Research Topics
| Mihai D NiculescuSummaryAffiliation: University of North Carolina Country: USA Publications
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Detail Information
Publications
Perinatal manipulation of α-linolenic acid intake induces epigenetic changes in maternal and offspring liversMihai D Niculescu
University of North Carolina Nutrition Research Institute, Kannapolis, North Carolina 28081, USA
FASEB J 27:350-8. 2013....
High fat diet-induced maternal obesity alters fetal hippocampal developmentMihai D Niculescu
Nutrition Research Institute, University of North Carolina, Chapel Hill, NC, United States
Int J Dev Neurosci 27:627-33. 2009....- Nutritional influence on epigenetics and effects on longevityMihai D Niculescu
UNC Nutrition Research Institute, Kannapolis, North Carolina, USA
Curr Opin Clin Nutr Metab Care 14:35-40. 2011..This review synthesizes recently published information regarding nutrition and its impact upon epigenetically mediated mechanisms involved in longevity and aging... - Lymphocyte gene expression in subjects fed a low-choline diet differs between those who develop organ dysfunction and those who do notMihai D Niculescu
Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
Am J Clin Nutr 86:230-9. 2007..The risk of developing such organ dysfunction is increased by the presence of single-nucleotide polymorphisms (SNPs) in genes involved in folate and choline metabolism... - Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 geneMihai G Mehedint
UNC Nutrition Research Institute at Kannapolis, University of North Carolina, 500 Laureate Way, Kannapolis, NC 28081, USA
FASEB J 24:184-95. 2010..01) in CD. These changes resulted in increased expression of calbindin 1 in CD (260%; P<0.05). Thus, CD modulates histone methylation in NPCs, and this could underlie the observed changes in neurogenesis... - Maternal α-linolenic acid availability during gestation and lactation alters the postnatal hippocampal development in the mouse offspringMihai D Niculescu
UNC Nutrition Research Institute, Kannapolis, NC 28081, USA Mihai
Int J Dev Neurosci 29:795-802. 2011..These results suggest that ALA is required in both fetal and postnatal stages of brain development... - Choline deficiency increases lymphocyte apoptosis and DNA damage in humansKerry-Ann da Costa
Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Am J Clin Nutr 84:88-94. 2006..Assessment of DNA damage and apoptosis in lymphocytes appears to be a clinically useful measure in humans (such as those receiving parenteral nutrition) in whom choline deficiency is suspected... - Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humansCorneliu N Craciunescu
Department of Nutrition, School of Public Health and Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7461, USA
Toxicol Sci 107:220-6. 2009..8 mg DEA per gram resulted in detectable plasma concentrations of DEA and dimethyldiethanolamine, but these were far below those concentrations associated with perturbed brain development in the mouse... - Perinatal choline influences brain structure and functionSteven H Zeisel
Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, 27599 7416, USA
Nutr Rev 64:197-203. 2006.... 
Gene expression profiling of choline-deprived neural precursor cells isolated from mouse brainMihai D Niculescu
Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, 2212 McGavran-Greenberg Hall, Chapel Hill, NC 27599-7461, USA
Brain Res Mol Brain Res 134:309-22. 2005..These findings support our previous work suggesting that choline deficiency decreases the proliferation of neural precursors and possibly increases premature neuronal differentiation and apoptosis...- The epigenetic effects of a high prenatal folate intake in male mouse fetuses exposed in utero to arsenicVerne Tsang
Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Toxicol Appl Pharmacol 264:439-50. 2012.... - Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytesMary Resseguie
Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
FASEB J 21:2622-32. 2007..This study is the first to explore the underlying mechanism of why dietary requirements for choline vary with estrogen status in humans... - Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and cholineMihai D Niculescu
Department of Nutrition, School of Public Health, School of Medicine, University of North Carolina, Chapel Hill 27599-7400, USA
J Nutr 132:2333S-2335S. 2002.... - Perinatal epigenetic determinants of cognitive and metabolic disordersDaniel S Lupu
UNC Nutrition Research Institute, Department of Nutrition, University of North Carolina at Chapel Hill, Kannapolis, NC, U S A
Aging Dis 3:444-53. 2012....