Mihai D Niculescu

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Nutritional epigenetics
    Mihai D Niculescu
    Nutrition Research Institute and Department of Nutrition, University of North Carolina at Chapel Hill, Kannapolis, North Carolina 28081, USA
    ILAR J 53:270-8. 2012
  2. doi request reprint Perinatal manipulation of α-linolenic acid intake induces epigenetic changes in maternal and offspring livers
    Mihai D Niculescu
    University of North Carolina Nutrition Research Institute, Kannapolis, North Carolina 28081, USA
    FASEB J 27:350-8. 2013
  3. doi request reprint Nutritional influence on epigenetics and effects on longevity
    Mihai D Niculescu
    UNC Nutrition Research Institute, Kannapolis, North Carolina, USA
    Curr Opin Clin Nutr Metab Care 14:35-40. 2011
  4. pmc High fat diet-induced maternal obesity alters fetal hippocampal development
    Mihai D Niculescu
    Nutrition Research Institute, University of North Carolina, Chapel Hill, NC, United States
    Int J Dev Neurosci 27:627-33. 2009
  5. pmc Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains
    Mihai D Niculescu
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, North Carolina, 27599 7461 USA
    FASEB J 20:43-9. 2006
  6. pmc Lymphocyte gene expression in subjects fed a low-choline diet differs between those who develop organ dysfunction and those who do not
    Mihai D Niculescu
    Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
    Am J Clin Nutr 86:230-9. 2007
  7. pmc Diethanolamine alters proliferation and choline metabolism in mouse neural precursor cells
    Mihai D Niculescu
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599 7461, USA
    Toxicol Sci 96:321-6. 2007
  8. pmc Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene
    Mihai G Mehedint
    UNC Nutrition Research Institute at Kannapolis, University of North Carolina, 500 Laureate Way, Kannapolis, NC 28081, USA
    FASEB J 24:184-95. 2010
  9. pmc Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans
    Corneliu N Craciunescu
    Department of Nutrition, School of Public Health and Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7461, USA
    Toxicol Sci 107:220-6. 2009
  10. doi request reprint Maternal α-linolenic acid availability during gestation and lactation alters the postnatal hippocampal development in the mouse offspring
    Mihai D Niculescu
    UNC Nutrition Research Institute, Kannapolis, NC 28081, USA Mihai
    Int J Dev Neurosci 29:795-802. 2011

Collaborators

  • Steven Zeisel
  • Rebecca C Fry
  • Zuzana Drobna
  • Corneliu N Craciunescu
  • Kerry Ann da Costa
  • Verne Tsang
  • Daniel S Lupu
  • Mihai G Mehedint
  • Mary Resseguie
  • Miroslav Styblo
  • Julia E Rager
  • Jesse Saunders
  • Diana Tint
  • David S Paul
  • Michael P Waalkes
  • Amy R Johnson
  • Leslie Fischer
  • Zhong Guo
  • Jiannan Song
  • Thomas A Randall
  • Leslie M Fischer

Detail Information

Publications19

  1. ncbi request reprint Nutritional epigenetics
    Mihai D Niculescu
    Nutrition Research Institute and Department of Nutrition, University of North Carolina at Chapel Hill, Kannapolis, North Carolina 28081, USA
    ILAR J 53:270-8. 2012
    ..Consequently, the results obtained from mouse studies should be carefully interpreted regarding their relevance to humans...
  2. doi request reprint Perinatal manipulation of α-linolenic acid intake induces epigenetic changes in maternal and offspring livers
    Mihai D Niculescu
    University of North Carolina Nutrition Research Institute, Kannapolis, North Carolina 28081, USA
    FASEB J 27:350-8. 2013
    ....
  3. doi request reprint Nutritional influence on epigenetics and effects on longevity
    Mihai D Niculescu
    UNC Nutrition Research Institute, Kannapolis, North Carolina, USA
    Curr Opin Clin Nutr Metab Care 14:35-40. 2011
    ..This review synthesizes recently published information regarding nutrition and its impact upon epigenetically mediated mechanisms involved in longevity and aging...
  4. pmc High fat diet-induced maternal obesity alters fetal hippocampal development
    Mihai D Niculescu
    Nutrition Research Institute, University of North Carolina, Chapel Hill, NC, United States
    Int J Dev Neurosci 27:627-33. 2009
    ....
  5. pmc Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains
    Mihai D Niculescu
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, North Carolina, 27599 7461 USA
    FASEB J 20:43-9. 2006
    ..These data suggest that choline deficiency-induced changes in gene methylation could mediate the expression of a cell cycle regulator and thereby alter brain development...
  6. pmc Lymphocyte gene expression in subjects fed a low-choline diet differs between those who develop organ dysfunction and those who do not
    Mihai D Niculescu
    Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
    Am J Clin Nutr 86:230-9. 2007
    ..The risk of developing such organ dysfunction is increased by the presence of single-nucleotide polymorphisms (SNPs) in genes involved in folate and choline metabolism...
  7. pmc Diethanolamine alters proliferation and choline metabolism in mouse neural precursor cells
    Mihai D Niculescu
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599 7461, USA
    Toxicol Sci 96:321-6. 2007
    ..Our study suggests that prenatal exposure to DEA may have a detrimental effect on brain development...
  8. pmc Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene
    Mihai G Mehedint
    UNC Nutrition Research Institute at Kannapolis, University of North Carolina, 500 Laureate Way, Kannapolis, NC 28081, USA
    FASEB J 24:184-95. 2010
    ..01) in CD. These changes resulted in increased expression of calbindin 1 in CD (260%; P<0.05). Thus, CD modulates histone methylation in NPCs, and this could underlie the observed changes in neurogenesis...
  9. pmc Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans
    Corneliu N Craciunescu
    Department of Nutrition, School of Public Health and Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7461, USA
    Toxicol Sci 107:220-6. 2009
    ..8 mg DEA per gram resulted in detectable plasma concentrations of DEA and dimethyldiethanolamine, but these were far below those concentrations associated with perturbed brain development in the mouse...
  10. doi request reprint Maternal α-linolenic acid availability during gestation and lactation alters the postnatal hippocampal development in the mouse offspring
    Mihai D Niculescu
    UNC Nutrition Research Institute, Kannapolis, NC 28081, USA Mihai
    Int J Dev Neurosci 29:795-802. 2011
    ..These results suggest that ALA is required in both fetal and postnatal stages of brain development...
  11. pmc Choline deficiency increases lymphocyte apoptosis and DNA damage in humans
    Kerry Ann da Costa
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Clin Nutr 84:88-94. 2006
    ..Whereas deficiency of the essential nutrient choline is associated with DNA damage and apoptosis in cell and rodent models, it has not been shown in humans...
  12. pmc Dietary isoflavones differentially induce gene expression changes in lymphocytes from postmenopausal women who form equol as compared with those who do not
    Mihai D Niculescu
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7461, USA
    J Nutr Biochem 18:380-90. 2007
    ....
  13. ncbi request reprint Gene expression profiling of choline-deprived neural precursor cells isolated from mouse brain
    Mihai D Niculescu
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, 2212 McGavran Greenberg Hall, Chapel Hill, NC 27599 7461, USA
    Brain Res Mol Brain Res 134:309-22. 2005
    ..These findings support our previous work suggesting that choline deficiency decreases the proliferation of neural precursors and possibly increases premature neuronal differentiation and apoptosis...
  14. pmc Perinatal choline influences brain structure and function
    Steven H Zeisel
    Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, 27599 7416, USA
    Nutr Rev 64:197-203. 2006
    ....
  15. pmc Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes
    Mary Resseguie
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
    FASEB J 21:2622-32. 2007
    ..This study is the first to explore the underlying mechanism of why dietary requirements for choline vary with estrogen status in humans...
  16. pmc The epigenetic effects of a high prenatal folate intake in male mouse fetuses exposed in utero to arsenic
    Verne Tsang
    Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Toxicol Appl Pharmacol 264:439-50. 2012
    ....
  17. pmc Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene
    Mihai D Niculescu
    Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, NC 27599 7461, USA
    J Neurochem 89:1252-9. 2004
    ..This may be a mechanism for our previously reported observation that stem cell proliferation in hippocampus neuroepithelium is decreased in choline-deficient rat and mouse fetuses...
  18. ncbi request reprint Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline
    Mihai D Niculescu
    Department of Nutrition, School of Public Health, School of Medicine, University of North Carolina, Chapel Hill 27599 7400, USA
    J Nutr 132:2333S-2335S. 2002
    ....
  19. pmc Perinatal epigenetic determinants of cognitive and metabolic disorders
    Daniel S Lupu
    UNC Nutrition Research Institute, Department of Nutrition, University of North Carolina at Chapel Hill, Kannapolis, NC, U S A
    Aging Dis 3:444-53. 2012
    ....