Eric Nofzinger

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Human regional cerebral glucose metabolism during non-rapid eye movement sleep in relation to waking
    Eric A Nofzinger
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Brain 125:1105-15. 2002
  2. ncbi request reprint Functional neuroimaging evidence for hyperarousal in insomnia
    Eric A Nofzinger
    Western Psychiatric Institute and Clinic, Sleep Neuroimaging Research Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 161:2126-8. 2004
  3. ncbi request reprint Neuroimaging of sleep and sleep disorders
    Eric A Nofzinger
    Sleep Neuroimaging Research Program, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Curr Neurol Neurosci Rep 6:149-55. 2006
  4. ncbi request reprint Regional cerebral metabolic correlates of WASO during NREM sleep in insomnia
    Eric A Nofzinger
    Western Psychiatric Institute and Clinic, Sleep Neuroimaging Research Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    J Clin Sleep Med 2:316-22. 2006
  5. ncbi request reprint Neuroimaging and sleep medicine
    Eric A Nofzinger
    Sleep Neuroimaging Research Program, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Sleep Med Rev 9:157-72. 2005
  6. ncbi request reprint Alterations in regional cerebral glucose metabolism across waking and non-rapid eye movement sleep in depression
    Eric A Nofzinger
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:387-96. 2005
  7. ncbi request reprint What can neuroimaging findings tell us about sleep disorders?
    Eric A Nofzinger
    Sleep Neuroimaging Research Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Sleep Med 5:S16-22. 2004
  8. ncbi request reprint Increased activation of anterior paralimbic and executive cortex from waking to rapid eye movement sleep in depression
    Eric A Nofzinger
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Arch Gen Psychiatry 61:695-702. 2004
  9. ncbi request reprint Advancing the neurobiology of insomnia, a commentary on: "Functional imaging of the sleeping brain" by Drummond et al
    Eric A Nofzinger
    Sleep Neuroimaging Research Program, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street Pittsburgh, PA 15213, USA
    Sleep Med Rev 8:243-7. 2004
  10. ncbi request reprint Functional neuroimaging of sleep disorders
    Eric A Nofzinger
    Sleep Neuroimaging Research Program, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Curr Pharm Des 14:3417-29. 2008

Research Grants

  1. SLEEP-GUIDED PET STUDIES IN DEPRESSION
    Eric Nofzinger; Fiscal Year: 2004
  2. Human Sleep Neuroscience
    Eric Nofzinger; Fiscal Year: 2007
  3. Sleep Neuroscience in Depression
    Eric Nofzinger; Fiscal Year: 2009

Detail Information

Publications34

  1. ncbi request reprint Human regional cerebral glucose metabolism during non-rapid eye movement sleep in relation to waking
    Eric A Nofzinger
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Brain 125:1105-15. 2002
    ....
  2. ncbi request reprint Functional neuroimaging evidence for hyperarousal in insomnia
    Eric A Nofzinger
    Western Psychiatric Institute and Clinic, Sleep Neuroimaging Research Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 161:2126-8. 2004
    ..The authors investigated the neurobiological basis of poor sleep and daytime fatigue in insomnia...
  3. ncbi request reprint Neuroimaging of sleep and sleep disorders
    Eric A Nofzinger
    Sleep Neuroimaging Research Program, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Curr Neurol Neurosci Rep 6:149-55. 2006
    ..Extensive advances have been made in the area of sleep apnea where physiologic challenges have been used to probe brain activity in the pathophysiology of sleep apnea syndrome...
  4. ncbi request reprint Regional cerebral metabolic correlates of WASO during NREM sleep in insomnia
    Eric A Nofzinger
    Western Psychiatric Institute and Clinic, Sleep Neuroimaging Research Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    J Clin Sleep Med 2:316-22. 2006
    ..To investigate the non-rapid eye movement (NREM) sleep-related regional cerebral metabolic correlates of wakefulness after sleep onset (WASO) in patients with primary insomnia...
  5. ncbi request reprint Neuroimaging and sleep medicine
    Eric A Nofzinger
    Sleep Neuroimaging Research Program, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Sleep Med Rev 9:157-72. 2005
    ....
  6. ncbi request reprint Alterations in regional cerebral glucose metabolism across waking and non-rapid eye movement sleep in depression
    Eric A Nofzinger
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:387-96. 2005
    ..Non-rapid eye movement sleep is associated with decreases in frontal, parietal, and temporal cortex metabolic activity compared with wakefulness...
  7. ncbi request reprint What can neuroimaging findings tell us about sleep disorders?
    Eric A Nofzinger
    Sleep Neuroimaging Research Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Sleep Med 5:S16-22. 2004
    ..This review discusses functional neuroimaging data on normal sleep, and on the pathophysiology of insomnia related to depression and primary insomnia...
  8. ncbi request reprint Increased activation of anterior paralimbic and executive cortex from waking to rapid eye movement sleep in depression
    Eric A Nofzinger
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Arch Gen Psychiatry 61:695-702. 2004
    ....
  9. ncbi request reprint Advancing the neurobiology of insomnia, a commentary on: "Functional imaging of the sleeping brain" by Drummond et al
    Eric A Nofzinger
    Sleep Neuroimaging Research Program, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street Pittsburgh, PA 15213, USA
    Sleep Med Rev 8:243-7. 2004
  10. ncbi request reprint Functional neuroimaging of sleep disorders
    Eric A Nofzinger
    Sleep Neuroimaging Research Program, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Curr Pharm Des 14:3417-29. 2008
    ....
  11. ncbi request reprint Functional neuroanatomical correlates of eye movements during rapid eye movement sleep in depressed patients
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, E 1116, Pittsburgh, PA 15213, USA
    Psychiatry Res 130:259-68. 2004
    ..The observed pattern of correlations suggests that average RC may be a marker of hypofrontality during REM sleep in depressed patients...
  12. pmc Sleep-specific mechanisms underlying posttraumatic stress disorder: integrative review and neurobiological hypotheses
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Room E 1124, Pittsburgh, PA 15213, USA
    Sleep Med Rev 12:185-95. 2008
    ..Testable hypotheses regarding the neurobiological underpinnings of PTSD across the sleep-wake cycle are offered...
  13. pmc Sleeping well, aging well: a descriptive and cross-sectional study of sleep in "successful agers" 75 and older
    Henry C Driscoll
    Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 16:74-82. 2008
    ....
  14. pmc Three-dimensional surface mapping of the caudate nucleus in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:4-12. 2009
    ....
  15. ncbi request reprint M1 muscarinic acetylcholine receptor agonism alters sleep without affecting memory consolidation
    Christoph Nissen
    Albert Ludwigs University Freiburg, Germany
    J Cogn Neurosci 18:1799-807. 2006
    ....
  16. pmc Diurnal variation in regional brain glucose metabolism in depression
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 62:438-45. 2007
    ..This study compared diurnal variation in mood and regional cerebral metabolic rate of glucose (rCMRglc) in depressed and healthy subjects...
  17. pmc Daytime symptoms in primary insomnia: a prospective analysis using ecological momentary assessment
    Daniel J Buysse
    Neuroscience Clinical and Translational Research Center, Department of Psychiatry, University of Pittsburgh, School of Medicine, USA
    Sleep Med 8:198-208. 2007
    ....
  18. pmc Protecting sleep, promoting health in later life: a randomized clinical trial
    Charles F Reynolds
    Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Psychosom Med 72:178-86. 2010
    ..5 years; and 2) if maintenance or enhancement of sleep continuity and depth promotes the maintenance or enhancement of health-related quality of life...
  19. pmc EEG spectral analysis in primary insomnia: NREM period effects and sex differences
    Daniel J Buysse
    Neuroscience Clinical and Translational Research Center and Sleep Medicine Institute, University ofPittsburgh School ofMedicine, Pittsburgh, PA, USA
    Sleep 31:1673-82. 2008
    ..To compare NREM EEG power in primary insomnia (PI) and good sleeper controls (GSC), examining both sex and NREM period effects; to examine relationships between EEG power, clinical characteristics, and self-reports of sleep...
  20. pmc Financial strain is a significant correlate of sleep continuity disturbances in late-life
    Martica Hall
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, United States
    Biol Psychol 77:217-22. 2008
    ..01). Our results show that chronic stress, as measured by ongoing financial strain, is a significant correlate of sleep disturbances in the elderly, even after adjusting for factors known to impact sleep in late-life...
  21. ncbi request reprint Impaired sleep-related memory consolidation in primary insomnia--a pilot study
    Christoph Nissen
    Department of Psychiatry and Psychotherapy, Albert Ludwigs University of Freiburg, Freiburg, Germany
    Sleep 29:1068-73. 2006
    ..To compare sleep-related consolidation of procedural memory in patients with primary insomnia and healthy controls...
  22. ncbi request reprint Sleep in healthy seniors: a diary study of the relation between bedtime and the amount of sleep obtained
    Timothy H Monk
    Clinical Neuroscience Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    J Sleep Res 15:256-60. 2006
    ..g. age-dependent alterations in phase angle and homeostatic sleep need)...
  23. ncbi request reprint Ecological study of sleep disruption in PTSD: a pilot study
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Room E 1124, Pittsburgh, PA 15213, USA
    Ann N Y Acad Sci 1071:438-41. 2006
    ..These preliminary findings suggest that ambulatory methods can capture objective signs of sleep disruption, and corroborate subjective complaints of disrupted sleep in PTSD...
  24. ncbi request reprint Symptom reports in severe chronic insomnia
    Douglas E Moul
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    Sleep 25:553-63. 2002
    ..To describe patterns and severities of the daytime and nighttime symptoms of chronic insomnia patients...
  25. ncbi request reprint Neurobiology of non-REM sleep in depression: further evidence for hypofrontality and thalamic dysregulation
    Anne Germain
    University of Pittsburgh School of Medicine, Department of Psychiatry, 3811 O Hara St, E 1116, Pittsburgh, PA 15213, USA
    Am J Psychiatry 161:1856-63. 2004
    ..The goal of this study was to investigate the functional neuroanatomical correlates of non-REM sleep relative to presleep wakefulness in depressed patients and healthy subjects...
  26. ncbi request reprint Regional brain glucose metabolism during morning and evening wakefulness in humans: preliminary findings
    Daniel J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
    Sleep 27:1245-54. 2004
    ..The goal of this pilot study was to examine regional relative brain glucose metabolism during morning and evening wakefulness in healthy humans...
  27. ncbi request reprint Differential effects of the muscarinic M1 receptor agonist RS-86 and the acetylcholine-esterase inhibitor donepezil on REM sleep regulation in healthy volunteers
    Christoph Nissen
    Department of Psychiatry and Psychotherapy, Albert Ludwigs University, Freiburg, Germany
    Neuropsychopharmacology 31:1294-300. 2006
    ....
  28. ncbi request reprint Age-related differences in the lifestyle regularity of seniors experiencing bereavement, care-giving, insomnia, and advancement into old-old age
    Timothy H Monk
    Clinical Neuroscience Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Chronobiol Int 23:831-41. 2006
    ..This may represent an adaptive behavioral response that might be used in future therapeutic approaches...
  29. ncbi request reprint Functional neuroimaging of sleep
    Eric A Nofzinger
    Sleep Neuroimaging Research Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Semin Neurol 25:9-18. 2005
    ....
  30. pmc A window into the invisible wound of war: functional neuroimaging of REM sleep in returning combat veterans with PTSD
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 211:176-9. 2013
    ..Hypermetabolism in brain regions involved in arousal regulation, fear responses, and reward processing persist during REM sleep in combat veterans with PTSD...
  31. ncbi request reprint Brain SPECT in sleep research
    Andreas Otte
    Sleep 26:227. 2003
  32. ncbi request reprint Nuclear medicine asleep in sleep research?
    Andreas Otte
    Eur J Nucl Med Mol Imaging 29:1417-20. 2002
  33. ncbi request reprint Neuroimaging the sleep disordered patient: a commentary
    Eric A Nofzinger
    Sleep Med 6:383-4. 2005
  34. ncbi request reprint Functional neuroimaging at the 2002 APSS 16th annual meeting in Seattle
    Andreas Otte
    Med Sci Monit 8:LE37-9. 2002

Research Grants11

  1. SLEEP-GUIDED PET STUDIES IN DEPRESSION
    Eric Nofzinger; Fiscal Year: 2004
    ..Findings from this study are expected to significantly advance our understanding of the pathophysiology of depression. ..
  2. Human Sleep Neuroscience
    Eric Nofzinger; Fiscal Year: 2007
    ..Content areas for mentoring young investigators include functional neuroimaging methods for use during sleep, the neuroscience of behavioral state regulation and in the ethical conduct of research. ..
  3. Sleep Neuroscience in Depression
    Eric Nofzinger; Fiscal Year: 2009
    ..Multiple linear regressions will be used to test the mediational models above. Findings from this study are expected to significantly advance our understanding of the neuroscience of depression. ..