A B Niculescu

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach
    A B Niculescu
    Department of Psychiatry, School of Medicine, University of California, San Diego, USA
    Physiol Genomics 4:83-91. 2000
  2. ncbi request reprint Convergent functional genomics: application to bipolar disorder
    A B Niculescu
    Department of Psychiatry, University of California, San Diego, USA
    Ann Med 33:263-71. 2001
  3. pmc Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms
    H Le-Niculescu
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Transl Psychiatry 1:e9. 2011
  4. ncbi request reprint Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms
    H Le-Niculescu
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA
    Am J Med Genet B Neuropsychiatr Genet 150:155-81. 2009
  5. doi request reprint Identifying blood biomarkers for mood disorders using convergent functional genomics
    H Le-Niculescu
    Laboratory of Neurophenomics, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
    Mol Psychiatry 14:156-74. 2009
  6. pmc Convergent Functional Genomics of bipolar disorder: from animal model pharmacogenomics to human genetics and biomarkers
    H Le-Niculescu
    Laboratory of Neurophenomics, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 2873, USA
    Neurosci Biobehav Rev 31:897-903. 2007
  7. pmc Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism
    H Le-Niculescu
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Transl Psychiatry 1:e4. 2011
  8. ncbi request reprint Coming to grips with complex disorders: genetic risk prediction in bipolar disorder using panels of genes identified through convergent functional genomics
    S D Patel
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Med Genet B Neuropsychiatr Genet 153:850-77. 2010
  9. pmc Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
    M Ayalew
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
    Mol Psychiatry 17:887-905. 2012
  10. pmc Genetic risk prediction and neurobiological understanding of alcoholism
    D F Levey
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
    Transl Psychiatry 4:e391. 2014

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach
    A B Niculescu
    Department of Psychiatry, School of Medicine, University of California, San Diego, USA
    Physiol Genomics 4:83-91. 2000
    ..Finally, the classification of these candidate genes into two prototypical categories, psychogenes and psychosis-suppressor genes, is described...
  2. ncbi request reprint Convergent functional genomics: application to bipolar disorder
    A B Niculescu
    Department of Psychiatry, University of California, San Diego, USA
    Ann Med 33:263-71. 2001
    ..A novel approach termed convergent functional genomics, which integrates gene profiling and positional cloning in order to rapidly identify candidate disease genes, is also described...
  3. pmc Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms
    H Le-Niculescu
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Transl Psychiatry 1:e9. 2011
    ....
  4. ncbi request reprint Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms
    H Le-Niculescu
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA
    Am J Med Genet B Neuropsychiatr Genet 150:155-81. 2009
    ..These become prime targets for hypothesis driven follow-up studies, new drug development and personalized medicine approaches...
  5. doi request reprint Identifying blood biomarkers for mood disorders using convergent functional genomics
    H Le-Niculescu
    Laboratory of Neurophenomics, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
    Mol Psychiatry 14:156-74. 2009
    ..Our studies suggest that blood biomarkers may offer an unexpectedly informative window into brain functioning and disease state...
  6. pmc Convergent Functional Genomics of bipolar disorder: from animal model pharmacogenomics to human genetics and biomarkers
    H Le-Niculescu
    Laboratory of Neurophenomics, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 2873, USA
    Neurosci Biobehav Rev 31:897-903. 2007
    ..The CFG approach may also be particularly useful for identification of blood biomarkers of the illness...
  7. pmc Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism
    H Le-Niculescu
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Transl Psychiatry 1:e4. 2011
    ..In conclusion, our work supports the potential utility of omega-3 fatty acids, specifically DHA, for a spectrum of psychiatric disorders such as stress disorders, bipolar disorder, alcoholism and beyond...
  8. ncbi request reprint Coming to grips with complex disorders: genetic risk prediction in bipolar disorder using panels of genes identified through convergent functional genomics
    S D Patel
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Med Genet B Neuropsychiatr Genet 153:850-77. 2010
    ..Lastly, we describe a prototype of how such testing could be used to categorize disease risk in individuals and aid personalized medicine approaches, in psychiatry and beyond...
  9. pmc Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
    M Ayalew
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
    Mol Psychiatry 17:887-905. 2012
    ..It also reveals the significant genetic overlap with other major psychiatric disorder domains, suggesting the need for improved nosology...
  10. pmc Genetic risk prediction and neurobiological understanding of alcoholism
    D F Levey
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
    Transl Psychiatry 4:e391. 2014
    ..This revealed the significant genetic overlap with other major psychiatric disorder domains, providing a basis for comorbidity and dual diagnosis, and placing alcohol use in the broader context of modulating the mental landscape. ..
  11. ncbi request reprint Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach
    Z A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Pharmacogenomics J 7:222-56. 2007
    ..In conjunction with a higher reactivity to its rewarding effects, they may able to ingest enough of this nonspecific drug for a strong hedonic and addictive effect to occur...
  12. ncbi request reprint Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach
    C A Ogden
    Laboratory of Neurophenomics, University of California, San Diego, CA, USA
    Mol Psychiatry 9:1007-29. 2004
    ....
  13. pmc Convergent functional genomics of stem cell-derived cells
    A B Niculescu
    Department of Psychiatry, Indiana University School of Medicine and Indianapolis VA Medical Center, Indianapolis, IN, USA
    Transl Psychiatry 3:e305. 2013
    ..I provide a brief overview and an example in support of such an approach. ..