Timothy B Niewold

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. doi request reprint Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients
    Mark A Jensen
    Correspondence to Professor Timothy B Niewold, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, 5841 S Maryland Ave, MC0930 Chicago, IL 60637, USA
    Ann Rheum Dis 72:596-601. 2013
  2. pmc Interferon alpha as a primary pathogenic factor in human lupus
    Timothy B Niewold
    Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, Illinois 60637, USA
    J Interferon Cytokine Res 31:887-92. 2011
  3. pmc IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus
    Timothy B Niewold
    Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, Illinois 60637, USA
    Ann Rheum Dis 71:463-8. 2012
  4. pmc Elevated serum interferon-alpha activity in juvenile dermatomyositis: associations with disease activity at diagnosis and after thirty-six months of therapy
    Timothy B Niewold
    University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637, USA
    Arthritis Rheum 60:1815-24. 2009
  5. pmc Gene-gene-sex interaction in cytokine gene polymorphisms revealed by serum interferon alpha phenotype in juvenile dermatomyositis
    Timothy B Niewold
    Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Pritzker School of Medicine, Chicago, IL 60637, USA
    J Pediatr 157:653-7. 2010
  6. pmc Age- and sex-related patterns of serum interferon-alpha activity in lupus families
    Timothy B Niewold
    Section of Rheumatology, University of Chicago, Chicago, Illinois 60637, USA
    Arthritis Rheum 58:2113-9. 2008
  7. pmc Serum type I interferon activity is dependent on maternal diagnosis in anti-SSA/Ro-positive mothers of children with neonatal lupus
    Timothy B Niewold
    University of Chicago, Section of Rheumatology, Chicago, Illinois 60637, USA
    Arthritis Rheum 58:541-6. 2008
  8. pmc Familial aggregation of autoimmune disease in juvenile dermatomyositis
    Timothy B Niewold
    University of Chicago, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, 924 E 57th St, R420, Chicago, IL 60637, USA
    Pediatrics 127:e1239-46. 2011
  9. pmc The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes
    Sandra Agik
    University of Chicago, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, 924 East 57th Street, R420, Chicago, IL 60637, USA
    J Rheumatol 39:73-8. 2012
  10. pmc Network analysis of associations between serum interferon-α activity, autoantibodies, and clinical features in systemic lupus erythematosus
    Corinna E Weckerle
    University of Chicago, Chicago, IL, USA
    Arthritis Rheum 63:1044-53. 2011

Collaborators

Detail Information

Publications44

  1. doi request reprint Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients
    Mark A Jensen
    Correspondence to Professor Timothy B Niewold, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, 5841 S Maryland Ave, MC0930 Chicago, IL 60637, USA
    Ann Rheum Dis 72:596-601. 2013
    ..Given the pathogenic role of IFN in SLE, we hypothesised that the IFN-induced immunosuppressive ILT3 receptor may be dysfunctional in human SLE...
  2. pmc Interferon alpha as a primary pathogenic factor in human lupus
    Timothy B Niewold
    Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, Illinois 60637, USA
    J Interferon Cytokine Res 31:887-92. 2011
    ..It is possible that some of these gain-of-function polymorphisms in the IFN-α pathway are useful in viral defense, and that risk of SLE is a burden we have taken on in the fight to defend ourselves against viral infection...
  3. pmc IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus
    Timothy B Niewold
    Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, Illinois 60637, USA
    Ann Rheum Dis 71:463-8. 2012
    ..Genetic variation in IRF5 is associated with SLE susceptibility; however, it is unclear how IRF5 functional genetic elements contribute to human disease...
  4. pmc Elevated serum interferon-alpha activity in juvenile dermatomyositis: associations with disease activity at diagnosis and after thirty-six months of therapy
    Timothy B Niewold
    University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637, USA
    Arthritis Rheum 60:1815-24. 2009
    ..The aim of this study was to examine serum IFNalpha activity in a cohort of children with juvenile DM to determine relationships between IFNalpha and indicators of disease activity and severity...
  5. pmc Gene-gene-sex interaction in cytokine gene polymorphisms revealed by serum interferon alpha phenotype in juvenile dermatomyositis
    Timothy B Niewold
    Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Pritzker School of Medicine, Chicago, IL 60637, USA
    J Pediatr 157:653-7. 2010
    ..To detect genetic polymorphisms associated with high serum interferon alpha (IFN-alpha) levels in juvenile dermatomyositis (JDM) and explore interactions in associated polymorphisms...
  6. pmc Age- and sex-related patterns of serum interferon-alpha activity in lupus families
    Timothy B Niewold
    Section of Rheumatology, University of Chicago, Chicago, Illinois 60637, USA
    Arthritis Rheum 58:2113-9. 2008
    ..The purpose of this study was to determine whether serum IFNalpha activity in SLE patients and their healthy first-degree relatives is highest in early adulthood, when the incidence of SLE is greatest...
  7. pmc Serum type I interferon activity is dependent on maternal diagnosis in anti-SSA/Ro-positive mothers of children with neonatal lupus
    Timothy B Niewold
    University of Chicago, Section of Rheumatology, Chicago, Illinois 60637, USA
    Arthritis Rheum 58:541-6. 2008
    ....
  8. pmc Familial aggregation of autoimmune disease in juvenile dermatomyositis
    Timothy B Niewold
    University of Chicago, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, 924 E 57th St, R420, Chicago, IL 60637, USA
    Pediatrics 127:e1239-46. 2011
    ..Interferon-α is thought to be a pathogenic factor in both systemic lupus erythematosus and juvenile dermatomyositis, and we have previously demonstrated familial aggregation of serum interferon-α...
  9. pmc The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes
    Sandra Agik
    University of Chicago, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, 924 East 57th Street, R420, Chicago, IL 60637, USA
    J Rheumatol 39:73-8. 2012
    ..We studied the UBE2L3 risk allele for association with SLE, interferon-α (IFN-α), and autoantibodies in a predominantly African American SLE cohort...
  10. pmc Network analysis of associations between serum interferon-α activity, autoantibodies, and clinical features in systemic lupus erythematosus
    Corinna E Weckerle
    University of Chicago, Chicago, IL, USA
    Arthritis Rheum 63:1044-53. 2011
    ..This study was undertaken to detect associations between clinical and serologic disease manifestations and serum IFNα activity in a large diverse SLE cohort, using multivariate and network analyses...
  11. pmc Large-scale analysis of tumor necrosis factor α levels in systemic lupus erythematosus
    Corinna E Weckerle
    University of Chicago, Chicago, Illinois
    Arthritis Rheum 64:2947-52. 2012
    ..The aim of this study was to look for associations between serum TNFα levels, clinical manifestations of SLE, autoantibodies, and serum interferon-α (IFNα) levels in a large multiancestral SLE cohort...
  12. pmc Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients
    Rafah Salloum
    University of Chicago, Chicago, IL, USA
    Arthritis Rheum 62:553-61. 2010
    ..This study was undertaken to determine whether variants of IRF7 act as risk factors for SLE by increasing IFNalpha production and whether autoantibodies are important to this phenomenon...
  13. pmc The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus
    Silvia N Kariuki
    University of Chicago, Chicago, Illinois 60637, USA
    Arthritis Rheum 58:2818-23. 2008
    ..The aim of this study was to determine whether the PTPN22 risk variant may shift serum cytokine profiles to higher IFNalpha activity, resulting in risk of disease...
  14. pmc Linkage of type I interferon activity and TNF-alpha levels in serum with sarcoidosis manifestations and ancestry
    Nadera J Sweiss
    Section of Rheumatology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e29126. 2011
    ..We investigated serum levels of these cytokines in a large multi-ancestral sarcoidosis population to determine correlations between cytokine levels and disease phenotypes...
  15. pmc Gene-expression-guided selection of candidate loci and molecular phenotype analyses enhance genetic discovery in systemic lupus erythematosus
    Yelena Koldobskaya
    Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA
    Clin Dev Immunol 2012:682018. 2012
    ..This study illustrates the use of gene expression data to rationally select candidate loci in autoimmune disease, and the utility of stratification by molecular phenotypes in the discovery of additional genetic associations in SLE...
  16. pmc Promoter variant of PIK3C3 is associated with autoimmunity against Ro and Sm epitopes in African-American lupus patients
    Silvia N Kariuki
    Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, 5841 S Maryland Ave MC 0930, Chicago, IL 60637, USA
    J Biomed Biotechnol 2010:826434. 2010
    ..Thus, rs3813065 C is associated with a particular autoantibody profile and altered expression of an MHC peptide processing enzyme, suggesting that this variant modulates serologic autoimmunity in African-American SLE patients...
  17. pmc Osteopontin alleles are associated with clinical characteristics in systemic lupus erythematosus
    Tarak Trivedi
    Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, 5841 S Maryland Avenue, MC0930, Chicago, IL 60637, USA
    J Biomed Biotechnol 2011:802581. 2011
    ....
  18. pmc Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus
    Silvia N Kariuki
    University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Arthritis Res Ther 12:R151. 2010
    ..These two heritable risk factors are shared between ancestral backgrounds. The aim of the study was to detect genetic factors associated with autoantibody profiles and serum IFN-α in SLE...
  19. pmc Circulating cytokines in sarcoidosis: phenotype-specific alterations for fibrotic and non-fibrotic pulmonary disease
    Karen C Patterson
    Section of Pulmonary and Critical Care, University of Chicago, Chicago, IL, United States
    Cytokine 61:906-11. 2013
    ..To gain more insight into the determinants of the fibrotic response, we also determined if the phenotypes of fibrotic and non-fibrotic pulmonary sarcoidosis have distinct cytokine profiles...
  20. pmc Lesional and nonlesional skin from patients with untreated juvenile dermatomyositis displays increased numbers of mast cells and mature plasmacytoid dendritic cells
    Sheela Shrestha
    Children s Memorial Research Center, Chicago, Illinois 60614 3363, USA
    Arthritis Rheum 62:2813-22. 2010
    ..To investigate the distribution of mast cells and dendritic cell (DC) subsets in paired muscle and skin (lesional/nonlesional) from untreated children with juvenile dermatomyositis (DM)...
  21. pmc Brief Report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of children with neonatal lupus
    Tharian S Cherian
    University of Chicago, Chicago, Illinois 60637, USA
    Arthritis Rheum 64:3383-7. 2012
    ..This study was undertaken to determine if the IRF5 genotype is associated with maternal diagnosis or progression of autoimmunity...
  22. pmc Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients
    Timothy B Niewold
    University of Chicago, Section of Rheumatology, Chicago, IL 60637, USA
    Arthritis Rheum 58:2481-7. 2008
    ..The aim of this study was to determine whether the IRF5 SLE risk haplotype mediates the risk of SLE by predisposing patients to the development of high levels of serum IFNalpha activity...
  23. pmc Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients
    Talin Robinson
    Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 187:1298-303. 2011
    ..Thus, the IFIH1 rs1990760 T allele was associated with dsDNA Abs, and in patients with anti-dsDNA Abs this risk allele increased sensitivity to IFN-α signaling. These studies suggest a role for the IFIH1 risk allele in SLE in vivo...
  24. pmc African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity
    James P Lodolce
    Department of Medicine, University of Chicago, Chicago, IL 60612, USA
    J Immunol 184:7001-9. 2010
    ..This is the first report of an association between TNFAIP3 polymorphisms and autoimmunity in African-Americans...
  25. pmc Genetic regulation of serum cytokines in systemic lupus erythematosus
    Silvia N Kariuki
    Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA
    Transl Res 155:109-17. 2010
    ..In this review, we summarize some recent work in the area of SLE cytokine genetics and describe the implications for SLE, autoimmunity, and immune system homeostasis, which are revealed by these investigations...
  26. pmc Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo
    Silvia N Kariuki
    Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 182:34-8. 2009
    ..These data provide biologic relevance for the risk variant of STAT4 in the IFN-alpha pathway in vivo...
  27. pmc Familial aggregation of high tumor necrosis factor alpha levels in systemic lupus erythematosus
    Dorothy Mangale
    Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA
    Clin Dev Immunol 2013:267430. 2013
    ..The high degree of concordance in SLE patients and their spouses suggests that environmental factors may also play a role in the observed familial aggregation...
  28. pmc Genetic ancestry, serum interferon-α activity, and autoantibodies in systemic lupus erythematosus
    Kichul Ko
    Section of Rheumatology, Gwen Knapp Center for Lupus Research, University of Chicago, Chicago, IL 60637, USA
    J Rheumatol 39:1238-40. 2012
    ..To investigate and refine the relationships among systemic lupus erythematosus (SLE) and related autoantibodies, interferon-α (IFN-α), and various ancestral backgrounds...
  29. pmc Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations
    Nadera J Sweiss
    Sarcoidosis and Scleroderma Clinic, Section of Rheumatology, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 5:e9088. 2010
    ..The goal of this study was to evaluate lymphocyte subsets in peripheral blood in a cohort of sarcoidosis patients to determine the prevalence, severity, and clinical features associated with lymphopenia in major lymphocyte subsets...
  30. pmc Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus
    Candace M Cham
    Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA
    Clin Dev Immunol 2012:780436. 2012
    ....
  31. ncbi request reprint Inhibition of interferon-beta responses in multiple sclerosis immune cells associated with high-dose statins
    Xuan Feng
    Department of Neurology, The University of Chicago, Chicago, IL 60637, USA
    Arch Neurol 69:1303-9. 2012
    ..To determine whether statins affect type 1 interferon responses in relapsing-remitting multiple sclerosis (RRMS)...
  32. doi request reprint The clinical and immunologic features of pulmonary fibrosis in sarcoidosis
    Karen C Patterson
    Section of Pulmonary and Critical Care, University of Chicago, Chicago, Ill
    Transl Res 160:321-31. 2012
    ..Elucidating the natural history of sarcoidosis-associated PF will inform our understanding of the fundamental derangements, and will enhance prognostication and the development of therapeutic strategies...
  33. pmc Interferon alpha in systemic lupus erythematosus
    Timothy B Niewold
    Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA
    J Biomed Biotechnol 2010:948364. 2010
    ..Interferon alpha influences the clinical picture of lupus and may represent a therapeutic target. This paper provides an overview of the cellular, genetic, and clinical aspects of interferon alpha in lupus...
  34. pmc Bone health issues in sarcoidosis
    Nadera J Sweiss
    Sections of Rheumatology and Pulmonary Medicine, University of Chicago Medical Center, 5841 South Maryland Avenue, MC0930, Room N005B, Chicago, IL 60637, USA
    Curr Rheumatol Rep 13:265-72. 2011
    ..Therefore, bone health may be impacted in several ways in sarcoidosis--by direct involvement with granulomas, vitamin D deficiency, or corticosteroid therapy...
  35. pmc The unexplained female predominance of systemic lupus erythematosus: clues from genetic and cytokine studies
    Corinna E Weckerle
    Section of Rheumatology, University of Chicago, 5841 S Maryland Ave MC 0930, Chicago, IL 60637, USA
    Clin Rev Allergy Immunol 40:42-9. 2011
    ..It seems quite possible that many of these sex-related differences could be important to reproductive fitness, which may explain the conservation of these immune system features and the observed female predominance of SLE...
  36. doi request reprint Type I interferon signature is high in lupus and neuromyelitis optica but low in multiple sclerosis
    Xuan Feng
    Department of Neurology, University of Chicago, Chicago, IL 60637, USA
    J Neurol Sci 313:48-53. 2012
    ..This study examines for the first time whether serum IFN-α/β activity and IFN-β-induced responses in peripheral blood mononuclear cells (MNC) are abnormally elevated in NMO, as they are in SLE, but contrast to low levels in MS...
  37. pmc Interferon regulatory factors in human lupus pathogenesis
    Rafah Salloum
    Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Pritzker School of Medicine, Chicago, IL 60637, USA
    Transl Res 157:326-31. 2011
    ....
  38. pmc Rheumatologic manifestations of sarcoidosis
    Nadera J Sweiss
    Section of Rheumatology, Department of Medicine, University of Chicago Medical Center, Chicago, IL 60637, USA
    Semin Respir Crit Care Med 31:463-73. 2010
    ..We present two cases of sarcoidosis with rheumatologic manifestations. Our intent is to encourage a multidisciplinary, translational approach to meet the challenges and difficulties in understanding and treating sarcoidosis...
  39. ncbi request reprint Systemic lupus erythematosus arising during interferon-alpha therapy for cryoglobulinemic vasculitis associated with hepatitis C
    Timothy B Niewold
    Department of Rheumatology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA
    Clin Rheumatol 24:178-81. 2005
    ..The development of SLE during therapy with IFN-alpha could be due to direct immunomodulation by IFN-alpha, and review of experimental data and prior case reports suggests a pathogenic role for IFN-alpha in SLE...
  40. pmc Augmented interferon-alpha pathway activation in patients with Sjögren's syndrome treated with etanercept
    Clio P Mavragani
    Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA
    Arthritis Rheum 56:3995-4004. 2007
    ..To address the hypothesis that tumor necrosis factor blockade can result in increased levels of interferon-alpha (IFNalpha) and BAFF, we quantified those mediators in plasma from etanercept- and placebo-treated SS patients...
  41. ncbi request reprint Concomitant interferon-alpha therapy and tumor necrosis factor alpha inhibition for rheumatoid arthritis and hepatitis C
    Timothy B Niewold
    Hospital for Special Surgery, New York, NY, USA
    Arthritis Rheum 54:2335-7. 2006
  42. ncbi request reprint Rituximab treatment of thrombotic thrombocytopenic purpura in the setting of connective tissue disease
    Timothy B Niewold
    Department of Rheumatology Hospital for Special Surgery, New York, New York 10021, USA
    J Rheumatol 33:1194-6. 2006
    ..Rituximab should be considered in this complex clinical setting, because it may decrease the production of multiple pathogenic autoantibodies...
  43. pmc Interferon alpha-induced lupus: proof of principle
    Timothy B Niewold
    J Clin Rheumatol 14:131-2. 2008