Research Topics
| Claus U NiemannSummaryAffiliation: University of California Country: USA Publications
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Publications
Ischemia-reperfusion injury is more severe in older versus young rat liversYeonho Park
Department of Surgery, Gachon Medical School, Gil Medical Center, Incheon, Korea
J Surg Res 137:96-102. 2007..The objective of this study was to investigate whether age influences the degree of warm ischemia-reperfusion injury in rat livers...- Intraoperative hemodynamics and liver function in adult-to-adult living liver donorsClaus U Niemann
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
Liver Transpl 8:1126-32. 2002..In addition, we show that functional recovery of the liver is likely to be slower than morphological recovery, and such clinical parameters as coagulation profile may not be a good index of fully restored hepatic function... - Recombinant factor VIIa reduces transfusion requirements in liver transplant patients with high MELD scoresC U Niemann
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
Transfus Med 16:93-100. 2006..In a selected group of patients with prolonged PT and high MELD score, the prophylactic application of rFVIIa at the start of the OLT may reduce perioperative transfusion requirements... - Ischemic preconditioning improves energy state and transplantation survival in obese Zucker rat liversClaus U Niemann
University of California at San Francisco, Department of Anesthesia and Perioperative Care, 521 Parnassus Avenue, C 450, San Francisco, CA 94143 0648, USA
Anesth Analg 101:1577-83. 2005..IP of liver grafts from obese rats before 4 h of CI increases 24-h survival of recipient animals from 25% to 88%... - Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusionClaus U Niemann
Anesthesia and Perioperative Care, Division of Liver Transplantation, University of California San Francisco, San Francisco, CA 94143 0648, USA
Surgery 140:404-12. 2006.... 
Short passive cooling protects rats during hepatectomy by inducing heat shock proteins and limiting the induction of pro-inflammatory cytokinesClaus U Niemann
Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94143 0648, USA
J Surg Res 158:43-52. 2010..The goal of the present study is to evaluate the effect of passive cooling caused by exposure to ambient conditions on hepatic injury in rats during warm ischemia followed by hepatectomy...- Acute kidney injury during liver transplantation as determined by neutrophil gelatinase-associated lipocalinClaus U Niemann
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
Liver Transpl 15:1852-60. 2009..These findings will allow the design of larger interventional studies. Our findings regarding the impact of surgical techniques and glucose require validation in larger studies... - Abdominal organ transplantationC U Niemann
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
Minerva Anestesiol 76:266-75. 2010..However, these disagreements are a reflection of the paucity of adequate data for some of the discussed topics... - Central venous pressure monitoring during living right donor hepatectomyClaus U Niemann
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
Liver Transpl 13:266-71. 2007..CVP monitoring did not appear to reduce blood loss when compared with patients without CVP monitoring. In centers with extensive experience, CVP monitoring may not be necessary in this highly selective patient population... - Quality improvement in transplant anesthesia: which way forward?Claus U Niemann
Department of Anesthesia and Perioperative Care, Division of Transplantation, University of California, San Francisco, California 94143 0648, USA
Curr Opin Organ Transplant 15:374-6. 2010..Perioperative care of transplant patients has only recently attracted attention and quality improvement efforts are not well established... - Evaluation of the splanchnic circulation with indocyanine green pharmacokinetics in liver transplant patientsClaus U Niemann
Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0648, USA
Liver Transpl 8:476-81. 2002..This model can be a useful tool to evaluate the effect of pharmacological manipulation of splanchnic hemodynamics... - Cyclosporine can increase isoflurane MACClaus U Niemann
Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143, USA
Anesth Analg 95:930-4, table of contents. 2002..IMPLICATIONS: The immunosuppressive drug, cyclosporine, which is frequently used after organ transplantation, increases the amount of a commonly used anesthetic (isoflurane) necessary to avoid movement to painful stimuli in the rat... - Donor pre-treatment with everolimus or cyclosporine does not reduce ischaemia-reperfusion injury in a rat kidney transplant modelGraciela Martinez-Palli
Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, USA
Nephrol Dial Transplant 26:1813-20. 2011..This study aimed to investigate the possible protective effects of donor pre-treatment with cyclosporine (CsA) or the mTOR inhibitor everolimus or their combination against IRI during renal transplantation in a rat model... 
Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusionJan Hirsch
Anesthesia and Perioperative Care, Mass Spectrometry Facility, University of California, San Francisco, CA, USA
Crit Care Med 36:1846-54. 2008..Hepatic ischemia-reperfusion can be associated with acute lung injury. Alveolar epithelial type II cells (ATII) play an important role in maintaining lung homeostasis in acute lung injury...- Acute hyperglycemia worsens hepatic ischemia/reperfusion injury in ratsMatthias Behrends
Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA 94143 0648, USA
J Gastrointest Surg 14:528-35. 2010..Acute hyperglycemia is known to worsen ischemia/reperfusion (I/R) injury following myocardial infarction and stroke. We investigated whether acute hyperglycemia worsens injury and amplifies the inflammatory response evoked by hepatic I/R... - Induction of intestinal ischemia reperfusion injury by portal vein outflow occlusion in ratsMarco Vincenti
Department of Surgery, Division of Transplantation, University of California, San Francisco, CA 94143 0648, USA
J Gastroenterol 45:1103-10. 2010..Metabolic changes are seen early in I/R. This study compares tissue histology, inflammation, and metabolic response during small bowel I/R due to superior MA or PV occlusion... - Remote renal injury following partial hepatic ischemia/reperfusion injury in ratsMatthias Behrends
Department of Anesthesia and Perioperative Care, University of California San Francisco, 521 Parnassus Avenue, S 455, San Francisco, CA 94143 0648, USA
J Gastrointest Surg 12:490-5. 2008..Severe hepatic ischemia results in a moderate impairment of renal function in rats but does not trigger an inflammatory response in the kidney and does not result in morphological damage of the kidney... - Predictors associated with terminal renal function in deceased organ donors in the intensive care unitAnnabel Blasi-Ibanez
Department of Anesthesia and Perioperative Care, University of California San Francisco, California, 94143 0648, USA
Anesthesiology 110:333-41. 2009..Factors determining renal function at organ recovery in deceased kidney donors are not well established... - Mild hypothermia reduces the inflammatory response and hepatic ischemia/reperfusion injury in ratsMatthias Behrends
Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, CA 94143 0648, USA
Liver Int 26:734-41. 2006..Hypothermia is known to protect against ischemia/reperfusion (I/R) injury. The mechanisms of protection are incompletely understood and a temperature threshold for protection has not been established... - Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in ratsJan Hirsch
Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 0446, USA
Mol Cell Proteomics 5:979-86. 2006..The ability to simultaneously monitor several pathways involved in reperfusion stress may result in important mechanistic insight and possibly new treatment options... - 1H-NMR-based metabolic signatures of clinical outcomes in trauma patients--beyond lactate and base deficitMitchell J Cohen
Department of Surgery, University of California, San Francisco, California, USA
J Trauma 69:31-40. 2010.... - Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in ratsRyutaro Hirose
Department of Surgery, Divisionof Transplantation, University of California, San Francisco, California 94143 0648, USA
Anesthesiology 108:402-14. 2008..The goal of this study was to examine whether transient hyperglycemia during or after renal ischemia-reperfusion increased renal dysfunction... - Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporineClaus U Niemann
Department of Anesthesia and Perioperative Care, University of California-San Francisco, San Francisco, CA, USA
J Pharmacol Exp Ther 302:1123-8. 2002..97; NAD(+): r = 0.82, P < 0.01). The reduction in cardiac energy metabolism before occlusion may be the cause of myocardial preservation during ischemia/reperfusion... - Multivessel coronary artery disease predicts mortality, length of stay, and pressor requirements after liver transplantationCelina M Yong
Division of Cardiology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
Liver Transpl 16:1242-8. 2010..This study provides preliminary evidence showing that there may be significant prognostic value in coronary angiography as a part of the pretransplant workup... - Elimination of indocyanine green in the perioperative evaluation of donor liver functionM Susan Mandell
Department of Anesthesiology, Division of Transplantation, University of Colorado Health Sciences Center, 4200 E Ninth Avenue, Denver, CO 80262, USA
Anesth Analg 95:1182-4, table of contents. 2002..IMPLICATIONS: The authors describe the intraoperative use of indocyanine green dye elimination to detect critical reductions in donor liver function... - Systemic inflammation, coagulopathy, and acute renal insufficiency following endovascular thoracoabdominal aortic aneurysm repairCatherine K Chang
Department of Surgery, Division of Vascular Surgery, University of California at San Francisco, San Francisco, Calif 94143 0222, USA
J Vasc Surg 49:1140-6. 2009..To characterize the inflammatory and coagulopathic response after endovascular thoracoabdominal aortic aneurysm (TAAA) repair and to evaluate the effect of the response on postoperative renal function... - Biochemical mechanisms of nephrotoxicity: application for metabolomicsClaus U Niemann
University of California San Francisco, Division of Transplantation, Department of Anesthesia and Perioperative Care, San Francisco, California, USA
Expert Opin Drug Metab Toxicol 3:527-44. 2007..Each of these pathways can be monitored by specific surrogate markers in urine and blood using modern metabolomics technologies... - Infrared pupillometry to detect the light reflex during cardiopulmonary resuscitation: a case seriesMatthias Behrends
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, United States
Resuscitation 83:1223-8. 2012..We asked whether the light reflex could be objectively measured during cardiopulmonary resuscitation in humans and whether the quality of the reflex was associated with outcome... - Intraoperative management of liver transplant patientsLinda L Liu
Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA 94143, USA
Transplant Rev (Orlando) 25:124-9. 2011..Existing evidence on intraoperative monitoring, intraoperative fluid and transfusion management, electrolyte and glucose management, postoperative patient disposition, and, lastly, anesthesia team management will be reviewed... - Intraoperative hyperglycemia augments ischemia reperfusion injury in renal transplantation: a prospective studyJustin Parekh
Department of Surgery, Division of Transplantation, University of California San Francisco, San Francisco, CA 94143, USA
J Transplant 2011:652458. 2011..Conclusions. Hyperglycemia is associated with increased ischemic injury in renal transplantation. Both creatinine and NGAL, a marker of ischemic injury and renal function, fall less rapidly in patients with elevated blood glucose... - Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitorsWolfgang Egge-Jacobsen
Department of Biopharmaceutical Sciences, University of California, San Francisco, California, USA
Ther Drug Monit 26:546-62. 2004..The assay allows fast analysis of patient samples for therapeutic drug monitoring (TDM) and has successfully been used for TDM and pharmacokinetic drug-drug interactions studies... - Postoperative infectious complications of abdominal solid organ transplantationNicole Hlava
Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, USA
J Intensive Care Med 24:3-17. 2009..On the basis of these factors, we put forth an algorithm for diagnosing and treating suspected infections in solid organ transplant recipients... - Mechanism of pupillary reflex dilation in awake volunteers and in organ donorsLaura L Yang
Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143-0648, USA
Anesthesiology 99:1281-6. 2003..Because it is not present in organ donors, the neural pathway must require a supraspinal component for completion... - Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxiaNatalie Serkova
Department of Biology and Chemistry, University of Bremen, Bremen, Germany
J Cereb Blood Flow Metab 22:342-52. 2002..Whether the overall effect was a reduction or protection of cell energy metabolism depended on the concentrations of both oxygen and cyclosporin A in the buffer solution... - Organ-specific response to inhibition of mitochondrial metabolism by cyclosporine in the ratNatalie Serkova
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
Transpl Int 16:748-55. 2003..The metabolic marker for nephrotoxicity, trimethylamine-N-oxide (TMAO), was elevated. While CyA decreased mitochondrial homeostasis in all organ systems, cellular adaptation was different and most efficient in the liver... - The effects of desflurane and propofol on portosystemic pressure in patients with portal hypertensionM Susan Mandell
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Anesth Analg 97:1573-7. 2003..This can cause errors in assessment of the success of medical therapy of portal hypertension. Propofol has less effect on the difference between the portal and systemic circulation... - Sirolimus delays recovery of rat kidney transplants after ischemia-reperfusion injuryT Florian Fuller
Department of Urology, , Humboldt University Berlin, Berlin, Germany
Transplantation 76:1594-9. 2003..The antiproliferative effect of SRL may translate into impairment of tubular repair and regeneration necessary for recovery after such injury... - Glutamine does not protect against hepatic warm ischemia/reperfusion injury in ratsJoonhwa Noh
Department of Urology, Kwangju Christian Hospital, Gwangju, Korea
J Gastrointest Surg 10:234-9. 2006..Pretreatment with glutamine did not reduce hepatic ischemia/reperfusion injury. The lack of protection was associated with an absence of HSP70 upregulation prior to ischemia... - Metabolic profiling of livers and blood from obese Zucker ratsNatalie J Serkova
Biomedical MRI/NMR, Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA
J Hepatol 44:956-62. 2006..CONCLUSIONS: In conclusion, NMR analysis on blood and liver tissue from obese Zucker rats reveals specific metabolic abnormalities in mitochondrial function and methionine metabolism, which result in a decreased hepatic energy state... - Beta-adrenergic blockade affects initial drug distribution due to decreased cardiac output and altered blood flow distributionMichael J Avram
Department of Anesthesiology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Ward Bldg 13 199, Chicago, IL 60611 3008, USA
J Pharmacol Exp Ther 311:617-24. 2004.... - Mild hypothermia provides significant protection against ischemia/reperfusion injury in livers of obese and lean ratsSoojinna Choi
Department of Surgery, Chonnam National University Medical School, Gwangju, Korea
Ann Surg 241:470-6. 2005..CONCLUSIONS: We demonstrated in a clinically relevant model that mild hypothermia significantly reduces hepatic injury in a warm ischemia model in lean and obese rats and significantly improved 24-hour survival in obese rats... - H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplantsNatalie Serkova
Department of Anesthesiology, Biomedical MRI/MRS, University of Colorado Health Sciences Center, Denver, Colorado, USA
Kidney Int 67:1142-51. 2005..96) and TMAO (r= 0.94). CONCLUSION: The (1)H-NMR metabolic profiles of both the mild and severe IR groups revealed significant changes consistent with graft histology, while the SCr did not... - Glutamine donor pretreatment in rat kidney transplants with severe preservation reperfusion injuryT Florian Fuller
Department of Urology, Charité University Hospital CCM, Berlin, Germany
J Surg Res 140:77-83. 2007..Glutamine (GLN) has been shown to confer cytoprotection by enhancing endogenous heat shock protein (HSP) expression. We hypothesized that GLN donor pretreatment protects rat renal grafts against severe preservation reperfusion injury (PRI)... - Early detection of graft failure using the blood metabolic profile of a liver recipientNatalie J Serkova
Department of Anesthesiology and Radiology, Biomedical MRI MRS Cancer Center Core, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Transplantation 83:517-21. 2007..This article reports the potential usefulness of quantitative H-NMR based metabolomics to diagnose early graft dysfunction in liver transplantation... - Increased severity of renal ischemia-reperfusion injury with venous clamping compared to arterial clamping in a rat modelYeonho Park
Department of Surgery, Gachon Medical School, Gil Medical Center, Incheon, Korea
Surgery 143:243-51. 2008..The goal of this study was to examine the injury pattern of renal venous outflow obstruction, compare this with the traditional model of arterial occlusion, and examine possible mechanisms... - Perioperative liver transplant best practices: weighing the evidenceM Susan Mandell
Curr Opin Organ Transplant 13:273-4. 2008 - Influence of donor pretreatment with N-acetylcysteine on ischemia/reperfusion injury in rat kidney graftsT Florian Fuller
Department of Urology, Charite University Hospital, Berlin, Germany
J Urol 171:1296-300. 2004..N-acetylcysteine (NAC) has been shown to ameliorate ischemic acute renal failure. We determined the effect of donor pretreatment with NAC on ischemia reperfusion (I/R) injury in rat kidney grafts...