Daniel K Nomura

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation
    Daniel K Nomura
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 334:809-13. 2011
  2. pmc Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer
    Daniel K Nomura
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Biol 18:846-56. 2011
  3. pmc Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo
    Jonathan Z Long
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:20270-5. 2009
  4. pmc Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism
    Jonathan Z Long
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N Torrey Pines Rd La Jolla, CA 92037, USA
    Chem Biol 16:744-53. 2009
  5. pmc Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis
    Daniel K Nomura
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 140:49-61. 2010
  6. pmc A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis
    Jae Won Chang
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Chem Biol 18:476-84. 2011
  7. pmc Activity-based protein profiling of organophosphorus and thiocarbamate pesticides reveals multiple serine hydrolase targets in mouse brain
    Daniel K Nomura
    Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Agric Food Chem 59:2808-15. 2011
  8. pmc Organophosphate-sensitive lipases modulate brain lysophospholipids, ether lipids and endocannabinoids
    John E Casida
    Environmental Chemistry and Toxicology Laboratory Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Chem Biol Interact 175:355-64. 2008
  9. pmc Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes
    Eduardo Dominguez
    Department of Chemical Physiology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA
    Nat Chem Biol 10:113-21. 2014
  10. pmc Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide
    Brad E Morrison
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 189:5498-502. 2012

Collaborators

Detail Information

Publications14

  1. pmc Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation
    Daniel K Nomura
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 334:809-13. 2011
    ....
  2. pmc Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer
    Daniel K Nomura
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Biol 18:846-56. 2011
    ....
  3. pmc Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo
    Jonathan Z Long
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:20270-5. 2009
    ....
  4. pmc Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism
    Jonathan Z Long
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N Torrey Pines Rd La Jolla, CA 92037, USA
    Chem Biol 16:744-53. 2009
    ..Collectively, these studies indicate that MAGL exerts tissue-dependent control over endocannabinoid and monoglyceride metabolism and designate JZL184 as a selective tool to characterize the functions of MAGL in vivo...
  5. pmc Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis
    Daniel K Nomura
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 140:49-61. 2010
    ..Together, these findings reveal how cancer cells can co-opt a lipolytic enzyme to translate their lipogenic state into an array of protumorigenic signals. PAPERFLICK:..
  6. pmc A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis
    Jae Won Chang
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Chem Biol 18:476-84. 2011
    ..These findings indicate that the KIAA1363-MAGE pathway is important for prostate cancer pathogenesis and designate JW480 as a versatile pharmacological probe for disrupting this pro-tumorigenic metabolic pathway...
  7. pmc Activity-based protein profiling of organophosphorus and thiocarbamate pesticides reveals multiple serine hydrolase targets in mouse brain
    Daniel K Nomura
    Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Agric Food Chem 59:2808-15. 2011
    ..This study reveals a multitude of secondary targets for OP and TC pesticides and underscores the utility of chemoproteomic platforms in gaining insights into biochemical pathways that are perturbed by these toxicants...
  8. pmc Organophosphate-sensitive lipases modulate brain lysophospholipids, ether lipids and endocannabinoids
    John E Casida
    Environmental Chemistry and Toxicology Laboratory Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Chem Biol Interact 175:355-64. 2008
    ..Only the first steps have been taken to achieve appropriate selective action for OP therapeutic agents...
  9. pmc Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes
    Eduardo Dominguez
    Department of Chemical Physiology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA
    Nat Chem Biol 10:113-21. 2014
    ....
  10. pmc Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide
    Brad E Morrison
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 189:5498-502. 2012
    ..In humans, Il13ra1 lies on the X chromosome within the PARK12 locus of susceptibility to Parkinson's disease, suggesting that IL-13Rα1 may have a role in the pathogenesis of this neurodegenerative disease...
  11. pmc Design, synthesis, and biological evaluation of a biyouyanagin compound library
    K C Nicolaou
    Department of Chemistry, Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:6715-20. 2011
    ....
  12. pmc Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors
    Daniel A Bachovchin
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:6811-6. 2011
    ....
  13. pmc The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice
    Florian Kopp
    Department of Chemical Physiology and The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA
    Chem Biol 17:831-40. 2010
    ....
  14. pmc Activity-based protein profiling for biochemical pathway discovery in cancer
    Daniel K Nomura
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Rev Cancer 10:630-8. 2010
    ....