Mark D Noble

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells
    Hsing Yu Chen
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA
    EMBO Mol Med 5:723-36. 2013
  2. doi request reprint iOPs: a new tool for studying myelin pathologies?
    Mark Noble
    University of Rochester Stem Cell and Regenerative Medicine Institute, Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Stem Cell 12:503-4. 2013
  3. doi request reprint Cell therapies for the central nervous system: how do we identify the best candidates?
    Mark Noble
    University of Rochester Stem Cell and Regenerative Medicine Institute and Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Curr Opin Neurol 24:570-6. 2011
  4. pmc Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Theor Biol Med Model 3:21. 2006
  5. pmc Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system
    Ruolan Han
    Department of Biomedical Genetics and University of Rochester Stem Cell and Regenerative Medicine Institute, University of Rochester Medical Center, Elmwood Avenue, Rochester, NY 14642, USA
    J Biol 7:12. 2008
  6. pmc Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury
    Jeannette E Davies
    Department of Neurosurgery, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, USA
    J Biol 7:24. 2008
  7. pmc CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo
    Joerg Dietrich
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Biol 5:22. 2006
  8. pmc Astrocytes derived from glial-restricted precursors promote spinal cord repair
    Jeannette E Davies
    Department of Neurosurgery, Baylor College of Medicine, 1709 Dryden Street, Suite 750, Houston, Texas 77030, USA
    J Biol 5:7. 2006
  9. ncbi request reprint Intersections between neurobiology and oncology: tumor origin, treatment and repair of treatment-associated damage
    Mark Noble
    Dept of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA
    Trends Neurosci 25:103-7. 2002
  10. ncbi request reprint Redox state as a central modulator of precursor cell function
    Mark Noble
    Department of Biomedical Genetics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Ann N Y Acad Sci 991:251-71. 2003

Collaborators

Detail Information

Publications27

  1. pmc Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells
    Hsing Yu Chen
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA
    EMBO Mol Med 5:723-36. 2013
    ....
  2. doi request reprint iOPs: a new tool for studying myelin pathologies?
    Mark Noble
    University of Rochester Stem Cell and Regenerative Medicine Institute, Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Stem Cell 12:503-4. 2013
    ..Recently in Nature Biotechnology, Najm et al. (2013) and Yang et al. (2013) generated these progenitors by direct reprogramming, bringing us closer to their use in disease analysis and autologous transplantation strategies...
  3. doi request reprint Cell therapies for the central nervous system: how do we identify the best candidates?
    Mark Noble
    University of Rochester Stem Cell and Regenerative Medicine Institute and Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Curr Opin Neurol 24:570-6. 2011
    ..Central to the obstacles to be overcome in moving promising cell-based therapies from the laboratory to the clinic is that of determining which of the many cell types being examined are optimal for repairing particular lesions...
  4. pmc Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Theor Biol Med Model 3:21. 2006
    ..The second is to generate time-lapse data that may help biomathematicians to build stochastic models of cell proliferation and differentiation under other experimental scenarios...
  5. pmc Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system
    Ruolan Han
    Department of Biomedical Genetics and University of Rochester Stem Cell and Regenerative Medicine Institute, University of Rochester Medical Center, Elmwood Avenue, Rochester, NY 14642, USA
    J Biol 7:12. 2008
    ..Nor are there any animal models that could enable the study of this important problem...
  6. pmc Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury
    Jeannette E Davies
    Department of Neurosurgery, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, USA
    J Biol 7:24. 2008
    ..This is of particular concern in the case of spinal cord injury, where recent studies have shown that transplanted neuroepithelial stem cells can generate pain syndromes...
  7. pmc CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo
    Joerg Dietrich
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Biol 5:22. 2006
    ..The underlying cellular basis for these adverse effects is poorly understood...
  8. pmc Astrocytes derived from glial-restricted precursors promote spinal cord repair
    Jeannette E Davies
    Department of Neurosurgery, Baylor College of Medicine, 1709 Dryden Street, Suite 750, Houston, Texas 77030, USA
    J Biol 5:7. 2006
    ..We reasoned therefore that pre-differentiation of embryonic neural precursors to astrocytes, which are thought to support axon growth in the injured immature CNS, would be more beneficial for CNS repair...
  9. ncbi request reprint Intersections between neurobiology and oncology: tumor origin, treatment and repair of treatment-associated damage
    Mark Noble
    Dept of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA
    Trends Neurosci 25:103-7. 2002
    ....
  10. ncbi request reprint Redox state as a central modulator of precursor cell function
    Mark Noble
    Department of Biomedical Genetics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Ann N Y Acad Sci 991:251-71. 2003
    ..Chiasm-derived cells, which exhibited self-renewal properties intermediate between cortex- and optic nerve-derived cells, were more reduced than optic nerve cells but more oxidized that cortical O-2A/OPCs...
  11. pmc Precursor cell biology and the development of astrocyte transplantation therapies: lessons from spinal cord injury
    Mark Noble
    University of Rochester Stem Cell and Regenerative Medicine Institute and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Neurotherapeutics 8:677-93. 2011
    ..Thus, these studies provide successful strategies for the use of astrocyte transplantation therapies for restoration of function following spinal cord injury...
  12. ncbi request reprint The cortical ancestry of oligodendrocytes: common principles and novel features
    M Noble
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Dev Neurosci 25:217-33. 2003
    ..Moreover, the A2B5+ precursor cells isolated from embryonic cortex are much more heterogeneous than is seen in the spinal cord at this age, even to the point of including an A2B5/PSA-NCAM double-positive cell that can generate neurons...
  13. ncbi request reprint Ethics in the trenches: a multifaceted analysis of the stem cell debate
    Mark Noble
    Department of Biomedical Genetics, Aab Institute for Biomedical Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA
    Stem Cell Rev 1:345-76. 2005
    ....
  14. ncbi request reprint The possible role of myelin destruction as a precipitating event in Alzheimer's disease
    Mark Noble
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Neurobiol Aging 25:25-31. 2004
  15. ncbi request reprint Getting a GR(i)P on oligodendrocyte development
    Mark Noble
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Dev Biol 265:33-52. 2004
    ....
  16. ncbi request reprint The complex identity of brain tumors: emerging concerns regarding origin, diversity and plasticity
    Mark Noble
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA
    Trends Neurosci 27:148-54. 2004
    ....
  17. ncbi request reprint Implications for CNS repair of redox modulation of cell survival, division and differentiation
    Mark Noble
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA
    Curr Alzheimer Res 3:37-47. 2006
    ..This review discusses our studies on the role in redox state as a critical modulator of cellular function, and considers the implications of these findings for optimizing tissue repair...
  18. ncbi request reprint Redox regulation of precursor cell function: insights and paradoxes
    Mark Noble
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Antioxid Redox Signal 7:1456-67. 2005
    ....
  19. ncbi request reprint Characterization of A2B5+ glial precursor cells from cryopreserved human fetal brain progenitor cells
    Joerg Dietrich
    Department of Biomedical Genetics, University of Rochester, Rochester, New York 14642, USA
    Glia 40:65-77. 2002
    ....
  20. ncbi request reprint Oxidative-reductionist approaches to stem and progenitor cell function
    Mark Noble
    Department of Biomedical Genetics, University of Rochester Stem Cell and Regenerative Medicine Institute, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Cell Stem Cell 8:1-2. 2011
    ..2011) demonstrate that oxidation promotes self-renewal of neuroepithelial stem cells, revealing fascinating differences-and surprising similarities-with how redox pathways regulate glial progenitor cells...
  21. ncbi request reprint Cancer stem cells
    Craig T Jordan
    James P Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, NY 14642, USA
    N Engl J Med 355:1253-61. 2006
  22. ncbi request reprint A stochastic model to analyze clonal data on multi-type cell populations
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York 14641, USA
    Biometrics 61:199-207. 2005
    ..This biological finding suggests that a molecular event determining the type of cell transformation is more likely to occur at the start rather than at the end of the mitotic cycle...
  23. ncbi request reprint Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Math Biosci 193:255-74. 2005
    ..The proposed method is illustrated with an analysis of the clonal development of O-2A progenitor cells isolated from the rat optic nerve and the corpus callosum...
  24. pmc Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neuroglial precursors
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Cancer Res 70:10051-9. 2010
    ..These changes of precursor cell function in the chemotherapy-exposed brain may have profound clinic implications...
  25. pmc Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function
    Zaibo Li
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS Biol 5:e35. 2007
    ....
  26. ncbi request reprint EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy
    Jörg Dietrich
    Department of Biomedical Genetics, Aab Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Med 11:277-83. 2005
    ..This raises the possibility that a deficiency in astrocyte function may contribute to the loss of white matter in VWM leukodystrophy...
  27. ncbi request reprint Directed nerve outgrowth is enhanced by engineered glial substrates
    Roy Biran
    The Keck Center for Tissue Engineering, Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    Exp Neurol 184:141-52. 2003
    ....

Research Grants20

  1. PRECURSOR CELL RENEWAL, OLIGODENDROCYTES & REMYELINATION
    Mark Noble; Fiscal Year: 2001
    ....
  2. CNS vulnerability to systemic chemotherapy: Causes and prevention
    Mark Noble; Fiscal Year: 2009
    ..Such protection can be achieved both by increasing the vulnerability of cancer cells to chemotherapy and by selectively protecting normal cells from the adverse effects of these therapeutic agents. ..
  3. Low-level toxicant perturbation of neural cell function
    Mark Noble; Fiscal Year: 2009
    ....
  4. Low-level toxicant perturbation of neural cell function
    Mark Noble; Fiscal Year: 2007
    ....
  5. Low-level toxicant perturbation of neural cell function
    Mark Noble; Fiscal Year: 2006
    ....
  6. CNS vulnerability to systemic chemotherapy: Causes and prevention
    Mark D Noble; Fiscal Year: 2010
    ..Such protection can be achieved both by increasing the vulnerability of cancer cells to chemotherapy and by selectively protecting normal cells from the adverse effects of these therapeutic agents. ..
  7. Oligodendrocytes & precursors: toxicity of chemotherapy
    Mark Noble; Fiscal Year: 2005
    ..In addition, we will identify and test means of selectively protecting normal cells from such damage without simultaneously protecting cancer cells in vitro as well as in vivo. ..
  8. CNS PRECURSOR CELL DYSFUNCTION IN DEVELOPMENTAL MALADIES
    Mark Noble; Fiscal Year: 2004
    ..abstract_text> ..
  9. CNS PRECURSOR CELL DYSFUNCTION IN DEVELOPMENTAL MALADIES
    Mark Noble; Fiscal Year: 2001
    ..abstract_text> ..
  10. PRECURSOR CELL RENEWAL, OLIGODENDROCYTES & REMYELINATION
    Mark Noble; Fiscal Year: 2000
    ....
  11. Oligodendrocytes & precursors: toxicity of chemotherapy
    Mark Noble; Fiscal Year: 2002
    ..In addition, we will identify and test means of selectively protecting normal cells from such damage without simultaneously protecting cancer cells in vitro as well as in vivo. ..
  12. CNS PRECURSOR CELL DYSFUNCTION IN DEVELOPMENTAL MALADIES
    Mark Noble; Fiscal Year: 2002
    ..abstract_text> ..
  13. CNS PRECURSOR CELL DYSFUNCTION IN DEVELOPMENTAL MALADIES
    Mark Noble; Fiscal Year: 2003
    ..abstract_text> ..
  14. Oligodendrocytes & precursors: toxicity of chemotherapy
    Mark Noble; Fiscal Year: 2003
    ..In addition, we will identify and test means of selectively protecting normal cells from such damage without simultaneously protecting cancer cells in vitro as well as in vivo. ..
  15. Oligodendrocytes & precursors: toxicity of chemotherapy
    Mark Noble; Fiscal Year: 2004
    ..In addition, we will identify and test means of selectively protecting normal cells from such damage without simultaneously protecting cancer cells in vitro as well as in vivo. ..
  16. Low-level toxicant perturbation of neural cell function
    Mark D Noble; Fiscal Year: 2010
    ....
  17. CNS PRECURSOR CELL DYSFUNCTION IN DEVELOPMENTAL MALADIES
    Mark Noble; Fiscal Year: 2005
    ..abstract_text> ..