ERNEST NOBLE

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi D2 and D4 dopamine receptor polymorphisms and personality
    E P Noble
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024 1759, USA
    Am J Med Genet 81:257-67. 1998
  2. ncbi Prolactin levels in antipsychotic treatment of patients with schizophrenia carrying the DRD2*A1 allele
    Ross McD Young
    Alcohol Research Center, Neuropsychiatric Institute, University of California, Los Angeles, CA 90024 1759, USA
    Br J Psychiatry 185:147-51. 2004
  3. ncbi D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes
    Ernest P Noble
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California, USA
    Am J Med Genet B Neuropsychiatr Genet 116:103-25. 2003
  4. ncbi The DRD2 gene in psychiatric and neurological disorders and its phenotypes
    E P Noble
    Alcohol Research Center, Department of Psychiatry and Biobehavioral Sciences and the Brain Research Institute, University of California, Los Angeles 90024, USA
    Pharmacogenomics 1:309-33. 2000
  5. ncbi Haplotypes at the DRD2 locus and severe alcoholism
    E P Noble
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California, USA
    Am J Med Genet 96:622-31. 2000
  6. ncbi D2 dopamine receptor and GABA(A) receptor beta3 subunit genes and alcoholism
    E P Noble
    Alcohol Research Center and Department of Psychiatry and Biobehavioral Sciences, UCLA, Neuropsychiatric Institute, Los Angeles, CA 90024 1759, USA
    Psychiatry Res 81:133-47. 1998
  7. ncbi The D2 dopamine receptor gene: a review of association studies in alcoholism and phenotypes
    E P Noble
    Alcohol Research Center, Department of Psychiatry and Biobehavioral Sciences, and the Brain Research Institute, University of California, Los Angeles, USA
    Alcohol 16:33-45. 1998
  8. ncbi D2 dopamine receptor (DRD2) gene, P300, and personality in children of alcoholics
    Tim Antolin
    Alcohol Research Center, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, 760 Westwood Plaza, Los Angeles, California 90095 1759, USA
    Psychiatry Res 166:91-101. 2009
  9. ncbi P300 development during adolescence: effects of DRD2 genotype
    Steven M Berman
    Department of Psychiatry and Biobehavioral Sciences, Alcohol Research Center, University of California, Los Angeles, CA 90024, USA
    Clin Neurophysiol 117:649-59. 2006
  10. ncbi DRD2 genotypes and substance use in adolescent children of alcoholics
    Bradley T Conner
    Department of Psychology, University of California, Los Angeles, USA
    Drug Alcohol Depend 79:379-87. 2005

Research Grants

  1. CNS AND GENETIC MARKERS IN CHILDREN OF ALCOHOLICS
    ERNEST NOBLE; Fiscal Year: 2002

Collaborators

Detail Information

Publications21

  1. ncbi D2 and D4 dopamine receptor polymorphisms and personality
    E P Noble
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024 1759, USA
    Am J Med Genet 81:257-67. 1998
    ..However, the combined DRD2 and DRD4 polymorphisms contribute more markedly to this behavior than when these two gene polymorphisms are individually considered...
  2. ncbi Prolactin levels in antipsychotic treatment of patients with schizophrenia carrying the DRD2*A1 allele
    Ross McD Young
    Alcohol Research Center, Neuropsychiatric Institute, University of California, Los Angeles, CA 90024 1759, USA
    Br J Psychiatry 185:147-51. 2004
    ..Hyperprolactinaemia induced by D(2) dopamine receptor antagonist antipsychotic medication can result in significant health problems...
  3. ncbi D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes
    Ernest P Noble
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California, USA
    Am J Med Genet B Neuropsychiatr Genet 116:103-25. 2003
    ..The involvement of the DRD2 gene in certain neuropsychiatric disorders opens up the potential of a targeted pharmacogenomic approach to the treatment of these disorders...
  4. ncbi The DRD2 gene in psychiatric and neurological disorders and its phenotypes
    E P Noble
    Alcohol Research Center, Department of Psychiatry and Biobehavioral Sciences and the Brain Research Institute, University of California, Los Angeles 90024, USA
    Pharmacogenomics 1:309-33. 2000
    ..The involvement of the DRD2 gene in certain neuropsychiatric disorders opens up the potential of a targeted pharmacogenomic approach to the prevention and treatment of these disorders...
  5. ncbi Haplotypes at the DRD2 locus and severe alcoholism
    E P Noble
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California, USA
    Am J Med Genet 96:622-31. 2000
    ..In sum, the study found significant evidence for association of the minor alleles in the untranslated sites of the DRD2 gene and their haplotypes with the more severe alcoholic phenotype...
  6. ncbi D2 dopamine receptor and GABA(A) receptor beta3 subunit genes and alcoholism
    E P Noble
    Alcohol Research Center and Department of Psychiatry and Biobehavioral Sciences, UCLA, Neuropsychiatric Institute, Los Angeles, CA 90024 1759, USA
    Psychiatry Res 81:133-47. 1998
    ..However, when the DRD2 and the GABRB3 variants are combined, the risk for alcoholism is more robust than when these variants are considered separately...
  7. ncbi The D2 dopamine receptor gene: a review of association studies in alcoholism and phenotypes
    E P Noble
    Alcohol Research Center, Department of Psychiatry and Biobehavioral Sciences, and the Brain Research Institute, University of California, Los Angeles, USA
    Alcohol 16:33-45. 1998
    ..The identification of phenotypes of DRD2 genotypes suggests that the observed intronic DRD2 mutations may have functional consequences that predispose individuals to a variety of substance use disorders...
  8. ncbi D2 dopamine receptor (DRD2) gene, P300, and personality in children of alcoholics
    Tim Antolin
    Alcohol Research Center, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, 760 Westwood Plaza, Los Angeles, California 90095 1759, USA
    Psychiatry Res 166:91-101. 2009
    ....
  9. ncbi P300 development during adolescence: effects of DRD2 genotype
    Steven M Berman
    Department of Psychiatry and Biobehavioral Sciences, Alcohol Research Center, University of California, Los Angeles, CA 90024, USA
    Clin Neurophysiol 117:649-59. 2006
    ..The present study examined whether the change in P300 amplitude during adolescence in sons of alcoholics and nonalcoholics is affected by D2 dopamine receptor (DRD2) polymorphism...
  10. ncbi DRD2 genotypes and substance use in adolescent children of alcoholics
    Bradley T Conner
    Department of Psychology, University of California, Los Angeles, USA
    Drug Alcohol Depend 79:379-87. 2005
    ..01) and Negative Affect (p=0.04). The results provide support for the DRD2 A1 allele as a marker identifying a subgroup of COAs at high risk for developing substance use problems...
  11. ncbi Effect of the TaqIA polymorphism on ethanol response in the brain
    Edythe D London
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, United States
    Psychiatry Res 174:163-70. 2009
    ..Although these results require replication in a larger sample, alcohol-induced negative reinforcement may explain the greater risk for alcoholism associated with the A1 allele...
  12. ncbi PTSD and dopaminergic genes, DRD2 and DAT, in multigenerational families exposed to the Spitak earthquake
    Julia N Bailey
    Department of Epidemiology, David Gethen School of Medicine, University of California, Los Angeles, California 90073, USA
    Psychiatry Res 178:507-10. 2010
    ..These findings contradict prior reports of positive associations between both DRD2 and DAT, and PTSD...
  13. ncbi Differential associations of sex and D2 dopamine receptor (DRD2) genotype with negative affect and other substance abuse risk markers in children of alcoholics
    Steven M Berman
    Alcohol Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90024, USA
    Alcohol 30:201-10. 2003
    ..001). Results indicate that both sex and DRD2 genotype modify associations between negative affect and other substance abuse risk markers...
  14. ncbi Heritabilities of symptoms of posttraumatic stress disorder, anxiety, and depression in earthquake exposed Armenian families
    Armen K Goenjian
    UCLA Duke University National Center for Child Traumatic Stress, University of California, Los Angeles, USA
    Psychiatr Genet 18:261-6. 2008
    ..To examine the heritabilities of symptoms of posttraumatic stress disorder (PTSD), anxiety, depression, and the shared genetic component of these symptoms among family members exposed to the 1988 Spitak earthquake in Armenia...
  15. ncbi Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics
    Terry Ritchie
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90024-1759, USA
    Neurochem Res 28:73-82. 2003
    ....
  16. ncbi D2 dopamine receptor gene polymorphism: paroxetine and social functioning in posttraumatic stress disorder
    Bruce R Lawford
    Greenslopes Private Hospital, Queensland, Brisbane, Australia
    Eur Neuropsychopharmacol 13:313-20. 2003
    ..The DRD2 A1 allele may prove to be a useful marker to assist clinicians in predicting which patients with PTSD are likely to obtain improvements in social functioning with paroxetine treatment...
  17. ncbi The A1 allele of the D2 dopamine receptor gene region, alcohol expectancies and drinking refusal self-efficacy are associated with alcohol dependence severity
    Jason P Connor
    Discipline of Psychiatry, The University of Queensland, Brisbane, Queensland, Australia
    Psychiatry Res 160:94-105. 2008
    ..The prevention and treatment possibilities that arise from understanding this trajectory are examined...
  18. ncbi Heavy nicotine and alcohol use in alcohol dependence is associated with D2 dopamine receptor (DRD2) polymorphism
    Jason P Connor
    Department of Psychiatry, The University of Queensland, Princess Alexandra Hospital, Brisbane 4102, Australia
    Addict Behav 32:310-9. 2007
    ..When the combined nicotine and alcohol dose was examined, A1+ allelic patients consumed significantly more of these drugs than their A1- allelic counterparts...
  19. ncbi The D2 dopamine receptor (DRD2) gene is associated with co-morbid depression, anxiety and social dysfunction in untreated veterans with post-traumatic stress disorder
    Bruce R Lawford
    Greenslopes Private Hospital, Brisbane, QLD, Australia
    Eur Psychiatry 21:180-5. 2006
    ..To identify clusters of patients with post-traumatic stress disorder (PTSD) according to symptom profile and to examine the association of the A1 allele of the D2 dopamine receptor (DRD2) gene with these clusters...
  20. ncbi Alcohol-related expectancies are associated with the D2 dopamine receptor and GABAA receptor beta3 subunit genes
    Ross McD Young
    School of Psychology and Counselling, Queensland University of Technology, Carseldine, Qld 4034, Australia
    Psychiatry Res 127:171-83. 2004
    ..The clinical implications, particularly with regard to patient-treatment matching and the development of an integrated psychological and pharmacogenetic approach, are discussed...
  21. ncbi Smoking and schizophrenia: is symptom profile related to smoking and which antipsychotic medication is of benefit in reducing cigarette use?
    Mark Barnes
    Division of Mental Health, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Aust N Z J Psychiatry 40:575-80. 2006
    ..The association between smoking and these key clinical parameters was examined. Additionally, severity of smoking across four different antipsychotic treatment groups was explored...

Research Grants6

  1. CNS AND GENETIC MARKERS IN CHILDREN OF ALCOHOLICS
    ERNEST NOBLE; Fiscal Year: 2002
    ..It is hoped that by understanding the underlying factors contributing to this problem, a more rational basis emerges for identifying high risk individuals and improving the efficacy of focused prevention efforts. ..