Research Topics
| Mark D NobleSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Detail Information
Publications
iOPs: A New Tool for Studying Myelin Pathologies?Mark Noble
University of Rochester Stem Cell and Regenerative Medicine Institute, Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA Electronic address
Cell Stem Cell 12:503-4. 2013..Recently in Nature Biotechnology, Najm et al. (2013) and Yang et al. (2013) generated these progenitors by direct reprogramming, bringing us closer to their use in disease analysis and autologous transplantation strategies...- Cell therapies for the central nervous system: how do we identify the best candidates?Mark Noble
University of Rochester Stem Cell and Regenerative Medicine Institute and Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642, USA
Curr Opin Neurol 24:570-6. 2011..Central to the obstacles to be overcome in moving promising cell-based therapies from the laboratory to the clinic is that of determining which of the many cell types being examined are optimal for repairing particular lesions... 
Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse dataOllivier Hyrien
Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA
Theor Biol Med Model 3:21. 2006..The second is to generate time-lapse data that may help biomathematicians to build stochastic models of cell proliferation and differentiation under other experimental scenarios...- Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous systemRuolan Han
Department of Biomedical Genetics and University of Rochester Stem Cell and Regenerative Medicine Institute, University of Rochester Medical Center, Elmwood Avenue, Rochester, NY 14642, USA
J Biol 7:12. 2008..Nor are there any animal models that could enable the study of this important problem... - Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injuryJeannette E Davies
Department of Neurosurgery, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, USA
J Biol 7:24. 2008..This is of particular concern in the case of spinal cord injury, where recent studies have shown that transplanted neuroepithelial stem cells can generate pain syndromes... - CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivoJoerg Dietrich
Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Biol 5:22. 2006..The underlying cellular basis for these adverse effects is poorly understood... - Astrocytes derived from glial-restricted precursors promote spinal cord repairJeannette E Davies
Department of Neurosurgery, Baylor College of Medicine, 1709 Dryden Street, Suite 750, Houston, Texas 77030, USA
J Biol 5:7. 2006..We reasoned therefore that pre-differentiation of embryonic neural precursors to astrocytes, which are thought to support axon growth in the injured immature CNS, would be more beneficial for CNS repair... 
The complex identity of brain tumors: emerging concerns regarding origin, diversity and plasticityMark Noble
Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA
Trends Neurosci 27:148-54. 2004....- Precursor cell biology and the development of astrocyte transplantation therapies: lessons from spinal cord injuryMark Noble
University of Rochester Stem Cell and Regenerative Medicine Institute and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Neurotherapeutics 8:677-93. 2011..Thus, these studies provide successful strategies for the use of astrocyte transplantation therapies for restoration of function following spinal cord injury... - Redox state as a central modulator of precursor cell functionMark Noble
Department of Biomedical Genetics, University of Rochester School of Medicine, Rochester, New York 14642, USA
Ann N Y Acad Sci 991:251-71. 2003..Chiasm-derived cells, which exhibited self-renewal properties intermediate between cortex- and optic nerve-derived cells, were more reduced than optic nerve cells but more oxidized that cortical O-2A/OPCs... - The cortical ancestry of oligodendrocytes: common principles and novel featuresM Noble
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
Dev Neurosci 25:217-33. 2003..Moreover, the A2B5+ precursor cells isolated from embryonic cortex are much more heterogeneous than is seen in the spinal cord at this age, even to the point of including an A2B5/PSA-NCAM double-positive cell that can generate neurons... - Ethics in the trenches: a multifaceted analysis of the stem cell debateMark Noble
Department of Biomedical Genetics, Aab Institute for Biomedical Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA
Stem Cell Rev 1:345-76. 2005.... - Intersections between neurobiology and oncology: tumor origin, treatment and repair of treatment-associated damageMark Noble
Dept of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA
Trends Neurosci 25:103-7. 2002.... - The possible role of myelin destruction as a precipitating event in Alzheimer's diseaseMark Noble
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
Neurobiol Aging 25:25-31. 2004 - Getting a GR(i)P on oligodendrocyte developmentMark Noble
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
Dev Biol 265:33-52. 2004.... - Implications for CNS repair of redox modulation of cell survival, division and differentiationMark Noble
Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA
Curr Alzheimer Res 3:37-47. 2006..This review discusses our studies on the role in redox state as a critical modulator of cellular function, and considers the implications of these findings for optimizing tissue repair... - Redox regulation of precursor cell function: insights and paradoxesMark Noble
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
Antioxid Redox Signal 7:1456-67. 2005.... - Characterization of A2B5+ glial precursor cells from cryopreserved human fetal brain progenitor cellsJoerg Dietrich
Department of Biomedical Genetics, University of Rochester, Rochester, New York 14642, USA
Glia 40:65-77. 2002.... - Oxidative-reductionist approaches to stem and progenitor cell functionMark Noble
Department of Biomedical Genetics, University of Rochester Stem Cell and Regenerative Medicine Institute, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Cell Stem Cell 8:1-2. 2011..2011) demonstrate that oxidation promotes self-renewal of neuroepithelial stem cells, revealing fascinating differences-and surprising similarities-with how redox pathways regulate glial progenitor cells... - Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neuroglial precursorsOllivier Hyrien
Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Cancer Res 70:10051-9. 2010..These analyses also provide novel tools that apply broadly to identify effects of chemotherapeutic agents and other physiological stressors... - A stochastic model to analyze clonal data on multi-type cell populationsOllivier Hyrien
Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York 14641, USA
Biometrics 61:199-207. 2005..This biological finding suggests that a molecular event determining the type of cell transformation is more likely to occur at the start rather than at the end of the mitotic cycle... - Estimating the life-span of oligodendrocytes from clonal data on their development in cell cultureOllivier Hyrien
Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
Math Biosci 193:255-74. 2005..The proposed method is illustrated with an analysis of the clonal development of O-2A progenitor cells isolated from the rat optic nerve and the corpus callosum... - Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell functionZaibo Li
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States of America
PLoS Biol 5:e35. 2007.... - Cancer stem cellsCraig T Jordan
James P. Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, NY 14642, USA
N Engl J Med 355:1253-61. 2006 - EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophyJörg Dietrich
Department of Biomedical Genetics, Aab Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
Nat Med 11:277-83. 2005..This raises the possibility that a deficiency in astrocyte function may contribute to the loss of white matter in VWM leukodystrophy... - Directed nerve outgrowth is enhanced by engineered glial substratesRoy Biran
The Keck Center for Tissue Engineering, Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
Exp Neurol 184:141-52. 2003....
Research Grants
- PRECURSOR CELL RENEWAL, OLIGODENDROCYTES & REMYELINATIONMark Noble; Fiscal Year: 2001....
- Low-level toxicant perturbation of neural cell functionMark Noble; Fiscal Year: 2007....
- CNS vulnerability to systemic chemotherapy: Causes and preventionMark Noble; Fiscal Year: 2009..Such protection can be achieved both by increasing the vulnerability of cancer cells to chemotherapy and by selectively protecting normal cells from the adverse effects of these therapeutic agents. ..
- Low-level toxicant perturbation of neural cell functionMark D Noble; Fiscal Year: 2010....
- CNS PRECURSOR CELL DYSFUNCTION IN DEVELOPMENTAL MALADIESMark Noble; Fiscal Year: 2005..abstract_text> ..
- Oligodendrocytes & precursors: toxicity of chemotherapyMark Noble; Fiscal Year: 2005..In addition, we will identify and test means of selectively protecting normal cells from such damage without simultaneously protecting cancer cells in vitro as well as in vivo. ..
- CNS vulnerability to systemic chemotherapy: Causes and preventionMark D Noble; Fiscal Year: 2010..Such protection can be achieved both by increasing the vulnerability of cancer cells to chemotherapy and by selectively protecting normal cells from the adverse effects of these therapeutic agents. ..