V G Nielsen

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. doi Carbon monoxide-releasing molecule-2 decreases fibrinolysis in human plasma
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Blood Coagul Fibrinolysis 20:448-55. 2009
  2. doi Corn trypsin inhibitor decreases tissue-type plasminogen activator-mediated fibrinolysis of human plasma
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    Blood Coagul Fibrinolysis 20:191-6. 2009
  3. ncbi Hemodilution modulates the time of onset and rate of fibrinolysis in human and rabbit plasma
    Vance G Nielsen
    Division of Cardiothoracic Anesthesia, Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    J Heart Lung Transplant 25:1344-52. 2006
  4. ncbi Contact activation prolongs clot lysis time in human plasma: role of thrombin-activatable fibrinolysis inhibitor and Factor XIII
    Vance G Nielsen
    Department of Anesthesiology, University of Alabama at Birmingham, 619 South 19th Street, Birmingham, AL 35249 6810, USA
    J Heart Lung Transplant 25:1247-52. 2006
  5. ncbi Argatroban, bivalirudin, and lepirudin do not decrease clot propagation and strength as effectively as heparin-activated antithrombin in vitro
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    J Heart Lung Transplant 25:653-63. 2006
  6. ncbi Protamine enhances fibrinolysis by decreasing clot strength: role of tissue factor-initiated thrombin generation
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama, Birmingham, Alabama 35249 6810, USA
    Ann Thorac Surg 81:1720-7. 2006
  7. ncbi Elastic modulus-based thrombelastographic quantification of plasma clot fibrinolysis with progressive plasminogen activation
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    Blood Coagul Fibrinolysis 17:75-81. 2006
  8. ncbi Effects of aprotinin on plasma coagulation kinetics determined by thrombelastography: role of Factor XI
    V G Nielsen
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35249 6810, USA
    Acta Anaesthesiol Scand 50:168-72. 2006
  9. ncbi Effects of Hextend hemodilution on plasma coagulation kinetics in the rabbit: role of factor XIII-mediated fibrin polymer crosslinking
    Vance G Nielsen
    Department of Anesthesiology, University of Alabama at Birmingham, 619 South 19th Street, 35249 6810, USA
    J Surg Res 132:17-22. 2006
  10. ncbi Effects of PentaLyte and Voluven hemodilution on plasma coagulation kinetics in the rabbit: role of thrombin-fibrinogen and factor XIII-fibrin polymer interactions
    V G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35249 6810, USA
    Acta Anaesthesiol Scand 49:1263-71. 2005

Collaborators

Detail Information

Publications66

  1. doi Carbon monoxide-releasing molecule-2 decreases fibrinolysis in human plasma
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Blood Coagul Fibrinolysis 20:448-55. 2009
    ..These findings serve as the rationale for further investigations to determine if carbon monoxide-releasing molecules could be utilized as hemostatic agents...
  2. doi Corn trypsin inhibitor decreases tissue-type plasminogen activator-mediated fibrinolysis of human plasma
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    Blood Coagul Fibrinolysis 20:191-6. 2009
    ..In addition to anti-FXIIa effects following celite activation, CTI likely exerts an anti-tPA effect, which contributed to hypofibrinolysis in this model...
  3. ncbi Hemodilution modulates the time of onset and rate of fibrinolysis in human and rabbit plasma
    Vance G Nielsen
    Division of Cardiothoracic Anesthesia, Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    J Heart Lung Transplant 25:1344-52. 2006
    ..However, chronically, VAD-mediated fibrinolysis may also diminish thromboembolic events. Management of VADs involves fluid administration. It was hypothesized that the fluid administered could modulate fibrinolysis...
  4. ncbi Contact activation prolongs clot lysis time in human plasma: role of thrombin-activatable fibrinolysis inhibitor and Factor XIII
    Vance G Nielsen
    Department of Anesthesiology, University of Alabama at Birmingham, 619 South 19th Street, Birmingham, AL 35249 6810, USA
    J Heart Lung Transplant 25:1247-52. 2006
    ..Thus, the goals of this study were to define how fibrinolysis is modulated in human plasma by contact or tissue factor (TF) activation, and what role TAFI and FXIII plays in this system...
  5. ncbi Argatroban, bivalirudin, and lepirudin do not decrease clot propagation and strength as effectively as heparin-activated antithrombin in vitro
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    J Heart Lung Transplant 25:653-63. 2006
    ..An in vitro thrombelastographic assessment of the effects of DTIs on clot kinetics was consequently performed to determine potential causes for this complication...
  6. ncbi Protamine enhances fibrinolysis by decreasing clot strength: role of tissue factor-initiated thrombin generation
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama, Birmingham, Alabama 35249 6810, USA
    Ann Thorac Surg 81:1720-7. 2006
    ..5 minutes; thus the purpose of this study was to determine if protamine could enhance fibrinolysis, explaining the delayed, protamine-associated hemorrhage observed in the postoperative period...
  7. ncbi Elastic modulus-based thrombelastographic quantification of plasma clot fibrinolysis with progressive plasminogen activation
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    Blood Coagul Fibrinolysis 17:75-81. 2006
    ..In summary, our results serve as the rational basis to utilize this elastic modulus-based approach to quantify the extent of fibrinolysis in clinical and laboratory settings, as well as potentially guiding antifibrinolytic therapy...
  8. ncbi Effects of aprotinin on plasma coagulation kinetics determined by thrombelastography: role of Factor XI
    V G Nielsen
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35249 6810, USA
    Acta Anaesthesiol Scand 50:168-72. 2006
    ..Thus, it was hypothesized that celite-activated thrombelastography coagulation kin-etics would be decreased via aprotinin-mediated FXI inhibition...
  9. ncbi Effects of Hextend hemodilution on plasma coagulation kinetics in the rabbit: role of factor XIII-mediated fibrin polymer crosslinking
    Vance G Nielsen
    Department of Anesthesiology, University of Alabama at Birmingham, 619 South 19th Street, 35249 6810, USA
    J Surg Res 132:17-22. 2006
    ..Thus, the purpose of the present study was to determine the effect of in vivo hemodilution with Hextend (6% hydroxyethyl starch, mean molecular weight 450 kDa) on plasma coagulation kinetics...
  10. ncbi Effects of PentaLyte and Voluven hemodilution on plasma coagulation kinetics in the rabbit: role of thrombin-fibrinogen and factor XIII-fibrin polymer interactions
    V G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35249 6810, USA
    Acta Anaesthesiol Scand 49:1263-71. 2005
    ..I proposed to determine the hemostatic effect of hemodilution with PentaLyte (6% HES, mean molecular weight 220 kDa) and Voluven (6% HES, 130 kDa)...
  11. ncbi Colloids decrease clot propagation and strength: role of factor XIII-fibrin polymer and thrombin-fibrinogen interactions
    V G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35249 6810, USA
    Acta Anaesthesiol Scand 49:1163-71. 2005
    ..Investigation to determine if clinical enhancement of FXIII activity and/or FI concentration (e.g. fresh-frozen plasma, cryoprecipitate) can attenuate colloid-mediated decreases in hemostasis is warranted...
  12. ncbi Antithrombin efficiency is maintained in vitro in human plasma following dilution with hydroxyethyl starches
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    Blood Coagul Fibrinolysis 16:319-22. 2005
    ..There were no significant differences between the conditions when AT-deficient plasma was utilized (R range, 404-440 s). Rather than interfere with AT activity, HES with an average molecular weight of 220-450 kDa maintain AT efficiency...
  13. ncbi Qualitative thrombelastographic detection of tissue factor in human plasma
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    Anesth Analg 104:59-64. 2007
    ..Thus, our goal in the present investigation was to establish a concentration-response relationship of the effect of TF on TEG variables, and determine specificity of TF-mediated events with a monoclonal TF antibody...
  14. ncbi Quantification of the effects of thrombin activatable fibrinolysis inhibitor and alpha2-antiplasmin on fibrinolysis in normal human plasma
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Alabama 35249 6810, USA
    Blood Coagul Fibrinolysis 18:29-33. 2007
    ..Future investigation of diseases involving hypofibrinolysis (e.g. left ventricular assist devices) could be conducted using this assay system...
  15. ncbi Hydroxyethyl starch enhances argatroban-mediated decreases in clot propagation and strength by diminishing thrombin-fibrinogen interactions
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Alabama 35249 6810, USA
    Blood Coagul Fibrinolysis 18:49-54. 2007
    ..Further investigation is warranted to determine whether this therapeutic approach can improve the safety of anticoagulation during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia...
  16. doi Argatroban enhances fibrinolysis by differential inhibition of thrombin-mediated activation of thrombin activatable fibrinolysis inhibitor and factor XIII
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    Blood Coagul Fibrinolysis 19:793-800. 2008
    ..The mechanism by which argatroban more efficiently enhanced fibrinolysis was via a differential inhibition of thrombin-mediated activation of TAFI and FXIII...
  17. doi Patient with hypofibrinolysis-mediated thromboembolism converted to a hypercoagulable/hyperfibrinolytic state via ventricular assist device placement
    Vance G Nielsen
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    J Heart Lung Transplant 27:1169-71. 2008
    ..Such complex patient-VAD-hemostatic-state interactions serve as the rationale for continuing investigation of the effects of mechanical circulation on the fibrinolytic system and thrombophilia...
  18. doi Mechanical circulatory device thrombosis: a new paradigm linking hypercoagulation and hypofibrinolysis
    Vance G Nielsen
    Departments of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    ASAIO J 54:351-8. 2008
    ....
  19. doi Clot life span model analysis of clot growth and fibrinolysis in normal subjects: role of thrombin activatable fibrinolysis inhibitor
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    Blood Coagul Fibrinolysis 19:283-7. 2008
    ..Study of disease states involving potential hypofibrinolysis (e.g., in-situ ventricular assist device, cancer) could be conducted using this system to link fibrinolytic vulnerability and thrombophilia...
  20. ncbi Beyond cell based models of coagulation: analyses of coagulation with clot "lifespan" resistance-time relationships
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, 901 South 19th Street, Basic Medical Research II, Room 206, Birmingham, Alabama 35249 6810, USA
    Thromb Res 122:145-52. 2008
    ....
  21. ncbi Hemostatic analysis of a 13 year old with antiphospholipid syndrome and restrictive pericarditis
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 2172, USA
    Blood Coagul Fibrinolysis 18:695-7. 2007
    ....
  22. ncbi Hydroxyethyl starch enhances fibrinolysis in human plasma by diminishing alpha2-antiplasmin-plasmin interactions
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    Blood Coagul Fibrinolysis 18:647-56. 2007
    ..Further laboratory and clinical investigation is warranted to better define the mechanisms by which HES enhances clot disintegration and to find new therapeutic roles for HES to either prevent or treat thrombosis...
  23. ncbi High-molecular-weight hydroxyethyl starch accelerates kallikrein-dependent clot initiation
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    J Trauma 62:1491-4. 2007
    ..Thus, this study proposed to define whether HES affects kallikrein-dependent clot initiation...
  24. ncbi A comparison of the Thrombelastograph and the ROTEM
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    Blood Coagul Fibrinolysis 18:247-52. 2007
    ..Given these data and the differences in proprietary activator, divergent results are expected, perhaps affecting clinical decision-making...
  25. ncbi Thrombelastographic method to quantify the contribution of factor XIII to coagulation kinetics
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Blood Coagul Fibrinolysis 18:145-50. 2007
    ..Further actuarial investigation will be required to determine the utility of this approach in the diagnosis and treatment of patients with either acquired FXIII deficiency or excess and concordant coagulopathy...
  26. ncbi Epsilon-aminocaproic acid inhibition of fibrinolysis in vitro: should the 'therapeutic' concentration be reconsidered?
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama, Birmingham, Alabama, USA
    Blood Coagul Fibrinolysis 18:35-9. 2007
    ..Further clinical investigation is warranted to determine whether smaller concentrations of EACA could provide a reduction in bleeding with a concomitant decrease in thrombotic complications...
  27. doi Clot lifespan model analysis of the effects of warfarin on thrombus growth and fibrinolysis: role of contact protein and tissue factor initiation
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    ASAIO J 55:33-40. 2009
    ..Only the time to maximum rate of lysis was correlated with INR (r=0.36, p=0.005). INR values have little correlation with the difference between contact protein and TF-activated coagulation/fibrinolysis...
  28. ncbi Hemostatic analysis of a patient undergoing off-pump coronary artery bypass surgery with argatroban anticoagulation
    Derek R Kieta
    Department of Anesthesiology, The University of Alabama at Birmingham, 619 South 19th Street, Birmingham, AL 35249 6810, USA
    Anesth Analg 96:956-8, table of contents. 2003
    ..This case describes the impact of argatroban and off-pump coronary revascularization on hemostasis as assessed by conventional hemostatic measures and Thrombelastography in a patient with heparin-induced thrombocytopenia...
  29. ncbi Xanthine oxidase inactivation attenuates postocclusion shock after descending thoracic aorta occlusion and reperfusion in rabbits
    V G Nielsen
    Department of Anesthesiology, University of Alabama at Birmingham 35233 6810, USA
    J Thorac Cardiovasc Surg 110:715-22. 1995
    ..007). Resuscitation requirements and systemic injury were reduced by inactivation of xanthine oxidase in a rabbit model that simulates the situation of human thoracic aorta operations...
  30. ncbi Hemodilution with albumin, but not Hextend, results in hypercoagulability as assessed by Thrombelastography in rabbits: role of heparin-dependent serpins and factor VIII complex
    Andrew T McCammon
    Department of Anesthesiology, The University of Alabama at Birmingham, 35249, USA
    Anesth Analg 95:844-50, table of contents. 2002
    ..These data serve as a rational basis to determine whether IVHD-mediated hypercoagulability encountered clinically may be attenuated or exacerbated by the choice of colloid administered...
  31. ncbi Extreme, progressive isovolemic hemodilution with 5% human albumin, PentaLyte, or Hextend does not cause hepatic ischemia or histologic injury in rabbits
    V G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, 35249 6810, USA
    Anesthesiology 90:1428-35. 1999
    ..The authors hypothesized that hepatic ischemia, systemic ischemia, and tissue injury would occur during hemodilution in rabbits, and that the severity of ischemia and injury may be dependent on the fluid administered...
  32. doi Carbon monoxide releasing molecule-2 enhances coagulation and diminishes fibrinolytic vulnerability in subjects exposed to warfarin
    Vance G Nielsen
    Department of Anesthesiology, Drexel University College of Medicine, and Hahnemann University Hospital, Philadelphia, PA 19102, USA
    Thromb Res 126:68-73. 2010
    ..We tested the hypothesis that plasma obtained from warfarin-treated subjects would demonstrate improved coagulation and decreased fibrinolytic vulnerability following exposure to CORM-2...
  33. ncbi Pentalyte does not decrease heparinoid release but does decrease circulating thrombotic mediator activity associated with aortic occlusion-reperfusion in rabbits
    V G Nielsen
    Department of Anesthesiology, Division of Cardiothoracic Anesthesia, The University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Anesth Analg 92:314-9. 2001
    ..PentaLyte administration does not decrease heparinoid release but does decrease thrombotic mediator release after aortic occlusion-reperfusion...
  34. ncbi Halothane and xanthine oxidase increase hepatocellular enzyme release and circulating lactate after ischemia-reperfusion in rabbits
    V G Nielsen
    Department of Anesthesiology, University of Alabama at Birmingham, 35233 6810, USA
    Anesthesiology 87:908-17. 1997
    ..Halogenated anesthetics modify oxidant-mediated injury. The current study determined if halothane modifies hepatocellular enzyme release (e.g., alanine aminotransferase) and circulating lactate after aortic occlusion-reperfusion...
  35. ncbi Desflurane increases pulmonary alveolar-capillary membrane permeability after aortic occlusion-reperfusion in rabbits: evidence of oxidant-mediated lung injury
    V G Nielsen
    Department of Anesthesiology, Center for Free Radical Biology, The University of Alabama at Birmingham, 35233 6810, USA
    Anesthesiology 88:1524-34. 1998
    ....
  36. ncbi Evaluation of the contribution of platelets to clot strength by thromboelastography in rabbits: the role of tissue factor and cytochalasin D
    V G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, 35249, USA
    Anesth Analg 91:35-9. 2000
    ..G(P) did not significantly correlate with platelet concentration in the absence or presence of tissue factor. The contribution of G(P) to G(T) is similar to that observed in humans...
  37. ncbi Thoracic aorta occlusion-reperfusion decreases hemostasis as assessed by thromboelastography in rabbits
    V G Nielsen
    Department of Anesthesiology, Division of Cardiothoracic Anesthesia, The University of Alabama at Birmingham, 35249, USA
    Anesth Analg 91:517-21. 2000
    ..Aortic occlusion-reperfusion decreased hemostatic function in rabbits primarily by decreasing the coagulation factor-dependent, platelet-independent contribution to clotting...
  38. ncbi DETANONOate, a nitric oxide donor, decreases amiloride-sensitive alveolar fluid clearance in rabbits
    V G Nielsen
    Department of Anesthesiology Divisions of Cardiothoracic Anesthesia and Anesthesiology Research, The University of Alabama at Birmingham, Birmingham, Alabama 35233 6810, USA
    Am J Respir Crit Care Med 161:1154-60. 2000
    ..DETANONOate does not influence total AFC secondary to an increase in the amiloride-insensitive fraction of AFC that is not associated with a decrease in alveolar Cl(-) secretion...
  39. ncbi Effects of coagulation factor deficiency on plasma coagulation kinetics determined via thrombelastography: critical roles of fibrinogen and factors II, VII, X and XII
    V G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35249 6810, USA vnielson uab edu
    Acta Anaesthesiol Scand 49:222-31. 2005
    ..Thrombelastography (TEG) is used to assess coagulopathy. However, a comprehensive characterization of the effects of specific coagulation factor deficiencies and mode of activation on TEG data does not exist...
  40. ncbi Extreme hemodilution in rabbits: an in vitro and in vivo Thrombelastographic analysis
    V G Nielsen
    Department of Anesthesiology, Divisions of Cardiothoracic Anesthesia and Anesthesiology Research, The University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Anesth Analg 90:541-5. 2000
    ..However, although in vivo hemodilution significantly (P < 0.05) decreased reaction time, increased the alpha angle, and decreased maximal amplitude, there were no significant fluid-dependent effects...
  41. ncbi Halothane does not decrease amiloride-sensitive alveolar fluid clearance in rabbits
    V G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Anesth Analg 90:1445-9. 2000
    ..Implications: Unlike the rat, the ability of the rabbit to clear fluid from the alveolar space through amiloride-sensitive pathways is not decreased by halothane anesthesia...
  42. ncbi Resuscitation with Hextend decreases endogenous circulating heparin activity and accelerates clot initiation after hemorrhage in the rabbit
    V G Nielsen
    Department of Anesthesiology, Divisions of Cardiothoracic Anesthesia and Anesthesiology Research, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    Anesth Analg 93:1106-10. 2001
    ..3 +/- 5.6 mU/mL after resuscitation). A Hextend)-mediated decrease of both heparin and antithrombin III activity may explain the acceleration of clot initiation compared with albumin administration after hemorrhage in the rabbit...
  43. ncbi Hemostatic analysis of a patient with hereditary angioedema undergoing coronary artery bypass grafting
    J D Chaney
    Department of Anesthesiology, The University of Alabama at Birmingham, 35249, USA
    Anesth Analg 93:1480-2, table of contents. 2001
    ..This case describes the impact of hereditary angioedema and cardiopulmonary bypass on hemostasis as assessed by thrombelastography...
  44. ncbi Endogenous heparin decreases the thrombotic response to hemorrhagic shock in rabbits
    V G Nielsen
    Department of Anesthesiology, Division of Cardiothoracic Anesthesia, The University of Alabama at Birmingham, 35249, USA
    J Crit Care 16:64-8. 2001
    ..Heparin-mediated regulation of hemostasis may serve as a protective mechanism in shock states...
  45. doi Carbon monoxide releasing molecule-2 increases the velocity of thrombus growth and strength in human plasma
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Blood Coagul Fibrinolysis 20:377-80. 2009
    ..Carbon monoxide and iCORM-2 derived from CORM-2 markedly enhance the velocity of clot growth and strength. These findings serve as the rationale for further investigations to determine if CORMs could be utilized as hemostatic agents...
  46. ncbi The hemostatic history of a 15-month-old child implanted with a Berlin heart left ventricular assist device
    Brad L Steenwyk
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35294 2172, USA
    Anesth Analg 104:538-40. 2007
    ..In summary, when proscribing anesthetic and surgical management of patients with a Berlin Heart, consideration of hypercoagulable features and anticoagulant therapy must be made to maximize patient safety...
  47. ncbi Nitric oxide decreases coagulation protein function in rabbits as assessed by thromboelastography
    V G Nielsen
    Department of Anesthesiology, Division of Cardiothoracic Anesthesia, The University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Anesth Analg 92:320-3. 2001
    ..3%). DETANONOate-derived NO significantly decreased coagulation protein function and platelet function. Coagulation protein function may be similarly affected in clinical situations involving the administration of NO or NO donors...
  48. ncbi The detection of changes in heparin activity in the rabbit: a comparison of anti-xa activity, thrombelastography, activated partial thromboplastin time, and activated coagulation time
    Vance G Nielsen
    Department of Anesthesiology Divisions of Cardiothoracic Anesthesia and Anesthesiology Research, The University of Alabama at Birmingham, 35249, USA
    Anesth Analg 95:1503-6, table of contents. 2002
    ..85, P < 0.0001), aPTT (r = 0.74, P < 0.0001), and ACT (r = 0.41, P = 0.005). In this model of small-dose heparin administration, TEG variables were more sensitive to changes in heparin activity than aPTT and ACT...
  49. ncbi Peroxynitrite decreases rabbit tissue factor activity in vitro
    Vance G Nielsen
    Department of Anesthesiology, The Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35249 6810, USA
    Anesth Analg 98:668-71, table of contents. 2004
    ..We determined that OONO(-) decreased rabbit TF activity in vitro via thrombelastography(R)...
  50. ncbi Peroxynitrite decreases hemostasis in human plasma in vitro
    Vance G Nielsen
    Department of Anesthesiology, The Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    Anesth Analg 99:21-6. 2004
    ..We conclude that OONO- may decrease hemostatic function in human plasma by nitration of key procoagulants and that OONO- may play a significant role in hemorrhagic states...
  51. ncbi Coagulopathy mediated by hepatoenteric ischemia-reperfusion in rabbits: role of xanthine oxidase
    Vance G Nielsen
    Department of Anesthesiology, University of Alabama at Birmingham, 619 South 19th Street, Birmingham, AL 35249, USA
    Transplantation 74:1181-3. 2002
    ..XO inactivation enhances hemostasis by decreasing circulating heparin activity and increasing coagulation protein function before ischemia-reperfusion...
  52. ncbi Peroxynitrite inactivates tissue plasminogen activator
    Vance G Nielsen
    Department of Anesthesiology, The Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    Anesth Analg 98:1312-7, table of contents. 2004
    ..001) different from the other three conditions. There were no significant differences between the other conditions. We conclude that tPA is inhibited by OONO(-), and that OONO(-) may have a role in clinical thrombotic scenarios...
  53. ncbi The impact of factor XIII on coagulation kinetics and clot strength determined by thrombelastography
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, 35249 6810, USA
    Anesth Analg 99:120-3. 2004
    ..89; P < 0.001). We concluded that FXHI significantly affects R, alpha, A, and G. Thus, transfusion decision making with protein-mediated thrombelastographic patterns must account for the contribution of both fibrinogen and FXIII...
  54. ncbi The impact of tissue factor pathway inhibitor on coagulation kinetics determined by thrombelastography
    Paul Audu
    Department of Anesthesiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Anesth Analg 103:841-5. 2006
    ..Thus, in this study we characterized the effect of TFPI on coagulation kinetics via TEG...
  55. ncbi Glucose-insulin-potassium infusion for myocardial protection during off-pump coronary artery surgery
    William A Lell
    Department of Anesthesiology, The University of Alabama at Birmingham, 35249 6810, USA
    Ann Thorac Surg 73:1246-51; discussion 1251-2. 2002
    ....
  56. doi Carbon monoxide releasing molecule-2 decreases thick diameter fibrin fibre formation in normal and Factor XIII deficient plasmas
    Vance G Nielsen
    Department of Anesthesiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Blood Coagul Fibrinolysis 21:101-5. 2010
    ..CORM-2 significantly modifies thrombin-mediated polymerization of fibrin. This finding may partially explain how CORM-2 exposure results in stronger thrombi resistant to fibrinolysis...
  57. ncbi The effect of dilution on plasma coagulation kinetics determined by thrombelastography is dependent on antithrombin activity and mode of activation
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, 619 So 19th St, Birmingham, AL 35249 6810, USA
    Anesth Analg 99:1587-92, table of contents. 2004
    ..Thus, our data indirectly support the concept that decreases in AT activity cause dilution-mediated hypercoagulability in plasma. Finally, celite activation permits quantification of dilution with TEG...
  58. doi Carbon monoxide releasing molecule-2 increases the velocity of thrombus growth and strength in hemophilia A, hemophilia B and factor VII-deficient plasmas
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Blood Coagul Fibrinolysis 21:41-5. 2010
    ..CORM-2 markedly enhanced the velocity of clot growth and strength in hemophiliac plasma. These findings serve as the rationale to determine whether CORMs could be utilized as hemostatic agents...
  59. ncbi Hemodilution with lactated Ringer's solution causes hypocoagulability in rabbits
    Vance G Nielsen
    Department of Anesthesiology, Division of Cardiothoracic Anesthesia, The University of Alabama at Birmingham, Alabama 35249 6810, USA
    Blood Coagul Fibrinolysis 15:55-9. 2004
    ..Hemodilution with LR caused hypocoagulability in the rabbit. A greater decrease in circulating procoagulant activity than anticoagulant activity appears to be the mechanism underlying HD-mediated decreases in hemostasis...
  60. ncbi Prophylactic value of preincision intra-aortic balloon pump: analysis of a statewide experience
    W L Holman
    Departments of Surgery, Medicine, and Anesthesiology, University of Alabama at Birmingham, Birmingham
    J Thorac Cardiovasc Surg 120:1112-9. 2000
    ....
  61. doi Practical approach to anticoagulation for cardiopulmonary bypass in the patient with congenital prolonged activated partial thromboplastin time
    Lana Cankovic
    Department of Anesthesiology, The University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35294, USA
    Blood Coagul Fibrinolysis 19:725-6. 2008
    ..This approach, and the other alternatives previously mentioned, can be utilized to safely care for these rare patients in the setting of cardiac surgery...
  62. ncbi Thrombelastographic measures of clot propagation: a comparison of alpha with the maximum rate of thrombus generation
    Truitt C Ellis
    Department of Anesthesiology, The University of Alabama at Birmingham, Alabama 35249 6810, USA
    Blood Coagul Fibrinolysis 18:45-8. 2007
    ..The MRTG should be progressively utilized to a greater extent in both laboratory and clinical settings to parametrically quantify clot growth kinetics with thrombelastography...
  63. ncbi Carbon monoxide releasing molecule-2 increases fibrinogen-dependent coagulation kinetics but does not enhance prothrombin activity
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, USA
    Blood Coagul Fibrinolysis 21:349-53. 2010
    ....
  64. ncbi Hypercoagulability in the perioperative period
    Vance G Nielsen
    Drexel University College of Medicine, Department of Anesthesiology, Philadelphia, Pennsylvania 19102, USA
    Best Pract Res Clin Anaesthesiol 24:133-44. 2010
    ....
  65. ncbi Fibrinogen and bleeding: old molecule--new ideas
    Vance G Nielsen
    Anesth Analg 105:902-3. 2007
  66. ncbi Effects of hydroxyethyl starch and calcium on platelet activation
    Vance G Nielsen
    Anesth Analg 100:1538; author reply 1538-9. 2005