Claus U Niemann

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Intraoperative hemodynamics and liver function in adult-to-adult living liver donors
    Claus U Niemann
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    Liver Transpl 8:1126-32. 2002
  2. ncbi request reprint Ischemia-reperfusion injury is more severe in older versus young rat livers
    Yeonho Park
    Department of Surgery, Gachon Medical School, Gil Medical Center, Incheon, Korea
    J Surg Res 137:96-102. 2007
  3. ncbi request reprint Central venous pressure monitoring during living right donor hepatectomy
    Claus U Niemann
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    Liver Transpl 13:266-71. 2007
  4. ncbi request reprint Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion
    Claus U Niemann
    Anesthesia and Perioperative Care, Division of Liver Transplantation, University of California San Francisco, San Francisco, CA 94143 0648, USA
    Surgery 140:404-12. 2006
  5. ncbi request reprint Recombinant factor VIIa reduces transfusion requirements in liver transplant patients with high MELD scores
    C U Niemann
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    Transfus Med 16:93-100. 2006
  6. ncbi request reprint Ischemic preconditioning improves energy state and transplantation survival in obese Zucker rat livers
    Claus U Niemann
    University of California at San Francisco, Department of Anesthesia and Perioperative Care, 521 Parnassus Avenue, C 450, San Francisco, CA 94143 0648, USA
    Anesth Analg 101:1577-83. 2005
  7. doi request reprint Short passive cooling protects rats during hepatectomy by inducing heat shock proteins and limiting the induction of pro-inflammatory cytokines
    Claus U Niemann
    Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94143 0648, USA
    J Surg Res 158:43-52. 2010
  8. doi request reprint Acute kidney injury during liver transplantation as determined by neutrophil gelatinase-associated lipocalin
    Claus U Niemann
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    Liver Transpl 15:1852-60. 2009
  9. ncbi request reprint Abdominal organ transplantation
    C U Niemann
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    Minerva Anestesiol 76:266-75. 2010
  10. doi request reprint Quality improvement in transplant anesthesia: which way forward?
    Claus U Niemann
    Department of Anesthesia and Perioperative Care, Division of Transplantation, University of California, San Francisco, California 94143 0648, USA
    Curr Opin Organ Transplant 15:374-6. 2010

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Intraoperative hemodynamics and liver function in adult-to-adult living liver donors
    Claus U Niemann
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    Liver Transpl 8:1126-32. 2002
    ..In addition, we show that functional recovery of the liver is likely to be slower than morphological recovery, and such clinical parameters as coagulation profile may not be a good index of fully restored hepatic function...
  2. ncbi request reprint Ischemia-reperfusion injury is more severe in older versus young rat livers
    Yeonho Park
    Department of Surgery, Gachon Medical School, Gil Medical Center, Incheon, Korea
    J Surg Res 137:96-102. 2007
    ..The objective of this study was to investigate whether age influences the degree of warm ischemia-reperfusion injury in rat livers...
  3. ncbi request reprint Central venous pressure monitoring during living right donor hepatectomy
    Claus U Niemann
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    Liver Transpl 13:266-71. 2007
    ..CVP monitoring did not appear to reduce blood loss when compared with patients without CVP monitoring. In centers with extensive experience, CVP monitoring may not be necessary in this highly selective patient population...
  4. ncbi request reprint Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion
    Claus U Niemann
    Anesthesia and Perioperative Care, Division of Liver Transplantation, University of California San Francisco, San Francisco, CA 94143 0648, USA
    Surgery 140:404-12. 2006
    ....
  5. ncbi request reprint Recombinant factor VIIa reduces transfusion requirements in liver transplant patients with high MELD scores
    C U Niemann
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    Transfus Med 16:93-100. 2006
    ..In a selected group of patients with prolonged PT and high MELD score, the prophylactic application of rFVIIa at the start of the OLT may reduce perioperative transfusion requirements...
  6. ncbi request reprint Ischemic preconditioning improves energy state and transplantation survival in obese Zucker rat livers
    Claus U Niemann
    University of California at San Francisco, Department of Anesthesia and Perioperative Care, 521 Parnassus Avenue, C 450, San Francisco, CA 94143 0648, USA
    Anesth Analg 101:1577-83. 2005
    ..IP of liver grafts from obese rats before 4 h of CI increases 24-h survival of recipient animals from 25% to 88%...
  7. doi request reprint Short passive cooling protects rats during hepatectomy by inducing heat shock proteins and limiting the induction of pro-inflammatory cytokines
    Claus U Niemann
    Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94143 0648, USA
    J Surg Res 158:43-52. 2010
    ..The goal of the present study is to evaluate the effect of passive cooling caused by exposure to ambient conditions on hepatic injury in rats during warm ischemia followed by hepatectomy...
  8. doi request reprint Acute kidney injury during liver transplantation as determined by neutrophil gelatinase-associated lipocalin
    Claus U Niemann
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    Liver Transpl 15:1852-60. 2009
    ..These findings will allow the design of larger interventional studies. Our findings regarding the impact of surgical techniques and glucose require validation in larger studies...
  9. ncbi request reprint Abdominal organ transplantation
    C U Niemann
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    Minerva Anestesiol 76:266-75. 2010
    ..However, these disagreements are a reflection of the paucity of adequate data for some of the discussed topics...
  10. doi request reprint Quality improvement in transplant anesthesia: which way forward?
    Claus U Niemann
    Department of Anesthesia and Perioperative Care, Division of Transplantation, University of California, San Francisco, California 94143 0648, USA
    Curr Opin Organ Transplant 15:374-6. 2010
    ..Perioperative care of transplant patients has only recently attracted attention and quality improvement efforts are not well established...
  11. ncbi request reprint Cyclosporine can increase isoflurane MAC
    Claus U Niemann
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143, USA
    Anesth Analg 95:930-4, table of contents. 2002
    ..Cyclosporine did not significantly increase HPWL. Contrary to our hypotheses, cyclosporine increases rather than decreases MAC, but does not confer appreciable analgesia...
  12. ncbi request reprint Evaluation of the splanchnic circulation with indocyanine green pharmacokinetics in liver transplant patients
    Claus U Niemann
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0648, USA
    Liver Transpl 8:476-81. 2002
    ..This model can be a useful tool to evaluate the effect of pharmacological manipulation of splanchnic hemodynamics...
  13. doi request reprint Donor pre-treatment with everolimus or cyclosporine does not reduce ischaemia-reperfusion injury in a rat kidney transplant model
    Graciela Martinez-Palli
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, USA
    Nephrol Dial Transplant 26:1813-20. 2011
    ..This study aimed to investigate the possible protective effects of donor pre-treatment with cyclosporine (CsA) or the mTOR inhibitor everolimus or their combination against IRI during renal transplantation in a rat model...
  14. pmc Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion
    Jan Hirsch
    Anesthesia and Perioperative Care, Mass Spectrometry Facility, University of California, San Francisco, CA, USA
    Crit Care Med 36:1846-54. 2008
    ..Hepatic ischemia-reperfusion can be associated with acute lung injury. Alveolar epithelial type II cells (ATII) play an important role in maintaining lung homeostasis in acute lung injury...
  15. doi request reprint Peri-operative hyperglycemia is associated with delayed graft function in deceased donor renal transplantation
    Justin Parekh
    Division of Transplantation, Department of Surgery, University of California, San Francisco, CA 94143, USA
    Clin Transplant 27:E424-30. 2013
    ..92, 95% CI 1.20-3.05, p = 0.01). We conclude that recipient blood glucose measured in the PACU is associated with DGF and begs the question of whether improved peri-operative glucose control will decrease the incidence of DGF...
  16. doi request reprint Induction of intestinal ischemia reperfusion injury by portal vein outflow occlusion in rats
    Marco Vincenti
    Department of Surgery, Division of Transplantation, University of California, San Francisco, CA 94143 0648, USA
    J Gastroenterol 45:1103-10. 2010
    ..Metabolic changes are seen early in I/R. This study compares tissue histology, inflammation, and metabolic response during small bowel I/R due to superior MA or PV occlusion...
  17. pmc Acute hyperglycemia worsens hepatic ischemia/reperfusion injury in rats
    Matthias Behrends
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA 94143 0648, USA
    J Gastrointest Surg 14:528-35. 2010
    ..Acute hyperglycemia is known to worsen ischemia/reperfusion (I/R) injury following myocardial infarction and stroke. We investigated whether acute hyperglycemia worsens injury and amplifies the inflammatory response evoked by hepatic I/R...
  18. doi request reprint Predictors associated with terminal renal function in deceased organ donors in the intensive care unit
    Annabel Blasi-Ibanez
    Department of Anesthesia and Perioperative Care, University of California San Francisco, California, 94143 0648, USA
    Anesthesiology 110:333-41. 2009
    ..Factors determining renal function at organ recovery in deceased kidney donors are not well established...
  19. ncbi request reprint Remote renal injury following partial hepatic ischemia/reperfusion injury in rats
    Matthias Behrends
    Department of Anesthesia and Perioperative Care, University of California San Francisco, 521 Parnassus Avenue, S 455, San Francisco, CA 94143 0648, USA
    J Gastrointest Surg 12:490-5. 2008
    ..Severe hepatic ischemia results in a moderate impairment of renal function in rats but does not trigger an inflammatory response in the kidney and does not result in morphological damage of the kidney...
  20. ncbi request reprint Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats
    Jan Hirsch
    Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 0446, USA
    Mol Cell Proteomics 5:979-86. 2006
    ..The ability to simultaneously monitor several pathways involved in reperfusion stress may result in important mechanistic insight and possibly new treatment options...
  21. ncbi request reprint Mild hypothermia reduces the inflammatory response and hepatic ischemia/reperfusion injury in rats
    Matthias Behrends
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, CA 94143 0648, USA
    Liver Int 26:734-41. 2006
    ..Hypothermia is known to protect against ischemia/reperfusion (I/R) injury. The mechanisms of protection are incompletely understood and a temperature threshold for protection has not been established...
  22. doi request reprint 1H-NMR-based metabolic signatures of clinical outcomes in trauma patients--beyond lactate and base deficit
    Mitchell J Cohen
    Department of Surgery, University of California, San Francisco, California, USA
    J Trauma 69:31-40. 2010
    ....
  23. doi request reprint Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in rats
    Ryutaro Hirose
    Department of Surgery, Divisionof Transplantation, University of California, San Francisco, California 94143 0648, USA
    Anesthesiology 108:402-14. 2008
    ..The goal of this study was to examine whether transient hyperglycemia during or after renal ischemia-reperfusion increased renal dysfunction...
  24. ncbi request reprint Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine
    Claus U Niemann
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, USA
    J Pharmacol Exp Ther 302:1123-8. 2002
    ..97; NAD(+): r = 0.82, P < 0.01). The reduction in cardiac energy metabolism before occlusion may be the cause of myocardial preservation during ischemia/reperfusion...
  25. doi request reprint Multivessel coronary artery disease predicts mortality, length of stay, and pressor requirements after liver transplantation
    Celina M Yong
    Division of Cardiology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Liver Transpl 16:1242-8. 2010
    ..This study provides preliminary evidence showing that there may be significant prognostic value in coronary angiography as a part of the pretransplant workup...
  26. ncbi request reprint Elimination of indocyanine green in the perioperative evaluation of donor liver function
    M Susan Mandell
    Department of Anesthesiology, Division of Transplantation, University of Colorado Health Sciences Center, 4200 E Ninth Avenue, Denver, CO 80262, USA
    Anesth Analg 95:1182-4, table of contents. 2002
    ..The authors describe the intraoperative use of indocyanine green dye elimination to detect critical reductions in donor liver function...
  27. ncbi request reprint Biochemical mechanisms of nephrotoxicity: application for metabolomics
    Claus U Niemann
    University of California San Francisco, Division of Transplantation, Department of Anesthesia and Perioperative Care, San Francisco, California, USA
    Expert Opin Drug Metab Toxicol 3:527-44. 2007
    ..Each of these pathways can be monitored by specific surrogate markers in urine and blood using modern metabolomics technologies...
  28. pmc Systemic inflammation, coagulopathy, and acute renal insufficiency following endovascular thoracoabdominal aortic aneurysm repair
    Catherine K Chang
    Department of Surgery, Division of Vascular Surgery, University of California at San Francisco, San Francisco, Calif 94143 0222, USA
    J Vasc Surg 49:1140-6. 2009
    ..To characterize the inflammatory and coagulopathic response after endovascular thoracoabdominal aortic aneurysm (TAAA) repair and to evaluate the effect of the response on postoperative renal function...
  29. doi request reprint Infrared pupillometry to detect the light reflex during cardiopulmonary resuscitation: a case series
    Matthias Behrends
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, United States
    Resuscitation 83:1223-8. 2012
    ..We asked whether the light reflex could be objectively measured during cardiopulmonary resuscitation in humans and whether the quality of the reflex was associated with outcome...
  30. ncbi request reprint Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors
    Wolfgang Egge-Jacobsen
    Department of Biopharmaceutical Sciences, University of California, San Francisco, California, USA
    Ther Drug Monit 26:546-62. 2004
    ..The assay allows fast analysis of patient samples for therapeutic drug monitoring (TDM) and has successfully been used for TDM and pharmacokinetic drug-drug interactions studies...
  31. pmc Intraoperative hyperglycemia augments ischemia reperfusion injury in renal transplantation: a prospective study
    Justin Parekh
    Department of Surgery, Division of Transplantation, University of California San Francisco, San Francisco, CA 94143, USA
    J Transplant 2011:652458. 2011
    ..Conclusions. Hyperglycemia is associated with increased ischemic injury in renal transplantation. Both creatinine and NGAL, a marker of ischemic injury and renal function, fall less rapidly in patients with elevated blood glucose...
  32. doi request reprint Intraoperative management of liver transplant patients
    Linda L Liu
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA 94143, USA
    Transplant Rev (Orlando) 25:124-9. 2011
    ..Existing evidence on intraoperative monitoring, intraoperative fluid and transfusion management, electrolyte and glucose management, postoperative patient disposition, and, lastly, anesthesia team management will be reviewed...
  33. doi request reprint Patients with chronic kidney disease
    Alicia Gruber Kalamas
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, 521 Parnassus Avenue, PO Box 0648, San Francisco, CA 94143 0648, USA Electronic address
    Med Clin North Am 97:1109-22. 2013
    ..This article reviews patient risk stratification, preoperative evaluation and management, and perioperative interventions for renal protection. ..
  34. doi request reprint Postoperative infectious complications of abdominal solid organ transplantation
    Nicole Hlava
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, USA
    J Intensive Care Med 24:3-17. 2009
    ..On the basis of these factors, we put forth an algorithm for diagnosing and treating suspected infections in solid organ transplant recipients...
  35. ncbi request reprint Mechanism of pupillary reflex dilation in awake volunteers and in organ donors
    Laura L Yang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0648, USA
    Anesthesiology 99:1281-6. 2003
    ....
  36. ncbi request reprint Organ-specific response to inhibition of mitochondrial metabolism by cyclosporine in the rat
    Natalie Serkova
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Transpl Int 16:748-55. 2003
    ..The metabolic marker for nephrotoxicity, trimethylamine-N-oxide (TMAO), was elevated. While CyA decreased mitochondrial homeostasis in all organ systems, cellular adaptation was different and most efficient in the liver...
  37. ncbi request reprint The effects of desflurane and propofol on portosystemic pressure in patients with portal hypertension
    M Susan Mandell
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Anesth Analg 97:1573-7. 2003
    ..Changes in the hepatic venous pressure gradient must be interpreted with caution during desflurane general anesthesia...
  38. ncbi request reprint Sirolimus delays recovery of rat kidney transplants after ischemia-reperfusion injury
    T Florian Fuller
    Department of Urology, Charite Hospital, Humboldt University Berlin, Berlin, Germany
    Transplantation 76:1594-9. 2003
    ..This study determined the impact of SRL on renal recovery after ischemia-reperfusion injury in a rat kidney transplant model...
  39. ncbi request reprint Beta-adrenergic blockade affects initial drug distribution due to decreased cardiac output and altered blood flow distribution
    Michael J Avram
    Department of Anesthesiology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Ward Bldg 13 199, Chicago, IL 60611 3008, USA
    J Pharmacol Exp Ther 311:617-24. 2004
    ....
  40. ncbi request reprint Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia
    Natalie Serkova
    Department of Biology and Chemistry, University of Bremen, Bremen, Germany
    J Cereb Blood Flow Metab 22:342-52. 2002
    ..Whether the overall effect was a reduction or protection of cell energy metabolism depended on the concentrations of both oxygen and cyclosporin A in the buffer solution...
  41. ncbi request reprint H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants
    Natalie Serkova
    Department of Anesthesiology, Biomedical MRI MRS, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Kidney Int 67:1142-51. 2005
    ..1)H-NMR (nuclear magnetic resonance spectroscopy) based metabolomics was used to establish IR-specific metabolic markers in both blood and kidney tissue. These markers were compared to SCr and graft histology...
  42. pmc Mild hypothermia provides significant protection against ischemia/reperfusion injury in livers of obese and lean rats
    Soojinna Choi
    Department of Surgery, Chonnam National University Medical School, Gwangju, Korea
    Ann Surg 241:470-6. 2005
    ..To evaluate the effect of anesthesia induced mild systemic hypothermia on hepatic injury in lean and obese rats during warm ischemia...
  43. ncbi request reprint Glutamine does not protect against hepatic warm ischemia/reperfusion injury in rats
    Joonhwa Noh
    Department of Urology, Kwangju Christian Hospital, Gwangju, Korea
    J Gastrointest Surg 10:234-9. 2006
    ..Pretreatment with glutamine did not reduce hepatic ischemia/reperfusion injury. The lack of protection was associated with an absence of HSP70 upregulation prior to ischemia...
  44. ncbi request reprint Metabolic profiling of livers and blood from obese Zucker rats
    Natalie J Serkova
    Biomedical MRI NMR, Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA
    J Hepatol 44:956-62. 2006
    ..Obesity frequently leads to changes in fatty acid metabolism with subsequent fatty infiltration in the liver...
  45. pmc Early detection of graft failure using the blood metabolic profile of a liver recipient
    Natalie J Serkova
    Department of Anesthesiology and Radiology, Biomedical MRI MRS Cancer Center Core, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Transplantation 83:517-21. 2007
    ..This article reports the potential usefulness of quantitative H-NMR based metabolomics to diagnose early graft dysfunction in liver transplantation...
  46. doi request reprint Increased severity of renal ischemia-reperfusion injury with venous clamping compared to arterial clamping in a rat model
    Yeonho Park
    Department of Surgery, Gachon Medical School, Gil Medical Center, Incheon, Korea
    Surgery 143:243-51. 2008
    ..The goal of this study was to examine the injury pattern of renal venous outflow obstruction, compare this with the traditional model of arterial occlusion, and examine possible mechanisms...
  47. ncbi request reprint Glutamine donor pretreatment in rat kidney transplants with severe preservation reperfusion injury
    T Florian Fuller
    Department of Urology, Charité University Hospital CCM, Berlin, Germany
    J Surg Res 140:77-83. 2007
    ..Glutamine (GLN) has been shown to confer cytoprotection by enhancing endogenous heat shock protein (HSP) expression. We hypothesized that GLN donor pretreatment protects rat renal grafts against severe preservation reperfusion injury (PRI)...
  48. doi request reprint Perioperative liver transplant best practices: weighing the evidence
    M Susan Mandell
    Curr Opin Organ Transplant 13:273-4. 2008
  49. ncbi request reprint Influence of donor pretreatment with N-acetylcysteine on ischemia/reperfusion injury in rat kidney grafts
    T Florian Fuller
    Department of Urology, Charite University Hospital, Berlin, Germany
    J Urol 171:1296-300. 2004
    ..N-acetylcysteine (NAC) has been shown to ameliorate ischemic acute renal failure. We determined the effect of donor pretreatment with NAC on ischemia reperfusion (I/R) injury in rat kidney grafts...