Janko Nikolich-Zugich

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. doi request reprint Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections
    Janko Nikolich-Zugich
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona, Tucson, Arizona 85724, USA
    Nat Rev Immunol 8:512-22. 2008
  2. pmc Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium
    Gang Li
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Aging Cell 11:968-77. 2012
  3. pmc Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life
    Megan J Smithey
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 189:5356-66. 2012
  4. pmc Age-related changes in CD8 T cell homeostasis and immunity to infection
    Janko Nikolich-Zugich
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, United States
    Semin Immunol 24:356-64. 2012
  5. pmc Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions
    Brian D Rudd
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Proc Natl Acad Sci U S A 108:13694-9. 2011
  6. doi request reprint Functional CD8 T cell memory responding to persistent latent infection is maintained for life
    Anna Lang
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 187:3759-68. 2011
  7. pmc Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice
    Megan J Smithey
    Department of Immunobiology and Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85719, USA
    Eur J Immunol 41:1352-64. 2011
  8. pmc Repeated in vivo stimulation of T and B cell responses in old mice generates protective immunity against lethal West Nile virus encephalitis
    Jennifer L Uhrlaub
    Department of Immunobiology, College of Medicine, University of Arizona, Tucson, AZ 85719, USA
    J Immunol 186:3882-91. 2011
  9. pmc Immune memory and aging: an infinite or finite resource?
    Janko Nikolich-Zugich
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, 1656 E Mabel St, Tucson, AZ 85719, USA
    Curr Opin Immunol 22:535-40. 2010
  10. ncbi request reprint Immune Memory-Boosting Dose of Rapamycin Impairs Macrophage Vesicle Acidification and Curtails Glycolysis in Effector CD8 Cells, Impairing Defense against Acute Infections
    Emily L Goldberg
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724 Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724 Department of Nutritional Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ 85721 and
    J Immunol 193:757-63. 2014

Collaborators

  • Gang Li
  • Vanessa Venturi
  • Sing Sing Way
  • D K Ingram
  • Ilhem Messaoudi
  • Anna Lang
  • Megan J Smithey
  • Brian D Rudd
  • Jennifer L Uhrlaub
  • Miles P Davenport
  • James D Brien
  • Miranda Fischer
  • Jessica Warner
  • Emily L Goldberg
  • Luka Cicin-Sain
  • Louis J Picker
  • Motomi Mori
  • Dragana Nikolich-Zugich
  • H Daniel Lacorazza
  • Joel Lemaoult
  • Vladimir Jankovic
  • Lydia K Lutes
  • Peter W Mason
  • James M Ertelt
  • Douglas G Widman
  • Kristin R Renkema
  • Partha Samadder
  • Alfred Legasse
  • Shannon Planer
  • Michael K Axthelm
  • Shane Tackitt
  • Byung Park
  • Noreen Currier
  • Mark A Lane
  • Brenna Hill
  • Buyng Park
  • Daniel C Douek
  • George S Roth
  • Julie Mattison
  • Beatrix M Metzner
  • Jose A Guevara-Patino
  • Ruben Dyall
  • Jose A Guevara Patino

Detail Information

Publications26

  1. doi request reprint Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections
    Janko Nikolich-Zugich
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona, Tucson, Arizona 85724, USA
    Nat Rev Immunol 8:512-22. 2008
    ..In this Review, I question whether latent persistent pathogens might be key factors that drive this imbalance and whether they determine the extent of age-associated immune deficiency...
  2. pmc Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium
    Gang Li
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Aging Cell 11:968-77. 2012
    ..These results suggest that age-associated changes in antigen uptake, pathogen sensing, and/or antigen presentation contribute to impaired adaptive immune responses to microbial pathogens with aging...
  3. pmc Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life
    Megan J Smithey
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 189:5356-66. 2012
    ....
  4. pmc Age-related changes in CD8 T cell homeostasis and immunity to infection
    Janko Nikolich-Zugich
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, United States
    Semin Immunol 24:356-64. 2012
    ..We specifically address phenotypic and numeric changes to the naïve CD8 T cell precursor pool, the impact of persistent viral infection(s) and inflammation, and contributions of the aging environment in which these cells are activated...
  5. pmc Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions
    Brian D Rudd
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Proc Natl Acad Sci U S A 108:13694-9. 2011
    ....
  6. doi request reprint Functional CD8 T cell memory responding to persistent latent infection is maintained for life
    Anna Lang
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 187:3759-68. 2011
    ..This finding demonstrates that functional effector memory T cells, including those expressing KLRG-1, are maintained and are functional for life, despite the presence of persistent viral infection...
  7. pmc Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice
    Megan J Smithey
    Department of Immunobiology and Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85719, USA
    Eur J Immunol 41:1352-64. 2011
    ....
  8. pmc Repeated in vivo stimulation of T and B cell responses in old mice generates protective immunity against lethal West Nile virus encephalitis
    Jennifer L Uhrlaub
    Department of Immunobiology, College of Medicine, University of Arizona, Tucson, AZ 85719, USA
    J Immunol 186:3882-91. 2011
    ....
  9. pmc Immune memory and aging: an infinite or finite resource?
    Janko Nikolich-Zugich
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, 1656 E Mabel St, Tucson, AZ 85719, USA
    Curr Opin Immunol 22:535-40. 2010
    ....
  10. ncbi request reprint Immune Memory-Boosting Dose of Rapamycin Impairs Macrophage Vesicle Acidification and Curtails Glycolysis in Effector CD8 Cells, Impairing Defense against Acute Infections
    Emily L Goldberg
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724 Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724 Department of Nutritional Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ 85721 and
    J Immunol 193:757-63. 2014
    ..This urges caution with regard to the relative therapeutic costs and benefits of Rapa treatment as means to improve immune memory. ..
  11. doi request reprint Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire
    Brian D Rudd
    Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 186:2056-64. 2011
    ..Implications for the rational design of vaccines for neonates and the elderly are discussed...
  12. doi request reprint Inflation and long-term maintenance of CD8 T cells responding to a latent herpesvirus depend upon establishment of latency and presence of viral antigens
    Anna Lang
    Department of Immunobiology and Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    J Immunol 183:8077-87. 2009
    ..Moreover, results with antiviral drugs suggest that this approach could be considered as a treatment modality for maintaining T cell diversity and/or function in old age...
  13. ncbi request reprint Age-related dysregulation of CD8+ T cell memory specific for a persistent virus is independent of viral replication
    Anna Lang
    Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Immunol 180:4848-57. 2008
    ..This collectively suggests that, in this model, the inflating cells may be selected for high responsiveness to environmental cytokines largely in an Ag-independent manner...
  14. pmc Dramatic increase in naive T cell turnover is linked to loss of naive T cells from old primates
    Luka Cicin-Sain
    Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Proc Natl Acad Sci U S A 104:19960-5. 2007
    ..Thus, homeostatic T cell proliferation exhibits temporal antagonistic pleiotropy, being beneficial to T cell maintenance in adulthood but detrimental to the long-term T cell maintenance in aging individuals...
  15. ncbi request reprint Phenotypic and functional T-cell aging in rhesus macaques (Macaca mulatta): differential behavior of CD4 and CD8 subsets
    Vladimir Jankovic
    Vaccine and Gene Therapy Institute and Division of Pathobiology, Oregon National Primate Research Center, Beaverton, OR, USA
    Blood 102:3244-51. 2003
    ..We suggest that some of the T-cell aging phenomenology in RMs can be ascribed to accentuation over time of the inherent differences in activation programs in CD8 and CD4 T cells...
  16. ncbi request reprint The role of mhc polymorphism in anti-microbial resistance
    Janko Nikolich-Zugich
    Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center of the Oregon Health, Science University, OHSU West Campus, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Microbes Infect 6:501-12. 2004
    ..Here, we examine the mechanistic relationship between mhc polymorphism and anti-microbial resistance/susceptibility...
  17. ncbi request reprint Exclusion and inclusion of TCR alpha proteins during T cell development in TCR-transgenic and normal mice
    H Daniel Lacorazza
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 173:5591-600. 2004
    ..In searching for the mechanism(s) governing this selective TCRalpha down-regulation, we present evidence for the role of protein tyrosine kinase signaling and coreceptor involvement. This mechanism may be operating in normal thymocytes...
  18. pmc Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense
    Ilhem Messaoudi
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, West Campus, 505 NW 185th Ave, Beaverton, OR 97006, USA
    J Exp Med 200:1347-58. 2004
    ....
  19. ncbi request reprint Development and migration of protective CD8+ T cells into the nervous system following ocular herpes simplex virus-1 infection
    Anna Lang
    Department of Molecular Microbiology and Immunology, Vaccine and Gene Therapy Institute, and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Immunol 174:2919-25. 2005
    ..Thus, CD8(+) T cells do not control HSV-1 spread from primary to tertiary tissues, but, rather, attack the virus in infected organs and control its replication in situ...
  20. pmc T cell aging: naive but not young
    Janko Nikolich-Zugich
    Oregon Health and Science University, Beaverton, OR 97006, USA
    J Exp Med 201:837-40. 2005
    ..Recent advances suggest that old mice can produce fully functional new T cells, opening both intriguing inquiry avenues and raising critical questions to be pursued...
  21. ncbi request reprint Mice and flies and monkeys too: caloric restriction rejuvenates the aging immune system of non-human primates
    Janko Nikolich-Zugich
    Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Exp Gerontol 40:884-93. 2005
    ....
  22. ncbi request reprint Molecular, cellular, and antigen requirements for development of age-associated T cell clonal expansions in vivo
    Ilhem Messaoudi
    Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Immunol 176:301-8. 2006
    ....
  23. ncbi request reprint Age-related CD8+ T cell clonal expansions express elevated levels of CD122 and CD127 and display defects in perceiving homeostatic signals
    Ilhem Messaoudi
    Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Immunol 177:2784-92. 2006
    ..The above results are discussed in light of possible mechanisms that afford selective survival advantage to TCE over other T cells in an aged T lymphocyte pool...
  24. pmc Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates
    Ilhem Messaoudi
    Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Proc Natl Acad Sci U S A 103:19448-53. 2006
    ..Our results provide evidence that CR can delay immune senescence in nonhuman primates, potentially contributing to an extended lifespan by reducing susceptibility to infectious disease...
  25. pmc Non-human primate models of T-cell reconstitution
    Janko Nikolich-Zugich
    Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, West Campus, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Semin Immunol 19:310-7. 2007
    ....
  26. ncbi request reprint Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense
    Ilhem Messaoudi
    Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Science 298:1797-800. 2002
    ..Thus, much of the beneficial effect of the mhc polymorphism in immune defense may be due to its critical influence on the properties of the selected CTL repertoire...