MICHAEL DAVID NORENBERG

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint Oxidative stress in the pathogenesis of hepatic encephalopathy
    M D Norenberg
    Department of Pathology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Metab Brain Dis 19:313-29. 2004
  2. doi request reprint Trauma-induced cell swelling in cultured astrocytes
    Arumugam R Jayakumar
    Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    J Neuropathol Exp Neurol 67:417-27. 2008
  3. pmc NFkappaB in the mechanism of ammonia-induced astrocyte swelling in culture
    Anne P Sinke
    Radboud University Nijmegen, Nijmegen, The Netherlands
    J Neurochem 106:2302-11. 2008
  4. pmc Marked potentiation of cell swelling by cytokines in ammonia-sensitized cultured astrocytes
    Kakulavarapu V Rama Rao
    Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33125, USA
    J Neuroinflammation 7:66. 2010
  5. ncbi request reprint The mitochondrial permeability transition in neurologic disease
    M D Norenberg
    Veterans Affairs Medical Center, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Neurochem Int 50:983-97. 2007
  6. ncbi request reprint New concepts in the mechanism of ammonia-induced astrocyte swelling
    M D Norenberg
    Veterans Affairs Medical Center, Miami, FL 33101, USA
    Metab Brain Dis 22:219-34. 2007
  7. ncbi request reprint Ammonia neurotoxicity and the mitochondrial permeability transition
    M D Norenberg
    Veterans Affairs Medical Center, Miami, Florida, USA
    J Bioenerg Biomembr 36:303-7. 2004
  8. doi request reprint Signaling factors in the mechanism of ammonia neurotoxicity
    M D Norenberg
    Department of Pathology D 33, University of Miami School of Medicine, P O Box 016960, Miami, FL 33101, USA
    Metab Brain Dis 24:103-17. 2009
  9. doi request reprint Central pontine myelinolysis: historical and mechanistic considerations
    Michael D Norenberg
    Departments of Pathology, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
    Metab Brain Dis 25:97-106. 2010
  10. ncbi request reprint The pathology of human spinal cord injury: defining the problems
    Michael D Norenberg
    Department of Pathology, University of Miami School of Medicine, The Miami Project to Cure Paralysis, and the Miami Veterans Affairs Medical Center Miami, Florida 33101, USA
    J Neurotrauma 21:429-40. 2004

Research Grants

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Oxidative stress in the pathogenesis of hepatic encephalopathy
    M D Norenberg
    Department of Pathology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Metab Brain Dis 19:313-29. 2004
    ..The consequences and potential therapeutic implications of oxidative stress in HE are also discussed...
  2. doi request reprint Trauma-induced cell swelling in cultured astrocytes
    Arumugam R Jayakumar
    Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    J Neuropathol Exp Neurol 67:417-27. 2008
    ..These findings demonstrate that direct mechanical injury to cultured astrocytes brings about cell swelling, and that blockade of oxidative/nitrosative stress, mPT, and MAPKs significantly reduce such swelling...
  3. pmc NFkappaB in the mechanism of ammonia-induced astrocyte swelling in culture
    Anne P Sinke
    Radboud University Nijmegen, Nijmegen, The Netherlands
    J Neurochem 106:2302-11. 2008
    ..NFkappaB activation appears to contribute to the mechanism of ammonia-induced astrocyte swelling, apparently through its up-regulation of iNOS protein expression and the subsequent generation of NO...
  4. pmc Marked potentiation of cell swelling by cytokines in ammonia-sensitized cultured astrocytes
    Kakulavarapu V Rama Rao
    Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33125, USA
    J Neuroinflammation 7:66. 2010
    ..Since cytokines are also well-known to activate NF-κB, this study examined for additive/synergistic effects of ammonia and cytokines in the activation of NF-κB and their role in astrocyte swelling...
  5. ncbi request reprint The mitochondrial permeability transition in neurologic disease
    M D Norenberg
    Veterans Affairs Medical Center, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Neurochem Int 50:983-97. 2007
    ....
  6. ncbi request reprint New concepts in the mechanism of ammonia-induced astrocyte swelling
    M D Norenberg
    Veterans Affairs Medical Center, Miami, FL 33101, USA
    Metab Brain Dis 22:219-34. 2007
    ..Blockade of this cascade may provide novel therapies for the brain edema associated with ALF...
  7. ncbi request reprint Ammonia neurotoxicity and the mitochondrial permeability transition
    M D Norenberg
    Veterans Affairs Medical Center, Miami, Florida, USA
    J Bioenerg Biomembr 36:303-7. 2004
    ..These studies suggest that oxidative stress and glutamine play major roles in the induction of the MPT associated with ammonia neurotoxicity...
  8. doi request reprint Signaling factors in the mechanism of ammonia neurotoxicity
    M D Norenberg
    Department of Pathology D 33, University of Miami School of Medicine, P O Box 016960, Miami, FL 33101, USA
    Metab Brain Dis 24:103-17. 2009
    ..These pathways and factors provide attractive targets for identifying agents potentially useful in the therapy of HE and other hyperammonemic disorders...
  9. doi request reprint Central pontine myelinolysis: historical and mechanistic considerations
    Michael D Norenberg
    Departments of Pathology, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
    Metab Brain Dis 25:97-106. 2010
    ..These advances show great promise in providing novel therapeutic options for the management of patients afflicted with CPM...
  10. ncbi request reprint The pathology of human spinal cord injury: defining the problems
    Michael D Norenberg
    Department of Pathology, University of Miami School of Medicine, The Miami Project to Cure Paralysis, and the Miami Veterans Affairs Medical Center Miami, Florida 33101, USA
    J Neurotrauma 21:429-40. 2004
    ..We anticipate that a better understanding of the pathological responses in the human will be useful to investigators in their studies on the pathogenesis and therapy of SCI...
  11. doi request reprint Inhibitors of the mitochondrial permeability transition reduce ammonia-induced cell swelling in cultured astrocytes
    Pichili V B Reddy
    Department of Pathology, Miller School of Medicine, University of Miami, Miami, Florida 33101, USA
    J Neurosci Res 87:2677-85. 2009
    ..A regression analysis indicated a high correlation between the effectiveness of reducing the mPT and cell swelling. Our data suggest that all these agents have therapeutic potential in mitigating brain edema in ALF...
  12. doi request reprint The Na-K-Cl Co-transporter in astrocyte swelling
    Arumugam R Jayakumar
    Department of Pathology D 33, University of Miami Miller School of Medicine, P O Box 016960, Miami, FL 33125, USA
    Metab Brain Dis 25:31-8. 2010
    ..This review will focus on mechanisms of NKCC1 activation and its contribution to astrocyte swelling/brain edema in neurological disorders, with particular emphasis on ammonia neurotoxicity and acute liver failure...
  13. ncbi request reprint Cerebrovascular resuscitation after polytrauma and fluid restriction
    Steven A Earle
    DeWitt Daughtry Family Department of Surgery, Divisions of Trauma and Surgical Critical Care, University of Miami Miller School of Medicine, Miami, FL, USA
    J Am Coll Surg 204:261-75. 2007
    ..We developed a clinically relevant polytrauma model to test the hypothesis that cerebrovascular resuscitation is optimized when intravenous fluid is restricted...
  14. pmc Brain edema in acute liver failure: inhibition by L-histidine
    Kakulavarapu V Rama Rao
    Department of Pathology, University of Miami, Miller School of Medicine, PO Box 016960, Miami, FL 33101, USA
    Am J Pathol 176:1400-8. 2010
    ..These changes were completely abolished by L-histidine, supporting a key role of mitochondrial glutamine transport and hydrolysis in the mechanism of the brain edema associated with ALF...
  15. ncbi request reprint Glutamine: a Trojan horse in ammonia neurotoxicity
    Jan Albrecht
    Department of Neurotoxicology, M Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Hepatology 44:788-94. 2006
    ..Future therapeutic approaches might include controlling excessive transport of newly synthesized glutamine to mitochondria and its subsequent hydrolysis...
  16. ncbi request reprint Alzheimer type II astrocytic changes following sub-acute exposure to manganese and its prevention by antioxidant treatment
    Alan S Hazell
    Department of Medicine, University of Montreal, Montreal, Que, Canada
    Neurosci Lett 396:167-71. 2006
    ....
  17. ncbi request reprint Oxidative and nitrosative stress in ammonia neurotoxicity
    Michael D Norenberg
    Hepatology 37:245-8. 2003
  18. doi request reprint The mitochondrial permeability transition, and oxidative and nitrosative stress in the mechanism of copper toxicity in cultured neurons and astrocytes
    Pichili V B Reddy
    Department of Pathology, University of Miami School of Medicine, Miami, FL 33101, USA
    Lab Invest 88:816-30. 2008
    ..These studies indicate that mPT, and oxidative and nitrosative stress represent major factors in copper-induced toxicity in astrocytes, whereas oxidative and nitrosative stress appears to play a major role in neuronal injury...
  19. ncbi request reprint Manganese induces the mitochondrial permeability transition in cultured astrocytes
    Kakulavarapu V Rama Rao
    Department of Pathology, University of Miami School of Medicine, Florida 33125, USA
    J Biol Chem 279:32333-8. 2004
    ..Induction of the MPT by manganese and associated mitochondrial dysfunction in astrocytes may represent key mechanisms in manganese neurotoxicity...
  20. ncbi request reprint Descending vasomotor pathways in humans: correlation between axonal preservation and cardiovascular dysfunction after spinal cord injury
    Julio C Furlan
    Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Canada
    J Neurotrauma 20:1351-63. 2003
    ..This information adds to our knowledge of pathobiology of cardiovascular dysfunction after human SCI and may ultimately suggest novel therapeutic strategies as regenerative and reparative approaches become translated to the clinic...
  21. ncbi request reprint Glutamine-induced free radical production in cultured astrocytes
    Arumugam R Jayakumar
    Department of Pathology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Glia 46:296-301. 2004
    ..The results indicate that astrocytes, but not neurons, generate free radicals following glutamine exposure. Glutamine-induced oxidative and/or nitrosative stress may represent a key mechanism in ammonia neurotoxicity...
  22. ncbi request reprint The cellular inflammatory response in human spinal cords after injury
    Jennifer C Fleming
    BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
    Brain 129:3249-69. 2006
    ....
  23. ncbi request reprint Astrocytes in cerebral ischemic injury: morphological and general considerations
    Kiran S Panickar
    Department of Pathology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Glia 50:287-98. 2005
    ..Interactions with neurons, microglia, and endothelial cells are also considered. This article highlights the critical role of astrocytes in the CNS response to ischemic injury...
  24. ncbi request reprint Suppression of ammonia-induced swelling by aspartate but not by ornithine in primary cultures of rat astrocytes
    Chinta R K Murthy
    Department of Animal Sciences, University of Hyderabad, Andhra Pradesh, Hyderabad, India
    Neurochem Int 41:171-6. 2002
    ....

Research Grants6

  1. The Permeability Transition in Hepatic Encephalopathy
    Michael Norenberg; Fiscal Year: 2007
    ..We believe that these studies will yield critical data bearing on the pathogenesis of HE, and may potentially aid in the development of novel therapeutic strategies for the treatment of this condition. ..
  2. NFkB in the Astrocyte Swelling/Brain Edema with Acute Liver Failure
    MICHAEL DAVID NORENBERG; Fiscal Year: 2010
    ..We propose to examine the role of the transcription factor NF-:B as a critical intermediary responsible for causing brain swelling in ALF. ..