M R Nicolls

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi LFA-1 (CD11a) as a therapeutic target
    M R Nicolls
    Department of Medicine, University of Colorado Health Science Center, Denver, Colorado, USA
    Am J Transplant 6:27-36. 2006
  2. ncbi Autoimmunity and pulmonary hypertension: a perspective
    M R Nicolls
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Eur Respir J 26:1110-8. 2005
  3. ncbi CD4-dependent generation of dominant transplantation tolerance induced by simultaneous perturbation of CD154 and LFA-1 pathways
    Mark R Nicolls
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
    J Immunol 169:4831-9. 2002
  4. ncbi Proteomics as a tool for discovery: proteins implicated in Alzheimer's disease are highly expressed in normal pancreatic islets
    Mark R Nicolls
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Barbara Davis Center for Childhood Diabetes, Denver, Colorado 80262, USA
    J Proteome Res 2:199-205. 2003
  5. ncbi The clinical and biological relationship between Type II diabetes mellitus and Alzheimer's disease
    Mark R Nicolls
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 E 9th Ave, Box C272, Denver, CO 80262, USA
    Curr Alzheimer Res 1:47-54. 2004
  6. ncbi The basis of immunogenicity of endocrine allografts
    M R Nicolls
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
    Crit Rev Immunol 21:87-101. 2001
  7. pmc Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling
    Laimute Taraseviciene-Stewart
    Division of Pulmonary Sciences, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Respir Crit Care Med 175:1280-9. 2007
  8. pmc Mechanisms of autoimmune emphysema
    Laimute Taraseviciene-Stewart
    Pulmonary Hypertension Center, University of Colorado School of Medicine, Denver, USA
    Proc Am Thorac Soc 3:486-7. 2006
  9. ncbi The matrix comes to lung transplantation
    Ashok N Babu
    Department of Surgery, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Transplantation 83:683-4. 2007
  10. ncbi Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation
    Rabab El Mezayen
    Department of Medicine, University of Colorado, Health Sciences Center, Denver, 80262, USA
    Immunol Lett 106:72-81. 2006

Detail Information

Publications27

  1. ncbi LFA-1 (CD11a) as a therapeutic target
    M R Nicolls
    Department of Medicine, University of Colorado Health Science Center, Denver, Colorado, USA
    Am J Transplant 6:27-36. 2006
    ..Thus, anti-LFA-1 forms a potential, but still largely unexploited, immunotherapy which may find its greatest application as an agent which augments other therapies...
  2. ncbi Autoimmunity and pulmonary hypertension: a perspective
    M R Nicolls
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Eur Respir J 26:1110-8. 2005
    ....
  3. ncbi CD4-dependent generation of dominant transplantation tolerance induced by simultaneous perturbation of CD154 and LFA-1 pathways
    Mark R Nicolls
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
    J Immunol 169:4831-9. 2002
    ..Interestingly, although the induction of this regulatory state was highly CD4 dependent, the adoptive transfer of tolerance was less CD4 dependent in vivo...
  4. ncbi Proteomics as a tool for discovery: proteins implicated in Alzheimer's disease are highly expressed in normal pancreatic islets
    Mark R Nicolls
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Barbara Davis Center for Childhood Diabetes, Denver, Colorado 80262, USA
    J Proteome Res 2:199-205. 2003
    ..These findings have therefore led to the hypothesis that these proteins may also play a role in type 2 diabetes...
  5. ncbi The clinical and biological relationship between Type II diabetes mellitus and Alzheimer's disease
    Mark R Nicolls
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 E 9th Ave, Box C272, Denver, CO 80262, USA
    Curr Alzheimer Res 1:47-54. 2004
    ..This review summarizes what is currently known about the clinical and biological relationships and similarities between Type II diabetes and Alzheimer's disease...
  6. ncbi The basis of immunogenicity of endocrine allografts
    M R Nicolls
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
    Crit Rev Immunol 21:87-101. 2001
    ..That is, donor hematopoietic cells, rather than tissue parenchymal cells, probably play a major role in providing antigens that stimulate cellular immunity...
  7. pmc Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling
    Laimute Taraseviciene-Stewart
    Division of Pulmonary Sciences, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Respir Crit Care Med 175:1280-9. 2007
    ..Severe pulmonary arterial hypertension (SPH) is a frequently lethal condition characterized by pulmonary vascular remodeling and right heart strain or failure. SPH is also often associated with autoimmune and collagen vascular disorders...
  8. pmc Mechanisms of autoimmune emphysema
    Laimute Taraseviciene-Stewart
    Pulmonary Hypertension Center, University of Colorado School of Medicine, Denver, USA
    Proc Am Thorac Soc 3:486-7. 2006
  9. ncbi The matrix comes to lung transplantation
    Ashok N Babu
    Department of Surgery, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Transplantation 83:683-4. 2007
    ....
  10. ncbi Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation
    Rabab El Mezayen
    Department of Medicine, University of Colorado, Health Sciences Center, Denver, 80262, USA
    Immunol Lett 106:72-81. 2006
    ..These findings suggest that TQ has an anti-inflammatory effect during the allergic response in the lung through the inhibition of PGD2 synthesis and Th2-driven immune response...
  11. pmc Hypoxia and the lung: beyond hypoxic vasoconstriction
    Mark R Nicolls
    Pulmonary Hypertension Center and Division of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Antioxid Redox Signal 9:741-3. 2007
    ..How hypoxia shapes immune responses through VEGF and its receptors on mast cells, eosinophils, and dendritic cells and through lung endothelial cell/lymphocyte interactions will be a productive area for future research...
  12. ncbi Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation
    Mohamed El Gazzar
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Int Immunopharmacol 6:1135-42. 2006
    ....
  13. ncbi Is alveolar destruction and emphysema in chronic obstructive pulmonary disease an immune disease?
    Laima Taraseviciene-Stewart
    University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Proc Am Thorac Soc 3:687-90. 2006
    ..Presently, we are in the process of investigating whether cigarette smoke extract causes emphysema. We recently identified anti-endothelial cell antibodies in the serum of patients with end-stage emphysema...
  14. ncbi Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma
    Mohamed El Gazzar
    Department of Medicine, University of Colorado Health Sciences Center, 4200 E Ninth Avenue, Denver, CO 80262, USA
    Biochim Biophys Acta 1760:1088-95. 2006
    ..These results demonstrate the anti-inflammatory effect of TQ in experimental asthma...
  15. ncbi The protective role of T-lymphocytes in pulmonary vascular remodeling
    L Taraseviciene-Stewart
    Pulmonary Hypertension Center, Denver, CO, USA
    Chest 128:571S-572S. 2005
  16. ncbi Interferon-gamma is not a universal requirement for islet allograft survival
    Mark R Nicolls
    Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, Barbara Davis Center for Childhood Diabetes, UCHSC, 4200 E 9th Ave, Denver, CO 80262, USA
    Transplantation 74:472-7. 2002
    ....
  17. pmc Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis
    Ashok N Babu
    Department of Surgery, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 117:3774-85. 2007
    ..One implication of this study is that bronchial artery revascularization at the time of lung transplantation may decrease the risk of subsequent airway fibrosis...
  18. ncbi Following universal prophylaxis with intravenous ganciclovir and cytomegalovirus immune globulin, valganciclovir is safe and effective for prevention of CMV infection following lung transplantation
    Martin R Zamora
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Am J Transplant 4:1635-42. 2004
    ..Following prophylaxis with i.v. GCV and CMV-IVIG, valganciclovir is safe and effective for prevention of CMV infection and disease in at-risk lung transplant recipients. The required length of prophylaxis was at least 180 days...
  19. ncbi An animal model of autoimmune emphysema
    Laimute Taraseviciene-Stewart
    Department of Medicine, Division of Pulmonary Sciences, UCHSC, 4200 East Ninth Ave, C272, Denver, CO 80262, USA
    Am J Respir Crit Care Med 171:734-42. 2005
    ..This study shows for the first time that humoral- and CD4+ cell-dependent mechanisms are sufficient to trigger the development of emphysema, suggesting that alveolar septal cell destruction might result from immune mechanisms...
  20. ncbi Simultaneous LFA-1 and CD40 ligand antagonism prevents airway remodeling in orthotopic airway transplantation: implications for the role of respiratory epithelium as a modulator of fibrosis
    Tomohiro Murakawa
    Department of Surgery, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 174:3869-79. 2005
    ..Therefore, there appears to be an intimate relationship between the morphology and level of chimerism of the respiratory epithelium and the degree of airway remodeling following alloimmune injury...
  21. ncbi Thymoquinone attenuates proinflammatory responses in lipopolysaccharide-activated mast cells by modulating NF-kappaB nuclear transactivation
    Mohamed A El Gazzar
    Department of Medicine, University of Colorado Health Sciences Center, 4200 E Ninth Avenue, Denver, CO 80262, USA
    Biochim Biophys Acta 1770:556-64. 2007
    ..Together, these results suggest that TQ attenuates the proinflammatory response in LPS-stimulated mast cells by modulating nuclear transactivation of NF-kappaB and TNFalpha production...
  22. ncbi Transfer of allograft specific tolerance requires CD4+CD25+T cells but not interleukin-4 or transforming growth factor-beta and cannot induce tolerance to linked antigens
    Bruce M Hall
    Immune Tolerance Laboratory, University of New South Wales, Australian Technology Park, New South Wales, Australia
    Transplantation 83:1075-84. 2007
    ..The mechanisms by which CD4+T cells, especially CD4+ CD25+T cells, transfer allograft specific tolerance are poorly defined. The role of cytokines and the effect on antigen-presenting cells is not resolved...
  23. ncbi Oxidant stress, immune dysregulation, and vascular function in type I diabetes
    Mark R Nicolls
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Antioxid Redox Signal 9:879-89. 2007
    ....
  24. ncbi Type 2 diabetes mellitus as a conformational disease
    Melvin R Hayden
    Department of Family and Community Medicine, University of Missouri, Columbia, USA
    JOP 6:287-302. 2005
    ....
  25. pmc Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin
    Rabab El Mezayen
    Department of Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Immunol Lett 111:36-44. 2007
    ..This mechanism may contribute to the amplification and persistence of the inflammatory response to bacterial infection...
  26. pmc Increased regulatory and decreased CD8+ cytotoxic T cells in the blood of patients with idiopathic pulmonary arterial hypertension
    Silvia Ulrich
    University of Colorado Health Science Center, Denver, Colo, USA
    Respiration 75:272-80. 2008
    ..An association between pulmonary arterial hypertension (PAH) and various immune disorders is well established. Recently, the role of an intact immune system in protecting against pulmonary angioproliferation was shown in an animal model...
  27. ncbi Gene microarray study corroborates proteomic findings in rodent islet cells
    Alessandra K Cardozo
    J Proteome Res 2:553-5. 2003
    ....