Research Topics
| MICHAEL DAVID NORENBERGSummaryAffiliation: University of Miami Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Oxidative stress in the pathogenesis of hepatic encephalopathyM D Norenberg
Department of Pathology, University of Miami School of Medicine, Miami, Florida 33101, USA
Metab Brain Dis 19:313-29. 2004..The consequences and potential therapeutic implications of oxidative stress in HE are also discussed...
Trauma-induced cell swelling in cultured astrocytesArumugam R Jayakumar
Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
J Neuropathol Exp Neurol 67:417-27. 2008..These findings demonstrate that direct mechanical injury to cultured astrocytes brings about cell swelling, and that blockade of oxidative/nitrosative stress, mPT, and MAPKs significantly reduce such swelling...
NFkappaB in the mechanism of ammonia-induced astrocyte swelling in cultureAnne P Sinke
Radboud University Nijmegen, Nijmegen, The Netherlands
J Neurochem 106:2302-11. 2008..NFkappaB activation appears to contribute to the mechanism of ammonia-induced astrocyte swelling, apparently through its up-regulation of iNOS protein expression and the subsequent generation of NO...- Marked potentiation of cell swelling by cytokines in ammonia-sensitized cultured astrocytesKakulavarapu V Rama Rao
Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33125, USA
J Neuroinflammation 7:66. 2010..Since cytokines are also well-known to activate NF-κB, this study examined for additive/synergistic effects of ammonia and cytokines in the activation of NF-κB and their role in astrocyte swelling... - The mitochondrial permeability transition in neurologic diseaseM D Norenberg
Veterans Affairs Medical Center, University of Miami Miller School of Medicine, Miami, FL 33101, USA
Neurochem Int 50:983-97. 2007.... - New concepts in the mechanism of ammonia-induced astrocyte swellingM D Norenberg
Veterans Affairs Medical Center, Miami, FL 33101, USA
Metab Brain Dis 22:219-34. 2007..Blockade of this cascade may provide novel therapies for the brain edema associated with ALF... - Ammonia neurotoxicity and the mitochondrial permeability transitionM D Norenberg
Veterans Affairs Medical Center, Miami, Florida, USA
J Bioenerg Biomembr 36:303-7. 2004..These studies suggest that oxidative stress and glutamine play major roles in the induction of the MPT associated with ammonia neurotoxicity... - Signaling factors in the mechanism of ammonia neurotoxicityM D Norenberg
Department of Pathology D 33, University of Miami School of Medicine, P O Box 016960, Miami, FL 33101, USA
Metab Brain Dis 24:103-17. 2009..These pathways and factors provide attractive targets for identifying agents potentially useful in the therapy of HE and other hyperammonemic disorders... - Central pontine myelinolysis: historical and mechanistic considerationsMichael D Norenberg
Departments of Pathology, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
Metab Brain Dis 25:97-106. 2010..These advances show great promise in providing novel therapeutic options for the management of patients afflicted with CPM... - The pathology of human spinal cord injury: defining the problemsMichael D Norenberg
Department of Pathology, University of Miami School of Medicine, The Miami Project to Cure Paralysis, and the Miami Veterans Affairs Medical Center Miami, Florida 33101, USA
J Neurotrauma 21:429-40. 2004..We anticipate that a better understanding of the pathological responses in the human will be useful to investigators in their studies on the pathogenesis and therapy of SCI... - Inhibitors of the mitochondrial permeability transition reduce ammonia-induced cell swelling in cultured astrocytesPichili V B Reddy
Department of Pathology, Miller School of Medicine, University of Miami, Miami, Florida 33101, USA
J Neurosci Res 87:2677-85. 2009..A regression analysis indicated a high correlation between the effectiveness of reducing the mPT and cell swelling. Our data suggest that all these agents have therapeutic potential in mitigating brain edema in ALF... - The Na-K-Cl Co-transporter in astrocyte swellingArumugam R Jayakumar
Department of Pathology D 33, University of Miami Miller School of Medicine, P O Box 016960, Miami, FL 33125, USA
Metab Brain Dis 25:31-8. 2010..This review will focus on mechanisms of NKCC1 activation and its contribution to astrocyte swelling/brain edema in neurological disorders, with particular emphasis on ammonia neurotoxicity and acute liver failure... - Cerebrovascular resuscitation after polytrauma and fluid restrictionSteven A Earle
DeWitt Daughtry Family Department of Surgery, Divisions of Trauma and Surgical Critical Care, University of Miami Miller School of Medicine, Miami, FL, USA
J Am Coll Surg 204:261-75. 2007..We developed a clinically relevant polytrauma model to test the hypothesis that cerebrovascular resuscitation is optimized when intravenous fluid is restricted... - Brain edema in acute liver failure: inhibition by L-histidineKakulavarapu V Rama Rao
Department of Pathology, University of Miami, Miller School of Medicine, PO Box 016960, Miami, FL 33101, USA
Am J Pathol 176:1400-8. 2010..These changes were completely abolished by L-histidine, supporting a key role of mitochondrial glutamine transport and hydrolysis in the mechanism of the brain edema associated with ALF... - Glutamine: a Trojan horse in ammonia neurotoxicityJan Albrecht
Department of Neurotoxicology, M Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
Hepatology 44:788-94. 2006..Future therapeutic approaches might include controlling excessive transport of newly synthesized glutamine to mitochondria and its subsequent hydrolysis... - Alzheimer type II astrocytic changes following sub-acute exposure to manganese and its prevention by antioxidant treatmentAlan S Hazell
Department of Medicine, University of Montreal, Montreal, Que, Canada
Neurosci Lett 396:167-71. 2006.... - Oxidative and nitrosative stress in ammonia neurotoxicityMichael D Norenberg
Hepatology 37:245-8. 2003 - The mitochondrial permeability transition, and oxidative and nitrosative stress in the mechanism of copper toxicity in cultured neurons and astrocytesPichili V B Reddy
Department of Pathology, University of Miami School of Medicine, Miami, FL 33101, USA
Lab Invest 88:816-30. 2008..These studies indicate that mPT, and oxidative and nitrosative stress represent major factors in copper-induced toxicity in astrocytes, whereas oxidative and nitrosative stress appears to play a major role in neuronal injury... - Manganese induces the mitochondrial permeability transition in cultured astrocytesKakulavarapu V Rama Rao
Department of Pathology, University of Miami School of Medicine, Florida 33125, USA
J Biol Chem 279:32333-8. 2004..Induction of the MPT by manganese and associated mitochondrial dysfunction in astrocytes may represent key mechanisms in manganese neurotoxicity... - Descending vasomotor pathways in humans: correlation between axonal preservation and cardiovascular dysfunction after spinal cord injuryJulio C Furlan
Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Canada
J Neurotrauma 20:1351-63. 2003..This information adds to our knowledge of pathobiology of cardiovascular dysfunction after human SCI and may ultimately suggest novel therapeutic strategies as regenerative and reparative approaches become translated to the clinic... - Glutamine-induced free radical production in cultured astrocytesArumugam R Jayakumar
Department of Pathology, University of Miami School of Medicine, Miami, Florida 33101, USA
Glia 46:296-301. 2004..The results indicate that astrocytes, but not neurons, generate free radicals following glutamine exposure. Glutamine-induced oxidative and/or nitrosative stress may represent a key mechanism in ammonia neurotoxicity... - The cellular inflammatory response in human spinal cords after injuryJennifer C Fleming
BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
Brain 129:3249-69. 2006.... - Astrocytes in cerebral ischemic injury: morphological and general considerationsKiran S Panickar
Department of Pathology, University of Miami School of Medicine, Miami, Florida 33101, USA
Glia 50:287-98. 2005..Interactions with neurons, microglia, and endothelial cells are also considered. This article highlights the critical role of astrocytes in the CNS response to ischemic injury... - Suppression of ammonia-induced swelling by aspartate but not by ornithine in primary cultures of rat astrocytesChinta R K Murthy
Department of Animal Sciences, University of Hyderabad, Andhra Pradesh, Hyderabad, India
Neurochem Int 41:171-6. 2002....
Research Grants
- The Permeability Transition in Hepatic EncephalopathyMichael Norenberg; Fiscal Year: 2007..We believe that these studies will yield critical data bearing on the pathogenesis of HE, and may potentially aid in the development of novel therapeutic strategies for the treatment of this condition. ..
- NFkB in the Astrocyte Swelling/Brain Edema with Acute Liver FailureMICHAEL DAVID NORENBERG; Fiscal Year: 2010..We propose to examine the role of the transcription factor NF-:B as a critical intermediary responsible for causing brain swelling in ALF. ..