Affiliation: University of Wisconsin
- Functional and anatomic consequences of subretinal dosing in the cynomolgus macaqueT Michael Nork
Comparative Ophthalmic Research Laboratories, University of Wisconsin, USA
Arch Ophthalmol 130:65-75. 2012..To characterize functional and anatomic sequelae of a bleb induced by subretinal injection...
- Prevention of experimental choroidal neovascularization and resolution of active lesions by VEGF trap in nonhuman primatesT Michael Nork
Comparative Ophthalmic Research Laboratories, Madison, Wisconsin, USA
Arch Ophthalmol 129:1042-52. 2011..To evaluate the efficacy of systemic and intravitreous administration of VEGF Trap (aflibercept) in a nonhuman primate model of choroidal neovascularization (CNV)...
- Serial multifocal electroretinograms during long-term elevation and reduction of intraocular pressure in non-human primatesT Michael Nork
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave F4 336, Madison, WI 53792 3220, USA
Doc Ophthalmol 120:273-89. 2010..These results demonstrate species-specific changes in cone-driven retinal function during periods of elevated IOP. These IOP-related effects can occur in the absence of retinal ganglion cells and may be reversible...
- Measurement of regional choroidal blood flow in rabbits and monkeys using fluorescent microspheresT Michael Nork
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison 53792 3220, USA
Arch Ophthalmol 124:860-8. 2006..To develop a quantitative measure of regional variation in choroidal blood flow (ChBF)...
- Interspecies and gender differences in multifocal electroretinograms of cynomolgus and rhesus macaquesCharlene B Y Kim
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI, USA
Doc Ophthalmol 109:73-86. 2004..There also were gender-associated differences that varied across species. Thus, investigators should exercise caution when data from species or gender are combined...
- Multifocal visual evoked potentials in the anesthetized non-human primateNathan A Maertz
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792-3220, USA
Curr Eye Res 31:885-93. 2006..Under the recording conditions described, mfVEPs are not contaminated by ERG activity. mfVEPs may be useful in animal models of diseases that differentially affect macular and peripheral visual field responsiveness...
- Effects of reference electrode location on monopolar-derived multifocal electroretinograms in cynomolgus monkeysCharlene B Y Kim
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792 3220, USA
Doc Ophthalmol 111:113-25. 2005..K1 and K2.1 implicit times in males were longer than in females. Quadrant groupings revealed generally larger K1 and K2.1 amplitudes in nasal than in temporal retina...
- Decrease of cone opsin mRNA in experimental ocular hypertensionHeather R Pelzel
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53704, USA
Mol Vis 12:1272-82. 2006..We speculate that these cells become stressed leading to a disruption in the expression of normal genes, such as that encoding opsin. There is some evidence that this effect is reversible, when IOP levels are reduced...
- Comparison of the distribution of glial fibrillary acidic protein, heat shock protein 60, and hypoxia-inducible factor-1alpha in retinas from glaucomatous and normal canine eyesCaitlin A Savagian
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53792 3220, USA
Am J Vet Res 69:265-72. 2008..To determine the effect of acute (clinical history of glaucoma for <or= 2 days) and chronic (clinical history of glaucoma for 7 days) goniodysgenesis-related glaucoma on various stress-inducible proteins in canine retinas...
- Sympathetic ophthalmia following evisceration: a rare caseGregory J Griepentrog
Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA
Ophthal Plast Reconstr Surg 21:316-8. 2005..We provide a brief review of sympathetic ophthalmia following evisceration and discuss the importance of a high degree of clinical suspicion and prompt treatment with high-dose systemic corticosteroids or other immunomodulators...
- The Role of Outer Retinal Injury in GlaucomaT Nork; Fiscal Year: 2004..abstract_text> ..