Y E Nikiforov

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi The molecular pathways induced by radiation and leading to thyroid carcinogenesis
    Yuri E Nikiforov
    Department of Pathology, University of Cincinnati, USA
    Cancer Treat Res 122:191-206. 2004
  2. ncbi PAX8-PPARgamma rearrangement in thyroid tumors: RT-PCR and immunohistochemical analyses
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0529, USA
    Am J Surg Pathol 26:1016-23. 2002
  3. ncbi Spatial positioning of RET and H4 following radiation exposure leads to tumor development
    Y E Nikiforov
    Department of Pathology, University of Cincinnatti, OH 45267 0529, USA
    ScientificWorldJournal 1:186-7. 2001
  4. ncbi Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Cincinnati, 231 Albert Sabin Way, P O Box 670529, Cincinnati, OH 45267 0529, USA
    Cancer Lett 209:1-6. 2004
  5. ncbi RET/PTC rearrangement in thyroid tumors
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Endocr Pathol 13:3-16. 2002
  6. ncbi Genetic alterations involved in the transition from well-differentiated to poorly differentiated and anaplastic thyroid carcinomas
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Endocr Pathol 15:319-27. 2004
  7. ncbi Solid variant of papillary thyroid carcinoma: incidence, clinical-pathologic characteristics, molecular analysis, and biologic behavior
    Y E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0529, USA
    Am J Surg Pathol 25:1478-84. 2001
  8. ncbi RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0529, USA
    J Clin Endocrinol Metab 88:2318-26. 2003
  9. ncbi High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
    Edna T Kimura
    Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Cancer Res 63:1454-7. 2003
  10. ncbi Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations
    Zhaowen Zhu
    Departments of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, 231 Albert Sabin Way, PO Box 670529, Cincinnati, OH 45267-0529, USA
    Am J Clin Pathol 120:71-7. 2003

Collaborators

Detail Information

Publications54

  1. ncbi The molecular pathways induced by radiation and leading to thyroid carcinogenesis
    Yuri E Nikiforov
    Department of Pathology, University of Cincinnati, USA
    Cancer Treat Res 122:191-206. 2004
  2. ncbi PAX8-PPARgamma rearrangement in thyroid tumors: RT-PCR and immunohistochemical analyses
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0529, USA
    Am J Surg Pathol 26:1016-23. 2002
    ..The absence of PAX8-PPARgamma rearrangements in Hurthle cell tumors and papillary thyroid carcinomas highlights the differences in the molecular pathogenesis of these thyroid tumors...
  3. ncbi Spatial positioning of RET and H4 following radiation exposure leads to tumor development
    Y E Nikiforov
    Department of Pathology, University of Cincinnatti, OH 45267 0529, USA
    ScientificWorldJournal 1:186-7. 2001
    ..However, since the DNA targets of ionizing radiation are randomly distributed throughout the cell nucleus, the reason for predilection for the RET rearrangements in thyroid cells was unclear...
  4. ncbi Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Cincinnati, 231 Albert Sabin Way, P O Box 670529, Cincinnati, OH 45267 0529, USA
    Cancer Lett 209:1-6. 2004
    ..These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors...
  5. ncbi RET/PTC rearrangement in thyroid tumors
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Endocr Pathol 13:3-16. 2002
    ..The occurrence of RET/PTC in Hashimoto thyroiditis and thyroid follicular adenomas and hyperplastic nodules reported in several studies has not been confirmed in other observations and remains controversial...
  6. ncbi Genetic alterations involved in the transition from well-differentiated to poorly differentiated and anaplastic thyroid carcinomas
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Endocr Pathol 15:319-27. 2004
    ..This suggests that poorly differentiated carcinoma, as a group, represents a distinct step in the evolution from well-differentiated to anaplastic thyroid carcinoma, rather than an entirely separate type of thyroid malignancy...
  7. ncbi Solid variant of papillary thyroid carcinoma: incidence, clinical-pathologic characteristics, molecular analysis, and biologic behavior
    Y E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0529, USA
    Am J Surg Pathol 25:1478-84. 2001
    ..However, it should be distinguished from poorly differentiated thyroid carcinoma, which has a reported lower survival rate compared with the solid variant of papillary carcinoma...
  8. ncbi RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0529, USA
    J Clin Endocrinol Metab 88:2318-26. 2003
    ..These results suggest that conventional follicular thyroid carcinomas develop through at least two distinct and virtually nonoverlapping molecular pathways initiated by either RAS point mutation or PAX8-PPAR gamma rearrangement...
  9. ncbi High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
    Edna T Kimura
    Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Cancer Res 63:1454-7. 2003
    ..Because these signaling proteins function along the same pathway in thyroid cells, this represents a unique paradigm of human tumorigenesis through mutation of three signaling effectors lying in tandem...
  10. ncbi Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations
    Zhaowen Zhu
    Departments of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, 231 Albert Sabin Way, PO Box 670529, Cincinnati, OH 45267-0529, USA
    Am J Clin Pathol 120:71-7. 2003
    ..These data indicate that the FV of papillary carcinoma has a distinct set of molecular alterations and is characterized by a high frequency of ras point mutations...
  11. ncbi Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneity
    Zhaowen Zhu
    Department of Pathology, University of Cincinnati, 231 Albert Sabin Way, P.O. Box 670529, Cincinnati, Ohio 45267-0529, USA
    J Clin Endocrinol Metab 91:3603-10. 2006
    ..CONCLUSIONS: Our data suggest that broad variability in the reported prevalence of RET/PTC rearrangement is at least in part a result of the use of different detection methods and tumor genetic heterogeneity...
  12. ncbi Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis
    Thomas J Giordano
    Department of Pathology, UH 2G332 0054, University of Michigan Medical School, Ann Arbor, 48109 0054, USA
    Oncogene 24:6646-56. 2005
    ....
  13. ncbi BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 88:5399-404. 2003
    ..They are associated with distinct phenotypical and biological properties of papillary carcinomas and may participate in progression to poorly differentiated and anaplastic carcinomas...
  14. ncbi Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon
    Jeffrey A Knauf
    Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 87:2150-9. 2002
    ..These data indicate that post-transcriptional changes in PKCepsilon are highly prevalent in thyroid tumors and may play a significant role in their development...
  15. ncbi Thyroid transcription factor-1, thyroglobulin, cytokeratin 7, and cytokeratin 20 in thyroid neoplasms
    P A Bejarano
    Department of Pathology, University of Miami School of Medicine, Florida 33136, USA
    Appl Immunohistochem Mol Morphol 8:189-94. 2000
    ..Thyroid tumors are CK7+/CK20-. The panel of antibodies for TG, TTF-1, CK7, and CK20 is useful when the thyroid origin of a metastatic tumor is a consideration...
  16. ncbi Encapsulated papillary oncocytic neoplasms of the thyroid: morphologic, immunohistochemical, and molecular analysis of 18 cases
    Randall Lyndon Woodford
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Surg Pathol 34:1582-90. 2010
    ..Our results confirm that EPONs are histologically, immunohistochemically, and molecularly distinct from papillary thyroid carcinoma and seem to be most related to follicular neoplasms...
  17. ncbi Prevalence of RET/PTC rearrangements in Hashimoto's thyroiditis and papillary thyroid carcinomas
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0529, USA
    Int J Surg Pathol 10:15-22. 2002
    ..These results suggest that, if the association between HT and thyroid cancer exists, its molecular basis is different from RET/PTC rearrangement...
  18. ncbi BRAF copy number gains in thyroid tumors detected by fluorescence in situ hybridization
    Raffaele Ciampi
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Endocr Pathol 16:99-105. 2005
    ..By Western blotting, the tumors carrying four copies of the gene revealed higher expression of BRAF protein, suggesting that copy number gain may represent another mechanism of BRAF activation in thyroid tumors...
  19. ncbi Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer
    Raffaele Ciampi
    Department of Pathology and Laboratory Medicine and Division of Endocrinology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0529, USA
    J Clin Invest 115:94-101. 2005
    ....
  20. ncbi Molecular diagnostics and predictors in thyroid cancer
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Thyroid 19:1351-61. 2009
    ....
  21. ncbi DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells
    M Gandhi
    Department of Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Oncogene 29:2272-80. 2010
    ..These results provide the direct evidence for the involvement of chromosomal fragile sites in the generation of cancer-specific rearrangements in human cells...
  22. ncbi Alterations of the BRAF gene in thyroid tumors
    Raffaele Ciampi
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0529, USA
    Endocr Pathol 16:163-72. 2005
    ..Yet another mechanism of BRAF activation may involve copy number gain, which is seen in a significant portion of thyroid follicular tumors of both conventional and oncocytic (Hürthle cell) types...
  23. ncbi RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis
    Raffaele Ciampi
    Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Endocrinology 148:936-41. 2007
    ..Molecular inhibitors that block RET/PTC or BRAF kinase activity have shown substantial therapeutic effects in the experimental systems and are currently being tested in clinical trials...
  24. ncbi Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation
    Jeffrey A Knauf
    Division of Endocrinology and Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0547, USA
    Cancer Res 65:4238-45. 2005
    ..This closely recapitulates the phenotype of BRAF-positive PTCs in humans and supports a key role for this oncogene in its pathogenesis...
  25. ncbi Contribution of molecular testing to thyroid fine-needle aspiration cytology of "follicular lesion of undetermined significance/atypia of undetermined significance"
    N Paul Ohori
    Department of Pathology, University of Pittsburgh Medical Center Presbyterian, Pittsburgh, Pennsylvania 15213, USA
    Cancer Cytopathol 118:17-23. 2010
    ..The use of ancillary molecular studies has not been widely explored for this diagnosis...
  26. ncbi BRAF kinase activation via chromosomal rearrangement in radiation-induced and sporadic thyroid cancer
    Raffaele Ciampi
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0529, USA
    Cell Cycle 4:547-8. 2005
    ....
  27. ncbi Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: a model of carcinogenic chromosomal rearrangement induced by ionizing radiation
    Christy M Caudill
    Department of Pathology, University of Cincinnati, 231 Albert Sabin Way, P.O. Box 670529, Cincinnati, Ohio 45267-0529, USA
    J Clin Endocrinol Metab 90:2364-9. 2005
    ..1-10 Gy gamma-radiation. This provides additional evidence for a direct link between this genetic event and radiation exposure and offers a powerful experimental system for studying radiation-induced carcinogenesis in the thyroid gland...
  28. ncbi Delineation, functional validation, and bioinformatic evaluation of gene expression in thyroid follicular carcinomas with the PAX8-PPARG translocation
    Thomas J Giordano
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Clin Cancer Res 12:1983-93. 2006
    ..These results have implications for the neoplastic mechanism of these follicular carcinomas...
  29. ncbi Molecular genetics of thyroid cancer: implications for diagnosis, treatment and prognosis
    Marina N Nikiforova
    Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Expert Rev Mol Diagn 8:83-95. 2008
    ..Detection of these genetic alterations using molecular techniques is important for preoperative fine-needle aspiration diagnosis, prognosis and treatment of thyroid cancer...
  30. ncbi Tumor-to-tumor metastases to follicular variant of papillary thyroid carcinoma: histologic, immunohistochemical, and molecular studies of two unusual cases
    Jing Yu
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Endocr Pathol 20:235-42. 2009
    ..A brief review of literature and discussion of tumor-to-tumor metastasis in thyroid neoplasms is also presented...
  31. ncbi HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma
    Raffaele Ciampi
    Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Endocr Relat Cancer 14:445-52. 2007
    ..Expression of the HOOK3-RET cDNA in NIH3T3 cells resulted in the formation of transformed foci and in tumor formation after injection into nude mice, confirming the oncogenic nature of HOOK3-RET...
  32. ncbi Interphase chromosome folding determines spatial proximity of genes participating in carcinogenic RET/PTC rearrangements
    M Gandhi
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0529, USA
    Oncogene 25:2360-6. 2006
    ..This study provides evidence for large-scale chromosome folding of the 10q11.2-21 region that offers a structural basis for nonrandom positioning and spatial proximity of potentially recombinogenic intrachromosomal loci...
  33. ncbi Radiation-induced thyroid cancer: what we have learned from chernobyl
    Yuri E Nikiforov
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Endocr Pathol 17:307-17. 2006
    ..On the molecular level, post-Chernobyl tumors are characterized by frequent occurrence of chromosomal rearrangements, such as RET/PTC, whereas point mutations of BRAF and other genes are much less common in this population...
  34. ncbi Mechanisms of chromosomal rearrangements in solid tumors: the model of papillary thyroid carcinoma
    Manoj Gandhi
    Department of Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Cell Endocrinol 321:36-43. 2010
    ....
  35. ncbi Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas
    Adebowale J Adeniran
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267-0529, USA
    Am J Surg Pathol 30:216-22. 2006
    ..These findings demonstrate that BRAF, RET/PTC, and RAS mutations are associated with distinct microscopic, clinical, and biologic features of thyroid papillary carcinomas...
  36. ncbi Detection of SYT-SSX rearrangements in synovial sarcomas by real-time one-step RT-PCR
    Marina N Nikiforova
    Department of Pathology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Dev Pathol 8:162-7. 2005
    ..In conclusion, we have developed a fast, accurate, and simple method for the detection of 2 major types of SYT-SSX rearrangement by using LightCycler RT-PCR and melting curve analysis...
  37. ncbi Proliferative activity of human thyroid cells in various age groups and its correlation with the risk of thyroid cancer after radiation exposure
    Ali G Saad
    Department of Pathology, University of Cincinnati, 231 Albert Sabin Way, P.O. Box 670529, Cincinnati, Ohio 45267-0529, USA
    J Clin Endocrinol Metab 91:2672-7. 2006
    ..However, the variation in the rate of cell proliferation is unlikely to be responsible entirely for this phenomenon and other factors may also be involved...
  38. ncbi MicroRNA expression profiles in thyroid tumors
    Marina N Nikiforova
    Department of Pathology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Endocr Pathol 20:85-91. 2009
    ..The purpose of this review is to summarize the existing findings of miRNA deregulation in thyroid tumors and its potential role in thyroid cancer biology and molecular diagnostics...
  39. ncbi MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utility
    Marina N Nikiforova
    Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Endocrinol Metab 93:1600-8. 2008
    ....
  40. ncbi Detection of IDH1 and IDH2 mutations by fluorescence melting curve analysis as a diagnostic tool for brain biopsies
    Craig Horbinski
    Department of Pathology, University of Kentucky, Lexington, Kentucky, USA
    J Mol Diagn 12:487-92. 2010
    ....
  41. ncbi Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumors
    Hui Zuo
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 70:1389-97. 2010
    ..Overall, our findings indicate that epigenetic or genetic loss of Rap1GAP is very common in thyroid cancer, where these events are sufficient to promote cell proliferation and invasion...
  42. ncbi Amiodarone-induced thyrotoxicosis and thyroid cancer: clinical, immunohistochemical, and molecular genetic studies of a case and review of the literature
    Aly Saad
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0529, USA
    Arch Pathol Lab Med 128:807-10. 2004
    ..The prevalence of thyroid cancer in patients with AIT is unknown. We report a case of papillary thyroid carcinoma associated with type 2 AIT...
  43. ncbi Gene position within chromosome territories correlates with their involvement in distinct rearrangement types in thyroid cancer cells
    Manoj S Gandhi
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Genes Chromosomes Cancer 48:222-8. 2009
    ....
  44. ncbi Thyroid carcinoma: molecular pathways and therapeutic targets
    Yuri E Nikiforov
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Mod Pathol 21:S37-43. 2008
    ..A number of compounds have been studied and showed antitumor effects in preclinical studies and are being tested in ongoing clinical trials...
  45. ncbi RET/PTC Rearrangement--a link between Hashimoto's thyroiditis and thyroid cancer...or not
    Yuri E Nikiforov
    J Clin Endocrinol Metab 91:2040-2. 2006
  46. ncbi Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement
    Fulvio Basolo
    Dipartimento di Oncologia, Universita degli Studi di Pisa, Pisa, Italy
    Int J Cancer 97:608-14. 2002
    ..Moreover, FB-2 cells produced high levels of interleukin (IL)-6 and IL-8...
  47. ncbi Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells
    Donata Vitagliano
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, University 'Federico II' c/o Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Naples, Italy
    Cancer Res 64:3823-9. 2004
    ..Therefore, in thyroid cancer, RET/PTC-mediated MAPK activation contributes to p27Kip1 deregulation. This pathway is implicated in cell cycle progression and in response to small molecule kinase inhibitors...
  48. ncbi Molecular profile of hyalinizing trabecular tumours of the thyroid: high prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutations
    Giuliana Salvatore
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, Via S. Pansini 5, 80131 Naples, Italy
    Eur J Cancer 41:816-21. 2005
    ..Thus, in clinical practice, the detection of B-raf mutations in a thyroid follicular tumour may prove to be a valuable tool, supplementing histological examination, and allowing a differential diagnosis between PTC and HTT...
  49. ncbi Analysis of BRAF point mutation and RET/PTC rearrangement refines the fine-needle aspiration diagnosis of papillary thyroid carcinoma
    Giuliana Salvatore
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche and Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, 80131 Napoli, Italy
    J Clin Endocrinol Metab 89:5175-80. 2004
    ..These results indicate that BRAF mutation and RET/PTC rearrangements are molecular markers of PTC that can be applied to FNA in adjunct to traditional cytology...
  50. ncbi Autonomously functioning thyroid nodules are not associated with BRAF mutations
    Edna T Kimura
    Clin Endocrinol (Oxf) 60:394-6. 2004
  51. ncbi Editorial: anaplastic carcinoma of the thyroid--will aurora B light a path for treatment?
    Yuri E Nikiforov
    J Clin Endocrinol Metab 90:1243-5. 2005
  52. ncbi Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach
    Marco Volante
    Department of Clinical and Biological Sciences at San Luigi Hospital, University of Turin, Turin, Italy
    Am J Surg Pathol 31:1256-64. 2007
    ..An algorithmic approach was devised for practical use in the diagnosis of this tumor...
  53. ncbi Follicular variant papillary thyroid carcinoma arising within an ovarian teratoma
    Mabel Ryder
    Division of Endocrinology, Memorial Sloan-Kettering Cancer Center, New York, USA
    Thyroid 17:179-80. 2007
  54. ncbi Utilization of ancillary studies in thyroid fine needle aspirates: a synopsis of the National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference
    Armando C Filie
    Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Diagn Cytopathol 36:438-41. 2008
    ..cancer.gov). This document summarizes matters regarding the utilization of ancillary studies in thyroid FNA (http://thyroidfna.cancer.gov/pages/info/agenda/)...