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model
    Anthony W Norman
    Department of Biochemistry, University of California, Riverside, California 92521, USA
    Nat Rev Drug Discov 3:27-41. 2004
  3. ncbi request reprint From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health
    Anthony W Norman
    Department of Biochemistry and Division of Biomedical Sciences, University of California, Riverside, CA, USA
    Am J Clin Nutr 88:491S-499S. 2008
    ....
  4. ncbi request reprint Ligand structure-function relationships in the vitamin D endocrine system from the perspective of drug development (including cancer treatment)
    Anthony W Norman
    Department of Biochemistry, Biomedical Sciences, University of California, Riverside, CA 92521, USA
    Recent Results Cancer Res 164:55-82. 2003
    ....
  5. ncbi request reprint Update on biological actions of 1alpha,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3
    Anthony W Norman
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Mol Cell Endocrinol 197:1-13. 2002
    ..This report summarizes the status of several current research frontiers in this arena of the vitamin D endocrine system...
  6. ncbi request reprint A specific binding protein/receptor for 1alpha,25-dihydroxyvitamin D(3) is present in an intestinal caveolae membrane fraction
    Anthony W Norman
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Biochem Biophys Res Commun 298:414-9. 2002
    ..Therefore, chick CMF may represent a good source for isolation and characterization of the putative VDR(mem) for 1alpha,25(OH)(2)D(3)...
  7. doi request reprint Vitamin D nutritional policy needs a vision for the future
    Anthony W Norman
    Department of Biochemistry and Division of Biomedical Sciences, University of California, Riverside, CA 92521, USA
    Exp Biol Med (Maywood) 235:1034-45. 2010
    ....
  8. ncbi request reprint Minireview: vitamin D receptor: new assignments for an already busy receptor
    Anthony W Norman
    Department of Biochemistry and Biomedical Sciences, University of California, Riverside, California 92506, USA
    Endocrinology 147:5542-8. 2006
    ....
  9. ncbi request reprint Applications of the Vitamin D sterol-Vitamin D receptor (VDR) conformational ensemble model
    Mathew T Mizwicki
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Steroids 70:464-71. 2005
    ..In addition, evidence that the model is consistent with the pH requirement for Vitamin D sterol-VDR crystallization will be presented...
  10. ncbi request reprint The vitamin D receptor is present in caveolae-enriched plasma membranes and binds 1 alpha,25(OH)2-vitamin D3 in vivo and in vitro
    Johanna A Huhtakangas
    Department of Biochemistry, University of California, Riverside, California 92521, USA
    Mol Endocrinol 18:2660-71. 2004
    ..This study supports the presence of VDR as the 1,25D-binding protein associated with plasma membrane caveolae...
  11. ncbi request reprint A perspective on how the Vitamin D sterol/Vitamin D receptor (VDR) conformational ensemble model can potentially be used to understand the structure-function results of A-ring modified Vitamin D sterols
    Mathew T Mizwicki
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    J Steroid Biochem Mol Biol 97:69-82. 2005
    ....
  12. ncbi request reprint 1alpha,25(OH)2 vitamin D3 actions on ion channels in osteoblasts
    Laura P Zanello
    Department of Biochemistry, University of California, Riverside, 92521, USA
    Steroids 71:291-7. 2006
    ..Rapid 1,25D actions on Cl(-) and Ca(2+) currents seem to couple to secretory activities in osteoblasts, thus contributing to bone mass formation...
  13. doi request reprint The vitamin D sterol-vitamin D receptor ensemble model offers unique insights into both genomic and rapid-response signaling
    Mathew T Mizwicki
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Sci Signal 2:re4. 2009
    ..We also discuss how these three factors collectively provide a rational explanation for the complexities of VDS regulation of cell biology and highlight the current limitations of the model...
  14. pmc On the mechanism underlying (23S)-25-dehydro-1alpha(OH)-vitamin D3-26,23-lactone antagonism of hVDRwt gene activation and its switch to a superagonist
    Mathew T Mizwicki
    Department of Biochemistry, University of California, Riverside, California 92521, USA
    J Biol Chem 284:36292-301. 2009
    ..Finally, the results/model generated, coupled with application of a VDR ensemble allosterics model, provide an understanding for the species specificity of MK...
  15. doi request reprint 1alpha,25(OH)2-Vitamin D3 stimulation of secretion via chloride channel activation in Sertoli cells
    Danusa Menegaz
    Department of Biochemistry, University of California, 900 University Ave, Riverside, CA 92521, USA
    J Steroid Biochem Mol Biol 119:127-34. 2010
    ..We conclude that 1,25(OH)2-D3 appears to be a modulator of male reproductive functions at least in part by stimulating Sertoli cell secretory functions...
  16. pmc Rapid modulation of osteoblast ion channel responses by 1alpha,25(OH)2-vitamin D3 requires the presence of a functional vitamin D nuclear receptor
    Laura P Zanello
    Department of Biochemistry, University of California, Riverside, CA 92521
    Proc Natl Acad Sci U S A 101:1589-94. 2004
    ..This is a demonstration of the requirement of a functional classic steroid receptor for the rapid hormonal modulation of electric currents linked to secretory activities in a target cell...
  17. ncbi request reprint Synthesis and NMR studies of (13)C-labeled vitamin D metabolites
    William H Okamura
    Department of Chemistry, University of California, Riverside, California 92521, USA
    J Org Chem 67:1637-50. 2002
    ....
  18. ncbi request reprint Electrical responses to 1alpha,25(OH)2-Vitamin D3 and their physiological significance in osteoblasts
    Laura P Zanello
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Steroids 69:561-5. 2004
    ..The absence of both 1,25D3 membrane and nuclear effects in VDR KO osteoblasts may explain bone abnormalities typically found in VDR KO mice...
  19. pmc A molecular description of ligand binding to the two overlapping binding pockets of the nuclear vitamin D receptor (VDR): structure-function implications
    Mathew T Mizwicki
    Department of Biochemistry, University of California, 5470 Boyce Hall, Riverside, CA 92521, USA
    J Steroid Biochem Mol Biol 121:98-105. 2010
    ....
  20. ncbi request reprint Presence of a truncated form of the vitamin D receptor (VDR) in a strain of VDR-knockout mice
    Craig M Bula
    Department of Biochemistry, University of California Riverside, 92521, USA
    Endocrinology 146:5581-6. 2005
    ..Thus, we have determined that this widely used strain of the VDR-KO mouse can express a form of the VDR that can bind ligand but not activate gene transcription...
  21. ncbi request reprint Multiple molecular mechanisms of 1 alpha,25(OH)2-vitamin D3 rapid modulation of three ion channel activities in osteoblasts
    Laura P Zanello
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Bone 33:71-9. 2003
    ..8 cells occur through multiple mechanisms that, on the one hand, involve a possible direct interaction with the L-type Ca(2+) channel molecule and, on the other hand, molecular pathways that may include a putative membrane receptor...
  22. ncbi request reprint Molecular tools for study of genomic and rapid signal transduction responses initiated by 1 alpha,25(OH)(2)-vitamin D(3)
    Anthony W Norman
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Steroids 67:457-66. 2002
    ..In conclusion, we have presented evidence that 1 alpha,25(OH)(2)D(3) mediated rapid response and genomic response signal transduction pathways utilize differing shapes of ligand, both as agonists and antagonists...
  23. ncbi request reprint Two key proteins of the vitamin D endocrine system come into crystal clear focus: comparison of the X-ray structures of the nuclear receptor for 1alpha,25(OH)2 vitamin D3, the plasma vitamin D binding protein, and their ligands
    Mathew T Mizwicki
    Department of Biochemistry, University of California, Riverside, California 92521, USA
    J Bone Miner Res 18:795-806. 2003
  24. ncbi request reprint Evidence that annexin II is not a putative membrane receptor for 1alpha,25(OH)2-vitamin D3
    Mathew T Mizwicki
    Department of Biochemistry, University of California, Riverside California 92521, USA
    J Cell Biochem 91:852-63. 2004
    ....
  25. ncbi request reprint Characterization of five 19-nor-analogs of 1alpha,25(OH)2-Vitamin D3 with 20-cyclopropyl-modified side-chains: implications for ligand binding and calcemic properties
    Christopher J Olivera
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    J Steroid Biochem Mol Biol 89:99-106. 2004
    ....
  26. pmc Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signaling
    Mathew T Mizwicki
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 101:12876-81. 2004
    ....
  27. pmc New insights into Vitamin D sterol-VDR proteolysis, allostery, structure-function from the perspective of a conformational ensemble model
    Mathew T Mizwicki
    Department of Biochemistry, University of California Riverside, Riverside, CA 92521, USA
    J Steroid Biochem Mol Biol 103:243-62. 2007
    ....
  28. pmc Conservative mutageneic perturbations of amino acids connecting helix 12 in the 1alpha,25(OH)2-D3 receptor (VDR) to the ligand cause significant transactivational effects
    Craig M Bula
    Department of Biochemistry, University of California Riverside, Riverside, CA 92521, USA
    J Steroid Biochem Mol Biol 103:286-92. 2007
    ..Importantly, the V418 location may accommodate larger sidechains and may even enhance the interaction with specific nuclear coactivators...
  29. ncbi request reprint Molecular mechanism of the vitamin D antagonistic actions of (23S)-25-dehydro-1alpha-hydroxyvitamin D3-26,23-lactone depends on the primary structure of the carboxyl-terminal region of the vitamin d receptor
    Eiji Ochiai
    Department of Biochemistry, University of California Riverside, Riverside, CA 92521, USA
    Mol Endocrinol 19:1147-57. 2005
    ....
  30. doi request reprint Prolactin blocks nuclear translocation of VDR by regulating its interaction with BRCA1 in osteosarcoma cells
    Changhui Deng
    Division of Biomedical Sciences, University of California, Riverside, California 92521, USA
    Mol Endocrinol 23:226-36. 2009
    ..This, to our knowledge, is the first demonstration of a role for BRCA1 in nuclear accumulation of a steroid hormone and the first demonstration that PRL has the potential to affect the cell cycle through effects on BRCA1...
  31. pmc Vitamin D receptor (VDR) regulation of voltage-gated chloride channels by ligands preferring a VDR-alternative pocket (VDR-AP)
    Danusa Menegaz
    Department of Biochemistry, University of California, Riverside, California 92521, USA
    Mol Endocrinol 25:1289-300. 2011
    ..The fact that 25D3 is equipotent to 1,25D3 in opening ORCC suggests that reconsideration of the ability of 25D3 to generate biological responses in vivo may be in order...
  32. ncbi request reprint The urgent need to recommend an intake of vitamin D that is effective
    Reinhold Vieth
    Am J Clin Nutr 85:649-50. 2007
  33. ncbi request reprint Evidence for distinct membrane receptors for 1 alpha,25-(OH)(2)D(3) and 24R,25-(OH)(2)D(3) in osteoblasts
    Barbara D Boyan
    Department of Orthopaedics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Steroids 67:235-46. 2002
    ..These results demonstrate that response to 1 alpha,25-(OH)(2)D(3) and 24R,25-(OH)(2)D(3) depends on osteoblast maturation state and suggest that specific and distinct membrane receptors are involved...
  34. ncbi request reprint 1alpha,25-dihydroxyvitamin D3 inhibits uncoupling protein 2 expression in human adipocytes
    Hang Shi
    University of Tennessee, Knoxville, Tennessee 37996, USA
    FASEB J 16:1808-10. 2002
    ..Thus, suppression of 1alpha,25-(OH)2-D3 and consequent up-regulation of UCP2 may contribute to our previous observation of increased thermogenesis in mice fed with high calcium diets...
  35. ncbi request reprint Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases
    Anthony M Vertino
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 280:14130-7. 2005
    ....
  36. ncbi request reprint Effect of 25-hydroxyl group orientation on biological activity and binding to the 1alpha,25-dihydroxy vitamin D3 receptor
    Elaine D Collins
    Department of Chemistry, San Jose State University, San Jose, CA 95192, USA
    J Steroid Biochem Mol Biol 94:279-88. 2005
    ..The 25-hydroxyl orientation combined with the 16,17-ene functionality of analog LA enhances its ability to interact with VDR and induce biological actions...
  37. ncbi request reprint The antagonism between 2-methyl-1,25-dihydroxyvitamin D3 and 2-methyl-20-epi-1,25-dihydroxyvitamin D3 in non-genomic pathway-mediated biological responses induced by 1alpha,25-dihydroxyvitamin D3 assessed by NB4 cell differentiation
    Daishiro Miura
    Teijin Institute for Bio Medical Research, Teijin Pharma Ltd, 4 3 2 Asahigaoka, Hino, Tokyo 191 8512, Japan
    J Steroid Biochem Mol Biol 94:469-79. 2005
    ..Further examination to elucidate the relationship between the altered ligand shape and receptors interaction will be important for molecular level understanding of the mechanism of antagonism of the non-genomic pathway...
  38. ncbi request reprint NIH deltanoids meeting on Vitamin D and cancer. Conclusion and strategic options
    Roger Bouillon
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 97:3-5. 2005
    ..In the mean time, the public should be informed about the risks of vitamin D deficiency and insufficiency and appropriate steps should be taken to improve the vitamin D nutritional status of large parts of the world population...
  39. doi request reprint Proceedings of the Fifth International Meeting on Rapid Responses to Steroid Hormones
    Brian Harvey
    Royal College of Surgeons, Ireland
    Steroids 73:851-2. 2008
  40. ncbi request reprint Vitamin D deficiency
    Roger Bouillon
    N Engl J Med 357:1980-1; author reply 1981-2. 2007
  41. ncbi request reprint Novel Gemini analogs of 1alpha,25-dihydroxyvitamin D(3) with enhanced transcriptional activity
    Franci A Weyts
    Department of Biochemistry and Molecular Biology UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Biochem Pharmacol 67:1327-36. 2004
    ..We conclude that enhanced potency of the novel Gemini analogs is at least partly due to increased metabolic stability of the analogs, resulting in more cofactor binding and elevated levels of transcription...
  42. ncbi request reprint 1alpha,25-dihydroxyvitamin D3 induces vascular smooth muscle cell migration via activation of phosphatidylinositol 3-kinase
    Michela C Rebsamen
    Vascular Medicine Research, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Mass 02139, USA
    Circ Res 91:17-24. 2002
    ....
  43. ncbi request reprint Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in breast cancer cells
    Ida Stenfeldt Mathiasen
    Apoptosis Laboratory, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    J Biol Chem 277:30738-45. 2002
    ..Thus, these compounds may prove useful in the treatment of tumors resistant to therapeutic agents dependent on the classical caspase cascade...
  44. ncbi request reprint IFN-gamma- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37
    Adrian R Martineau
    Wellcome Trust Center for Research in Clinical Tropical Medicine, Division of Medicine, Wright Fleming Institute, Imperial College London, United Kingdom
    J Immunol 178:7190-8. 2007
    ..7%. These findings suggest that vitamin D contributes to protection against TB by "nonclassical" mechanisms that include the induction of antimicrobial peptides...

Research Grants16

  1. STUDIES ON VITAMIN D AND CALCIUM METABOLISM
    Anthony Norman; Fiscal Year: 2007
    ....
  2. STUDIES ON VITAMIN D AND CALCIUM METABOLISM
    Anthony Norman; Fiscal Year: 2005
    ..This may allow specific therapeutic intervention (e.g. type 1 diabetes, leukemia cancer control, psoriasis, immune disorders or osteoporosis) without hypercalcemia. ..