Yuri Nikiforov

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint New strategies in diagnosing cancer in thyroid nodules: impact of molecular markers
    Yuri E Nikiforov
    Authors Affiliations Department of Pathology and Laboratory Medicine, and Division of Endocrine Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania
    Clin Cancer Res 19:2283-8. 2013
  2. doi request reprint Molecular testing for mutations in improving the fine-needle aspiration diagnosis of thyroid nodules
    Yuri E Nikiforov
    Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 94:2092-8. 2009
  3. pmc Thyroid carcinoma: molecular pathways and therapeutic targets
    Yuri E Nikiforov
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Mod Pathol 21:S37-43. 2008
  4. ncbi request reprint Radiation-induced thyroid cancer: what we have learned from chernobyl
    Yuri E Nikiforov
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Endocr Pathol 17:307-17. 2006
  5. doi request reprint Molecular analysis of thyroid tumors
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Mod Pathol 24:S34-43. 2011
  6. doi request reprint Molecular diagnostics of thyroid tumors
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Arch Pathol Lab Med 135:569-77. 2011
  7. doi request reprint Molecular genetics and diagnosis of thyroid cancer
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, PUH C 606, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Nat Rev Endocrinol 7:569-80. 2011
  8. pmc Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 96:3390-7. 2011
  9. ncbi request reprint BRAF copy number gains in thyroid tumors detected by fluorescence in situ hybridization
    Raffaele Ciampi
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Endocr Pathol 16:99-105. 2005
  10. doi request reprint Molecular diagnostics and predictors in thyroid cancer
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Thyroid 19:1351-61. 2009

Research Grants

Collaborators

Detail Information

Publications63

  1. doi request reprint New strategies in diagnosing cancer in thyroid nodules: impact of molecular markers
    Yuri E Nikiforov
    Authors Affiliations Department of Pathology and Laboratory Medicine, and Division of Endocrine Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania
    Clin Cancer Res 19:2283-8. 2013
    ..Clin Cancer Res; 19(9); 2283-8. ©2013 AACR...
  2. doi request reprint Molecular testing for mutations in improving the fine-needle aspiration diagnosis of thyroid nodules
    Yuri E Nikiforov
    Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 94:2092-8. 2009
    ..However, 10-40% of nodules are diagnosed as indeterminate by cytology, making it difficult to optimally manage these patients...
  3. pmc Thyroid carcinoma: molecular pathways and therapeutic targets
    Yuri E Nikiforov
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Mod Pathol 21:S37-43. 2008
    ..A number of compounds have been studied and showed antitumor effects in preclinical studies and are being tested in ongoing clinical trials...
  4. ncbi request reprint Radiation-induced thyroid cancer: what we have learned from chernobyl
    Yuri E Nikiforov
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Endocr Pathol 17:307-17. 2006
    ..On the molecular level, post-Chernobyl tumors are characterized by frequent occurrence of chromosomal rearrangements, such as RET/PTC, whereas point mutations of BRAF and other genes are much less common in this population...
  5. doi request reprint Molecular analysis of thyroid tumors
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Mod Pathol 24:S34-43. 2011
    ..This review discusses major molecular alterations known to occur in thyroid cancer, focusing on those markers that have been extensively characterized, carry clinical significance, and are being introduced into pathology practice...
  6. doi request reprint Molecular diagnostics of thyroid tumors
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Arch Pathol Lab Med 135:569-77. 2011
    ..Papillary carcinoma and follicular carcinoma are the most common types of thyroid cancer and represent those tumor types for which use of molecular markers for diagnosis and prognostication is of high clinical significance...
  7. doi request reprint Molecular genetics and diagnosis of thyroid cancer
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, PUH C 606, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Nat Rev Endocrinol 7:569-80. 2011
    ....
  8. pmc Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 96:3390-7. 2011
    ..Fine-needle aspiration (FNA) cytology provides a definitive diagnosis of benign or malignant disease in many cases, whereas about 25% of nodules are indeterminate, hindering most appropriate management...
  9. ncbi request reprint BRAF copy number gains in thyroid tumors detected by fluorescence in situ hybridization
    Raffaele Ciampi
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Endocr Pathol 16:99-105. 2005
    ..By Western blotting, the tumors carrying four copies of the gene revealed higher expression of BRAF protein, suggesting that copy number gain may represent another mechanism of BRAF activation in thyroid tumors...
  10. doi request reprint Molecular diagnostics and predictors in thyroid cancer
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Thyroid 19:1351-61. 2009
    ....
  11. ncbi request reprint Genetic alterations involved in the transition from well-differentiated to poorly differentiated and anaplastic thyroid carcinomas
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Endocr Pathol 15:319-27. 2004
    ..This suggests that poorly differentiated carcinoma, as a group, represents a distinct step in the evolution from well-differentiated to anaplastic thyroid carcinoma, rather than an entirely separate type of thyroid malignancy...
  12. pmc Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer
    Raffaele Ciampi
    Department of Pathology and Laboratory Medicine and Division of Endocrinology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0529, USA
    J Clin Invest 115:94-101. 2005
    ....
  13. doi request reprint A novel complex BRAF mutation detected in a solid variant of papillary thyroid carcinoma
    Simion Chiosea
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA
    Endocr Pathol 20:122-6. 2009
    ..This mutation was identified both in the preoperative fine needle aspirate sample and in the surgical specimen after total thyroidectomy. Other rare BRAF mutations in PTC are reviewed...
  14. ncbi request reprint BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 88:5399-404. 2003
    ..They are associated with distinct phenotypical and biological properties of papillary carcinomas and may participate in progression to poorly differentiated and anaplastic carcinomas...
  15. ncbi request reprint Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis
    Thomas J Giordano
    Department of Pathology, UH 2G332 0054, University of Michigan Medical School, Ann Arbor, 48109 0054, USA
    Oncogene 24:6646-56. 2005
    ....
  16. ncbi request reprint Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Cincinnati, 231 Albert Sabin Way, P O Box 670529, Cincinnati, OH 45267 0529, USA
    Cancer Lett 209:1-6. 2004
    ..These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors...
  17. doi request reprint The histopathology of BRAF-V600E-mutated lung adenocarcinoma
    Samuel A Yousem
    Department of Pathology, Presbyterian Campus, UPMC Presbyterian Shadyside, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 32:1317-21. 2008
    ..Adenocarcinomas with this clinicopathologic phenotype may be worthwhile investigating for BRAF-V600E mutation as more genetically oriented drug therapies emerge...
  18. pmc MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utility
    Marina N Nikiforova
    Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Endocrinol Metab 93:1600-8. 2008
    ....
  19. ncbi request reprint Molecular genetics of thyroid cancer: implications for diagnosis, treatment and prognosis
    Marina N Nikiforova
    Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Expert Rev Mol Diagn 8:83-95. 2008
    ..Detection of these genetic alterations using molecular techniques is important for preoperative fine-needle aspiration diagnosis, prognosis and treatment of thyroid cancer...
  20. ncbi request reprint RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0529, USA
    J Clin Endocrinol Metab 88:2318-26. 2003
    ..These results suggest that conventional follicular thyroid carcinomas develop through at least two distinct and virtually nonoverlapping molecular pathways initiated by either RAS point mutation or PAX8-PPAR gamma rearrangement...
  21. pmc Summary statement: utility of molecular marker testing in thyroid cancer
    Linwah Yip
    Division of Endocrine Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Surgery 148:1313-5. 2010
    ..The 2010 Annual Meeting of the American Association for Endocrine Surgeons featured a symposium dedicated to molecular marker testing in thyroid cancer and its potential clinical applicability...
  22. ncbi request reprint High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
    Edna T Kimura
    Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Cancer Res 63:1454-7. 2003
    ..Because these signaling proteins function along the same pathway in thyroid cells, this represents a unique paradigm of human tumorigenesis through mutation of three signaling effectors lying in tandem...
  23. doi request reprint Optimizing surgical treatment of papillary thyroid carcinoma associated with BRAF mutation
    Linwah Yip
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Surgery 146:1215-23. 2009
    ..It is not known whether pre-operative identification of BRAF mutations in cytologic specimens should alter surgical management...
  24. ncbi request reprint BRAF kinase activation via chromosomal rearrangement in radiation-induced and sporadic thyroid cancer
    Raffaele Ciampi
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0529, USA
    Cell Cycle 4:547-8. 2005
    ....
  25. doi request reprint MicroRNA expression profiles in thyroid tumors
    Marina N Nikiforova
    Department of Pathology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Endocr Pathol 20:85-91. 2009
    ..The purpose of this review is to summarize the existing findings of miRNA deregulation in thyroid tumors and its potential role in thyroid cancer biology and molecular diagnostics...
  26. doi request reprint Contribution of molecular testing to thyroid fine-needle aspiration cytology of "follicular lesion of undetermined significance/atypia of undetermined significance"
    N Paul Ohori
    Department of Pathology, University of Pittsburgh Medical Center Presbyterian, Pittsburgh, Pennsylvania 15213, USA
    Cancer Cytopathol 118:17-23. 2010
    ..The use of ancillary molecular studies has not been widely explored for this diagnosis...
  27. doi request reprint RAS mutation-positive follicular variant of papillary thyroid carcinoma arising in a struma ovarii
    Christopher Coyne
    Dept of Endocrinology, UPMC, Suite 3B, Falk Medical Bldg, 3601 5th Ave, Pittsburgh, PA 15213, USA
    Endocr Pathol 21:144-7. 2010
    ..It provides evidence that tumors developing in this setting involve molecular mechanisms similar to those implicated in tumors developing in the thyroid gland...
  28. ncbi request reprint Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneity
    Zhaowen Zhu
    Department of Pathology, University of Cincinnati, 231 Albert Sabin Way, P O Box 670529, Cincinnati, Ohio 45267 0529, USA
    J Clin Endocrinol Metab 91:3603-10. 2006
    ..RET/PTC rearrangements have been reported in papillary thyroid carcinomas with variable frequency in studies that used different detection methods...
  29. doi request reprint Adequacy of surgeon-performed ultrasound-guided thyroid fine-needle aspiration biopsy
    Amol M Bhatki
    Department of Otolaryngology Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Otolaryngol Head Neck Surg 139:27-31. 2008
    ..To determine the diagnostic accuracy of specimens obtained by a surgeon performing office-based ultrasound (US)-guided fine-needle aspiration biopsy (FNAB) of thyroid nodules...
  30. doi request reprint Encapsulated papillary oncocytic neoplasms of the thyroid: morphologic, immunohistochemical, and molecular analysis of 18 cases
    Randall Lyndon Woodford
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Surg Pathol 34:1582-90. 2010
    ..Our results confirm that EPONs are histologically, immunohistochemically, and molecularly distinct from papillary thyroid carcinoma and seem to be most related to follicular neoplasms...
  31. ncbi request reprint RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis
    Raffaele Ciampi
    Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Endocrinology 148:936-41. 2007
    ..Molecular inhibitors that block RET/PTC or BRAF kinase activity have shown substantial therapeutic effects in the experimental systems and are currently being tested in clinical trials...
  32. ncbi request reprint Delineation, functional validation, and bioinformatic evaluation of gene expression in thyroid follicular carcinomas with the PAX8-PPARG translocation
    Thomas J Giordano
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Clin Cancer Res 12:1983-93. 2006
    ..These results have implications for the neoplastic mechanism of these follicular carcinomas...
  33. ncbi request reprint Alterations of the BRAF gene in thyroid tumors
    Raffaele Ciampi
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0529, USA
    Endocr Pathol 16:163-72. 2005
    ..Yet another mechanism of BRAF activation may involve copy number gain, which is seen in a significant portion of thyroid follicular tumors of both conventional and oncocytic (Hürthle cell) types...
  34. ncbi request reprint Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations
    Zhaowen Zhu
    Departments of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, 231 Albert Sabin Way, PO Box 670529, Cincinnati, OH 45267 0529, USA
    Am J Clin Pathol 120:71-7. 2003
    ..These data indicate that the FV of papillary carcinoma has a distinct set of molecular alterations and is characterized by a high frequency of ras point mutations...
  35. ncbi request reprint Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas
    Adebowale J Adeniran
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Am J Surg Pathol 30:216-22. 2006
    ..These findings demonstrate that BRAF, RET/PTC, and RAS mutations are associated with distinct microscopic, clinical, and biologic features of thyroid papillary carcinomas...
  36. ncbi request reprint Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation
    Jeffrey A Knauf
    Division of Endocrinology and Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0547, USA
    Cancer Res 65:4238-45. 2005
    ..This closely recapitulates the phenotype of BRAF-positive PTCs in humans and supports a key role for this oncogene in its pathogenesis...
  37. pmc Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumors
    Hui Zuo
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 70:1389-97. 2010
    ..Overall, our findings indicate that epigenetic or genetic loss of Rap1GAP is very common in thyroid cancer, where these events are sufficient to promote cell proliferation and invasion...
  38. ncbi request reprint Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: a model of carcinogenic chromosomal rearrangement induced by ionizing radiation
    Christy M Caudill
    Department of Pathology, University of Cincinnati, 231 Albert Sabin Way, P O Box 670529, Cincinnati, Ohio 45267 0529, USA
    J Clin Endocrinol Metab 90:2364-9. 2005
    ..1-10 Gy gamma-radiation. This provides additional evidence for a direct link between this genetic event and radiation exposure and offers a powerful experimental system for studying radiation-induced carcinogenesis in the thyroid gland...
  39. doi request reprint Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomas
    Craig Horbinski
    Department of Pathology, University of Kentucky, 800 Rose St, Lexington, KY 40536, USA
    Acta Neuropathol 119:641-9. 2010
    ..Nevertheless, such tumors may have altered sensitivity to pathway-specific adjuvant therapy. Additionally, deletion on 17p13 may be an adverse prognostic biomarker in cerebellar tumors...
  40. ncbi request reprint Pharmacodynamic effect of iopanoic acid on free T(3) and T(4) levels in amiodarone-induced thyrotoxicosis
    Laura Matrka
    Department of Otolaryngology Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0528, USA
    Ear Nose Throat J 87:702-4. 2008
    ..We also discuss the different pharmacodynamic effects that iopanoic acid has on FT(3) and FT(4) levels...
  41. pmc Mechanisms of chromosomal rearrangements in solid tumors: the model of papillary thyroid carcinoma
    Manoj Gandhi
    Department of Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Cell Endocrinol 321:36-43. 2010
    ....
  42. ncbi request reprint PAX8-PPARgamma rearrangement in thyroid tumors: RT-PCR and immunohistochemical analyses
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0529, USA
    Am J Surg Pathol 26:1016-23. 2002
    ..The absence of PAX8-PPARgamma rearrangements in Hurthle cell tumors and papillary thyroid carcinomas highlights the differences in the molecular pathogenesis of these thyroid tumors...
  43. pmc Gene position within chromosome territories correlates with their involvement in distinct rearrangement types in thyroid cancer cells
    Manoj S Gandhi
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Genes Chromosomes Cancer 48:222-8. 2009
    ....
  44. doi request reprint Tumor-to-tumor metastases to follicular variant of papillary thyroid carcinoma: histologic, immunohistochemical, and molecular studies of two unusual cases
    Jing Yu
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Endocr Pathol 20:235-42. 2009
    ..A brief review of literature and discussion of tumor-to-tumor metastasis in thyroid neoplasms is also presented...
  45. ncbi request reprint RET/PTC rearrangement in thyroid tumors
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Endocr Pathol 13:3-16. 2002
    ..The occurrence of RET/PTC in Hashimoto thyroiditis and thyroid follicular adenomas and hyperplastic nodules reported in several studies has not been confirmed in other observations and remains controversial...
  46. ncbi request reprint The molecular pathways induced by radiation and leading to thyroid carcinogenesis
    Yuri E Nikiforov
    Department of Pathology, University of Cincinnati, USA
    Cancer Treat Res 122:191-206. 2004
  47. ncbi request reprint Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon
    Jeffrey A Knauf
    Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 87:2150-9. 2002
    ..These data indicate that post-transcriptional changes in PKCepsilon are highly prevalent in thyroid tumors and may play a significant role in their development...
  48. ncbi request reprint HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma
    Raffaele Ciampi
    Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Endocr Relat Cancer 14:445-52. 2007
    ..Expression of the HOOK3-RET cDNA in NIH3T3 cells resulted in the formation of transformed foci and in tumor formation after injection into nude mice, confirming the oncogenic nature of HOOK3-RET...
  49. ncbi request reprint Proliferative activity of human thyroid cells in various age groups and its correlation with the risk of thyroid cancer after radiation exposure
    Ali G Saad
    Department of Pathology, University of Cincinnati, 231 Albert Sabin Way, P O Box 670529, Cincinnati, Ohio 45267 0529, USA
    J Clin Endocrinol Metab 91:2672-7. 2006
    ..One of the factors responsible for this phenomenon may be more rapid cell proliferation in children...
  50. ncbi request reprint Prevalence of RET/PTC rearrangements in Hashimoto's thyroiditis and papillary thyroid carcinomas
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0529, USA
    Int J Surg Pathol 10:15-22. 2002
    ..These results suggest that, if the association between HT and thyroid cancer exists, its molecular basis is different from RET/PTC rearrangement...
  51. ncbi request reprint Amiodarone-induced thyrotoxicosis and thyroid cancer: clinical, immunohistochemical, and molecular genetic studies of a case and review of the literature
    Aly Saad
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0529, USA
    Arch Pathol Lab Med 128:807-10. 2004
    ..The prevalence of thyroid cancer in patients with AIT is unknown. We report a case of papillary thyroid carcinoma associated with type 2 AIT...
  52. ncbi request reprint Detection of SYT-SSX rearrangements in synovial sarcomas by real-time one-step RT-PCR
    Marina N Nikiforova
    Department of Pathology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Dev Pathol 8:162-7. 2005
    ..In conclusion, we have developed a fast, accurate, and simple method for the detection of 2 major types of SYT-SSX rearrangement by using LightCycler RT-PCR and melting curve analysis...
  53. pmc Detection of IDH1 and IDH2 mutations by fluorescence melting curve analysis as a diagnostic tool for brain biopsies
    Craig Horbinski
    Department of Pathology, University of Kentucky, Lexington, Kentucky, USA
    J Mol Diagn 12:487-92. 2010
    ....
  54. ncbi request reprint Molecular profile of hyalinizing trabecular tumours of the thyroid: high prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutations
    Giuliana Salvatore
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, Via S Pansini 5, 80131 Naples, Italy
    Eur J Cancer 41:816-21. 2005
    ..Thus, in clinical practice, the detection of B-raf mutations in a thyroid follicular tumour may prove to be a valuable tool, supplementing histological examination, and allowing a differential diagnosis between PTC and HTT...
  55. ncbi request reprint Analysis of BRAF point mutation and RET/PTC rearrangement refines the fine-needle aspiration diagnosis of papillary thyroid carcinoma
    Giuliana Salvatore
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche and Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, 80131 Napoli, Italy
    J Clin Endocrinol Metab 89:5175-80. 2004
    ..These results indicate that BRAF mutation and RET/PTC rearrangements are molecular markers of PTC that can be applied to FNA in adjunct to traditional cytology...
  56. ncbi request reprint Editorial: anaplastic carcinoma of the thyroid--will aurora B light a path for treatment?
    Yuri E Nikiforov
    J Clin Endocrinol Metab 90:1243-5. 2005
  57. ncbi request reprint Autonomously functioning thyroid nodules are not associated with BRAF mutations
    Edna T Kimura
    Clin Endocrinol (Oxf) 60:394-6. 2004
  58. ncbi request reprint Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells
    Donata Vitagliano
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II c o Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Naples, Italy
    Cancer Res 64:3823-9. 2004
    ..Therefore, in thyroid cancer, RET/PTC-mediated MAPK activation contributes to p27Kip1 deregulation. This pathway is implicated in cell cycle progression and in response to small molecule kinase inhibitors...
  59. ncbi request reprint Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement
    Fulvio Basolo
    Dipartimento di Oncologia, Universita degli Studi di Pisa, Pisa, Italy
    Int J Cancer 97:608-14. 2002
    ..Moreover, FB-2 cells produced high levels of interleukin (IL)-6 and IL-8...
  60. doi request reprint Utilization of ancillary studies in thyroid fine needle aspirates: a synopsis of the National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference
    Armando C Filie
    Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Diagn Cytopathol 36:438-41. 2008
    ..cancer.gov). This document summarizes matters regarding the utilization of ancillary studies in thyroid FNA (http://thyroidfna.cancer.gov/pages/info/agenda/)...
  61. ncbi request reprint Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach
    Marco Volante
    Department of Clinical and Biological Sciences at San Luigi Hospital, University of Turin, Turin, Italy
    Am J Surg Pathol 31:1256-64. 2007
    ..An algorithmic approach was devised for practical use in the diagnosis of this tumor...
  62. ncbi request reprint Follicular variant papillary thyroid carcinoma arising within an ovarian teratoma
    Mabel Ryder
    Division of Endocrinology, Memorial Sloan Kettering Cancer Center, New York, USA
    Thyroid 17:179-80. 2007
  63. ncbi request reprint RET/PTC Rearrangement--a link between Hashimoto's thyroiditis and thyroid cancer...or not
    Yuri E Nikiforov
    J Clin Endocrinol Metab 91:2040-2. 2006

Research Grants9

  1. Mechanisms of RET/PTC Rearrangement in Thyroid Cancer
    Yuri Nikiforov; Fiscal Year: 2007
    ....
  2. Mechanisms of RET/PTC Rearrangement in Thyroid Cancer
    Yuri E Nikiforov; Fiscal Year: 2010
    ....
  3. Mechanisms of RET/PTC rearrangements in thyroid cancer
    Yuri Nikiforov; Fiscal Year: 2005
    ..These studies will extend our understanding of the mechanisms of radiation-induced carcinogenesis in the thyroid gland. In addition, they are likely to have importance for a broad range of chromosomal rearrangements found in cancer. ..