Research Topics
Species | Yuri NikiforovSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Molecular genetics and diagnosis of thyroid cancerYuri E Nikiforov
Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, PUH C 606, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Nat Rev Endocrinol 7:569-80. 2011....- Molecular diagnostics of thyroid tumorsYuri E Nikiforov
Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Arch Pathol Lab Med 135:569-77. 2011..Papillary carcinoma and follicular carcinoma are the most common types of thyroid cancer and represent those tumor types for which use of molecular markers for diagnosis and prognostication is of high clinical significance... - Molecular analysis of thyroid tumorsYuri E Nikiforov
Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Mod Pathol 24:S34-43. 2011..This review discusses major molecular alterations known to occur in thyroid cancer, focusing on those markers that have been extensively characterized, carry clinical significance, and are being introduced into pathology practice... 
Radiation-induced thyroid cancer: what we have learned from chernobylYuri E Nikiforov
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Endocr Pathol 17:307-17. 2006..On the molecular level, post-Chernobyl tumors are characterized by frequent occurrence of chromosomal rearrangements, such as RET/PTC, whereas point mutations of BRAF and other genes are much less common in this population...
Thyroid carcinoma: molecular pathways and therapeutic targetsYuri E Nikiforov
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
Mod Pathol 21:S37-43. 2008..A number of compounds have been studied and showed antitumor effects in preclinical studies and are being tested in ongoing clinical trials...- Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samplesYuri E Nikiforov
Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Clin Endocrinol Metab 96:3390-7. 2011..Fine-needle aspiration (FNA) cytology provides a definitive diagnosis of benign or malignant disease in many cases, whereas about 25% of nodules are indeterminate, hindering most appropriate management... - Molecular testing for mutations in improving the fine-needle aspiration diagnosis of thyroid nodulesYuri E Nikiforov
Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
J Clin Endocrinol Metab 94:2092-8. 2009..However, 10-40% of nodules are diagnosed as indeterminate by cytology, making it difficult to optimally manage these patients... - Molecular diagnostics and predictors in thyroid cancerMarina N Nikiforova
Department of Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Thyroid 19:1351-61. 2009.... - BRAF copy number gains in thyroid tumors detected by fluorescence in situ hybridizationRaffaele Ciampi
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Endocr Pathol 16:99-105. 2005..By Western blotting, the tumors carrying four copies of the gene revealed higher expression of BRAF protein, suggesting that copy number gain may represent another mechanism of BRAF activation in thyroid tumors... - Genetic alterations involved in the transition from well-differentiated to poorly differentiated and anaplastic thyroid carcinomasYuri E Nikiforov
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
Endocr Pathol 15:319-27. 2004..This suggests that poorly differentiated carcinoma, as a group, represents a distinct step in the evolution from well-differentiated to anaplastic thyroid carcinoma, rather than an entirely separate type of thyroid malignancy... - Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancerRaffaele Ciampi
Department of Pathology and Laboratory Medicine and Division of Endocrinology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0529, USA
J Clin Invest 115:94-101. 2005.... - A novel complex BRAF mutation detected in a solid variant of papillary thyroid carcinomaSimion Chiosea
Department of Pathology and Laboratory Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA
Endocr Pathol 20:122-6. 2009..This mutation was identified both in the preoperative fine needle aspirate sample and in the surgical specimen after total thyroidectomy. Other rare BRAF mutations in PTC are reviewed... - Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysisThomas J Giordano
Department of Pathology, UH 2G332 0054, University of Michigan Medical School, Ann Arbor, 48109 0054, USA
Oncogene 24:6646-56. 2005.... - Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomasMarina N Nikiforova
Department of Pathology and Laboratory Medicine, University of Cincinnati, 231 Albert Sabin Way, P O Box 670529, Cincinnati, OH 45267 0529, USA
Cancer Lett 209:1-6. 2004..These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors... - BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomasMarina N Nikiforova
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
J Clin Endocrinol Metab 88:5399-404. 2003..They are associated with distinct phenotypical and biological properties of papillary carcinomas and may participate in progression to poorly differentiated and anaplastic carcinomas... - The histopathology of BRAF-V600E-mutated lung adenocarcinomaSamuel A Yousem
Department of Pathology, Presbyterian Campus, UPMC Presbyterian Shadyside, Pittsburgh, PA 15213, USA
Am J Surg Pathol 32:1317-21. 2008..Adenocarcinomas with this clinicopathologic phenotype may be worthwhile investigating for BRAF-V600E mutation as more genetically oriented drug therapies emerge... - RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinomaMarina N Nikiforova
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0529, USA
J Clin Endocrinol Metab 88:2318-26. 2003..These results suggest that conventional follicular thyroid carcinomas develop through at least two distinct and virtually nonoverlapping molecular pathways initiated by either RAS point mutation or PAX8-PPAR gamma rearrangement... - High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinomaEdna T Kimura
Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
Cancer Res 63:1454-7. 2003..Because these signaling proteins function along the same pathway in thyroid cells, this represents a unique paradigm of human tumorigenesis through mutation of three signaling effectors lying in tandem... - MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utilityMarina N Nikiforova
Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
J Clin Endocrinol Metab 93:1600-8. 2008.... - Molecular genetics of thyroid cancer: implications for diagnosis, treatment and prognosisMarina N Nikiforova
Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Expert Rev Mol Diagn 8:83-95. 2008..Detection of these genetic alterations using molecular techniques is important for preoperative fine-needle aspiration diagnosis, prognosis and treatment of thyroid cancer... - Summary statement: utility of molecular marker testing in thyroid cancerLinwah Yip
Division of Endocrine Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Surgery 148:1313-5. 2010..The 2010 Annual Meeting of the American Association for Endocrine Surgeons featured a symposium dedicated to molecular marker testing in thyroid cancer and its potential clinical applicability... - RAS mutation-positive follicular variant of papillary thyroid carcinoma arising in a struma ovariiChristopher Coyne
Dept of Endocrinology, UPMC, Suite 3B, Falk Medical Bldg, 3601 5th Ave, Pittsburgh, PA 15213, USA
Endocr Pathol 21:144-7. 2010..It provides evidence that tumors developing in this setting involve molecular mechanisms similar to those implicated in tumors developing in the thyroid gland... - Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneityZhaowen Zhu
Department of Pathology, University of Cincinnati, 231 Albert Sabin Way, P.O. Box 670529, Cincinnati, Ohio 45267-0529, USA
J Clin Endocrinol Metab 91:3603-10. 2006..CONCLUSIONS: Our data suggest that broad variability in the reported prevalence of RET/PTC rearrangement is at least in part a result of the use of different detection methods and tumor genetic heterogeneity... - BRAF kinase activation via chromosomal rearrangement in radiation-induced and sporadic thyroid cancerRaffaele Ciampi
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0529, USA
Cell Cycle 4:547-8. 2005.... - MicroRNA expression profiles in thyroid tumorsMarina N Nikiforova
Department of Pathology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Endocr Pathol 20:85-91. 2009..The purpose of this review is to summarize the existing findings of miRNA deregulation in thyroid tumors and its potential role in thyroid cancer biology and molecular diagnostics... - Contribution of molecular testing to thyroid fine-needle aspiration cytology of "follicular lesion of undetermined significance/atypia of undetermined significance"N Paul Ohori
Department of Pathology, University of Pittsburgh Medical Center Presbyterian, Pittsburgh, Pennsylvania 15213, USA
Cancer Cytopathol 118:17-23. 2010..The use of ancillary molecular studies has not been widely explored for this diagnosis... - Optimizing surgical treatment of papillary thyroid carcinoma associated with BRAF mutationLinwah Yip
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Surgery 146:1215-23. 2009..It is not known whether pre-operative identification of BRAF mutations in cytologic specimens should alter surgical management... - Adequacy of surgeon-performed ultrasound-guided thyroid fine-needle aspiration biopsyAmol M Bhatki
Department of Otolaryngology Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Otolaryngol Head Neck Surg 139:27-31. 2008..To determine the diagnostic accuracy of specimens obtained by a surgeon performing office-based ultrasound (US)-guided fine-needle aspiration biopsy (FNAB) of thyroid nodules... - Encapsulated papillary oncocytic neoplasms of the thyroid: morphologic, immunohistochemical, and molecular analysis of 18 casesRandall Lyndon Woodford
Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
Am J Surg Pathol 34:1582-90. 2010..Our results confirm that EPONs are histologically, immunohistochemically, and molecularly distinct from papillary thyroid carcinoma and seem to be most related to follicular neoplasms... - RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesisRaffaele Ciampi
Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Endocrinology 148:936-41. 2007..Molecular inhibitors that block RET/PTC or BRAF kinase activity have shown substantial therapeutic effects in the experimental systems and are currently being tested in clinical trials... - Alterations of the BRAF gene in thyroid tumorsRaffaele Ciampi
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0529, USA
Endocr Pathol 16:163-72. 2005..Yet another mechanism of BRAF activation may involve copy number gain, which is seen in a significant portion of thyroid follicular tumors of both conventional and oncocytic (Hürthle cell) types... - Delineation, functional validation, and bioinformatic evaluation of gene expression in thyroid follicular carcinomas with the PAX8-PPARG translocationThomas J Giordano
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Clin Cancer Res 12:1983-93. 2006..These results have implications for the neoplastic mechanism of these follicular carcinomas... - Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutationsZhaowen Zhu
Departments of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, 231 Albert Sabin Way, PO Box 670529, Cincinnati, OH 45267-0529, USA
Am J Clin Pathol 120:71-7. 2003..These data indicate that the FV of papillary carcinoma has a distinct set of molecular alterations and is characterized by a high frequency of ras point mutations... - Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomasAdebowale J Adeniran
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267-0529, USA
Am J Surg Pathol 30:216-22. 2006..These findings demonstrate that BRAF, RET/PTC, and RAS mutations are associated with distinct microscopic, clinical, and biologic features of thyroid papillary carcinomas... - Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiationJeffrey A Knauf
Division of Endocrinology and Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0547, USA
Cancer Res 65:4238-45. 2005..This closely recapitulates the phenotype of BRAF-positive PTCs in humans and supports a key role for this oncogene in its pathogenesis... - Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumorsHui Zuo
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Cancer Res 70:1389-97. 2010..Overall, our findings indicate that epigenetic or genetic loss of Rap1GAP is very common in thyroid cancer, where these events are sufficient to promote cell proliferation and invasion... - Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: a model of carcinogenic chromosomal rearrangement induced by ionizing radiationChristy M Caudill
Department of Pathology, University of Cincinnati, 231 Albert Sabin Way, P.O. Box 670529, Cincinnati, Ohio 45267-0529, USA
J Clin Endocrinol Metab 90:2364-9. 2005..1-10 Gy gamma-radiation. This provides additional evidence for a direct link between this genetic event and radiation exposure and offers a powerful experimental system for studying radiation-induced carcinogenesis in the thyroid gland... - Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomasCraig Horbinski
Department of Pathology, University of Kentucky, 800 Rose St, Lexington, KY 40536, USA
Acta Neuropathol 119:641-9. 2010..Nevertheless, such tumors may have altered sensitivity to pathway-specific adjuvant therapy. Additionally, deletion on 17p13 may be an adverse prognostic biomarker in cerebellar tumors... - Pharmacodynamic effect of iopanoic acid on free T(3) and T(4) levels in amiodarone-induced thyrotoxicosisLaura Matrka
Department of Otolaryngology Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0528, USA
Ear Nose Throat J 87:702-4. 2008..We also discuss the different pharmacodynamic effects that iopanoic acid has on FT(3) and FT(4) levels... - PAX8-PPARgamma rearrangement in thyroid tumors: RT-PCR and immunohistochemical analysesMarina N Nikiforova
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0529, USA
Am J Surg Pathol 26:1016-23. 2002..The absence of PAX8-PPARgamma rearrangements in Hurthle cell tumors and papillary thyroid carcinomas highlights the differences in the molecular pathogenesis of these thyroid tumors... - RET/PTC rearrangement in thyroid tumorsYuri E Nikiforov
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
Endocr Pathol 13:3-16. 2002..The occurrence of RET/PTC in Hashimoto thyroiditis and thyroid follicular adenomas and hyperplastic nodules reported in several studies has not been confirmed in other observations and remains controversial... - Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilonJeffrey A Knauf
Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
J Clin Endocrinol Metab 87:2150-9. 2002..These data indicate that post-transcriptional changes in PKCepsilon are highly prevalent in thyroid tumors and may play a significant role in their development... - Mechanisms of chromosomal rearrangements in solid tumors: the model of papillary thyroid carcinomaManoj Gandhi
Department of Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Mol Cell Endocrinol 321:36-43. 2010.... - Tumor-to-tumor metastases to follicular variant of papillary thyroid carcinoma: histologic, immunohistochemical, and molecular studies of two unusual casesJing Yu
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Endocr Pathol 20:235-42. 2009..A brief review of literature and discussion of tumor-to-tumor metastasis in thyroid neoplasms is also presented... - The molecular pathways induced by radiation and leading to thyroid carcinogenesisYuri E Nikiforov
Department of Pathology, University of Cincinnati, USA
Cancer Treat Res 122:191-206. 2004 - Gene position within chromosome territories correlates with their involvement in distinct rearrangement types in thyroid cancer cellsManoj S Gandhi
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Genes Chromosomes Cancer 48:222-8. 2009.... - Proliferative activity of human thyroid cells in various age groups and its correlation with the risk of thyroid cancer after radiation exposureAli G Saad
Department of Pathology, University of Cincinnati, 231 Albert Sabin Way, P.O. Box 670529, Cincinnati, Ohio 45267-0529, USA
J Clin Endocrinol Metab 91:2672-7. 2006..However, the variation in the rate of cell proliferation is unlikely to be responsible entirely for this phenomenon and other factors may also be involved... - HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinomaRaffaele Ciampi
Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Endocr Relat Cancer 14:445-52. 2007..Expression of the HOOK3-RET cDNA in NIH3T3 cells resulted in the formation of transformed foci and in tumor formation after injection into nude mice, confirming the oncogenic nature of HOOK3-RET... - Detection of SYT-SSX rearrangements in synovial sarcomas by real-time one-step RT-PCRMarina N Nikiforova
Department of Pathology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Pediatr Dev Pathol 8:162-7. 2005..In conclusion, we have developed a fast, accurate, and simple method for the detection of 2 major types of SYT-SSX rearrangement by using LightCycler RT-PCR and melting curve analysis... - Amiodarone-induced thyrotoxicosis and thyroid cancer: clinical, immunohistochemical, and molecular genetic studies of a case and review of the literatureAly Saad
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0529, USA
Arch Pathol Lab Med 128:807-10. 2004..The prevalence of thyroid cancer in patients with AIT is unknown. We report a case of papillary thyroid carcinoma associated with type 2 AIT... - Prevalence of RET/PTC rearrangements in Hashimoto's thyroiditis and papillary thyroid carcinomasMarina N Nikiforova
Department of Pathology and Laboratory Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0529, USA
Int J Surg Pathol 10:15-22. 2002..These results suggest that, if the association between HT and thyroid cancer exists, its molecular basis is different from RET/PTC rearrangement... - Detection of IDH1 and IDH2 mutations by fluorescence melting curve analysis as a diagnostic tool for brain biopsiesCraig Horbinski
Department of Pathology, University of Kentucky, Lexington, Kentucky, USA
J Mol Diagn 12:487-92. 2010.... - Analysis of BRAF point mutation and RET/PTC rearrangement refines the fine-needle aspiration diagnosis of papillary thyroid carcinomaGiuliana Salvatore
Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche and Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, 80131 Napoli, Italy
J Clin Endocrinol Metab 89:5175-80. 2004..These results indicate that BRAF mutation and RET/PTC rearrangements are molecular markers of PTC that can be applied to FNA in adjunct to traditional cytology... - Molecular profile of hyalinizing trabecular tumours of the thyroid: high prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutationsGiuliana Salvatore
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, Via S. Pansini 5, 80131 Naples, Italy
Eur J Cancer 41:816-21. 2005..Thus, in clinical practice, the detection of B-raf mutations in a thyroid follicular tumour may prove to be a valuable tool, supplementing histological examination, and allowing a differential diagnosis between PTC and HTT... - Follicular variant papillary thyroid carcinoma arising within an ovarian teratomaMabel Ryder
Division of Endocrinology, Memorial Sloan-Kettering Cancer Center, New York, USA
Thyroid 17:179-80. 2007 - Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approachMarco Volante
Department of Clinical and Biological Sciences at San Luigi Hospital, University of Turin, Turin, Italy
Am J Surg Pathol 31:1256-64. 2007..An algorithmic approach was devised for practical use in the diagnosis of this tumor... - Autonomously functioning thyroid nodules are not associated with BRAF mutationsEdna T Kimura
Clin Endocrinol (Oxf) 60:394-6. 2004 - Utilization of ancillary studies in thyroid fine needle aspirates: a synopsis of the National Cancer Institute Thyroid Fine Needle Aspiration State of the Science ConferenceArmando C Filie
Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA
Diagn Cytopathol 36:438-41. 2008..cancer.gov). This document summarizes matters regarding the utilization of ancillary studies in thyroid FNA (http://thyroidfna.cancer.gov/pages/info/agenda/)... - Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cellsDonata Vitagliano
Dipartimento di Biologia e Patologia Cellulare e Molecolare, University 'Federico II' c/o Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Naples, Italy
Cancer Res 64:3823-9. 2004..Therefore, in thyroid cancer, RET/PTC-mediated MAPK activation contributes to p27Kip1 deregulation. This pathway is implicated in cell cycle progression and in response to small molecule kinase inhibitors... - Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangementFulvio Basolo
Dipartimento di Oncologia, Universita degli Studi di Pisa, Pisa, Italy
Int J Cancer 97:608-14. 2002..Moreover, FB-2 cells produced high levels of interleukin (IL)-6 and IL-8... - Editorial: anaplastic carcinoma of the thyroid--will aurora B light a path for treatment?Yuri E Nikiforov
J Clin Endocrinol Metab 90:1243-5. 2005 - RET/PTC Rearrangement--a link between Hashimoto's thyroiditis and thyroid cancer...or notYuri E Nikiforov
J Clin Endocrinol Metab 91:2040-2. 2006
Research Grants
- Mechanisms of RET/PTC Rearrangement in Thyroid CancerYuri Nikiforov; Fiscal Year: 2007....
- Mechanisms of RET/PTC Rearrangement in Thyroid CancerYuri E Nikiforov; Fiscal Year: 2010....
- Mechanisms of RET/PTC rearrangements in thyroid cancerYuri Nikiforov; Fiscal Year: 2005..These studies will extend our understanding of the mechanisms of radiation-induced carcinogenesis in the thyroid gland. In addition, they are likely to have importance for a broad range of chromosomal rearrangements found in cancer. ..