Research Topics
| P NopoulosSummaryAffiliation: University of Iowa Country: USA Publications
Research Grants
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Detail Information
Publications
Behavioral effects of congenital ventromedial prefrontal cortex malformationAaron D Boes
Department of Pediatric Neurology, Massachusetts General Hospital, Harvard University, Boston, MA 02114, USA
BMC Neurol 11:151. 2011..Here we describe a 14 year-old boy, B.W., with neurological and psychiatric sequelae stemming from focal cortical malformation of the left vmPFC...- Brain tissue- and region-specific abnormalities on volumetric MRI scans in 21 patients with Bardet-Biedl syndrome (BBS)Kim M Keppler-Noreuil
Department of Pediatrics, Division of Medical Genetics, The University of Iowa Children s Hospital, Iowa City, IA 52242, USA
BMC Med Genet 12:101. 2011..The present study represents the largest systematic evaluation for the presence of structural brain malformations and/or progressive changes, which may contribute to these functional problems... 
Enlarged cavum septi pellucidi in patients with schizophrenia: clinical and cognitive correlatesP Nopoulos
Mental Health Clinic Research Centre, University of Iowa College of Medicine, Iowa City 52242, USA
J Neuropsychiatry Clin Neurosci 12:344-9. 2000..Thus, the greater the size of the anomaly, the greater the cognitive deficit. No relationship was found between severity of CSP and symptom measures...
Long-term outcome of brain structure in premature infants: effects of liberal vs restricted red blood cell transfusionsPeg C Nopoulos
University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
Arch Pediatr Adolesc Med 165:443-50. 2011..To assess the long-term outcome of brain structure in preterm infants, at an average age of 12 years, who received a red blood cell transfusion for anemia of prematurity...- Cerebral cortex structure in prodromal Huntington diseasePeggy C Nopoulos
Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, IA 52242, USA
Neurobiol Dis 40:544-54. 2010..Early in the course of HD, the cortex shows changes that are manifest as cortical thinning and are most robust in the posterior and superior regions of the cerebrum... - Ventral frontal cortex morphology in adult males with isolated orofacial clefts: relationship to abnormalities in social functionPeg Nopoulos
Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
Cleft Palate Craniofac J 42:138-44. 2005..This study was designed to evaluate the morphology of the ventral frontal cortex in men with nonsyndromic clefts of the lip and/or palate, and the morphology's relationship to social function... - Cognitive dysfunction in adults with Van der Woude syndromePeg Nopoulos
Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
Genet Med 9:213-8. 2007..Given the similarities between Van der Woude syndrome and isolated cleft of the lip and/or palate, the current study was designed to evaluate the pattern of cognitive function in adults with Van der Woude syndrome... - Abnormal brain structure in adults with Van der Woude syndromeP Nopoulos
Department of Psychiatry, University of Iowa College of Medicine, IA 52242, USA
Clin Genet 71:511-7. 2007.... - Abnormal brain structure in children with isolated clefts of the lip or palatePeg Nopoulos
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Arch Pediatr Adolesc Med 161:753-8. 2007..To evaluate brain structure in a sample of children with isolated clefts of the lip and/or palate (ICLP)... - Morphology of the cerebral cortex in preclinical Huntington's diseasePeg Nopoulos
Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, IA, USA
Am J Psychiatry 164:1428-34. 2007..Cortical morphology was evaluated in subjects with known gene expansion for Huntington's disease and no manifest disease... - Cognitive dysfunction in adult males with non-syndromic clefts of the lip and/or palatePeg Nopoulos
Psychiatry Research, University of Iowa College of Medicine, 1 180 MEB, 500 Newton Road, Iowa City 52242, USA
Neuropsychologia 40:2178-84. 2002..As the development of the face is highly interdependent with the development of the brain, it is theorized that the etiology of these cognitive deficits is a primary problem with abnormal brain development... - Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative matingPeg Nopoulos
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Behav Brain Funct 7:45. 2011..The current study shows a significant correlation between the CAG repeat length of the maternal and paternal allele in the Huntingtin gene among healthy subjects, suggesting assortative mating... - Hyperactivity, impulsivity, and inattention in boys with cleft lip and palate: relationship to ventromedial prefrontal cortex morphologyPeggy Nopoulos
Carver College of Medicine, University of Iowa, W278 GH, 200 Hawkins Drive, Iowa City, IA, 52242, USA
J Neurodev Disord 2:235-42. 2010.... - Developmental brain anomalies in children with attention-deficit hyperactivity disorderP Nopoulos
Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
J Child Neurol 15:102-8. 2000..These findings support and extend the idea that ADHD is of developmental origin, and further suggest that the timing of aberrant brain development could be in early gestation... - Increased incidence of a midline brain anomaly in patients with nonsyndromic clefts of the lip and/or palateP Nopoulos
Department of Psychiatry, University of Iowa College of Medicine, 500 Newton Road, Iowa City, IA 52242, USA
J Neuroimaging 11:418-24. 2001.... - Abnormal brain morphology in patients with isolated cleft lip, cleft palate, or both: a preliminary analysisP Nopoulos
Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
Cleft Palate Craniofac J 37:441-6. 2000..The aim of this study was to determine whether adult men with cleft lip and palate (CLP) have aberrant cerebral morphology... - Longitudinal study of cognitive function in first-episode and recent-onset schizophreniaS Gold
Department of Psychiatry, University of Iowa, USA
Am J Psychiatry 156:1342-8. 1999..Few studies have examined the longitudinal stability of cognitive function and the relationship between cognitive performance and clinical symptoms over time in a cohort of well-treated patients with schizophrenia... - Longitudinal assessment of premorbid cognitive functioning in patients with schizophrenia through examination of standardized scholastic test performanceRebecca Fuller
Department of Psychiatry, Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52240, USA
Am J Psychiatry 159:1183-9. 2002..The purpose of this study was to investigate the longitudinal course of premorbid cognitive functioning in individuals with schizophrenia by using prospective data obtained from scholastic test results... - Prevalence of depressive symptoms early in the course of schizophreniaT H Wassink
Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa College of Medicine, Iowa City 52242, USA
Am J Psychiatry 156:315-6. 1999..The rate of depressive symptoms early in the course of schizophrenia was determined... - Structure and function of the superior temporal plane in adult males with cleft lip and palate: pathologic enlargement with no relationship to childhood hearing deficitsA S Shriver
Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
J Child Psychol Psychiatry 47:994-1002. 2006.... - Morphology of the anterior cingulate gyrus in patients with schizophrenia: relationship to typical neuroleptic exposureAlison Kopelman
University of Iowa Health Care, Department of Psychiatry, 1-180 MEB, 500 Newton Rd, Iowa City, IA 52242-1057, USA
Am J Psychiatry 162:1872-8. 2005..Future research is needed to determine the functional consequences of these changes and relationship to atypical neuroleptic use... - Morphometry of the superior temporal plane in schizophrenia: relationship to clinical correlatesBenedicto Crespo-Facorro
Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
J Neuropsychiatry Clin Neurosci 16:284-94. 2004.... - Morphology of the ventral frontal cortex: relationship to femininity and social cognitionJessica L Wood
Mental Health Clinical Research Center, Iowa City, IA, USA
Cereb Cortex 18:534-40. 2008..In addition, higher degrees of femininity correlated with better performance on the IPT. Taken together, these data suggest a complex relationship between femininity, social cognition, and the structure of the SG... - Quantitative in vivo measurement of gyrification in the human brain: changes associated with agingV A Magnotta
Mental Health Clinical Research Center, The University of Iowa College of Medicine and Hospitals and Clinics, Iowa City 52242, USA
Cereb Cortex 9:151-60. 1999..Measurements of sulcal and gyral shape may be useful in studying the mechanisms of both neurodevelopmental and neurodegenerative changes that occur during brain maturation and aging... - Change in basal ganglia volume over 2 years in patients with schizophrenia: typical versus atypical neurolepticsP W Corson
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242, USA
Am J Psychiatry 156:1200-4. 1999.... - Functional abnormalities in the neural circuitry of reading in men with nonsyndromic clefts of the lip or palateGrant Goldsberry
Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Cleft Palate Craniofac J 43:683-90. 2006..CONCLUSIONS: These results indicate that subjects with NSCLP show abnormalities in the function of the distributed neural circuitry used for oral reading... - Untreated initial psychosis: its relation to quality of life and symptom remission in first-episode schizophreniaB C Ho
Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Am J Psychiatry 157:808-15. 2000..If untreated psychosis is neurotoxic, this would form a strong basis for early intervention in schizophrenia... - Right ventromedial prefrontal cortex: a neuroanatomical correlate of impulse control in boysAaron D Boes
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Soc Cogn Affect Neurosci 4:1-9. 2009..These results are consistent with the notion that right vmPFC provides a neuroanatomical correlate of the normal variance in impulse control observed in boys... - Ventral frontal cortex in children: morphology, social cognition and femininity/masculinityJessica L Wood
University of Iowa Carver College of Medicine, Mental Health Clinical Research Center, W278 GH, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
Soc Cogn Affect Neurosci 3:168-76. 2008..No volume differences by sex or significant correlations were found with the OFC. These data suggest a complex relationship between femininity, social cognition and SG morphology... - Three-dimensional morphometric analysis of brain shape in nonsyndromic orofacial cleftingSeth M Weinberg
Department of Psychiatry, University of Iowa Hospital and Clinics, Iowa City, USA
J Anat 214:926-36. 2009.... - Effects of unilateral clefts on brain structureEllen van der Plas
Department of Psychiatry, University of Iowa Hospital and Clinics, 200 Hawkins Dr, W278 GH, Iowa City, IA 52242, USA
Arch Pediatr Adolesc Med 164:763-8. 2010..To evaluate potential abnormalities in brain structure of children and adolescents with unilateral clefts... - Biological and environmental predictors of behavioral sequelae in children born pretermAmy L Conrad
Department of Psychiatry Research, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
Pediatrics 125:e83-9. 2010.... - Amygdala volume correlates positively with fearfulness in normal healthy girlsEllen A A van der Plas
University of Iowa Neuroscience Program, Department of Psychiatry, University of Iowa Carver College of Medicine, 200 Hawkins Drive, W285 GH, Iowa City, Iowa 52242, USA
Soc Cogn Affect Neurosci 5:424-31. 2010..Given the role of enlarged amygdala volume in pathology, these findings may indicate that variation in amygdala morphology marks susceptibility to internalizing disorders... - Challenges assessing clinical endpoints in early Huntington diseaseJane S Paulsen
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1000, USA
Mov Disord 25:2595-603. 2010..We conclude that future clinical trials designed for very early disease will require the development of new and more sensitive measures of real-life function... - Sex differences in parietal lobe morphology: relationship to mental rotation performanceTim Koscik
University of Iowa Neuroscience Graduate Program Drive, Department of Neurology, 200 Hawkins Drive, Iowa City, IA 52242, USA
Brain Cogn 69:451-9. 2009..These findings support the possibility that the sexual dimorphism in the structure of the parietal lobe is a neurobiological substrate for the sex difference in performance on the mental rotations test... - Right anterior cingulate: a neuroanatomical correlate of aggression and defiance in boysAaron D Boes
Department of Psychiatry and Medical Scientist Training Program, University of Iowa Carver College of Medicine, USA
Behav Neurosci 122:677-84. 2008..The authors discuss this finding in light of its implications for understanding the neural correlates of antisocial behavior... - Structural brain abnormalities in adult males with clefts of the lip and/or palatePeg Nopoulos
Department of Psychiatry, University of Iowa Hospital, Iowa City, Iowa 52242, USA
Genet Med 4:1-9. 2002..Furthermore, these structural abnormalities were directly related to cognitive dysfunction. CONCLUSIONS: These findings highlight the important relationship and interplay between face and brain development... - Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophreniaBeng Choon Ho
Mental Health Clinical Research Center, Iowa City, Iowa, USA
Arch Gen Psychiatry 60:585-94. 2003..However, whether these abnormalities progressively worsen during the subsequent course of the disorder remains unresolved... - Insular cortex abnormalities in schizophrenia: Relationship to symptoms and typical neuroleptic exposureMarcus Pressler
Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Biol Psychiatry 57:394-8. 2005..Previously, we found that neuroleptic-naive subjects had abnormally small insular volumes compared with control subjects, with volume directly related to severity of psychotic symptoms... - Subgenual prefrontal cortex volumes in major depressive disorder and schizophrenia: diagnostic specificity and prognostic implicationsWilliam Coryell
Department of Psychiatry, 2 205 MEB, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1000, USA
Am J Psychiatry 162:1706-12. 2005..There are, as yet, few data to address the specificity of these abnormalities to depressive disorders or to characterize their stability over time... - Effects of atypical and typical neuroleptics on anterior cingulate volume in schizophreniaLaurie McCormick
The University of Iowa, Carver College of Medicine, Department of Psychiatry, W278 GH, University of Iowa Hospitals and Clinics, Mental Health Clinical Research Center, 200 Hawkins Drive, Iowa City, IA 52242, USA
Schizophr Res 80:73-84. 2005..The increase in anterior cingulate volume with typicals is correlated to improved psychotic symptoms over time... - Secondary prevention of schizophrenia: utility of standardized scholastic tests in early identificationBeng Choon Ho
Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Ann Clin Psychiatry 17:11-8. 2005..Early detection and prompt treatment may improve outcome in schizophrenia. In this study, we examine the value of using pre-morbid cognitive impairment in early detection... - Social function in boys with cleft lip and palate: relationship to ventral frontal cortex morphologyAaron D Boes
University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Behav Brain Res 181:224-31. 2007..These results are consistent with the possibility that aberrant VFC development may partially underlie social dysfunction in boys with ICLP... - Rostral anterior cingulate cortex volume correlates with depressed mood in normal healthy childrenAaron D Boes
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
Biol Psychiatry 63:391-7. 2008.... - Risperidone and the treatment of psychiatric, motor, and cognitive symptoms in Huntington's diseaseKevin Duff
Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
Ann Clin Psychiatry 20:1-3. 2008..Huntington's disease (HD) is a progressive, neuropsychiatric disorder, and limited reports indicate that risperidone might improve motor and psychiatric functioning for these patients... - Incidence of neurological soft signs in children with isolated cleft of the lip or palateAmy L Conrad
Department of Psychiatry Research, University of Iowa Hospitals and Clinics, College of Medicine, Iowa City, IA 52242, USA
Percept Mot Skills 106:197-206. 2008..Subjects with iCL/P scored significantly higher on all neurological soft signs variables. These higher scores were associated with younger age. Findings lend support to the hypothesis of aberrant brain development in children with iCL/P... - Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugsNancy C Andreasen
Mental Health Clinical Research Center, Department of Psychiatry, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1057, USA
Biol Psychiatry 67:255-62. 2010..An expert consensus group has published charts of equivalent doses for various antipsychotic medications for first- and second-generation medications. These charts were used in this study... - CAG-repeat length and the age of onset in Huntington disease (HD): a review and validation study of statistical approachesDouglas R Langbehn
Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1000, USA
Am J Med Genet B Neuropsychiatr Genet 153:397-408. 2010..The Langbehn et al. model appears accurate enough to have substantial utility in various research contexts. We also emphasize remaining caveats, many of which are relevant for any direct application to genetic counseling... - Color enhancement of multispectral MR images: improving the visualization of subcortical structuresJ Ward
Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
J Comput Assist Tomogr 25:942-9. 2001..quot; They were developed to improve the delineation of small brain structures composed of mixed tissue types, such as the basal ganglia... - Globus pallidus volume is related to symptom severity in neuroleptic naive patients with schizophreniaRuth Spinks
Schizophrenia Research Center, University of Iowa, Iowa City, IA 52242, United States
Schizophr Res 73:229-33. 2005..The volume for the GP, GPe, and internal segment (GPi) did not differ between groups... - Morphology of the ventral frontal cortex in schizophrenia: relationship with social dysfunctionEran Chemerinski
Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242-1057, USA
Biol Psychiatry 52:1-8. 2002..CONCLUSIONS: Morphology of the VFC is directly related to abnormal social function in schizophrenia, including measures of social dysfunction that predate the onset of illness...
Research Grants
- Brain Structure, Function, and Growth in Children with Oral CleftPeggy C Nopoulos; Fiscal Year: 2010..In addition, the study will evaluate the relationship between measures of brain structure/function and genes associated with oral clefts. ..
- Brain Structure and Function in Children at Risk for Huntington's DiseasePeggy C Nopoulos; Fiscal Year: 2010..Changes in brain structure and/or function in the gene positive group would lend significant support to the notion that this disease has an important developmental component. ..
- Brain Structure, Function, and Growth in Children with Oral CleftPeggy Nopoulos; Fiscal Year: 2009..In addition, the study will evaluate the relationship between measures of brain structure/function and genes associated with oral clefts. ..
- Brain Structure/Function in Children with Oral CleftsPeggy Nopoulos; Fiscal Year: 2006..Evaluating the relationship between brain structure/function and genes known to be associated with non-syndromic clefts may shed light on possible etiologic mechanisms at the molecular level. ..
- BRAIN STRUCTURE/FUNCTION IN OROFACIAL CLEFTING DISORDERSPeggy Nopoulos; Fiscal Year: 2003..This award will also provide the candidate with the background necessary for ongoing research and funding leading to an independent research career. ..
- Brain Structure and Function in Children at Risk for Huntington's DiseasePeggy C Nopoulos; Fiscal Year: 2010..Changes in brain structure and/or function in the gene positive group would lend significant support to the notion that this disease has an important developmental component. ..