Michael Niederweis

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Identification of two Mycobacterium smegmatis lipoproteins exported by a SecA2-dependent pathway
    Henry S Gibbons
    Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7290, USA
    J Bacteriol 189:5090-100. 2007
  2. pmc Functional expression of the Flp recombinase in Mycobacterium bovis BCG
    Houhui Song
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294, USA
    Gene 399:112-9. 2007
  3. ncbi request reprint Purification of porins from Mycobacterium smegmatis
    Christian Heinz
    Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Germany
    Methods Mol Biol 228:139-50. 2003
  4. ncbi request reprint Mycobacterial porins--new channel proteins in unique outer membranes
    Michael Niederweis
    Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Staudtstr 5, 91058 Erlangen, Germany
    Mol Microbiol 49:1167-77. 2003
  5. pmc Porins are required for uptake of phosphates by Mycobacterium smegmatis
    Frank Wolschendorf
    Department of Microbiology, University of Alabama at Birmingham, Mail Box 24, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294, USA
    J Bacteriol 189:2435-42. 2007
  6. pmc MspA nanopores from subunit dimers
    Mikhail Pavlenok
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 7:e38726. 2012
  7. pmc DNA-free RNA preparations from mycobacteria
    Joachim Stephan
    Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Staudtstr, 5, D 91058 Erlangen, Germany
    BMC Microbiol 4:45. 2004
  8. doi request reprint Nutrient acquisition by mycobacteria
    Michael Niederweis
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294, USA
    Microbiology 154:679-92. 2008
  9. pmc Mycobacterial outer membranes: in search of proteins
    Michael Niederweis
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294, USA
    Trends Microbiol 18:109-16. 2010
  10. pmc Discovery of a siderophore export system essential for virulence of Mycobacterium tuberculosis
    Ryan M Wells
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Pathog 9:e1003120. 2013

Research Grants

  1. Copper transport in Mycobacterium tuberculosis
    Michael Niederweis; Fiscal Year: 2010
  2. Copper transport in Mycobacterium tuberculosis
    Michael Niederweis; Fiscal Year: 2009
  3. Porins of Mycobacterium tuberculosis
    Michael Niederweis; Fiscal Year: 2006
  4. Porins of Mycobacterium tuberculosis
    Michael Niederweis; Fiscal Year: 2007
  5. Porins of Mycobacterium tuberculosis
    Michael Niederweis; Fiscal Year: 2009

Collaborators

Detail Information

Publications45

  1. pmc Identification of two Mycobacterium smegmatis lipoproteins exported by a SecA2-dependent pathway
    Henry S Gibbons
    Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7290, USA
    J Bacteriol 189:5090-100. 2007
    ..smegmatis and M. tuberculosis...
  2. pmc Functional expression of the Flp recombinase in Mycobacterium bovis BCG
    Houhui Song
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294, USA
    Gene 399:112-9. 2007
    ..smegmatis, but can also be used in slow growing mycobacteria such as M. tuberculosis for constructing unmarked mutations. Other more sophisticated applications in mycobacterial genetics would also profit from the improved Flp/FRT system...
  3. ncbi request reprint Purification of porins from Mycobacterium smegmatis
    Christian Heinz
    Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Germany
    Methods Mol Biol 228:139-50. 2003
  4. ncbi request reprint Mycobacterial porins--new channel proteins in unique outer membranes
    Michael Niederweis
    Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Staudtstr 5, 91058 Erlangen, Germany
    Mol Microbiol 49:1167-77. 2003
    ..smegmatis for hydrophilic solutes. The importance of the synergism between slow transport through the porins and drug efflux or inactivation for the development of drugs against M. tuberculosis is discussed...
  5. pmc Porins are required for uptake of phosphates by Mycobacterium smegmatis
    Frank Wolschendorf
    Department of Microbiology, University of Alabama at Birmingham, Mail Box 24, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294, USA
    J Bacteriol 189:2435-42. 2007
    ..However, porins that could mediate the diffusion of phosphates across the OM of M. bovis BCG and Mycobacterium tuberculosis are unknown...
  6. pmc MspA nanopores from subunit dimers
    Mikhail Pavlenok
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 7:e38726. 2012
    ..This approach will be valuable both in understanding transport across the outer membrane in mycobacteria and in tailoring MspA for nanopore sequencing of DNA...
  7. pmc DNA-free RNA preparations from mycobacteria
    Joachim Stephan
    Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Staudtstr, 5, D 91058 Erlangen, Germany
    BMC Microbiol 4:45. 2004
    ..To understand mycobacterial pathogenesis analysis of gene expression by quantification of RNA levels becomes increasingly important. However, current preparation methods yield mycobacterial RNA that is contaminated with chromosomal DNA...
  8. doi request reprint Nutrient acquisition by mycobacteria
    Michael Niederweis
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294, USA
    Microbiology 154:679-92. 2008
    ..tuberculosis will not only promote our understanding of the physiology of this important human pathogen, but might also be exploited to improve tuberculosis chemotherapy...
  9. pmc Mycobacterial outer membranes: in search of proteins
    Michael Niederweis
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294, USA
    Trends Microbiol 18:109-16. 2010
    ..Through comparison to transport processes in Gram-negative bacteria, we highlight several hypothetical outer membrane proteins of M. tuberculosis that await discovery...
  10. pmc Discovery of a siderophore export system essential for virulence of Mycobacterium tuberculosis
    Ryan M Wells
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Pathog 9:e1003120. 2013
    ..In conclusion, this study identified the first components of novel siderophore export systems which are essential for virulence of Mtb...
  11. pmc Rv1698 of Mycobacterium tuberculosis represents a new class of channel-forming outer membrane proteins
    Axel Siroy
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Biol Chem 283:17827-37. 2008
    ..tuberculosis. Rv1698 has single homologs of unknown functions in Corynebacterineae and thus represents the first member of a new class of channel proteins specific for mycolic acid-containing outer membranes...
  12. pmc Copper-boosting compounds: a novel concept for antimycobacterial drug discovery
    Alexander Speer
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Antimicrob Agents Chemother 57:1089-91. 2013
    ..tuberculosis and demonstrate that such copper-boosting compounds are effective against replicating and nonreplicating M. tuberculosis strains...
  13. pmc Identification of a novel multidrug efflux pump of Mycobacterium tuberculosis
    Olga Danilchanka
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, Alabama 35294, USA
    Antimicrob Agents Chemother 52:2503-11. 2008
    ..Both effects were abrogated in the presence of the efflux pump inhibitor reserpine. These results demonstrate that Rv0194 is a novel multidrug efflux pump of M. tuberculosis...
  14. pmc An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity
    Olga Danilchanka
    Departments of Microbiology and Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL 35294
    Proc Natl Acad Sci U S A 111:6750-5. 2014
    ..Furthermore, we demonstrate that the C-terminal domain of CpnT causes necrotic cell death in eukaryotic cells. Thus, CpnT has a dual function in uptake of nutrients and induction of host cell death by M. tuberculosis. ..
  15. pmc Role of porins for uptake of antibiotics by Mycobacterium smegmatis
    Olga Danilchanka
    Department of Microbiology, University of Alabama at Birmingham, Alabama 35294, USA
    Antimicrob Agents Chemother 52:3127-34. 2008
    ..avium, M. chelonae, and M. fortuitum, which have Msp-like porins, to acquire resistance to fluoroquinolones...
  16. pmc Functions of the periplasmic loop of the porin MspA from Mycobacterium smegmatis
    Jason Huff
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 284:10223-31. 2009
    ..This is the first study identifying a molecular determinant of solute translocation in a mycobacterial porin...
  17. doi request reprint Construction of unmarked deletion mutants in mycobacteria
    Houhui Song
    Department of Microbiology, University of Alabama at Birmingham, Alabama 35294, USA
    Methods Mol Biol 465:279-95. 2009
    ..In this chapter, we describe strategies and methods of how to use sequence-specific recombination mediated by Flp and Cre to construct mutants of Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis...
  18. pmc Expression of the ompATb operon accelerates ammonia secretion and adaptation of Mycobacterium tuberculosis to acidic environments
    Houhui Song
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294, USA
    Mol Microbiol 80:900-18. 2011
    ..Taken together, these results show that the ompATb operon is necessary for rapid ammonia secretion and adaptation of M. tuberculosis to acidic environments in vitro but not in mice...
  19. pmc Mycobacterium tuberculosis is resistant to streptolydigin
    Alexander Speer
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294, USA
    Tuberculosis (Edinb) 93:401-4. 2013
    ..smegmatis, the absence of MspA-like porins probably contributes to the resistance of Mtb to streptolydigin. This study shows that streptolydigin is not a suitable drug in TB treatment regimens...
  20. pmc Copper resistance is essential for virulence of Mycobacterium tuberculosis
    Frank Wolschendorf
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 108:1621-6. 2011
    ..Hence, this study reveals an Achilles heel of Mtb that might be a promising target for tuberculosis chemotherapy...
  21. pmc Self-poisoning of Mycobacterium tuberculosis by interrupting siderophore recycling
    Christopher M Jones
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294
    Proc Natl Acad Sci U S A 111:1945-50. 2014
    ..This study indicates that targeting siderophore export/recycling would deliver a one-two punch to Mtb: restricting access to iron and causing toxic intracellular siderophore accumulation. ..
  22. pmc Uptake of sulfate but not phosphate by Mycobacterium tuberculosis is slower than that for Mycobacterium smegmatis
    Houhui Song
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Bacteriol 194:956-64. 2012
    ..tuberculosis. However, the uptake of these anions by M. tuberculosis is orders of magnitude faster than diffusion through lipid membranes, indicating that unknown outer membrane proteins are required to facilitate this process...
  23. pmc Identification of outer membrane proteins of Mycobacterium tuberculosis
    Houhui Song
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294, USA
    Tuberculosis (Edinb) 88:526-44. 2008
    ..tuberculosis likely has many OMPs with beta-barrel structure. Our findings pave the way to identify the set of proteins which functionalize the outer membrane of M. tuberculosis...
  24. pmc Mycobacterium tuberculosis can utilize heme as an iron source
    Christopher M Jones
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294, USA
    J Bacteriol 193:1767-70. 2011
    ..Here, we demonstrate that Mycobacterium tuberculosis can utilize heme as an iron source, suggesting that M. tuberculosis possesses a yet-unknown heme acquisition system...
  25. doi request reprint Antimycobacterial activity in vitro of pigments isolated from Antarctic bacteria
    Nazia Mojib
    Department of Biology, University of Alabama at Birmingham, 35294 1170, USA
    Antonie Van Leeuwenhoek 98:531-40. 2010
    ..Our results indicate these pigments isolated from Antarctic bacteria might be valuable lead compounds for new antimycobacterial drugs used for chemotherapy of tuberculosis...
  26. pmc Role of porins in iron uptake by Mycobacterium smegmatis
    Christopher M Jones
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, Alabama 35294, USA
    J Bacteriol 192:6411-7. 2010
    ..These results provide, to our knowledge, the first experimental evidence that general porins are indeed the outer membrane conduit of low-affinity iron acquisition systems in bacteria...
  27. pmc Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs
    Zuzana Svetlikova
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Antimicrob Agents Chemother 53:4015-8. 2009
    ..chelonae to drugs, there is thus some concern that the widespread use of glutaraldehyde and ortho-phthalaldehyde in clinical settings may select for drug-resistant bacteria...
  28. pmc A multicopper oxidase is required for copper resistance in Mycobacterium tuberculosis
    Jennifer L Rowland
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Bacteriol 195:3724-33. 2013
    ..Our study revealed MmcO as an important copper resistance mechanism of M. tuberculosis, which possibly acts by oxidation of toxic Cu(I) in the periplasm. ..
  29. pmc Resistance mechanisms of Mycobacterium tuberculosis against phagosomal copper overload
    Jennifer L Rowland
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294, USA
    Tuberculosis (Edinb) 92:202-10. 2012
    ..These findings reveal an intricate interplay between the host which aims to overload the phagosome with copper and M. tuberculosis which utilizes several mechanisms to reduce the toxic effects of excess copper...
  30. pmc Multidrug resistance of a porin deletion mutant of Mycobacterium smegmatis
    Joachim Stephan
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th St South, Birmingham, AL 35294, USA
    Antimicrob Agents Chemother 48:4163-70. 2004
    ..smegmatis to antibiotics. An understanding of the pathways across the outer membrane is essential to the successful design of chemotherapeutic agents with activities against mycobacteria...
  31. pmc Taking phage integration to the next level as a genetic tool for mycobacteria
    Jason Huff
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294, USA
    Gene 468:8-19. 2010
    ..tuberculosis strains with multiple integrations of gfp increased concomitantly with the copy number demonstrating that these vectors can be used to generate stronger phenotypes and/or to analyze several genes simultaneously in vivo...
  32. pmc Hit-and-run stimulation: a novel concept to reactivate latent HIV-1 infection without cytokine gene induction
    Frank Wolschendorf
    Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Virol 84:8712-20. 2010
    ..In the absence of such a positive feedback mechanism, cellular gene expression was not sustained, suggesting that strategies modulating the NF-kappaB activity profile could be used to selectively trigger HIV-1 reactivation...
  33. pmc Expression of the major porin gene mspA is regulated in Mycobacterium smegmatis
    Dietmar Hillmann
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294, USA
    J Bacteriol 189:958-67. 2007
    ..These results show for the first time that M. smegmatis regulates porin gene expression to optimize uptake of certain nutrients and to protect itself from toxic solutes...
  34. pmc A genomic view of sugar transport in Mycobacterium smegmatis and Mycobacterium tuberculosis
    Fritz Titgemeyer
    Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Staudtstrasse 5, D 91058 Erlangen, Germany
    J Bacteriol 189:5903-15. 2007
    ..smegmatis and M. tuberculosis in their natural habitats, the soil and the human body, respectively...
  35. ncbi request reprint Identification and semi-quantitative analysis of Mycobacterium tuberculosis H37Rv ftsZ gene-specific promoter activity-containing regions
    Sougata Roy
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India
    Res Microbiol 155:817-26. 2004
    ..tuberculosis quantitatively confirmed these promoter activities. Thus, at least three independent regions in the immediate upstream sequence of MtftsZ contain promoter activity, with the major contribution coming from ftsQ ORF...
  36. ncbi request reprint Consecutive gene deletions in Mycobacterium smegmatis using the yeast FLP recombinase
    Joachim Stephan
    Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Staudtstr 5, D 91058 Erlangen, Germany
    Gene 343:181-90. 2004
    ..These results show that the Flp/FRT system is a suitable genetic tool for constructing unmarked mutations and for the analysis of redundant genes by consecutive gene deletions in M. smegmatis...
  37. ncbi request reprint A tetrameric porin limits the cell wall permeability of Mycobacterium smegmatis
    Harald Engelhardt
    Max Planck Institut fur Biochemie, Abteilung Molekulare Strukturbiologie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    J Biol Chem 277:37567-72. 2002
    ..The length of MspA is sufficient to span the outer membrane and contributes in combination with the tapering end of the pore and the low number of pores to the low permeability of the cell wall of M. smegmatis for hydrophilic compounds...
  38. ncbi request reprint Characterization of nanostructured surfaces generated by reconstitution of the porin MspA from Mycobacterium smegmatis
    Michael Wörner
    Department of Chemical and Process Engineering, University of Karlsruhe, 76128 Karlsruhe, Germany
    Small 3:1084-97. 2007
    ....
  39. ncbi request reprint The core of the tetrameric mycobacterial porin MspA is an extremely stable beta-sheet domain
    Christian Heinz
    Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Staudtstr 5, Germany
    J Biol Chem 278:8678-85. 2003
    ..Thus, MspA may be of special interest for biotechnological applications...
  40. ncbi request reprint The MspA porin promotes growth and increases antibiotic susceptibility of both Mycobacterium bovis BCG and Mycobacterium tuberculosis
    Claudia Mailaender
    Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Staudtstr 5, D 91058 Erlangen, Germany
    Microbiology 150:853-64. 2004
    ..This study provides the first experimental evidence that porins are important for drug susceptibility of M. tuberculosis...
  41. ncbi request reprint The growth rate of Mycobacterium smegmatis depends on sufficient porin-mediated influx of nutrients
    Joachim Stephan
    Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Staudtstrasse 5, D 91058 Erlangen, Germany
    Mol Microbiol 58:714-30. 2005
    ..smegmatis dropped drastically with its porin-mediated OM permeability in contrast to porin mutants of Escherichia coli. These results show that porin-mediated influx of nutrients is a major determinant of the growth rate of M. smegmatis...
  42. pmc Disclosure of the mycobacterial outer membrane: cryo-electron tomography and vitreous sections reveal the lipid bilayer structure
    Christian Hoffmann
    Max Planck Institut fur Biochemie, Abteilung Molekulare Strukturbiologie, D 82152 Martinsried, Germany
    Proc Natl Acad Sci U S A 105:3963-7. 2008
    ..These results are crucial for the investigation and understanding of transport processes across the mycobacterial cell wall, and they are of particular medical relevance in the case of pathogenic mycobacteria...
  43. ncbi request reprint Porins limit the intracellular persistence of Mycobacterium smegmatis
    Soroush Sharbati-Tehrani
    Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Microbiology 151:2403-10. 2005
    ..smegmatis depends upon the permeability of the outer membrane...
  44. ncbi request reprint Topology of the porin MspA in the outer membrane of Mycobacterium smegmatis
    Maysa Mahfoud
    Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Staudtstrasse 5, D 91058 Erlangen, Germany
    J Biol Chem 281:5908-15. 2006
    ..4-nm long part of the hydrophilic rim domain are embedded into the OM of M. smegmatis. This is the first report suggesting that elements other than hydrophobic alpha-helices or beta-sheets are integrated into a lipid membrane...
  45. ncbi request reprint The structure of a mycobacterial outer-membrane channel
    Michael Faller
    Institut fur Organische Chemie und Biochemie, Albert Ludwigs Universitat, Albertstrasse 21, 79104 Freiburg im Breisgau, Germany
    Science 303:1189-92. 2004
    ..MspA contains two consecutive beta barrels with nonpolar outer surfaces that form a ribbon around the porin, which is too narrow to fit the thickness of the mycobacterial outer membrane in contemporary models...

Research Grants6

  1. Copper transport in Mycobacterium tuberculosis
    Michael Niederweis; Fiscal Year: 2010
    ..tuberculosis is required for efflux of copper. This protein is surface-accessible and represents the first outer membrane component of any efflux system in mycobacteria. ..
  2. Copper transport in Mycobacterium tuberculosis
    Michael Niederweis; Fiscal Year: 2009
    ..tuberculosis is required for efflux of copper. This protein is surface-accessible and represents the first outer membrane component of any efflux system in mycobacteria. ..
  3. Porins of Mycobacterium tuberculosis
    Michael Niederweis; Fiscal Year: 2006
    ..These studies will not only be essential for the design of new TB drugs, but will also be of fundamental interest for our understanding of nutrient uptake by M. tuberculosis. ..
  4. Porins of Mycobacterium tuberculosis
    Michael Niederweis; Fiscal Year: 2007
    ..These studies will not only be essential for the design of new TB drugs, but will also be of fundamental interest for our understanding of nutrient uptake by M. tuberculosis. ..
  5. Porins of Mycobacterium tuberculosis
    Michael Niederweis; Fiscal Year: 2009
    ..These studies will not only be essential for the design of new TB drugs, but will also be of fundamental interest for our understanding of nutrient uptake by M. tuberculosis. ..