Suzanne M Noble

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans
    Suzanne M Noble
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143 2200, USA
    Eukaryot Cell 4:298-309. 2005
  2. ncbi request reprint Genetics of Candida albicans, a diploid human fungal pathogen
    Suzanne M Noble
    Department of Microbiology and Immunology, University of California San Francisco, CA 94143 2200, USA
    Annu Rev Genet 41:193-211. 2007
  3. pmc Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
    Suzanne M Noble
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    Nat Genet 42:590-8. 2010
  4. pmc An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth
    Sarah L Elson
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 5:e1000664. 2009
  5. pmc An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis
    Changbin Chen
    Department of Medicine, Division of Infectious Diseases, University of California San Francisco, USA
    Cell Host Microbe 10:118-35. 2011
  6. pmc Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence
    Bethann S Hromatka
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Biol Cell 16:4814-26. 2005
  7. pmc Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host
    Changbin Chen
    Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California, United States of America
    PLoS Pathog 8:e1002956. 2012
  8. pmc A phenotypic profile of the Candida albicans regulatory network
    Oliver R Homann
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    PLoS Genet 5:e1000783. 2009
  9. doi request reprint Genetics and molecular biology in Candida albicans
    Aaron D Hernday
    Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California, USA
    Methods Enzymol 470:737-58. 2010
  10. pmc Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism
    Kalyan Pande
    Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California, USA
    Nat Genet 45:1088-91. 2013

Research Grants

  1. A Genetic Approach to Virulence in C. albicans
    Suzanne Noble; Fiscal Year: 2007

Collaborators

Detail Information

Publications11

  1. pmc Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans
    Suzanne M Noble
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143 2200, USA
    Eukaryot Cell 4:298-309. 2005
    ..albicans strains. We demonstrate these procedures for two well-studied genes, TUP1 and EFG1, as well as a novel gene, RBD1. These tools should permit large-scale genetic analysis of this important human pathogen...
  2. ncbi request reprint Genetics of Candida albicans, a diploid human fungal pathogen
    Suzanne M Noble
    Department of Microbiology and Immunology, University of California San Francisco, CA 94143 2200, USA
    Annu Rev Genet 41:193-211. 2007
    ..In this review, we describe recent developments in population genetics, the mating process, and gene disruption technology that are providing much needed experimental insights into the biology of C. albicans...
  3. pmc Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
    Suzanne M Noble
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    Nat Genet 42:590-8. 2010
    ..Analysis of such mutants revealed that virulence requires the glycolipid glucosylceramide. To our knowledge, this is the first C. albicans small molecule that has been found to be required specifically for virulence...
  4. pmc An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth
    Sarah L Elson
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 5:e1000664. 2009
    ..The differences in mRNA cargos likely reflect the distinct selective pressures acting on the two species...
  5. pmc An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis
    Changbin Chen
    Department of Medicine, Division of Infectious Diseases, University of California San Francisco, USA
    Cell Host Microbe 10:118-35. 2011
    ..Thus, C. albicans can alternate between genetic programs conferring resistance to iron depletion in the bloodstream versus iron toxicity in the gut, and this may represent a fundamental attribute of gastrointestinal commensal-pathogens...
  6. pmc Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence
    Bethann S Hromatka
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Biol Cell 16:4814-26. 2005
    ....
  7. pmc Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host
    Changbin Chen
    Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California, United States of America
    PLoS Pathog 8:e1002956. 2012
    ..Analysis of sfu1 and ssn3 mutants in a mammalian model of disseminated candidiasis indicates that these post-transcriptional regulatory mechanisms serve as a means for precise titration of C. albicans virulence...
  8. pmc A phenotypic profile of the Candida albicans regulatory network
    Oliver R Homann
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    PLoS Genet 5:e1000783. 2009
    ..These observations support the idea that many wiring changes affect the detailed architecture of the circuit, but not its overall output...
  9. doi request reprint Genetics and molecular biology in Candida albicans
    Aaron D Hernday
    Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California, USA
    Methods Enzymol 470:737-58. 2010
    ..The ease of these techniques, combined with the high-quality C. albicans genome sequences now available, has greatly increased the quality and pace of research into this important pathogen...
  10. pmc Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism
    Kalyan Pande
    Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California, USA
    Nat Genet 45:1088-91. 2013
    ..The white-GUT switch illuminates how a microorganism can use distinct genetic programs to transition between commensalism and invasive pathogenesis. ..
  11. pmc Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans
    Oliver W Liu
    Department of Biochemistry and Biophysics, University of California, San Francisco, 600 16th St, GH N372C, San Francisco, CA 94158, USA
    Cell 135:174-88. 2008
    ..In particular, we describe a GATA family transcription factor that inhibits phagocytosis by murine macrophages independently of the capsule, indicating a previously unknown mechanism of innate immune modulation...

Research Grants1

  1. A Genetic Approach to Virulence in C. albicans
    Suzanne Noble; Fiscal Year: 2007
    ..Results from this work should enhance our understanding of fungal pathogenesis and identify novel targets for antifungal therapy. ..