Janko Nikolich-Zugich

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories
    Janko Nikolich-Zugich
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724 and Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724
    J Immunol 193:2622-9. 2014
  2. pmc Key role of T cell defects in age-related vulnerability to West Nile virus
    James D Brien
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Exp Med 206:2735-45. 2009
  3. pmc Immune response to the West Nile virus in aged non-human primates
    Anne M Wertheimer
    Arizona Center on Aging, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 5:e15514. 2010
  4. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
  5. pmc Age-related changes in CD8 T cell homeostasis and immunity to infection
    Janko Nikolich-Zugich
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, United States
    Semin Immunol 24:356-64. 2012
  6. pmc Immune memory and aging: an infinite or finite resource?
    Janko Nikolich-Zugich
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, 1656 E Mabel St, Tucson, AZ 85719, USA
    Curr Opin Immunol 22:535-40. 2010
  7. pmc Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions
    Brian D Rudd
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Proc Natl Acad Sci U S A 108:13694-9. 2011
  8. pmc Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium
    Gang Li
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Aging Cell 11:968-77. 2012
  9. pmc Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life
    Megan J Smithey
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 189:5356-66. 2012
  10. pmc Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice
    Megan J Smithey
    Department of Immunobiology and Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85719, USA
    Eur J Immunol 41:1352-64. 2011

Research Grants

  1. TCR--PEPTIDE--MHC INTERACTION IN T CELL CROSSREACTIVITY
    Janko Nikolich Zugich; Fiscal Year: 2004
  2. Critical determinants of CD8+ T-cell-mediated protection
    Janko Nikolich Zugich; Fiscal Year: 2009

Collaborators

  • Gang Li
  • Vanessa Venturi
  • Sing Sing Way
  • Milica Vukmanovic-Stejic
  • Arne N Akbar
  • Heddwen L Brooks
  • M Jane Mohler
  • Megan J Smithey
  • Janko Nikolich Zugich
  • Jennifer L Uhrlaub
  • Brian D Rudd
  • Anne M Wertheimer
  • Emily L Goldberg
  • Kristin R Renkema
  • Miles P Davenport
  • Anna Lang
  • James D Brien
  • Gregory D Sempowski
  • Jason L Pugh
  • M Jane Mohler
  • Rafael Solana
  • Alec Hirsch
  • Clayton A Wiley
  • Wade M Chew
  • Melissa J Romero-Aleshire
  • Kirsten H Limesand
  • Melissa S Ventevogel
  • Carmine Martinez
  • Jeffrey Kaye
  • Lydia K Lutes
  • Nancy R Manley
  • Marcel R m van den Brink
  • Michael S Bennett
  • Byung Park
  • Thomas M Seed
  • Dragana Nikolich-Zugich
  • Alona S Sukhina
  • Bijan Najafi
  • Mindy J Fain
  • Vesna Pulko
  • Noreen L Currier
  • Angela Wu
  • Evelyna Derhovanessian
  • Victor Appay
  • Tamas Fulop
  • Sheila Govind
  • Jerrald L Rector
  • Raquel Tarazona
  • Jos A Bosch
  • Sara Cantisán
  • Florian Kern
  • Mark Beswick
  • Ann Hill
  • Mikko Hurme
  • Luka Cicin-Sain
  • George C Wang
  • Mark R Wills
  • Allison E Aiello
  • Beatriz Sanchez-Correa
  • Elissaveta Naumova
  • Delphine Sauce
  • Rene van Lier
  • Andrea B Maier
  • Miguel Lopez-Botet
  • Anis Larbi
  • Daniela Frasca
  • Sara Ferrando-Martínez
  • Maciej Zielinski
  • Paul Moss
  • Paolo Sansoni
  • Natalie Riddell
  • Beatrix Grubeck-Loebenstein
  • Alejandra Pera
  • Janet E McElhaney
  • Graham Pawelec
  • Carmen Campos
  • Peter W Mason
  • Partha Samadder
  • James M Ertelt
  • Douglas G Widman
  • Alfred Legasse
  • Scott W Wong
  • Peter Didier
  • Kristy O Murray
  • Jerald Sprague
  • Jennifer Wilk
  • Guruprasad Medigeshi
  • Robert B Tesh
  • Michael K Axthelm

Detail Information

Publications23

  1. pmc Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories
    Janko Nikolich-Zugich
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724 and Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724
    J Immunol 193:2622-9. 2014
    ....
  2. pmc Key role of T cell defects in age-related vulnerability to West Nile virus
    James D Brien
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Exp Med 206:2735-45. 2009
    ..These findings identify potential targets for immunomodulation and treatment to combat lethal WNV infection in the elderly...
  3. pmc Immune response to the West Nile virus in aged non-human primates
    Anne M Wertheimer
    Arizona Center on Aging, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 5:e15514. 2010
    ..Understanding the basis of this susceptibility requires development of suitable animal models. Here, we investigated the immune response to WNV in old non-human primates...
  4. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
    ..Here we summarize the major findings of this workshop...
  5. pmc Age-related changes in CD8 T cell homeostasis and immunity to infection
    Janko Nikolich-Zugich
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, United States
    Semin Immunol 24:356-64. 2012
    ..We specifically address phenotypic and numeric changes to the naïve CD8 T cell precursor pool, the impact of persistent viral infection(s) and inflammation, and contributions of the aging environment in which these cells are activated...
  6. pmc Immune memory and aging: an infinite or finite resource?
    Janko Nikolich-Zugich
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, 1656 E Mabel St, Tucson, AZ 85719, USA
    Curr Opin Immunol 22:535-40. 2010
    ....
  7. pmc Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions
    Brian D Rudd
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Proc Natl Acad Sci U S A 108:13694-9. 2011
    ....
  8. pmc Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium
    Gang Li
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Aging Cell 11:968-77. 2012
    ..These results suggest that age-associated changes in antigen uptake, pathogen sensing, and/or antigen presentation contribute to impaired adaptive immune responses to microbial pathogens with aging...
  9. pmc Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life
    Megan J Smithey
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 189:5356-66. 2012
    ....
  10. pmc Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice
    Megan J Smithey
    Department of Immunobiology and Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85719, USA
    Eur J Immunol 41:1352-64. 2011
    ....
  11. pmc Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire
    Brian D Rudd
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 186:2056-64. 2011
    ..Implications for the rational design of vaccines for neonates and the elderly are discussed...
  12. pmc Functional CD8 T cell memory responding to persistent latent infection is maintained for life
    Anna Lang
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 187:3759-68. 2011
    ..This finding demonstrates that functional effector memory T cells, including those expressing KLRG-1, are maintained and are functional for life, despite the presence of persistent viral infection...
  13. pmc Inflation and long-term maintenance of CD8 T cells responding to a latent herpesvirus depend upon establishment of latency and presence of viral antigens
    Anna Lang
    Department of Immunobiology and Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 183:8077-87. 2009
    ..Moreover, results with antiviral drugs suggest that this approach could be considered as a treatment modality for maintaining T cell diversity and/or function in old age...
  14. pmc Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging
    Kristin R Renkema
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724
    J Immunol 192:151-9. 2014
    ....
  15. pmc Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms
    Emily L Goldberg
    Departments of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ, USA Department of Nutritional Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ, USA
    Aging Cell 14:130-8. 2015
    ..We conclude that neither rapa feeding nor CR, in the current form/administration regimen, may be optimal strategies for extending healthy immune function and, with it, lifespan. ..
  16. pmc Repeated in vivo stimulation of T and B cell responses in old mice generates protective immunity against lethal West Nile virus encephalitis
    Jennifer L Uhrlaub
    Department of Immunobiology, College of Medicine, University of Arizona, Tucson, AZ 85719, USA
    J Immunol 186:3882-91. 2011
    ....
  17. doi request reprint Lost in translation: mice, men and cutaneous immunity in old age
    Megan J Smithey
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ, 85724, USA
    Biogerontology 16:203-8. 2015
    ..We report here on what worked, what didn't, and what we learned along the way. ..
  18. pmc Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans
    Anne M Wertheimer
    Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724
    J Immunol 192:2143-55. 2014
    ..These findings provide important new insights into the age-related changes in the peripheral blood pool of older adults, demonstrating that aging and CMV exert both distinct and joint influence upon blood T cell homeostasis in humans. ..
  19. doi request reprint Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections
    Janko Nikolich-Zugich
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona, Tucson, Arizona 85724, USA
    Nat Rev Immunol 8:512-22. 2008
    ..In this Review, I question whether latent persistent pathogens might be key factors that drive this imbalance and whether they determine the extent of age-associated immune deficiency...
  20. pmc Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections
    Emily L Goldberg
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724 Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724 Department of Nutritional Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ 85721 and
    J Immunol 193:757-63. 2014
    ..This urges caution with regard to the relative therapeutic costs and benefits of Rapa treatment as means to improve immune memory. ..
  21. pmc Diversity of the CD8+ T cell repertoire elicited against an immunodominant epitope does not depend on the context of infection
    Brian D Rudd
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 184:2958-65. 2010
    ....
  22. pmc Histone deacetylation critically determines T cell subset radiosensitivity
    Jason L Pugh
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724 Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724 Graduate Interdisciplinary Program in Genetics, University of Arizona, Tucson, AZ 85719
    J Immunol 193:1451-8. 2014
    ..We conclude that an open genome-wide chromatin state is the key determinant of efficient immediate repair of DNA damage in T cells, explaining the observed T cell subset radiosensitivity differences. ..
  23. doi request reprint The Frailty syndrome: clinical measurements and basic underpinnings in humans and animals
    M Jane Mohler
    Arizona Center on Aging, University of Arizona College of Medicine Tucson, 1501 N Campbell Avenue, P O Box 245017, Tucson, AZ 85724, USA Division of Geriatrics, General Internal Medicine and Palliative Medicine, Department of Medicine, University of Arizona College of Medicine Tucson, 1501 N Campbell Avenue, P O Box 245017, Tucson, AZ 85724, USA Interdisciplinary Consortium on Advanced Motion Performance iCAMP, Department of Surgery, University of Arizona College of Medicine Tucson, 1501 N Campbell Avenue, P O Box 245017, Tucson, AZ 85724, USA Electronic address
    Exp Gerontol 54:6-13. 2014
    ....

Research Grants2

  1. TCR--PEPTIDE--MHC INTERACTION IN T CELL CROSSREACTIVITY
    Janko Nikolich Zugich; Fiscal Year: 2004
    ..2. To determine the x-ray structures of the monospecific and crossreactive TCRs with the appropriate pep:MHC complexes, and use site-directed mutagenesis to definitively dissect crossreactive recognition. ..
  2. Critical determinants of CD8+ T-cell-mediated protection
    Janko Nikolich Zugich; Fiscal Year: 2009
    ..abstract_text> ..