Research Topics
| Dennis E NiewoehnerSummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
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Detail Information
Publications
Risk indexes for exacerbations and hospitalizations due to COPDDennis E Niewoehner
Department of Medicine at Veterans Affairs Medical Centers in Minneapolis, MN 55417, USA
Chest 131:20-8. 2007..Our objective was to develop risk indexes for exacerbations and hospitalizations due to exacerbations that might be applied to the individual patient...- The role of systemic corticosteroids in acute exacerbation of chronic obstructive pulmonary diseaseDennis E Niewoehner
Pulmonary Section, Veterans Affairs Medical Center, and University of Minnesota, Minneapolis, Minnesota 55417, USA
Am J Respir Med 1:243-8. 2002..Hyperglycemia is the most common adverse event, but secondary infections, mental disturbances, and myopathies may also occur... 
Therapeutic conversion of the combination of ipratropium and albuterol to tiotropium in patients with chronic obstructive pulmonary diseaseDennis E Niewoehner
Department of Medicine at Veterans Affairs Medical Centers in Minneapolis, Minneapolis, MN 55417, USA
Pulm Pharmacol Ther 22:587-92. 2009..This trial compared tiotropium, once daily, as a potential alternative to patients already taking the ipratropium/albuterol combination...- Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: a randomized trialDennis E Niewoehner
Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
Ann Intern Med 143:317-26. 2005..Patients with chronic obstructive pulmonary disease (COPD) frequently develop exacerbations, leading to major clinical and health resource use ramifications... - Relation of chronic obstructive pulmonary disease exacerbations to FEV(1)--an intricate tangoDennis E Niewoehner
Pulmonary and Critical Care Section, Veterans Administration Medical Center and University of Minnesota, Minneapolis, MN 55417, USA
Respiration 77:229-35. 2009.... 
Role of tiotropium in the treatment of COPDKathryn L Rice
University of Minnesota, Minneapolis, MN, USA
Int J Chron Obstruct Pulmon Dis 2:95-105. 2007..Medico economic analyses suggest that treatment with tiotropium may also be cost-effective, primarily by reducing costs associated with hospitalizations...- The impact of severe exacerbations on quality of life and the clinical course of chronic obstructive pulmonary diseaseDennis E Niewoehner
University of Minnesota, Minneapolis, Minnesota, USA
Am J Med 119:38-45. 2006..COPD management should include drugs and other interventions that reduce the frequency of exacerbations and minimize their negative impact on the clinical course of the disease... - Responses to tiotropium in African-American and Caucasian patients with chronic obstructive pulmonary diseaseKathryn L Rice
Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
Transl Res 152:88-94. 2008..African Americans used fewer respiratory medications than Caucasians in this study. We conclude that tiotropium reduces COPD exacerbations and associated health-care use to a similar extent in African Americans compared with Caucasians... - Disease management program for chronic obstructive pulmonary disease: a randomized controlled trialKathryn L Rice
Pulmonary Section, Department of Medicine, VA Medical Center, Minneapolis, Minnesota 55417, USA
Am J Respir Crit Care Med 182:890-6. 2010..Objectives: To determine whether a simplified disease management program reduces hospital admissions and emergency department (ED) visits due to COPD... - Management of acute exacerbations of chronic obstructive pulmonary disease in the elderly : an appraisal of published evidenceKen M Kunisaki
University of Minnesota, Minneapolis, Minnesota, USA
Drugs Aging 24:303-24. 2007..Mucolytic agents, pulmonary rehabilitation, and case management programmes may also reduce exacerbation risk, but the current evidence supporting these interventions is weaker... - Vitamin D levels and risk of acute exacerbations of chronic obstructive pulmonary disease: a prospective cohort studyKen M Kunisaki
Pulmonary Section, Minneapolis Veterans Affairs Medical Center, Minnesota 55417, USA
Am J Respir Crit Care Med 185:286-90. 2012..We hypothesized that low blood levels of 25(OH)D in patients with chronic obstructive pulmonary disease (COPD) would be associated with an increased risk of acute exacerbations of COPD (AECOPD)... - Exhaled nitric oxide, systemic inflammation, and the spirometric response to inhaled fluticasone propionate in severe chronic obstructive pulmonary disease: a prospective studyKen M Kunisaki
Division of Pulmonary, Allergy, Critical Care and Sleep, University of Minnesota, USA
Ther Adv Respir Dis 2:55-64. 2008..We evaluated the ability of exhaled nitric oxide (FENO) and serum inflammatory markers (C-reactive protein [CRP], interleukin-6 [IL-6], and interleukin-8 [IL-8]) to independently predict spirometric responses to ICS in patients with COPD... - Clinical efficacy of OM-85 BV in COPD and chronic bronchitis: a systematic reviewMark D Sprenkle
Division of Pulmonary and Critical Care Medicine, Hennepin County Medical Center, Pulmonary Medicine 865B, 701 Park Ave, Minneapolis, Minnesota 55415, USA
COPD 2:167-75. 2005..Further randomized controlled trials enrolling large numbers of persons with well-defined COPD are necessary to confirm the effectiveness of this agent... - Interventions to prevent chronic obstructive pulmonary disease exacerbationsDennis E Niewoehner
Pulmonary Section, Veterans Affairs Medical Center, and Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55417, USA
Am J Med 117:41S-48S. 2004..This article discusses pharmacologic therapy and other measures for preventing exacerbations and hospitalizations due to exacerbations of COPD... - The Veterans Short Form 36 questionnaire is predictive of mortality and health-care utilization in a population of veterans with a self-reported diagnosis of asthma or COPDMark D Sprenkle
Division of Pulmonary and Critical Care Medicine, Hennepin County Medical Center, Minneapolis, MN 55415, USA
Chest 126:81-9. 2004..However, as their predictive capacity for mortality or medical utilization is less well defined, we sought to examine the relationship of a general measure of HRQL and outcomes in persons with obstructive lung disease... - Inhaled corticosteroids for chronic obstructive pulmonary disease: a status reportDennis E Niewoehner
Am J Respir Crit Care Med 175:103-4. 2007 - Screening for lung cancer: the guidelinesPeter B Bach
Health Outcomes Research Group, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 221, New York, NY 10021, USA
Chest 123:83S-88S. 2003..We recommend that individuals should only be screened with LDCT in the context of well-designed clinical trials...
Research Grants
- Drug therapy for preventing COPD exacerbationsDennis Niewoehner; Fiscal Year: 2003..Both trials are designed with 80% power to show a 30% reduction in severe exacerbations at a significance level of 0.05. ..