Janko Nikolich-Zugich

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
  2. pmc Age-related changes in CD8 T cell homeostasis and immunity to infection
    Janko Nikolich-Zugich
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, United States
    Semin Immunol 24:356-64. 2012
  3. pmc Immune memory and aging: an infinite or finite resource?
    Janko Nikolich-Zugich
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, 1656 E Mabel St, Tucson, AZ 85719, USA
    Curr Opin Immunol 22:535-40. 2010
  4. pmc Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions
    Brian D Rudd
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Proc Natl Acad Sci U S A 108:13694-9. 2011
  5. pmc Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium
    Gang Li
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Aging Cell 11:968-77. 2012
  6. pmc Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life
    Megan J Smithey
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 189:5356-66. 2012
  7. pmc Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice
    Megan J Smithey
    Department of Immunobiology and Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85719, USA
    Eur J Immunol 41:1352-64. 2011
  8. doi request reprint Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire
    Brian D Rudd
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 186:2056-64. 2011
  9. doi request reprint Functional CD8 T cell memory responding to persistent latent infection is maintained for life
    Anna Lang
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 187:3759-68. 2011
  10. doi request reprint Inflation and long-term maintenance of CD8 T cells responding to a latent herpesvirus depend upon establishment of latency and presence of viral antigens
    Anna Lang
    Department of Immunobiology and Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 183:8077-87. 2009

Research Grants

  1. Critical determinants of CD8+ T-cell-mediated protection
    Janko Nikolich Zugich; Fiscal Year: 2009
  2. T Cell Homeostasis and Function in Immune Senescence
    Janko Nikolich Zugich; Fiscal Year: 2010
  3. T Cell Homeostasis and Function in Immune Senescence
    Janko Nikolich Zugich; Fiscal Year: 2005
  4. TCR--PEPTIDE--MHC INTERACTION IN T CELL CROSSREACTIVITY
    Janko Nikolich Zugich; Fiscal Year: 2004
  5. MECHANISMS OF REDUCED T-CELL IMMUNITY IN OLDER ADULTS
    Janko Nikolich Zugich; Fiscal Year: 2010

Collaborators

  • Gang Li
  • Vanessa Venturi
  • Sing Sing Way
  • Janko Nikolich Zugich
  • Brian D Rudd
  • Megan J Smithey
  • Miles P Davenport
  • Anna Lang
  • Kristin R Renkema
  • Rafael Solana
  • Jennifer L Uhrlaub
  • James D Brien
  • Angela Wu
  • Alejandra Pera
  • Mikko Hurme
  • Paul Moss
  • Jos A Bosch
  • Beatriz Sanchez-Correa
  • Maciej Zielinski
  • Daniela Frasca
  • Evelyna Derhovanessian
  • Allison E Aiello
  • Beatrix Grubeck-Loebenstein
  • Miguel Lopez-Botet
  • Graham Pawelec
  • Jerrald L Rector
  • Arne N Akbar
  • Tamas Fulop
  • Raquel Tarazona
  • Mark Beswick
  • Sara Ferrando-Martínez
  • Anis Larbi
  • Sara Cantisán
  • Natalie Riddell
  • Ann Hill
  • Florian Kern
  • Luka Cicin-Sain
  • Sheila Govind
  • Delphine Sauce
  • Paolo Sansoni
  • Janet E McElhaney
  • Carmen Campos
  • Mark R Wills
  • Rene van Lier
  • Andrea B Maier
  • George C Wang
  • Victor Appay
  • Elissaveta Naumova
  • Peter W Mason
  • Douglas G Widman
  • James M Ertelt
  • Partha Samadder

Detail Information

Publications14

  1. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
    ..Here we summarize the major findings of this workshop...
  2. pmc Age-related changes in CD8 T cell homeostasis and immunity to infection
    Janko Nikolich-Zugich
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, United States
    Semin Immunol 24:356-64. 2012
    ..We specifically address phenotypic and numeric changes to the naïve CD8 T cell precursor pool, the impact of persistent viral infection(s) and inflammation, and contributions of the aging environment in which these cells are activated...
  3. pmc Immune memory and aging: an infinite or finite resource?
    Janko Nikolich-Zugich
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, 1656 E Mabel St, Tucson, AZ 85719, USA
    Curr Opin Immunol 22:535-40. 2010
    ....
  4. pmc Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions
    Brian D Rudd
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Proc Natl Acad Sci U S A 108:13694-9. 2011
    ....
  5. pmc Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium
    Gang Li
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Aging Cell 11:968-77. 2012
    ..These results suggest that age-associated changes in antigen uptake, pathogen sensing, and/or antigen presentation contribute to impaired adaptive immune responses to microbial pathogens with aging...
  6. pmc Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life
    Megan J Smithey
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 189:5356-66. 2012
    ....
  7. pmc Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice
    Megan J Smithey
    Department of Immunobiology and Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85719, USA
    Eur J Immunol 41:1352-64. 2011
    ....
  8. doi request reprint Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire
    Brian D Rudd
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 186:2056-64. 2011
    ..Implications for the rational design of vaccines for neonates and the elderly are discussed...
  9. doi request reprint Functional CD8 T cell memory responding to persistent latent infection is maintained for life
    Anna Lang
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 187:3759-68. 2011
    ..This finding demonstrates that functional effector memory T cells, including those expressing KLRG-1, are maintained and are functional for life, despite the presence of persistent viral infection...
  10. doi request reprint Inflation and long-term maintenance of CD8 T cells responding to a latent herpesvirus depend upon establishment of latency and presence of viral antigens
    Anna Lang
    Department of Immunobiology and Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 183:8077-87. 2009
    ..Moreover, results with antiviral drugs suggest that this approach could be considered as a treatment modality for maintaining T cell diversity and/or function in old age...
  11. pmc Repeated in vivo stimulation of T and B cell responses in old mice generates protective immunity against lethal West Nile virus encephalitis
    Jennifer L Uhrlaub
    Department of Immunobiology, College of Medicine, University of Arizona, Tucson, AZ 85719, USA
    J Immunol 186:3882-91. 2011
    ....
  12. doi request reprint Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging
    Kristin R Renkema
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724
    J Immunol 192:151-9. 2014
    ....
  13. doi request reprint Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections
    Janko Nikolich-Zugich
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona, Tucson, Arizona 85724, USA
    Nat Rev Immunol 8:512-22. 2008
    ..In this Review, I question whether latent persistent pathogens might be key factors that drive this imbalance and whether they determine the extent of age-associated immune deficiency...
  14. doi request reprint Diversity of the CD8+ T cell repertoire elicited against an immunodominant epitope does not depend on the context of infection
    Brian D Rudd
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 184:2958-65. 2010
    ....

Research Grants22

  1. Critical determinants of CD8+ T-cell-mediated protection
    Janko Nikolich Zugich; Fiscal Year: 2009
    ..abstract_text> ..
  2. T Cell Homeostasis and Function in Immune Senescence
    Janko Nikolich Zugich; Fiscal Year: 2010
    ....
  3. T Cell Homeostasis and Function in Immune Senescence
    Janko Nikolich Zugich; Fiscal Year: 2005
    ..The studies should elucidate the mechanisms behind generation and maintenance of TCE and further clarify the impact of TCE on the senescent immune system. ..
  4. TCR--PEPTIDE--MHC INTERACTION IN T CELL CROSSREACTIVITY
    Janko Nikolich Zugich; Fiscal Year: 2004
    ..2. To determine the x-ray structures of the monospecific and crossreactive TCRs with the appropriate pep:MHC complexes, and use site-directed mutagenesis to definitively dissect crossreactive recognition. ..
  5. MECHANISMS OF REDUCED T-CELL IMMUNITY IN OLDER ADULTS
    Janko Nikolich Zugich; Fiscal Year: 2010
    ....