D E Niewoehner
Affiliation: University of Minnesota
- Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease. Department of Veterans Affairs Cooperative Study GroupD E Niewoehner
Veterans Affairs Medical Center in Minneapolis, MN 55417, USA
N Engl J Med 340:1941-7. 1999..The primary end point was treatment failure, defined as death from any cause or the need for intubation and mechanical ventilation, readmission to the hospital for COPD, or intensification of drug therapy...
- Steroid-induced osteoporosis. Are your asthmatic patients at risk?C B Niewoehner
Division of Endocrinology, Metabolism, and Nutrition, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
Postgrad Med 105:79-83, 87-8, 91. 1999..However, evidence is lacking on the risks of long-term use of higher doses. Regardless of dose, all patients given long-term systemic corticosteroids should be carefully examined and, if necessary, treated for bone loss...
- Relation of FEV(1) to clinical outcomes during exacerbations of chronic obstructive pulmonary disease. Department of Veterans Affairs Cooperative Study GroupD E Niewoehner
Veterans Affairs Medical Centers, Minneapolis, Minnesota 55417, USA
Am J Respir Crit Care Med 161:1201-5. 2000..01). We conclude that FEV(1) measurements at admission and over the first several days of hospitalization are highly predictive of clinical outcomes during exacerbations of COPD...
- Withdrawal of chronic systemic corticosteroids in patients with COPD: a randomized trialK L Rice
Department of Medicine and Geriatric Research Center, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
Am J Respir Crit Care Med 162:174-8. 2000..Larger studies may be warranted to establish the relative risks and benefits of chronic corticosteroid treatment of patients with COPD...
- Role of corticosteroids in acute exacerbations of chronic obstructive pulmonary diseaseD E Niewoehner
Pulmonary Section, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
Curr Opin Pulm Med 7:75-8. 2001..Treatment should not extend longer than 2 weeks. The optimal starting dose is not known. Hyperglycemia and possibly an increased rate of secondary infections are expected complications of treatment...
- Vitamin D status and longitudinal lung function decline in the Lung Health StudyK M Kunisaki
Minneapolis Veterans Affairs Medical Center, Pulmonary, Minneapolis, MN 55417, USA
Eur Respir J 37:238-43. 2011..Although vitamin D insufficiency and deficiency are common among continuous smokers with established mild-to-moderate chronic obstructive pulmonary disease, baseline 25(OH)D levels are not predictive of subsequent lung function decline...