Andrew B Norman

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Characterization of the distribution of the cocaine priming threshold and the effect of SCH23390
    Andrew B Norman
    Department of Psychiatry, Division of Neuroscience, University of Cincinnati, College of Medicine, P O Box 670559, OH 45267 0559, USA
    Brain Res 946:253-61. 2002
  2. pmc Competitive dopamine receptor antagonists increase the equiactive cocaine concentration during self-administration
    Andrew B Norman
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0583, USA
    Synapse 65:404-11. 2011
  3. pmc A recombinant humanized anti-cocaine monoclonal antibody inhibits the distribution of cocaine to the brain in rats
    Andrew B Norman
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio
    Drug Metab Dispos 42:1125-31. 2014
  4. pmc Predicting the clinical efficacy and potential adverse effects of a humanized anticocaine monoclonal antibody
    Andrew B Norman
    Department of Pharmacology and Cell Biophysics and Department of Psychiatry and Behavioral Neuroscience, College of Medicine, University of Cincinnati, Cincinnati, OH 45237 0506, USA
    Immunotherapy 4:335-43. 2012
  5. pmc The affinity of D2-like dopamine receptor antagonists determines the time to maximal effect on cocaine self-administration
    Andrew B Norman
    Department of Psychiatry and Behavioral Neuroscience, College of Medicine, University of Cincinnati, 2170 E Galbraith Rd, Cincinnati, OH 45237 0506, USA
    J Pharmacol Exp Ther 338:724-8. 2011
  6. pmc Using the self-administration of apomorphine and cocaine to measure the pharmacodynamic potencies and pharmacokinetics of competitive dopamine receptor antagonists
    Andrew B Norman
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Neurosci Methods 194:252-8. 2011
  7. pmc The effect of a chimeric human/murine anti-cocaine monoclonal antibody on cocaine self-administration in rats
    Andrew B Norman
    Department of Psychiatry, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0583, USA
    J Pharmacol Exp Ther 328:873-81. 2009
  8. pmc A chimeric human/murine anticocaine monoclonal antibody inhibits the distribution of cocaine to the brain in mice
    Andrew B Norman
    Division of Neuroscience, Department of Psychiatry, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    J Pharmacol Exp Ther 320:145-53. 2007
  9. pmc The compulsion zone: a pharmacological theory of acquired cocaine self-administration
    Andrew B Norman
    Division of Neuroscience, Department of Psychiatry, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    Brain Res 1116:143-52. 2006
  10. pmc Maintained cocaine self-administration is determined by quantal responses: implications for the measurement of antagonist potency
    Andrew B Norman
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio
    J Pharmacol Exp Ther 348:311-5. 2014

Research Grants

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Characterization of the distribution of the cocaine priming threshold and the effect of SCH23390
    Andrew B Norman
    Department of Psychiatry, Division of Neuroscience, University of Cincinnati, College of Medicine, P O Box 670559, OH 45267 0559, USA
    Brain Res 946:253-61. 2002
    ..This technique provides a quantitative method for the measurement of antagonist-induced increases in the cocaine priming threshold...
  2. pmc Competitive dopamine receptor antagonists increase the equiactive cocaine concentration during self-administration
    Andrew B Norman
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0583, USA
    Synapse 65:404-11. 2011
    ..This results in the decreased interinjection intervals...
  3. pmc A recombinant humanized anti-cocaine monoclonal antibody inhibits the distribution of cocaine to the brain in rats
    Andrew B Norman
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio
    Drug Metab Dispos 42:1125-31. 2014
    ..The inhibition of cocaine distribution to the brain confirms the humanized mAb, h2E2, as a lead candidate for development as an immunotherapy for cocaine abuse. ..
  4. pmc Predicting the clinical efficacy and potential adverse effects of a humanized anticocaine monoclonal antibody
    Andrew B Norman
    Department of Pharmacology and Cell Biophysics and Department of Psychiatry and Behavioral Neuroscience, College of Medicine, University of Cincinnati, Cincinnati, OH 45237 0506, USA
    Immunotherapy 4:335-43. 2012
    ..A humanized mAb should minimize adverse events related to the immunogenicity of the mAb protein, and the specificity for cocaine should avoid adverse events related to interactions with physiologically relevant endogenous proteins...
  5. pmc The affinity of D2-like dopamine receptor antagonists determines the time to maximal effect on cocaine self-administration
    Andrew B Norman
    Department of Psychiatry and Behavioral Neuroscience, College of Medicine, University of Cincinnati, 2170 E Galbraith Rd, Cincinnati, OH 45237 0506, USA
    J Pharmacol Exp Ther 338:724-8. 2011
    ..It is concluded that the cocaine self-administration paradigm offers a reliable and predictive bioassay for measuring the affinity of a competitive antagonist for D(2)-like dopamine receptors...
  6. pmc Using the self-administration of apomorphine and cocaine to measure the pharmacodynamic potencies and pharmacokinetics of competitive dopamine receptor antagonists
    Andrew B Norman
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Neurosci Methods 194:252-8. 2011
    ..Agonist self-administration represents a sensitive in vivo pharmacological assay system that provides information useful for pharmacokinetic/pharmacodynamic modeling of antagonist effects...
  7. pmc The effect of a chimeric human/murine anti-cocaine monoclonal antibody on cocaine self-administration in rats
    Andrew B Norman
    Department of Psychiatry, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0583, USA
    J Pharmacol Exp Ther 328:873-81. 2009
    ..5 and 11.6 days for 2E2 and 0.4 and 6.0 days for control IgG. 2E2 had a long-lasting effect on cocaine-induced priming, which may predict its efficacy as an immunotherapy for cocaine abuse...
  8. pmc A chimeric human/murine anticocaine monoclonal antibody inhibits the distribution of cocaine to the brain in mice
    Andrew B Norman
    Division of Neuroscience, Department of Psychiatry, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    J Pharmacol Exp Ther 320:145-53. 2007
    ..These data support the concept of immunotherapy for drug abuse...
  9. pmc The compulsion zone: a pharmacological theory of acquired cocaine self-administration
    Andrew B Norman
    Division of Neuroscience, Department of Psychiatry, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    Brain Res 1116:143-52. 2006
    ..This novel pharmacokinetic/pharmacodynamic theory provides a basis for a comprehensive understanding of the cocaine self-administration paradigm...
  10. pmc Maintained cocaine self-administration is determined by quantal responses: implications for the measurement of antagonist potency
    Andrew B Norman
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio
    J Pharmacol Exp Ther 348:311-5. 2014
    ..Therefore, the measurement of antagonist potency requires only a single unit dose of cocaine, selected on the basis of convenience, and using multiple cocaine unit doses is redundant...
  11. ncbi request reprint The self-administration of WIN 35,428 and cocaine: comparisons of satiety threshold and elimination half-life in rats
    Andrew B Norman
    Department of Psychiatry, Division of Neuroscience, College of Medicine, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Eur J Pharmacol 483:281-7. 2004
    ..1 and 69.4 min, respectively. The approximately 43-fold lower rate of consumption of WIN 35,428 relative to cocaine was a product of the seven-fold greater pharmacodynamic potency and the six-fold greater pharmacokinetic potency...
  12. pmc Long-term behavioral consequences of prenatal MDMA exposure
    Valerie B Thompson
    Neuroscience Graduate Program, University of Cincinnati, 231 Albert Sabin Way, CVC Room 5940, ML 0537, Cincinnati, OH 45267, USA
    Physiol Behav 96:593-601. 2009
    ....
  13. pmc Real time computation of in vivo drug levels during drug self-administration experiments
    Vladimir L Tsibulsky
    Division of Neuroscience, Department of Psychiatry, College of Medicine, University of Cincinnati, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Brain Res Brain Res Protoc 15:38-45. 2005
    ..This method of drug level computation can be employed not only for self-administration but also for other behavioral paradigms to advance pharmacokinetic/pharmacodynamic modeling...
  14. ncbi request reprint Mathematical models of behavior of individual animals
    Vladimir L Tsibulsky
    Division of Neuroscience, Department of Psychiatry, College of Medicine, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Curr Pharm Des 13:1571-95. 2007
    ..Examples are perception and discrimination models, drug effects models and individual-based population models. A brief overview of the utility of each mathematical model is provided for each section...
  15. ncbi request reprint Three-dimensional quantitative structure-activity relationship modeling of cocaine binding by a novel human monoclonal antibody
    Stefan Paula
    Department of Pharmacology and Cell Biophysics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0575, USA
    J Med Chem 47:133-42. 2004
    ..Overall, the cocaine binding properties of mAb 2E2 support its clinical potential for development as a treatment of cocaine overdose and addiction...
  16. ncbi request reprint Cocaine increases mortality and cardiac mass in a murine transgenic model of acquired immune deficiency syndrome
    Roy L Sutliff
    Department of Experimental Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Lab Invest 83:983-9. 2003
    ..Histopathologically, perivascular fibrosis and interstitial fibrosis were evident in cocaine-treated TG. Data suggest that additive cardiac insults (from AIDS and cocaine) result in combined deleterious effects...

Research Grants3

  1. PASSIVE IMMUNITY TO COCAINE USING NOVEL HUMAN ANTIBODIES
    Andrew Norman; Fiscal Year: 2003
    ..These studies will form the basis for an application to the FDA for advancement of an identified human monoclonal anti-cocaine antibody to Phase II clinical trials to determine the efficacy of a passive immunotherapy of cocaine abuse. ..
  2. A Human Antibody as an Immunotherapy for Cocaine Abuse
    Andrew Norman; Fiscal Year: 2007
    ..This application details studies that will advance a unique predominantly human sequence anti- cocaine monoclonal antibody towards clinical trials for the prevention of relapse in cocaine abuse. ..