Roger Nicoll

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint My close encounter with GABA(B) receptors
    Roger A Nicoll
    Department of Cellular and Molecular Pharmacology, Genentech Hall, Mission Bay Campus, University of California at San Francisco, San Francisco, CA 94143, USA
    Biochem Pharmacol 68:1667-74. 2004
  2. ncbi request reprint The brain's own marijuana
    Roger A Nicoll
    University of California, San Francisco, USA
    Sci Am 291:68-75. 2004
  3. pmc SynDIG1 promotes excitatory synaptogenesis independent of AMPA receptor trafficking and biophysical regulation
    Kathryn L Lovero
    Departments of Cellular and Molecular Pharmacology and Physiology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e66171. 2013
  4. pmc Expression mechanisms underlying long-term potentiation: a postsynaptic view
    Roger A Nicoll
    Departments of Cellular and Molecular Pharmacology and Physiology, University of California San Francisco, San Francisco, CA 94143, USA
    Philos Trans R Soc Lond B Biol Sci 358:721-6. 2003
  5. ncbi request reprint Synaptic plasticity at hippocampal mossy fibre synapses
    Roger A Nicoll
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Nat Rev Neurosci 6:863-76. 2005
  6. ncbi request reprint Auxiliary subunits assist AMPA-type glutamate receptors
    Roger A Nicoll
    Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94143, USA
    Science 311:1253-6. 2006
  7. pmc Genetic analysis of neuronal ionotropic glutamate receptor subunits
    Adam J Granger
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94143, USA
    J Physiol 589:4095-101. 2011
  8. ncbi request reprint TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity
    Nathalie Rouach
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Nat Neurosci 8:1525-33. 2005
  9. ncbi request reprint Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs
    Susumu Tomita
    Department of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA
    Neuron 45:269-77. 2005
  10. ncbi request reprint Phosphorylation of the postsynaptic density-95 (PSD-95)/discs large/zona occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors
    Dane M Chetkovich
    Department of Neurology, University of California at San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 22:5791-6. 2002

Collaborators

Detail Information

Publications71

  1. ncbi request reprint My close encounter with GABA(B) receptors
    Roger A Nicoll
    Department of Cellular and Molecular Pharmacology, Genentech Hall, Mission Bay Campus, University of California at San Francisco, San Francisco, CA 94143, USA
    Biochem Pharmacol 68:1667-74. 2004
    ..This greatly enhances the precision of excitatory synaptic transmission. GABA(B) IPSPs are recruited with repetitive and synchronous activity and are postulated to modulate the rhythmic network activity of cortical tissue...
  2. ncbi request reprint The brain's own marijuana
    Roger A Nicoll
    University of California, San Francisco, USA
    Sci Am 291:68-75. 2004
  3. pmc SynDIG1 promotes excitatory synaptogenesis independent of AMPA receptor trafficking and biophysical regulation
    Kathryn L Lovero
    Departments of Cellular and Molecular Pharmacology and Physiology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e66171. 2013
    ..Our findings suggest that SynDIG1 is not a typical auxiliary subunit to AMPA receptors, but instead is a protein critical to excitatory synaptogenesis...
  4. pmc Expression mechanisms underlying long-term potentiation: a postsynaptic view
    Roger A Nicoll
    Departments of Cellular and Molecular Pharmacology and Physiology, University of California San Francisco, San Francisco, CA 94143, USA
    Philos Trans R Soc Lond B Biol Sci 358:721-6. 2003
    ....
  5. ncbi request reprint Synaptic plasticity at hippocampal mossy fibre synapses
    Roger A Nicoll
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Nat Rev Neurosci 6:863-76. 2005
    ..Here we describe recent work from several laboratories on the various forms of synaptic plasticity at hippocampal mossy fibre synapses. We conclude that these contacts have just begun to reveal their many secrets...
  6. ncbi request reprint Auxiliary subunits assist AMPA-type glutamate receptors
    Roger A Nicoll
    Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94143, USA
    Science 311:1253-6. 2006
    ..TARPs provide the first example of auxiliary subunits of ionotropic receptors. Here we review the pivotal role that TARPs play in the life cycle of AMPA receptors...
  7. pmc Genetic analysis of neuronal ionotropic glutamate receptor subunits
    Adam J Granger
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94143, USA
    J Physiol 589:4095-101. 2011
    ....
  8. ncbi request reprint TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity
    Nathalie Rouach
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Nat Neurosci 8:1525-33. 2005
    ....
  9. ncbi request reprint Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs
    Susumu Tomita
    Department of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA
    Neuron 45:269-77. 2005
    ..These results establish stargazin as a critical substrate in the bidirectional control of synaptic strength, which is thought to underlie aspects of learning and memory...
  10. ncbi request reprint Phosphorylation of the postsynaptic density-95 (PSD-95)/discs large/zona occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors
    Dane M Chetkovich
    Department of Neurology, University of California at San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 22:5791-6. 2002
    ..These data suggest that phosphorylation of the stargazin PDZ ligand can disrupt stargazin interaction with PSD-95 and thereby regulate synaptic AMPAR function...
  11. ncbi request reprint Synaptic strength regulated by palmitate cycling on PSD-95
    Alaa El Din El-Husseini
    Department of Physiology, University of California, San Francisco, CA 94143, USA
    Cell 108:849-63. 2002
    ..These studies suggest that palmitate cycling on PSD-95 can regulate synaptic strength and regulates aspects of activity-dependent plasticity...
  12. ncbi request reprint Postsynaptic density-95 mimics and occludes hippocampal long-term potentiation and enhances long-term depression
    Valentin Stein
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    J Neurosci 23:5503-6. 2003
    ..In addition, LTP is completely occluded in cells expressing PSD-95, whereas LTD is greatly enhanced. These results suggest that common mechanisms are involved in controlling synaptic AMPA receptors by PSD-95 and synaptic plasticity...
  13. ncbi request reprint Interaction with the unfolded protein response reveals a role for stargazin in biosynthetic AMPA receptor transport
    Wim Vandenberghe
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 25:1095-102. 2005
    ..These findings uncover a role for stargazin in AMPA receptor trafficking through the early compartments of the biosynthetic pathway. Furthermore, they provide evidence for modulation of AMPA receptor trafficking by the UPR...
  14. ncbi request reprint Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses
    Susumu Tomita
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143 2140, USA
    Science 303:1508-11. 2004
    ..This did not require ion flux or intracellular second messengers. This allosteric mechanism for AMPA receptor dissociation from TARPs may participate in glutamate-mediated internalization of receptors in synaptic plasticity...
  15. ncbi request reprint Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites
    Robert T Fremeau
    Department of Neurology, Graduate Programs in Neuroscience and Cell Biology, University of California San Francisco School of Medicine, CA 94143, USA
    Science 304:1815-9. 2004
    ..The loss of VGLUT1 also reduced the reserve pool of synaptic vesicles. Thus, VGLUT1 plays an unanticipated role in membrane trafficking at the nerve terminal...
  16. pmc Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number
    Eric Schnell
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 99:13902-7. 2002
    ..Finally, we make compensatory mutations to both PSD-95 and stargazin to demonstrate the central role of direct interactions between them in determining the number of synaptic AMPARs...
  17. ncbi request reprint Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins
    Guillermo M Elias
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 52:307-20. 2006
    ..These studies establish a PSD-MAGUK-specific regulation of AMPA-R synaptic expression that establishes and maintains glutamatergic synaptic transmission in the mammalian central nervous system...
  18. ncbi request reprint Rapid bidirectional switching of synaptic NMDA receptors
    Camilla Bellone
    Departments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 55:779-85. 2007
    ..This switching, which is at least as rapid as that seen with AMPARs, will have immediate and dramatic consequences on the integrative capacity of the synapse...
  19. pmc The stoichiometry of AMPA receptors and TARPs varies by neuronal cell type
    Yun Shi
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 62:633-40. 2009
    ....
  20. pmc NMDA receptors inhibit synapse unsilencing during brain development
    Hillel Adesnik
    Departments of Cellular and Molecular Pharmacology, Physiology, and Neurology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 105:5597-602. 2008
    ....
  21. pmc Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach
    Wei Lu
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 62:254-68. 2009
    ..This study provides a functional quantification of the subunit composition of AMPARs in the CNS and suggests novel roles for AMPAR subunits in receptor trafficking...
  22. ncbi request reprint Excitatory synaptic transmission persists independently of the glutamate-glutamine cycle
    Kaiwen Kam
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143 2140, USA
    J Neurosci 27:9192-200. 2007
    ..We conclude that neurons have the capacity to store or produce glutamate for long periods of time, independently of glia and the glutamate-glutamine cycle...
  23. pmc Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses
    Kimberly A Moore
    Department of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 100:14397-402. 2003
    ....
  24. pmc Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination
    Akihiko Kato
    Department of Physiology, University of California San Francisco, 600 16th Street, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:5600-5. 2005
    ..These results suggest that homeostatic control of synaptic NR1 involves receptor retrotranslocation and degradation by the ubiquitin-proteasome pathway...
  25. pmc TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating
    Aaron D Milstein
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 55:905-18. 2007
    ....
  26. pmc Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating
    Yun Shi
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 107:16315-9. 2010
    ..This neuronal role is more consistent with that of an endoplasmic reticulum (ER) chaperone rather than a bona fide auxiliary subunit...
  27. ncbi request reprint Stargazin interacts functionally with the AMPA receptor glutamate-binding module
    Susumu Tomita
    Department of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA
    Neuropharmacology 52:87-91. 2007
    ..These studies identify a functional interaction of stargazin with the extracellular glutamate-binding domain of AMPA receptors...
  28. ncbi request reprint Conservation of glutamate receptor 2-containing AMPA receptors during long-term potentiation
    Hillel Adesnik
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:4598-602. 2007
    ..Here, we rigorously test these hypotheses and conclude that calcium-permeable AMPA receptors are not inserted during LTP nor does potentiation require ongoing activity to be maintained...
  29. ncbi request reprint Interaction of transmembrane AMPA receptor regulatory proteins with multiple membrane associated guanylate kinases
    Srikanth Dakoji
    Department of Physiology, UCSF School of Medicine, University of California at San Francisco, Genentech Hall 600 16th Street, N272 F, San Francisco, CA 94143 2140, USA
    Neuropharmacology 45:849-56. 2003
    ..This work identifies biochemical promiscuity for interaction of the TARP C-termini with PDZ domains in vitro, but also shows that only specific synaptic PDZ proteins associate with TARPs in brain...
  30. ncbi request reprint TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists
    Karen Menuz
    Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94143, USA
    Science 318:815-7. 2007
    ..Our results demonstrate that the presence of an auxiliary subunit can determine whether a compound functions as an agonist or antagonist...
  31. ncbi request reprint Synaptic trafficking of glutamate receptors by MAGUK scaffolding proteins
    Guillermo M Elias
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Trends Cell Biol 17:343-52. 2007
    ..These studies highlight the remarkable orchestration of AMPA-type glutamate receptor synaptic trafficking by multiple MAGUKs at different synapses within the same neuron and at different developmental stages...
  32. ncbi request reprint AMPA receptor trafficking at excitatory synapses
    David S Bredt
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 40:361-79. 2003
    ..Furthermore, neuronal activity controls synaptic AMPA receptor trafficking, and this dynamic process plays a key role in the synaptic plasticity that is thought to underlie aspects of learning and memory...
  33. pmc Regulation of AMPA receptor gating and pharmacology by TARP auxiliary subunits
    Aaron D Milstein
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Trends Pharmacol Sci 29:333-9. 2008
    ..Here, we summarize recent work and discuss remaining questions concerning the structure and function of native TARP-AMPA receptor complexes...
  34. ncbi request reprint Arc/Arg3.1: linking gene expression to synaptic plasticity and memory
    Anastassios V Tzingounis
    Departments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 52:403-7. 2006
    ..Finally, Arc/Arg3.1 knockout mice show memory retention deficits. These recent developments provide new insights into the function of this popular activity-dependent neuronal marker...
  35. pmc Critical role for TARPs in early development despite broad functional redundancy
    Karen Menuz
    Department of Cellular and Molecular Pharmacology, University of California, Campus Box 2140, 600 16th Street, San Francisco, CA 94143 2140, USA
    Neuropharmacology 56:22-9. 2009
    ..Together, our data indicate that TARPs, in particular gamma-2, are essential for early development, and that most neurons express multiple members of this functionally redundant protein family...
  36. pmc TARP redundancy is critical for maintaining AMPA receptor function
    Karen Menuz
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 28:8740-6. 2008
    ..This study establishes a new role for TARPs in regulating AMPA receptor assembly and suggests that TARPs are necessary for proper AMPA receptor localization and function in most, if not all, neurons of the CNS...
  37. pmc TARP modulation of synaptic AMPA receptor trafficking and gating depends on multiple intracellular domains
    Aaron D Milstein
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:11348-51. 2009
    ....
  38. ncbi request reprint Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97
    Nikolaj Klocker
    Department of Physiology, University of California, San Francisco, CA 94143, USA
    Eur J Neurosci 16:1517-22. 2002
    ....
  39. pmc Molecular constituents of neuronal AMPA receptors
    Yuko Fukata
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 169:399-404. 2005
    ..These studies establish TARPs as the auxiliary components of neuronal AMPARs...
  40. pmc Stargazin is an AMPA receptor auxiliary subunit
    Wim Vandenberghe
    Department of Physiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:485-90. 2005
    ..1N, do not show significant association with AMPA receptor complexes on native gels. These data identify stargazin as an auxiliary subunit for a neurotransmitter-gated ion channel...
  41. pmc The role of SAP97 in synaptic glutamate receptor dynamics
    MacKenzie A Howard
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 107:3805-10. 2010
    ..However, due to functional redundancy, other PSD-MAGUKs can presumably compensate when SAP97 is conditionally deleted during development...
  42. ncbi request reprint Glutamine uptake by neurons: interaction of protons with system a transporters
    Farrukh A Chaudhry
    Department of Neurology, University of California San Francisco School of Medicine, San Francisco, California 94143 0435, USA
    J Neurosci 22:62-72. 2002
    ..Differences between System N and A transporters in coupling to H+ thus contribute to the delivery of glutamine from glia to neurons. Nonetheless, although they are not transported, H+ inhibit SA1 and SA2 by competing with Na+...
  43. ncbi request reprint Photoinactivation of native AMPA receptors reveals their real-time trafficking
    Hillel Adesnik
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Neuron 48:977-85. 2005
    ....
  44. pmc AMPA receptors and stargazin-like transmembrane AMPA receptor-regulatory proteins mediate hippocampal kainate neurotoxicity
    Susumu Tomita
    Department of Physiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:18784-8. 2007
    ..This work decisively demonstrates that TARP-associated AMPA receptors mediate kainate neurotoxicity and identifies TARPs as targets for modulating neurotoxic properties of AMPA receptors...
  45. pmc Single-cell optogenetic excitation drives homeostatic synaptic depression
    Carleton P Goold
    Departments of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158, USA
    Neuron 68:512-28. 2010
    ..The synaptic depression of AMPARs but not of NMDARs requires protein synthesis and the GluA2 AMPAR subunit, indicating that downstream of CaM kinase activation divergent pathways regulate homeostatic AMPAR and NMDAR depression...
  46. pmc Loss of inhibitory neuron AMPA receptors contributes to ataxia and epilepsy in stargazer mice
    Karen Menuz
    Departments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, San Francisco, California 94143 USA
    J Neurosci 28:10599-603. 2008
    ....
  47. ncbi request reprint Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels
    Jack Mellor
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Science 295:143-7. 2002
    ..Thus, Ih channels play an important role in the long-lasting control of transmitter release and neuronal excitability...
  48. pmc Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
    Venu M Nemani
    Departments of Neurology and Physiology, Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 65:66-79. 2010
    ..Increased levels of alpha-synuclein thus produce a specific, physiological defect in synaptic vesicle recycling that precedes detectable neuropathology...
  49. pmc Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins
    Susumu Tomita
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 161:805-16. 2003
    ..These studies indicate a general role for TARPs in controlling synaptic AMPA receptors throughout the central nervous system...
  50. pmc Silent synapses and the emergence of a postsynaptic mechanism for LTP
    Geoffrey A Kerchner
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, California 94143 2140, USA
    Nat Rev Neurosci 9:813-25. 2008
    ..Out of this literature has emerged a model for synapse unsilencing that highlights the central role for postsynaptic AMPA-receptor trafficking in the expression of excitatory synaptic plasticity...
  51. pmc Synaptic AMPA receptor subunit trafficking is independent of the C terminus in the GluR2-lacking mouse
    Sandip Panicker
    Department of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 105:1032-7. 2008
    ..These findings suggest that the GluR2 C terminus is not required for GluR2 synaptic insertion...
  52. ncbi request reprint Stargazin differentially controls the trafficking of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and kainate receptors
    Lu Chen
    Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94143, USA
    Mol Pharmacol 64:703-6. 2003
    ..These results suggest that stargazin action is highly selective for AMPA receptors...
  53. ncbi request reprint Endocannabinoids contribute to short-term but not long-term mGluR-induced depression in the hippocampus
    Nathalie Rouach
    Departments of Cellular and Molecular Pharmacology and Physiology, University of California San Francisco, Genentech Hall, 600 16th Street, Box 2140, San Francisco, CA 94143, USA
    Eur J Neurosci 18:1017-20. 2003
    ..These findings suggest that endocannabinoids, acting on a non-CB1 cannabinoid receptor, contribute to the acute depression but not to DHPG-LTD. Presumably some other retrograde signalling mechanism is responsible for DHPG-LTD...
  54. pmc Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex
    Olav Olsen
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 170:1127-34. 2005
    ..These findings are consistent with a model whereby the MALS-CASK-liprin-alpha complex recruits components of the synaptic release machinery to adhesive proteins of the active zone...
  55. pmc Stargazin controls the pharmacology of AMPA receptor potentiators
    Susumu Tomita
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:10064-7. 2006
    ..This work demonstrates that stargazin controls AMPAR potentiator pharmacology, which has important implications for development of AMPAR potentiators as therapeutic agents...
  56. ncbi request reprint Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling
    Susan M Voglmaier
    Department of Neurology, Graduate Programs in Cell Biology, Neuroscience and Biomedical Sciences, UCSF School of Medicine, 600 16th Street, San Francisco, California 94143, USA
    Neuron 51:71-84. 2006
    ..After stimulation, however, inhibition of the AP3 pathway prevents the full recovery of VGLUT1 by endocytosis, implicating the AP3 pathway specifically in compensatory endocytosis...
  57. ncbi request reprint Identification of PSD-95 palmitoylating enzymes
    Masaki Fukata
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    Neuron 44:987-96. 2004
    ..This study suggests that P-PATs regulate synaptic function through PSD-95 palmitoylation...
  58. ncbi request reprint Synaptic transmission regulated by a presynaptic MALS/Liprin-alpha protein complex
    Olav Olsen
    Departments of Physiology and Cellular and Molecular Pharmacology, University of California San Francisco, 600 16th Street, San Francisco, CA, USA
    Curr Opin Cell Biol 18:223-7. 2006
    ....
  59. pmc The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus
    Anastassios V Tzingounis
    Department of Cellular and Molecular Pharmacology and Department of Physiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 107:10232-7. 2010
    ..Our results demonstrate that KCNQ5 channels contribute to the afterhyperpolarization currents in hippocampus in a cell type-specific manner...
  60. ncbi request reprint New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors
    Akihiko S Kato
    Neuroscience Discovery, Lilly Research Laboratories, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:4969-77. 2007
    ..These studies define gamma-7 as a new member of the TARP family that can differentially influence AMPA receptors in cerebellar neurons...
  61. pmc Hippocalcin gates the calcium activation of the slow afterhyperpolarization in hippocampal pyramidal cells
    Anastassios V Tzingounis
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 53:487-93. 2007
    ..This implies that hippocalcin must bind to the plasma membrane to mediate its effects. These findings support a model in which the calcium sensor for the sAHP channels is not preassociated with the channel complex...
  62. pmc Potentiation of synaptic AMPA receptors induced by the deletion of NMDA receptors requires the GluA2 subunit
    Wei Lu
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94143, USA
    J Neurophysiol 105:923-8. 2011
    ..We find that the AMPAR enhancement following NMDAR deletion requires the GluA2 subunit, but not the GluA1 subunit, indicating a key role for GluA2 in the regulation of AMPAR trafficking in developing synapses...
  63. pmc Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling
    Guangnan Li
    Program in Neuroscience, and Department of Neurology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 28:1085-98. 2008
    ....
  64. ncbi request reprint GABA generates excitement
    Valentin Stein
    Departments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 37:375-8. 2003
    ..Here we discuss the evolving story on chloride ion homeostasis in CNS neurons and its role in the bipolar life of the GABA(A) receptor...
  65. ncbi request reprint Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission
    Yuko Fukata
    Laboratory of Genomics and Proteomics, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474 8522, Japan
    Science 313:1792-5. 2006
    ..The mutated form of LGI1 fails to bind to ADAM22. ADAM22 is anchored to the postsynaptic density by cytoskeletal scaffolds containing stargazin. These studies in rat brain indicate possible avenues for understanding human epilepsy...
  66. ncbi request reprint Presynaptic NMDA receptors get into the act
    Anastassios V Tzingounis
    Nat Neurosci 7:419-20. 2004
  67. ncbi request reprint Endocannabinoid signaling in the brain
    Rachel I Wilson
    Division of Biology, 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Science 296:678-82. 2002
    ..Cannabinoids may affect memory, cognition, and pain perception by means of this cellular mechanism...
  68. pmc Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3
    Nathalie Strutz-Seebohm
    Department of Physiology I, University of Tuebingen, 72076 Tuebingen, Germany
    J Physiol 565:381-90. 2005
    ..The present observations disclose a novel mechanism in the regulation of GluR1...
  69. ncbi request reprint Stargazin modulates AMPA receptor gating and trafficking by distinct domains
    Susumu Tomita
    Department of Physiology
    Nature 435:1052-8. 2005
    ....
  70. ncbi request reprint Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation
    Dietmar Schmitz
    Neuroscience Research Center, Charite, Humboldt University Berlin, Schumannstr 20 21, 10117 Berlin, Germany
    Nat Neurosci 6:1058-63. 2003
    ..Such a mechanism greatly increases the computational power of this form of plasticity...
  71. ncbi request reprint Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression
    Wade Morishita
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304 5485, USA
    Neuropharmacology 52:71-6. 2007
    ..These results demonstrate that activation of NR2B-containing NMDARs is not an absolute requirement for the induction of LTD in the hippocampus...

Research Grants19

  1. Synaptic Glutamate Receptor Trafficking.
    Roger Nicoll; Fiscal Year: 2009
    ..In addition, TARPs modify the pharmacological properties of AMPAkines and, thus, represent a novel target for drug design. ..
  2. SYNAPTIC ACTIONS OF OPIOID PEPTIDES IN THE HIPPOCAMPUS
    Roger Nicoll; Fiscal Year: 2000
    ....
  3. ASSEMBLY AND TARGETING OF NEURAL RECEPTORS AND CHANNELS
    Roger Nicoll; Fiscal Year: 2006
    ..abstract_text> ..
  4. Synaptic plasticity regulated by stargazin-like gamma-8
    Roger Nicoll; Fiscal Year: 2009
    ..The elucidation of the cellular and molecular mechanisms will provide a platform for the development of a rational therapeutic approach for such diseases as Alzheimer's Disease. ..
  5. AMPA Receptor Subunits and Plasticity
    Roger A Nicoll; Fiscal Year: 2010
    ..The elucidation of the cellular and molecular mechanisms will provide a platform for the development of a rational therapeutic approach for such diseases as Alzheimer's Disease. ..
  6. CELLULAR AND MOLECULAR SUBSTRATES OF SYNAPTIC PLASTICITY
    Roger Nicoll; Fiscal Year: 2007
    ..The experiments outlined will provide fundamental insight into the cellular underpinnings of learning and memory and by extension to the numerous conditions that result in cognitive impairment. ..
  7. Synaptic Glutamate Receptor Trafficking.
    Roger Nicoll; Fiscal Year: 2007
    ..In addition, TARPs modify the pharmacological properties of AMPAkines and, thus, represent a novel target for drug design. ..
  8. Synaptic plasticity regulated by stargazin-like gamma-8
    Roger Nicoll; Fiscal Year: 2007
    ..Understanding mechanisms that control synaptic targeting of glutamate receptors will help clarify the role that this plasticity plays in learning and memory. ..
  9. Synaptic signaling regulated by MALS family PDZ proteins
    Roger Nicoll; Fiscal Year: 2007
    ..Because MALS proteins regulate growth factor receptors and interact with NMDA type glutamate receptors at synapses, this work will be relevant to both tissue development and synaptic plasticity. ..
  10. Synaptic plasticity regulated by stargazin-like gamma-8
    Roger Nicoll; Fiscal Year: 2006
    ..Understanding mechanisms that control synaptic targeting of glutamate receptors will help clarify the role that this plasticity plays in learning and memory. ..
  11. SYNAPTIC ACTIONS OF OPIOID PEPTIDES IN THE HIPPOCAMPUS
    Roger Nicoll; Fiscal Year: 2001
    ....
  12. SYNAPTIC ACTIONS OF OPIOID PEPTIDES IN THE HIPPOCAMPUS
    Roger Nicoll; Fiscal Year: 1999
    ....
  13. Synaptic Glutamate Receptor Trafficking.
    Roger A Nicoll; Fiscal Year: 2010
    ..In addition, TARPs modify the pharmacological properties of AMPAkines and, thus, represent a novel target for drug design. ..