Robert Nickells

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Spink2 Modulates Apoptotic Susceptibility and Is a Candidate Gene in the Rgcs1 QTL That Affects Retinal Ganglion Cell Death after Optic Nerve Damage
    Joel A Dietz
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 9:e93564. 2014
  2. pmc A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death
    Sheila J Semaan
    Department of Opthalmology and Visual Sciences, University of Wisconsin, School of Medicine and Public Health, 1300 University Avenue, Madison, WI 53706, U S A
    ASN Neuro 2:e00032. 2010
  3. pmc Evaluation of the percentage of ganglion cells in the ganglion cell layer of the rodent retina
    Cassandra L Schlamp
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA
    Mol Vis 19:1387-96. 2013
  4. pmc The effect of glial fibrillary acidic protein expression on neurite outgrowth from retinal explants in a permissive environment
    Kimberly A Toops
    Departments of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53706, USA
    BMC Res Notes 5:693. 2012
  5. doi request reprint Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy
    Robert W Nickells
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Annu Rev Neurosci 35:153-79. 2012
  6. pmc Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice
    Joel A Dietz
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA
    BMC Neurosci 9:74. 2008
  7. pmc Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosis
    Heather R Pelzel
    Department of Biomolecular Chemistry, University of Wisconsin, 1300 University Ave, 6671 MSC, Madison, WI 53706, USA
    BMC Neurosci 11:62. 2010
  8. pmc Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice
    Yan Li
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
    BMC Neurosci 8:19. 2007
  9. pmc Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric
    Cassandra L Schlamp
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA
    BMC Neurosci 7:66. 2006
  10. pmc The apoptotic response in HCT116BAX-/- cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion protein
    Sheila J Semaan
    Department of Ophthalmology and Visual Sciences, Medical Sciences Center, 1300 University Ave, University of Wisconsin, School of Medicine and Public Health, Madison, WI 53706, USA
    BMC Cancer 10:554. 2010

Research Grants

  1. Transcriptional silencing in damaged retinal ganglia
    Robert Nickells; Fiscal Year: 2004
  2. Characterization of RGC death susceptibility alleles
    Robert W Nickells; Fiscal Year: 2010
  3. MOLECULAR MECHANISM OF RETINAL GANGLION CELL DEATH
    Robert Nickells; Fiscal Year: 2009
  4. Characterization of RGC death susceptibility alleles
    Robert Nickells; Fiscal Year: 2009
  5. The molecular mechanism of retinal ganglion cell death
    Robert Nickells; Fiscal Year: 2007
  6. Mapping RGC susceptibility alleles
    Robert Nickells; Fiscal Year: 2007
  7. The molecular mechanism of retinal ganglion cell death
    Robert Nickells; Fiscal Year: 2006
  8. The molecular mechanism of retinal ganglion cell death
    Robert Nickells; Fiscal Year: 2005
  9. MOLECULAR MECHANISM OF RETINAL GANGLION CELL DEATH
    Robert W Nickells; Fiscal Year: 2010

Detail Information

Publications23

  1. pmc Spink2 Modulates Apoptotic Susceptibility and Is a Candidate Gene in the Rgcs1 QTL That Affects Retinal Ganglion Cell Death after Optic Nerve Damage
    Joel A Dietz
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 9:e93564. 2014
    ....
  2. pmc A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death
    Sheila J Semaan
    Department of Opthalmology and Visual Sciences, University of Wisconsin, School of Medicine and Public Health, 1300 University Avenue, Madison, WI 53706, U S A
    ASN Neuro 2:e00032. 2010
    ..These studies implicated quantitative expression of the Bax gene as playing a possible role in neuronal susceptibility to damaging stimuli...
  3. pmc Evaluation of the percentage of ganglion cells in the ganglion cell layer of the rodent retina
    Cassandra L Schlamp
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA
    Mol Vis 19:1387-96. 2013
    ..This estimate is useful to extrapolate ganglion cell loss in models of optic nerve disease, but the values reported in the literature are highly variable depending on the methods used to obtain them...
  4. pmc The effect of glial fibrillary acidic protein expression on neurite outgrowth from retinal explants in a permissive environment
    Kimberly A Toops
    Departments of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53706, USA
    BMC Res Notes 5:693. 2012
    ..We utilized transgenic mice expressing a range of Gfap to titrate the amount of GFAP in retinal explants to investigate the relationship between GFAP concentration and the regenerative potential of retinal ganglion cells...
  5. doi request reprint Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy
    Robert W Nickells
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Annu Rev Neurosci 35:153-79. 2012
    ..We also identify areas that require further investigation and focus on mechanisms identified in other neurodegenerations that may contribute to RGC dysfunction and demise in glaucoma...
  6. pmc Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice
    Joel A Dietz
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA
    BMC Neurosci 9:74. 2008
    ..To assess this further, we bred and phenotyped a large population of F2 mice derived from a resistant inbred strain (DBA/2J) and a susceptible strain (BALB/cByJ)...
  7. pmc Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosis
    Heather R Pelzel
    Department of Biomolecular Chemistry, University of Wisconsin, 1300 University Ave, 6671 MSC, Madison, WI 53706, USA
    BMC Neurosci 11:62. 2010
    ....
  8. pmc Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice
    Yan Li
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
    BMC Neurosci 8:19. 2007
    ....
  9. pmc Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric
    Cassandra L Schlamp
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA
    BMC Neurosci 7:66. 2006
    ....
  10. pmc The apoptotic response in HCT116BAX-/- cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion protein
    Sheila J Semaan
    Department of Ophthalmology and Visual Sciences, Medical Sciences Center, 1300 University Ave, University of Wisconsin, School of Medicine and Public Health, Madison, WI 53706, USA
    BMC Cancer 10:554. 2010
    ....
  11. pmc Variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins
    Robert W Nickells
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, 1300 University Ave, Madison, WI 53706, USA
    Exp Eye Res 91:2-8. 2010
    ..Studies of retinal ganglion cell apoptosis indicate that a threshold of BAX expression is required for its successful activation, which is independent of the overall concentration of anti-apoptotic proteins in these cells...
  12. ncbi request reprint Involvement of the Bcl2 gene family in the signaling and control of retinal ganglion cell death
    Robert W Nickells
    Department of Ophthalmology and Visual Sciences University of Wisconsin, Madison, WI 53706, USA
    Prog Brain Res 173:423-35. 2008
    ..A hypothetical model of how all these molecules interact in glaucoma is presented...
  13. ncbi request reprint Ganglion cell death in glaucoma: from mice to men
    Robert W Nickells
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, WI 53706, USA
    Vet Ophthalmol 10:88-94. 2007
    ..This review briefly summarizes some of the most significant developments in glaucoma research, with respect to the process of ganglion cell degeneration...
  14. ncbi request reprint From ocular hypertension to ganglion cell death: a theoretical sequence of events leading to glaucoma
    Robert W Nickells
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisc 53706, USA
    Can J Ophthalmol 42:278-87. 2007
    ..As ganglion cell structures disappear through the processes of cell death, glia are again involved, but this time to replace the lost neural tissue with a glial scar (stage 5)...
  15. pmc Surgical lowering of elevated intraocular pressure in monkeys prevents progression of glaucomatous disease
    Robert W Nickells
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53706, USA
    Exp Eye Res 84:729-36. 2007
    ....
  16. ncbi request reprint Adenovirus-mediated gene therapy using human p21WAF-1/Cip-1 to prevent wound healing in a rabbit model of glaucoma filtration surgery
    Todd W Perkins
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, 1300 University Ave, Room 6640 MSC, Madison, WI 53706 1532, USA
    Arch Ophthalmol 120:941-9. 2002
    ..To determine if adenovirus-mediated p21(WAF-1/Cip-1) (p21) gene therapy can prevent fibroproliferation and wound healing in a rabbit model of glaucoma filtration surgery...
  17. ncbi request reprint Vitamin D analogues increase p53, p21, and apoptosis in a xenograft model of human retinoblastoma
    Isabelle Audo
    Department of Ophthalmology, University of Wisconsin Madison Medical School, Madison, WI 53706, USA
    Invest Ophthalmol Vis Sci 44:4192-9. 2003
    ..To study the antineoplastic effect of vitamin D analogues in a xenograft model of human retinoblastoma...
  18. ncbi request reprint Vitamin D analogs, a new treatment for retinoblastoma: The first Ellsworth Lecture
    Daniel M Albert
    Department of Ophthalmology and Visual Sciences, School of Medicine, Madison, WI 53792 3284, USA
    Ophthalmic Genet 23:137-56. 2002
    ..We identified vitamin D receptors in retinoblastoma and examined the effectiveness and mechanism of action of these analogs...
  19. ncbi request reprint The molecular biology of retinal ganglion cell death: caveats and controversies
    Robert W Nickells
    Department of Ophthalmology and Visual Science, University of Wisconsin, Madison, WI 53706, USA
    Brain Res Bull 62:439-46. 2004
    ..Consequently, it may be important to provide additional treatment to restore normal cell function in conjunction with therapies aimed at preventing their death...
  20. ncbi request reprint p53 regulates apoptotic retinal ganglion cell death induced by N-methyl-D-aspartate
    Yan Li
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53706, USA
    Mol Vis 8:341-50. 2002
    ....
  21. pmc Insertion of the beta Geo promoter trap into the Fem1c gene of ROSA3 mice
    Cassandra L Schlamp
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53704, USA
    Mol Cell Biol 24:3794-803. 2004
    ....
  22. ncbi request reprint Decrease of cone opsin mRNA in experimental ocular hypertension
    Heather R Pelzel
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53704, USA
    Mol Vis 12:1272-82. 2006
    ..As a measure of this effect, we examined the levels of rod opsin, and red/green and blue cone opsin mRNAs in monkeys with experimental ocular hypertension and glaucoma and in human eyes from donors with diagnosed glaucoma...
  23. ncbi request reprint Increased expression of iron-regulating genes in monkey and human glaucoma
    Ronald H Farkas
    Guerrieri Center for Genetic Engineering and Molecular Ophthalmology, Wilmer Ophthalmological Institute, Baltimore, Maryland 21287, USA
    Invest Ophthalmol Vis Sci 45:1410-7. 2004
    ..To understand the mechanisms mediating retinal ganglion cell loss in glaucoma, the gene expression patterns were compared for transferrin, ceruloplasmin, and ferritin between normal and glaucomatous retina in monkey and human eyes...

Research Grants10

  1. Transcriptional silencing in damaged retinal ganglia
    Robert Nickells; Fiscal Year: 2004
    ....
  2. Characterization of RGC death susceptibility alleles
    Robert W Nickells; Fiscal Year: 2010
    ..Finding and characterizing these alleles will lead to better diagnosis and treatment regimes for individuals with glaucoma. ..
  3. MOLECULAR MECHANISM OF RETINAL GANGLION CELL DEATH
    Robert Nickells; Fiscal Year: 2009
    ..In addition to these aims, experiments are also proposed to investigate further a key regulatory element and binding protein complex in the Bax promoter that quantitatively affects normal gene expression. ..
  4. Characterization of RGC death susceptibility alleles
    Robert Nickells; Fiscal Year: 2009
    ..Finding and characterizing these alleles will lead to better diagnosis and treatment regimes for individuals with glaucoma. ..
  5. The molecular mechanism of retinal ganglion cell death
    Robert Nickells; Fiscal Year: 2007
    ..The findings of Aim 1 will also enhance our treatment of glaucoma by helping to identify the genetic basis of the variable susceptibility to optic nerve damage at the level of Bax gene function. ..
  6. Mapping RGC susceptibility alleles
    Robert Nickells; Fiscal Year: 2007
    ....
  7. The molecular mechanism of retinal ganglion cell death
    Robert Nickells; Fiscal Year: 2006
    ..The findings of Aim 1 will also enhance our treatment of glaucoma by helping to identify the genetic basis of the variable susceptibility to optic nerve damage at the level of Bax gene function. ..
  8. The molecular mechanism of retinal ganglion cell death
    Robert Nickells; Fiscal Year: 2005
    ..The findings of Aim 1 will also enhance our treatment of glaucoma by helping to identify the genetic basis of the variable susceptibility to optic nerve damage at the level of Bax gene function. ..
  9. MOLECULAR MECHANISM OF RETINAL GANGLION CELL DEATH
    Robert W Nickells; Fiscal Year: 2010
    ..In addition to these aims, experiments are also proposed to investigate further a key regulatory element and binding protein complex in the Bax promoter that quantitatively affects normal gene expression. ..