Stephen Nishimura

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders
    Stephen L Nishimura
    Department of Anatomic Pathology, University of California San Francisco, San Francisco, CA 94143, USA
    Am J Pathol 175:1362-70. 2009
  2. ncbi request reprint Sarcoidosis following HIV infection: evidence for CD4+ lymphocyte dependence
    David G Morris
    Interstitial Lung Disease Program, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94142 0854, USA
    Chest 124:929-35. 2003
  3. pmc The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1
    Dezhi Mu
    Department of Pathology, University of California at San Francisco Mt Zion Cancer Center, San Francisco, CA 94143, USA
    J Cell Biol 157:493-507. 2002
  4. pmc Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis
    Hua Su
    Center of Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
    Am J Pathol 176:1018-27. 2010
  5. pmc Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients
    Jun Araya
    Department of Pathology, Lung Biology Center, UCSF, San Francisco, California 94110, USA
    J Clin Invest 117:3551-62. 2007
  6. pmc Integrin-mediated transforming growth factor-beta activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit
    Jun Araya
    Department of Pathology, Bldg 3, Rm 207, 1001 Potrero Ave, San Francisco, CA 94110, USA
    Am J Pathol 169:405-15. 2006
  7. pmc Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure
    Claus Neurohr
    Department of Medicine, Lung Biology Center, University of California, San Francisco, 94143 2922, USA
    Am J Respir Cell Mol Biol 35:252-9. 2006
  8. pmc Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch
    Stephanie Cambier
    Department of Pathology, University of California San Francisco, San Francisco, CA 94110, USA
    Am J Pathol 166:1883-94. 2005
  9. pmc Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue
    Lars Fjellbirkeland
    Department of Anatomic Pathology and Lung Biology Center, San Francisco General Hospital, University of California at San Francisco Mt Zion Cancer Center, San Francisco, California 94110, USA
    Am J Pathol 163:533-42. 2003
  10. pmc Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway
    Jennifer A Markovics
    Department of Pathology, Pulmonary Division, School of Medicine, University of California, San Francisco, California 94110, USA
    J Biol Chem 285:24695-706. 2010

Research Grants

Collaborators

  • DEAN C SHEPPARD
  • Laurence Huang
  • David G Morris
  • Nancy J Boudreau
  • Stephanie Cambier
  • Jun Araya
  • Jennifer A Markovics
  • David Jablons
  • Arthur Hill
  • V Courtney Broaddus
  • Hua Su
  • Dezhi Mu
  • Lars Fjellbirkeland
  • Walter Finkbeiner
  • Claus Neurohr
  • Gregory Dolganov
  • Andrew W Bollen
  • Paul J Wolters
  • Michael T Lawton
  • Helen Kim
  • Fanxia Shen
  • Pui Yan Kwok
  • Stephen Sidney
  • Ludmila Pawlikowska
  • Guo Yuan Yang
  • Louis Reichardt
  • Hideya Kitamura
  • Jennifer Markovics
  • William L Young
  • Andrea Barzcak
  • Kirk Jones
  • David J Erle
  • Paul Wolters
  • Yuanyuan Xiao
  • Alanna Morris
  • Steven Einheber
  • Rodney Collins
  • Stephanie Gline
  • Paul Brunetta
  • John S Munger
  • Jody L Baron
  • Hisaaki Kawakatsu

Detail Information

Publications10

  1. pmc Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders
    Stephen L Nishimura
    Department of Anatomic Pathology, University of California San Francisco, San Francisco, CA 94143, USA
    Am J Pathol 175:1362-70. 2009
    ..Amplification of integrin-mediated TGF-beta activation in fibrotic disorders and data from preclinical models suggest that integrins may therefore represent novel targets for antifibrotic therapies...
  2. ncbi request reprint Sarcoidosis following HIV infection: evidence for CD4+ lymphocyte dependence
    David G Morris
    Interstitial Lung Disease Program, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94142 0854, USA
    Chest 124:929-35. 2003
    ..The chronic granulomatous inflammation of sarcoidosis has been hypothesized to depend on the CD4+ T-helper lymphocyte. HIV infection, which depletes these cells, has been reported to attenuate the manifestations of sarcoidosis...
  3. pmc The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1
    Dezhi Mu
    Department of Pathology, University of California at San Francisco Mt Zion Cancer Center, San Francisco, CA 94143, USA
    J Cell Biol 157:493-507. 2002
    ..These data elucidate a novel mechanism of cellular homeostasis achieved through the coordination of the activities of members of three major gene families involved in cell-matrix interactions...
  4. pmc Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis
    Hua Su
    Center of Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
    Am J Pathol 176:1018-27. 2010
    ..These three lines of evidence from human studies and a mouse model suggest that reduced expression of integrin beta8 may be involved in the pathogenesis of sporadic BAVMs...
  5. pmc Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients
    Jun Araya
    Department of Pathology, Lung Biology Center, UCSF, San Francisco, California 94110, USA
    J Clin Invest 117:3551-62. 2007
    ..Our findings have identified TGF-beta as a potential therapeutic target for COPD...
  6. pmc Integrin-mediated transforming growth factor-beta activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit
    Jun Araya
    Department of Pathology, Bldg 3, Rm 207, 1001 Potrero Ave, San Francisco, CA 94110, USA
    Am J Pathol 169:405-15. 2006
    ..These findings elucidate the function and complex regulation of integrin-mediated activation of TGF-beta within the EMTU...
  7. pmc Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure
    Claus Neurohr
    Department of Medicine, Lung Biology Center, University of California, San Francisco, 94143 2922, USA
    Am J Respir Cell Mol Biol 35:252-9. 2006
    ..Wounding induced activation of TGF-beta through effects of both integrins, but antibodies against alphavbeta8 enhanced the degree of wound closure, whereas antibodies against alphavbeta6 did not...
  8. pmc Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch
    Stephanie Cambier
    Department of Pathology, University of California San Francisco, San Francisco, CA 94110, USA
    Am J Pathol 166:1883-94. 2005
    ....
  9. pmc Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue
    Lars Fjellbirkeland
    Department of Anatomic Pathology and Lung Biology Center, San Francisco General Hospital, University of California at San Francisco Mt Zion Cancer Center, San Francisco, California 94110, USA
    Am J Pathol 163:533-42. 2003
    ..These data provide compelling evidence for a functional role for integrin-mediated activation of TGF-beta in control of human airway epithelial proliferation in vivo...
  10. pmc Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway
    Jennifer A Markovics
    Department of Pathology, Pulmonary Division, School of Medicine, University of California, San Francisco, California 94110, USA
    J Biol Chem 285:24695-706. 2010
    ..These results place integrin beta8 expression and activity under the control of ubiquitous transcription factors in a stress-activated and pro-inflammatory pathway...

Research Grants12

  1. Integrin alphavbeta8 Inhibits Airway Epithelial Cell Growth
    Stephen L Nishimura; Fiscal Year: 2010
    ..This proposal is the first step in testing the therapeutic potential of inhibiting av8 function in COPD. ..
  2. Integrin alphavbeta8 Inhibits Airway Epithelial Cell Growth
    Stephen Nishimura; Fiscal Year: 2009
    ..This proposal is the first step in testing the therapeutic potential of inhibiting av8 function in COPD. ..
  3. Integrin alphavbeta8 Inhibits Airway Epithelial Cell Growth
    Stephen Nishimura; Fiscal Year: 2007
    ..This proposal is the first step in testing the therapeutic potential of inhibiting av¿8 function in COPD. ..
  4. Integrin Regulation of Airway Epithelial Proliferation
    Stephen Nishimura; Fiscal Year: 2006
    ..Specific Aim 3: To test the mechanism of integrin-mediated regulation of cell proliferation in a biologically relevant model of the human airway. ..
  5. Integrin avB8 Inhibits Airway Epithelial Cell Growth
    Stephen Nishimura; Fiscal Year: 2005
    ....
  6. Role of Squamous Metaplasia in Small Airways Disease in COPD
    Stephen L Nishimura; Fiscal Year: 2010
    ..These will be key experiments that will identify av6 and squamous metaplasia as therapeutic agents in COPD. ..