Oxana Norkina


Affiliation: University of Kansas Medical Center
Country: USA


  1. De Lisle R, Mueller R, Boyd M. Impaired mucosal barrier function in the small intestine of the cystic fibrosis mouse. J Pediatr Gastroenterol Nutr. 2011;53:371-9 pubmed publisher
    ..Exogenous IAP improve permeability and strongly reduce bacterial overgrowth in CF mice, suggesting this may be a useful therapy for CF. ..
  2. De Lisle R. Disrupted tight junctions in the small intestine of cystic fibrosis mice. Cell Tissue Res. 2014;355:131-42 pubmed publisher
    ..These changes in TJ protein localization in CF are likely to be involved in the increased permeability of the CF small intestine to macromolecules and TNF? may be a causative factor. ..
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    De Lisle R, Roach E, Norkina O. Eradication of small intestinal bacterial overgrowth in the cystic fibrosis mouse reduces mucus accumulation. J Pediatr Gastroenterol Nutr. 2006;42:46-52 pubmed
    ..Control of bacterial overgrowth is expected to reduce mucus accumulation and may improve intestinal function and overall health in CF. ..
  4. De Lisle R. Pass the bicarb: the importance of HCO3- for mucin release. J Clin Invest. 2009;119:2535-7 pubmed publisher
    ..The authors propose a model whereby CFTR-mediated bicarbonate secretion must be concurrent with mucin exocytosis for proper mucin release. ..
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    De Lisle R, Roach E, Jansson K. Effects of laxative and N-acetylcysteine on mucus accumulation, bacterial load, transit, and inflammation in the cystic fibrosis mouse small intestine. Am J Physiol Gastrointest Liver Physiol. 2007;293:G577-84 pubmed
    ..These results suggest that both mucus accumulation and slowed interdigestive small intestinal transit contribute to SIBO in the CF intestine. ..
  6. De Lisle R, Mueller R, Roach E. Lubiprostone ameliorates the cystic fibrosis mouse intestinal phenotype. BMC Gastroenterol. 2010;10:107 pubmed publisher
    ..The unexpected observation of increased mucus accumulation in the crypts of lubiprostone-treated CF mice suggests the possibility that lubiprostone increases mucus secretion. ..
  7. De Lisle R. Lubiprostone stimulates small intestinal mucin release. BMC Gastroenterol. 2012;12:156 pubmed publisher
    ..Thus, in addition to chronic constipation, there is greater potential for the therapeutic applications of lubiprostone. ..
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    De Lisle R, Petitt M, Huff J, Isom K, Agbas A. MUCLIN expression in the cystic fibrosis transmembrane conductance regulator knockout mouse. Gastroenterology. 1997;113:521-32 pubmed
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    De Lisle R. Role of sulfated O-linked glycoproteins in zymogen granule formation. J Cell Sci. 2002;115:2941-52 pubmed

More Information


  1. Norkina O, Burnett T, De Lisle R. Bacterial overgrowth in the cystic fibrosis transmembrane conductance regulator null mouse small intestine. Infect Immun. 2004;72:6040-9 pubmed
    ..These data suggest that bacterial overgrowth in the CF mouse small intestine has a role in inflammation and contributes to the failure to thrive in this mouse model of CF. ..
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    De Lisle R, Norkina O, Roach E, Ziemer D. Expression of pro-Muclin in pancreatic AR42J cells induces functional regulated secretory granules. Am J Physiol Cell Physiol. 2005;289:C1169-78 pubmed
    ..Overall, the data show that pro-Muclin acts as a sorting receptor that can induce RSG, and that its cytosolic tail is important in this process. ..
  3. De Lisle R, Xu W, Roe B, Ziemer D. Effects of Muclin (Dmbt1) deficiency on the gastrointestinal system. Am J Physiol Gastrointest Liver Physiol. 2008;294:G717-27 pubmed publisher
    ..Thus Muclin deficiency impairs trafficking of regulated proteins to a stimulus-releasable pool in the exocrine pancreas. ..
  4. De Lisle R, Meldi L, Roach E, Flynn M, Sewell R. Mast cells and gastrointestinal dysmotility in the cystic fibrosis mouse. PLoS ONE. 2009;4:e4283 pubmed publisher
    ..The results indicate that mast cells are not involved in gastrointestinal dysmotility but their activation can stimulate small intestinal transit in cystic fibrosis. ..
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    De Lisle R, Isom K, Ziemer D, Cotton C. Changes in the exocrine pancreas secondary to altered small intestinal function in the CF mouse. Am J Physiol Gastrointest Liver Physiol. 2001;281:G899-906 pubmed
  6. De Lisle R, Sewell R, Meldi L. Enteric circular muscle dysfunction in the cystic fibrosis mouse small intestine. Neurogastroenterol Motil. 2010;22:341-e87 pubmed publisher
    ..CONCLUSIONS & INFERENCES These results suggest that the enteric microbiota modulates PGE(2) levels in a complex manner, which affects enteric smooth muscle activity and contributes to slower small intestinal transit in CF...