Research Topics
| Eric NofzingerSummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
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Detail Information
Publications
Human regional cerebral glucose metabolism during non-rapid eye movement sleep in relation to wakingEric A Nofzinger
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213 2593, USA
Brain 125:1105-15. 2002....- Functional neuroimaging evidence for hyperarousal in insomniaEric A Nofzinger
Western Psychiatric Institute and Clinic, Sleep Neuroimaging Research Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
Am J Psychiatry 161:2126-8. 2004..The authors investigated the neurobiological basis of poor sleep and daytime fatigue in insomnia... - Alterations in regional cerebral glucose metabolism across waking and non-rapid eye movement sleep in depressionEric A Nofzinger
Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 62:387-96. 2005..Non-rapid eye movement sleep is associated with decreases in frontal, parietal, and temporal cortex metabolic activity compared with wakefulness... - Regional cerebral metabolic correlates of WASO during NREM sleep in insomniaEric A Nofzinger
Western Psychiatric Institute and Clinic, Sleep Neuroimaging Research Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
J Clin Sleep Med 2:316-22. 2006..To investigate the non-rapid eye movement (NREM) sleep-related regional cerebral metabolic correlates of wakefulness after sleep onset (WASO) in patients with primary insomnia... - Neuroimaging of sleep and sleep disordersEric A Nofzinger
Sleep Neuroimaging Research Program, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Curr Neurol Neurosci Rep 6:149-55. 2006..Extensive advances have been made in the area of sleep apnea where physiologic challenges have been used to probe brain activity in the pathophysiology of sleep apnea syndrome... - What can neuroimaging findings tell us about sleep disorders?Eric A Nofzinger
Sleep Neuroimaging Research Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Sleep Med 5:S16-22. 2004..This review discusses functional neuroimaging data on normal sleep, and on the pathophysiology of insomnia related to depression and primary insomnia... - Increased activation of anterior paralimbic and executive cortex from waking to rapid eye movement sleep in depressionEric A Nofzinger
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213 2593, USA
Arch Gen Psychiatry 61:695-702. 2004.... - Advancing the neurobiology of insomnia, a commentary on: "Functional imaging of the sleeping brain" by Drummond et alEric A Nofzinger
Sleep Neuroimaging Research Program, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street Pittsburgh, PA 15213, USA
Sleep Med Rev 8:243-7. 2004 - Functional neuroimaging of sleep disordersEric A Nofzinger
Sleep Neuroimaging Research Program, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Curr Pharm Des 14:3417-29. 2008.... - Neuroimaging and sleep medicineEric A Nofzinger
Sleep Neuroimaging Research Program, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Sleep Med Rev 9:157-72. 2005.... - Functional neuroanatomical correlates of eye movements during rapid eye movement sleep in depressed patientsAnne Germain
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, E 1116, Pittsburgh, PA 15213, USA
Psychiatry Res 130:259-68. 2004..The observed pattern of correlations suggests that average RC may be a marker of hypofrontality during REM sleep in depressed patients... - Sleep-specific mechanisms underlying posttraumatic stress disorder: integrative review and neurobiological hypothesesAnne Germain
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Room E 1124, Pittsburgh, PA 15213, USA
Sleep Med Rev 12:185-95. 2008..Testable hypotheses regarding the neurobiological underpinnings of PTSD across the sleep-wake cycle are offered... - Sleeping well, aging well: a descriptive and cross-sectional study of sleep in "successful agers" 75 and olderHenry C Driscoll
Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 16:74-82. 2008.... - Three-dimensional surface mapping of the caudate nucleus in late-life depressionMeryl A Butters
Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 17:4-12. 2009.... - Diurnal variation in regional brain glucose metabolism in depressionAnne Germain
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 62:438-45. 2007..This study compared diurnal variation in mood and regional cerebral metabolic rate of glucose (rCMRglc) in depressed and healthy subjects... - M1 muscarinic acetylcholine receptor agonism alters sleep without affecting memory consolidationChristoph Nissen
Albert Ludwigs University Freiburg, Germany
J Cogn Neurosci 18:1799-807. 2006.... - Daytime symptoms in primary insomnia: a prospective analysis using ecological momentary assessmentDaniel J Buysse
Neuroscience Clinical and Translational Research Center, Department of Psychiatry, University of Pittsburgh, School of Medicine, USA
Sleep Med 8:198-208. 2007.... - Financial strain is a significant correlate of sleep continuity disturbances in late-lifeMartica Hall
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, United States
Biol Psychol 77:217-22. 2008..01). Our results show that chronic stress, as measured by ongoing financial strain, is a significant correlate of sleep disturbances in the elderly, even after adjusting for factors known to impact sleep in late-life... - EEG spectral analysis in primary insomnia: NREM period effects and sex differencesDaniel J Buysse
Neuroscience Clinical and Translational Research Center and Sleep Medicine Institute, University ofPittsburgh School ofMedicine, Pittsburgh, PA, USA
Sleep 31:1673-82. 2008..To compare NREM EEG power in primary insomnia (PI) and good sleeper controls (GSC), examining both sex and NREM period effects; to examine relationships between EEG power, clinical characteristics, and self-reports of sleep... - Impaired sleep-related memory consolidation in primary insomnia--a pilot studyChristoph Nissen
Department of Psychiatry and Psychotherapy, Albert Ludwigs University of Freiburg, Freiburg, Germany
Sleep 29:1068-73. 2006..To compare sleep-related consolidation of procedural memory in patients with primary insomnia and healthy controls... - Sleep in healthy seniors: a diary study of the relation between bedtime and the amount of sleep obtainedTimothy H Monk
Clinical Neuroscience Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
J Sleep Res 15:256-60. 2006..g. age-dependent alterations in phase angle and homeostatic sleep need)... - Ecological study of sleep disruption in PTSD: a pilot studyAnne Germain
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Room E 1124, Pittsburgh, PA 15213, USA
Ann N Y Acad Sci 1071:438-41. 2006..These preliminary findings suggest that ambulatory methods can capture objective signs of sleep disruption, and corroborate subjective complaints of disrupted sleep in PTSD... - Symptom reports in severe chronic insomniaDouglas E Moul
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
Sleep 25:553-63. 2002..To describe patterns and severities of the daytime and nighttime symptoms of chronic insomnia patients... - Neurobiology of non-REM sleep in depression: further evidence for hypofrontality and thalamic dysregulationAnne Germain
University of Pittsburgh School of Medicine, Department of Psychiatry, 3811 O Hara St, E 1116, Pittsburgh, PA 15213, USA
Am J Psychiatry 161:1856-63. 2004..The goal of this study was to investigate the functional neuroanatomical correlates of non-REM sleep relative to presleep wakefulness in depressed patients and healthy subjects... - Regional brain glucose metabolism during morning and evening wakefulness in humans: preliminary findingsDaniel J Buysse
Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
Sleep 27:1245-54. 2004..The goal of this pilot study was to examine regional relative brain glucose metabolism during morning and evening wakefulness in healthy humans... - Differential effects of the muscarinic M1 receptor agonist RS-86 and the acetylcholine-esterase inhibitor donepezil on REM sleep regulation in healthy volunteersChristoph Nissen
Department of Psychiatry and Psychotherapy, Albert Ludwigs University, Freiburg, Germany
Neuropsychopharmacology 31:1294-300. 2006.... - Age-related differences in the lifestyle regularity of seniors experiencing bereavement, care-giving, insomnia, and advancement into old-old ageTimothy H Monk
Clinical Neuroscience Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Chronobiol Int 23:831-41. 2006..This may represent an adaptive behavioral response that might be used in future therapeutic approaches... - Protecting sleep, promoting health in later life: a randomized clinical trialCharles F Reynolds
Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Psychosom Med 72:178-86. 2010..5 years; and 2) if maintenance or enhancement of sleep continuity and depth promotes the maintenance or enhancement of health-related quality of life... - Functional neuroimaging of sleepEric A Nofzinger
Sleep Neuroimaging Research Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Semin Neurol 25:9-18. 2005.... - Brain SPECT in sleep researchAndreas Otte
Sleep 26:227. 2003 - Nuclear medicine asleep in sleep research?Andreas Otte
Eur J Nucl Med Mol Imaging 29:1417-20. 2002 - Neuroimaging the sleep disordered patient: a commentaryEric A Nofzinger
Sleep Med 6:383-4. 2005 - Functional neuroimaging at the 2002 APSS 16th annual meeting in SeattleAndreas Otte
Med Sci Monit 8:LE37-9. 2002
Research Grants
- SLEEP-GUIDED PET STUDIES IN DEPRESSIONEric Nofzinger; Fiscal Year: 2004..Findings from this study are expected to significantly advance our understanding of the pathophysiology of depression. ..
- Human Sleep NeuroscienceEric Nofzinger; Fiscal Year: 2007..Content areas for mentoring young investigators include functional neuroimaging methods for use during sleep, the neuroscience of behavioral state regulation and in the ethical conduct of research. ..
- Sleep Neuroscience in DepressionEric Nofzinger; Fiscal Year: 2009..Multiple linear regressions will be used to test the mediational models above. Findings from this study are expected to significantly advance our understanding of the neuroscience of depression. ..