Daniel K Nomura

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids
    Rebecca A Kohnz
    Program in Metabolic Biology, University of California, Berkeley, 127 Morgan Hall, Berkeley, CA 94720, USA
    Chem Soc Rev 43:6859-69. 2014
  2. pmc Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer
    Daniel K Nomura
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Biol 18:846-56. 2011
  3. pmc Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation
    Daniel K Nomura
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 334:809-13. 2011
  4. pmc Activation of the endocannabinoid system by organophosphorus nerve agents
    Daniel K Nomura
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, 114 Wellman Hall, Berkeley, California 94720 3112, USA
    Nat Chem Biol 4:373-8. 2008
  5. pmc Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo
    Jonathan Z Long
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:20270-5. 2009
  6. pmc Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels
    Daniel K Nomura
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, 115 Wellman Hall, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem Lett 18:5875-8. 2008
  7. pmc Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification
    Daniel K Nomura
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, 115 Wellman Hall, University of California, Berkeley, CA 94720 3112, USA
    Toxicol Appl Pharmacol 228:42-8. 2008
  8. pmc Activity-based protein profiling of organophosphorus and thiocarbamate pesticides reveals multiple serine hydrolase targets in mouse brain
    Daniel K Nomura
    Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Agric Food Chem 59:2808-15. 2011
  9. pmc Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism
    Jonathan Z Long
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N Torrey Pines Rd La Jolla, CA 92037, USA
    Chem Biol 16:744-53. 2009
  10. pmc Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity
    Daniel I Benjamin
    Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, and Division of Cell and Developmental Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720
    Proc Natl Acad Sci U S A 110:14912-7. 2013

Collaborators

Detail Information

Publications40

  1. doi request reprint Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids
    Rebecca A Kohnz
    Program in Metabolic Biology, University of California, Berkeley, 127 Morgan Hall, Berkeley, CA 94720, USA
    Chem Soc Rev 43:6859-69. 2014
    ....
  2. pmc Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer
    Daniel K Nomura
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Biol 18:846-56. 2011
    ....
  3. pmc Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation
    Daniel K Nomura
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 334:809-13. 2011
    ....
  4. pmc Activation of the endocannabinoid system by organophosphorus nerve agents
    Daniel K Nomura
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, 114 Wellman Hall, Berkeley, California 94720 3112, USA
    Nat Chem Biol 4:373-8. 2008
    ..Arachidonic acid levels are decreased by the organophosphorus agents in amounts equivalent to elevations in 2-AG, which indicates that endocannabinoid and eicosanoid signaling pathways may be coordinately regulated in the brain...
  5. pmc Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo
    Jonathan Z Long
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:20270-5. 2009
    ....
  6. pmc Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels
    Daniel K Nomura
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, 115 Wellman Hall, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem Lett 18:5875-8. 2008
    ..Apparent direct OP inhibition of CB1 agonist binding may be due instead to metabolic stabilization of 2-AG in brain membranes as the actual inhibitor...
  7. pmc Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification
    Daniel K Nomura
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, 115 Wellman Hall, University of California, Berkeley, CA 94720 3112, USA
    Toxicol Appl Pharmacol 228:42-8. 2008
    ..This study establishes the relevance of KIAA1363 in ether lipid metabolism and OP detoxification...
  8. pmc Activity-based protein profiling of organophosphorus and thiocarbamate pesticides reveals multiple serine hydrolase targets in mouse brain
    Daniel K Nomura
    Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Agric Food Chem 59:2808-15. 2011
    ..This study reveals a multitude of secondary targets for OP and TC pesticides and underscores the utility of chemoproteomic platforms in gaining insights into biochemical pathways that are perturbed by these toxicants...
  9. pmc Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism
    Jonathan Z Long
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N Torrey Pines Rd La Jolla, CA 92037, USA
    Chem Biol 16:744-53. 2009
    ..Collectively, these studies indicate that MAGL exerts tissue-dependent control over endocannabinoid and monoglyceride metabolism and designate JZL184 as a selective tool to characterize the functions of MAGL in vivo...
  10. pmc Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity
    Daniel I Benjamin
    Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, and Division of Cell and Developmental Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720
    Proc Natl Acad Sci U S A 110:14912-7. 2013
    ....
  11. pmc Serine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions
    Daniel K Nomura
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, 115 Wellman Hall, University of California, Berkeley, California 94720 3112, USA
    Chem Res Toxicol 19:1142-50. 2006
    ..The structural modeling of KIAA1363 helps us understand OP structure-activity relationships and the toxicological relevance of this detoxifying enzyme...
  12. ncbi request reprint Cannabinoid CB1 receptor as a target for chlorpyrifos oxon and other organophosphorus pesticides
    Gary B Quistad
    Department of Environmental Science, Policy and Management, Environmental Chemistry and Toxicology Laboratory, University of California, Berkeley, CA 94720 3112, USA
    Toxicol Lett 135:89-93. 2002
    ..3H-ethyl]Chlorpyrifos oxon may be suitable for radiolabeling and characterization of this proposed nucleophilic site...
  13. pmc Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis
    Daniel K Nomura
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 140:49-61. 2010
    ..Together, these findings reveal how cancer cells can co-opt a lipolytic enzyme to translate their lipogenic state into an array of protumorigenic signals. PAPERFLICK:..
  14. ncbi request reprint Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors
    Yoffi Segall
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem Lett 13:3301-3. 2003
    ..N-(2-Hydroxyethyl)arachidonylsulfonamide (4) is at least 2500-fold less potent than N-(2-hydroxyethyl)arachidonamide (anandamide) (1) at the CB1 agonist site...
  15. ncbi request reprint Toxicological and structural features of organophosphorus and organosulfur cannabinoid CB1 receptor ligands
    Yoffi Segall
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Toxicol Sci 76:131-7. 2003
    ..On the other hand, the most potent CB1 inhibitors examined here are also NTE-LysoPLA inhibitors and cause delayed toxicity in mice...
  16. pmc A brain detoxifying enzyme for organophosphorus nerve poisons
    Daniel K Nomura
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Proc Natl Acad Sci U S A 102:6195-200. 2005
    ..KIAA1363 therefore is the principal enzyme for metabolizing low levels of CPO in brain and may play a more general role in detoxification of OP nerve poisons...
  17. pmc Organophosphate-sensitive lipases modulate brain lysophospholipids, ether lipids and endocannabinoids
    John E Casida
    Environmental Chemistry and Toxicology Laboratory Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 3112, USA
    Chem Biol Interact 175:355-64. 2008
    ..Only the first steps have been taken to achieve appropriate selective action for OP therapeutic agents...
  18. pmc Metabolic profiling reveals PAFAH1B3 as a critical driver of breast cancer pathogenicity
    Melinda M Mulvihill
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, 127 Morgan Hall, Berkeley, CA 94720, USA
    Chem Biol 21:831-40. 2014
    ..Our studies provide a map of altered metabolism that underlies breast cancer progression and put forth PAFAH1B3 as a critical metabolic node in breast cancer. ..
  19. pmc Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes
    Eduardo Dominguez
    Department of Chemical Physiology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA
    Nat Chem Biol 10:113-21. 2014
    ....
  20. ncbi request reprint Each lipase has a unique sensitivity profile for organophosphorus inhibitors
    Gary B Quistad
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Toxicol Sci 91:166-72. 2006
    ..In general, each lipase (like each serine hydrolase) has a different spectrum of OP sensitivity, and individual OPs have unique ranking of potency for inhibition of serine hydrolases...
  21. pmc Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids
    Sharon M Louie
    Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA
    Biochim Biophys Acta 1831:1566-72. 2013
    ..This article is part of a special issue entitled Lipid Metabolism in Cancer. ..
  22. pmc A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis
    Jae Won Chang
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Chem Biol 18:476-84. 2011
    ..These findings indicate that the KIAA1363-MAGE pathway is important for prostate cancer pathogenesis and designate JW480 as a versatile pharmacological probe for disrupting this pro-tumorigenic metabolic pathway...
  23. pmc Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemia
    Patrick J Morris
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, 127 Morgan Hall, Berkeley, California 94720, United States
    ACS Chem Biol 9:1097-103. 2014
    ..Our findings suggest novel toxicities that may arise from OPFR exposure and highlight the utility of chemoproteomic and metabolomic platforms in the toxicological characterization of environmental chemicals. ..
  24. pmc Therapeutic potential of monoacylglycerol lipase inhibitors
    Melinda M Mulvihill
    Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, 127 Morgan Hall, Berkeley, CA 94720, USA
    Life Sci 92:492-7. 2013
    ..This review will discuss the diverse (patho)physiological roles of MAGL and the therapeutic potential of MAGL inhibitors in treating a vast array of complex human diseases...
  25. pmc Inositol phosphate recycling regulates glycolytic and lipid metabolism that drives cancer aggressiveness
    Daniel I Benjamin
    Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California 94720, United States
    ACS Chem Biol 9:1340-50. 2014
    ..Taken together these findings reveal a novel mode of glycolytic control in cancer cells that can serve to promote key oncogenic lipid signaling pathways that drive cancer pathogenicity...
  26. pmc Global profiling strategies for mapping dysregulated metabolic pathways in cancer
    Daniel I Benjamin
    Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, 127 Morgan Hall, Berkeley, CA 94720, USA
    Cell Metab 16:565-77. 2012
    ..We will also discuss questions and challenges that must be addressed to more completely describe, and eventually control, the diverse metabolic pathways that support tumorigenesis...
  27. doi request reprint Chemical genetics screening reveals KIAA1363 as a cytokine-lowering target
    Devon M Hunerdosse
    Program in Metabolic Biology, University of California, Berkeley, Berkeley, California 94720, United States
    ACS Chem Biol 9:2905-13. 2014
    ..Our study highlights the application of combining chemical genetics with chemoproteomic and metabolomic approaches toward identifying and characterizing anti-inflammatory smal molecules and their targets. ..
  28. pmc The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice
    Florian Kopp
    Department of Chemical Physiology and The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA
    Chem Biol 17:831-40. 2010
    ....
  29. pmc Multidimensional profiling platforms reveal metabolic dysregulation caused by organophosphorus pesticides
    Daniel Medina-Cleghorn
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, 127 Morgan Hall, Berkeley, California 94720, United States
    ACS Chem Biol 9:423-32. 2014
    ....
  30. pmc Mechanisms linking obesity and cancer
    Sharon M Louie
    Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, 127 Morgan Hall, Berkeley, CA 94710, USA
    Biochim Biophys Acta 1831:1499-508. 2013
    ..This article is part of a Special Issue entitled Lipid Metabolism in Cancer. ..
  31. doi request reprint Employing a combinatorial expression approach to characterize xylose utilization in Saccharomyces cerevisiae
    Luke N Latimer
    Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA Energy Biosciences Institute, Berkeley, CA 94720, USA Electronic address
    Metab Eng 25:20-9. 2014
    ....
  32. pmc Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide
    Brad E Morrison
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 189:5498-502. 2012
    ..In humans, Il13ra1 lies on the X chromosome within the PARK12 locus of susceptibility to Parkinson's disease, suggesting that IL-13Rα1 may have a role in the pathogenesis of this neurodegenerative disease...
  33. pmc Design, synthesis, and biological evaluation of a biyouyanagin compound library
    K C Nicolaou
    Department of Chemistry, Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:6715-20. 2011
    ....
  34. doi request reprint Exploring metabolic pathways and regulation through functional chemoproteomic and metabolomic platforms
    Daniel Medina-Cleghorn
    Program in Metabolic Biology and Molecular Toxicology, Department of Nutritional Sciences and Toxicology, 127 Morgan Hall, Berkeley, CA 94720, USA
    Chem Biol 21:1171-84. 2014
    ....
  35. doi request reprint Metabolomic strategies to map functions of metabolic pathways
    Melinda M Mulvihill
    Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California
    Am J Physiol Endocrinol Metab 307:E237-44. 2014
    ..This review focuses on recent discoveries made using metabolic mapping technologies to uncover novel pathways and metabolite-mediated posttranslational modifications and epigenetic alterations and their impact on physiology and disease. ..
  36. pmc Chemical approaches to study metabolic networks
    Daniel Medina-Cleghorn
    Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, 127 Morgan Hall, Berkeley, CA 94720, USA
    Pflugers Arch 465:427-40. 2013
    ..This review will highlight the chemical technologies that have been successfully used to characterize metabolism, and put forth some of the challenges we face as we expand our map of metabolic pathways...
  37. ncbi request reprint Selective inhibitors of fatty acid amide hydrolase relative to neuropathy target esterase and acetylcholinesterase: toxicological implications
    Gary B Quistad
    Environmental Chemistry and Toxicology Laboratory, University of California, Berkeley, California 94720 3112, USA
    Toxicol Appl Pharmacol 179:57-63. 2002
    ..Thus, FAAH inhibition in mouse brain does not appear to be a primary target for organophosphorus pesticide-induced neurotoxic action (cholinergic or intermediate syndrome or delayed neurotoxicity)...
  38. doi request reprint Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function
    Martín Valdearcos
    Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell Rep 9:2124-38. 2014
    ..We thus show that microglia sense SFAs and orchestrate an inflammatory process in the MBH that alters neuronal function when SFA consumption is high. ..
  39. pmc Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors
    Daniel A Bachovchin
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:6811-6. 2011
    ....
  40. pmc Activity-based protein profiling for biochemical pathway discovery in cancer
    Daniel K Nomura
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Rev Cancer 10:630-8. 2010
    ....