Genomes and Genes
Affiliation: University of California
- Notch1 represses osteogenic pathways in aortic valve cellsVishal Nigam
Gladstone Institute of Cardiovascular Disease and Departments of Pediatrics, University of California, San Francisco, CA 94158, USA
J Mol Cell Cardiol 47:828-34. 2009..siRNA-mediated knockdown of Bmp2 blocked the calcification induced by Notch inhibition in AVICs. These findings suggest that Notch1 signaling in aortic valve cells represses osteoblast-like calcification pathways mediated by Bmp2...
- Notch post-translationally regulates β-catenin protein in stem and progenitor cellsChulan Kwon
Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, San Francisco, 1650 Owens Street, San Francisco, California 94158, USA
Nat Cell Biol 13:1244-51. 2011..It did, however, require the endocytic adaptor protein Numb and lysosomal activity. This study reveals a previously unrecognized function of Notch in negatively titrating active β-catenin protein levels in stem and progenitor cells...
- Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valvesVishal Nigam
Department of Pediatrics Cardiology, University of California, San Francisco, USA
J Heart Valve Dis 19:459-65. 2010..In-vitro experiments were also carried out to determine if these miRNAs could modulate calcification-related genes...
- A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fateChulan Kwon
Gladstone Institute of Cardiovascular Disease and Departments of Pediatrics and Biochemistry and Biophysics, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
Nat Cell Biol 11:951-7. 2009..These findings reveal a regulatory network controlling CPC expansion and cell fate that involves unanticipated functions of beta-catenin, Notch1 and Isl1 that may be leveraged for regenerative approaches involving CPCs...