Alex S Nord

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells
    Alex S Nord
    Department of Medicine, MacDonald Medical Research Laboratories, University of California at Los Angeles, California, USA
    PLoS ONE 2:e617. 2007
  2. pmc Comparison of tagging single-nucleotide polymorphism methods in association analyses
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    BMC Proc 1:S6. 2007
  3. pmc Accurate and exact CNV identification from targeted high-throughput sequence data
    Alex S Nord
    Department of Genome Sciences, University of Washington, Seattle, 98195 7720, USA
    BMC Genomics 12:184. 2011
  4. pmc Reduced transcript expression of genes affected by inherited and de novo CNVs in autism
    Alex S Nord
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Eur J Hum Genet 19:727-31. 2011
  5. pmc Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing
    Tom Walsh
    Division of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 108:18032-7. 2011
  6. pmc Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing
    Tom Walsh
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:12629-33. 2010
  7. pmc Genomic duplication and overexpression of TJP2/ZO-2 leads to altered expression of apoptosis genes in progressive nonsyndromic hearing loss DFNA51
    Tom Walsh
    Department of Medicine Medical Genetics, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 87:101-9. 2010
  8. pmc Formation of chimeric genes by copy-number variation as a mutational mechanism in schizophrenia
    Caitlin Rippey
    Departments of Medicine and of Genome Sciences, University of Washington, Seattle, WA 98195, USA Electronic address
    Am J Hum Genet 93:697-710. 2013
  9. doi request reprint Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia
    Tom Walsh
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Science 320:539-43. 2008
  10. pmc ColoSeq provides comprehensive lynch and polyposis syndrome mutational analysis using massively parallel sequencing
    Colin C Pritchard
    Department of Laboratory Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA
    J Mol Diagn 14:357-66. 2012

Detail Information

Publications13

  1. pmc Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells
    Alex S Nord
    Department of Medicine, MacDonald Medical Research Laboratories, University of California at Los Angeles, California, USA
    PLoS ONE 2:e617. 2007
    ..However, the rules governing its efficiency are not fully understood, and the effects of vector design on the likelihood of gene-trapping events have not been tested on a genome-wide scale...
  2. pmc Comparison of tagging single-nucleotide polymorphism methods in association analyses
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    BMC Proc 1:S6. 2007
    ..e., whether a SNP or haplotype is responsible); unfortunately, this is often unknown at the time of SNP selection. Additional evaluations using empirical and simulated data are needed...
  3. pmc Accurate and exact CNV identification from targeted high-throughput sequence data
    Alex S Nord
    Department of Genome Sciences, University of Washington, Seattle, 98195 7720, USA
    BMC Genomics 12:184. 2011
    ..However, methods for CNV detection from targeted enrichment are lacking. We present a method combining coverage with map information for the identification of deletions and duplications in targeted sequence data...
  4. pmc Reduced transcript expression of genes affected by inherited and de novo CNVs in autism
    Alex S Nord
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Eur J Hum Genet 19:727-31. 2011
    ..These results suggest that for some genes affected by CNVs in autism, reduced transcript expression may be a mechanism of pathogenesis during neurodevelopment...
  5. pmc Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing
    Tom Walsh
    Division of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 108:18032-7. 2011
    ..Clinical genetic testing is currently done gene by gene, with each test costing thousands of dollars. In contrast, massively parallel sequencing allows such testing for many genes simultaneously at low cost...
  6. pmc Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing
    Tom Walsh
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:12629-33. 2010
    ..This approach enables widespread genetic testing and personalized risk assessment for breast and ovarian cancer...
  7. pmc Genomic duplication and overexpression of TJP2/ZO-2 leads to altered expression of apoptosis genes in progressive nonsyndromic hearing loss DFNA51
    Tom Walsh
    Department of Medicine Medical Genetics, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 87:101-9. 2010
    ....
  8. pmc Formation of chimeric genes by copy-number variation as a mutational mechanism in schizophrenia
    Caitlin Rippey
    Departments of Medicine and of Genome Sciences, University of Washington, Seattle, WA 98195, USA Electronic address
    Am J Hum Genet 93:697-710. 2013
    ....
  9. doi request reprint Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia
    Tom Walsh
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Science 320:539-43. 2008
    ..These results suggest that multiple, individually rare mutations altering genes in neurodevelopmental pathways contribute to schizophrenia...
  10. pmc ColoSeq provides comprehensive lynch and polyposis syndrome mutational analysis using massively parallel sequencing
    Colin C Pritchard
    Department of Laboratory Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA
    J Mol Diagn 14:357-66. 2012
    ..ColoSeq offers a powerful, cost-effective means of genetic testing for Lynch and polyposis syndromes that eliminates the need for stepwise testing and multiple follow-up clinical visits...
  11. pmc Polymorphisms of the IL1-receptor antagonist gene (IL1RN) are associated with multiple markers of systemic inflammation
    Alexander P Reiner
    Department of Epidemiology, Box 357236, University of Washington, Seattle, Washington 98195, USA
    Arterioscler Thromb Vasc Biol 28:1407-12. 2008
    ..Circulating levels of acute phase reactant proteins such as plasma C-reactive protein (CRP) are likely influenced by multiple genes regulating the innate immune response...
  12. ncbi request reprint TagSNP evaluation for the association of 42 inflammation loci and vascular disease: evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects
    Christopher S Carlson
    Division of Public Health Sciences, The Fred Hutchinson Cancer Research Center, The University of Washington, Seattle, WA, USA
    Hum Genet 121:65-75. 2007
    ..The NFKBIA and IL10RA expression levels significantly differed between subjects with CAAD and controls. These results support a role for genetic variation related to inflammation in CAAD and a causal role for specific gene products...
  13. pmc Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk
    James Ronald
    Department of Medicine, Division of Medical Genetics, University of Washington Medical Center Box 357720, Seattle, WA 98195 7720, USA
    Stroke 42:2-9. 2011
    ..The relationship between genetic variation in the LPA gene region and CAAD risk remains unknown...