Ruthann Nichols

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Structure-activity studies of RFamide-related peptide-1 identify a functional receptor antagonist and novel cardiac myocyte signaling pathway involved in contractile performance
    Ruthann Nichols
    Department of Biological Chemistry, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Med Chem 55:7736-45. 2012
  2. ncbi Structure, function, and expression of Drosophila melanogaster FMRFamide-related peptides
    R Nichols
    Biological Chemistry Department, University of Michigan, Ann Arbor 48109 1048, USA
    Ann N Y Acad Sci 897:264-72. 1999
  3. ncbi Differential processing of neuropeptides influences Drosophila heart rate
    R Nichols
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 1048, USA
    J Neurogenet 13:89-104. 1999
  4. ncbi Plasticity in the effects of sulfated and nonsulfated sulfakinin on heart contractions
    Ruthann Nichols
    Biological Chemistry Department, University of Michigan Medical School, Medical Science Research Building III, Ann Arbor, MI, 48109 0606, USA
    Front Biosci (Landmark Ed) 14:4035-43. 2009
  5. pmc The different effects of structurally related sulfakinins on Drosophila melanogaster odor preference and locomotion suggest involvement of distinct mechanisms
    Ruthann Nichols
    Biological Chemistry Department, University of Michigan Medical School, Ann Arbor, MI 48109 0606, USA
    Peptides 29:2128-35. 2008
  6. ncbi Signaling pathways and physiological functions of Drosophila melanogaster FMRFamide-related peptides
    Ruthann Nichols
    Biological Chemistry Department, University of Michigan, Ann Arbor, Michigan 48109 0606, USA
    Annu Rev Entomol 48:485-503. 2003
  7. ncbi Myotropic peptides in Drosophila melanogaster and the genes that encode them
    Ruthann Nichols
    Biological Chemistry Department, University of Michigan, Ann Arbor 48109, USA
    J Neurogenet 16:1-28. 2002
  8. pmc The discovery of novel neuropeptides takes flight
    Ruthann Nichols
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109 0606, USA
    Genome Biol 3:reviews1032. 2002
  9. ncbi FMRFamide-related peptides and serotonin regulate Drosophila melanogaster heart rate: mechanisms and structure requirements
    Ruthann Nichols
    University of Michigan Medical School, Biological Chemistry Department, 4444 Medical Science Building I, Ann Arbor, MI 48109 0606, USA
    Peptides 27:1130-7. 2006
  10. ncbi Antisera to multiple antigenic peptides detect neuropeptide processing
    R Nichols
    Department of Biological Chemistry, University of Michigan, Ann Arbor, USA
    Neuropeptides 33:35-40. 1999

Research Grants

  1. Novel Genes Involved in Drug Response
    Ruthann Nichols; Fiscal Year: 2002

Collaborators

Detail Information

Publications35

  1. pmc Structure-activity studies of RFamide-related peptide-1 identify a functional receptor antagonist and novel cardiac myocyte signaling pathway involved in contractile performance
    Ruthann Nichols
    Department of Biological Chemistry, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Med Chem 55:7736-45. 2012
    ..Protein kinase C (PKC) but not PKA inhibitor diminished the influence of hRFRP-1 on the Ca(2+) transient. Molecules targeting this pathway may help address cardiovascular disease...
  2. ncbi Structure, function, and expression of Drosophila melanogaster FMRFamide-related peptides
    R Nichols
    Biological Chemistry Department, University of Michigan, Ann Arbor 48109 1048, USA
    Ann N Y Acad Sci 897:264-72. 1999
    ..Thus, these data suggest that one or more Drosophila FaRPs or structurally related peptides remain to be discovered...
  3. ncbi Differential processing of neuropeptides influences Drosophila heart rate
    R Nichols
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 1048, USA
    J Neurogenet 13:89-104. 1999
    ....
  4. ncbi Plasticity in the effects of sulfated and nonsulfated sulfakinin on heart contractions
    Ruthann Nichols
    Biological Chemistry Department, University of Michigan Medical School, Medical Science Research Building III, Ann Arbor, MI, 48109 0606, USA
    Front Biosci (Landmark Ed) 14:4035-43. 2009
    ..Our data demonstrate a role for plasticity in the effects of sulfakinins on heart contractions, and suggest multiple mechanisms are involved...
  5. pmc The different effects of structurally related sulfakinins on Drosophila melanogaster odor preference and locomotion suggest involvement of distinct mechanisms
    Ruthann Nichols
    Biological Chemistry Department, University of Michigan Medical School, Ann Arbor, MI 48109 0606, USA
    Peptides 29:2128-35. 2008
    ..Our novel data suggest distinct mechanisms underlie the effects of DSK I and DSK II peptides on odor preference and locomotion, parameters important to many facets of animal survival...
  6. ncbi Signaling pathways and physiological functions of Drosophila melanogaster FMRFamide-related peptides
    Ruthann Nichols
    Biological Chemistry Department, University of Michigan, Ann Arbor, Michigan 48109 0606, USA
    Annu Rev Entomol 48:485-503. 2003
    ..melanogaster FMRFamide (dFMRFamide), myosuppressin (Dms), and sulfakinin (Dsk) genes are reviewed, and predictions are made on their signaling pathways and biological functions...
  7. ncbi Myotropic peptides in Drosophila melanogaster and the genes that encode them
    Ruthann Nichols
    Biological Chemistry Department, University of Michigan, Ann Arbor 48109, USA
    J Neurogenet 16:1-28. 2002
    ..Here, we review research on D. melanogaster AST, FMRFamide-containing, myosuppressin, and sulfakinin peptides...
  8. pmc The discovery of novel neuropeptides takes flight
    Ruthann Nichols
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109 0606, USA
    Genome Biol 3:reviews1032. 2002
    ..The results shed light on neuropeptide synthesis and function(s) in both vertebrates and insects...
  9. ncbi FMRFamide-related peptides and serotonin regulate Drosophila melanogaster heart rate: mechanisms and structure requirements
    Ruthann Nichols
    University of Michigan Medical School, Biological Chemistry Department, 4444 Medical Science Building I, Ann Arbor, MI 48109 0606, USA
    Peptides 27:1130-7. 2006
    ..Our data provide evidence for the complexity of FaRP and 5-HT interactions to regulate frequency of heart contractions in vivo. Our results also confirm the biological importance of FaRP N-terminal amino acid extensions...
  10. ncbi Antisera to multiple antigenic peptides detect neuropeptide processing
    R Nichols
    Department of Biological Chemistry, University of Michigan, Ann Arbor, USA
    Neuropeptides 33:35-40. 1999
    ....
  11. ncbi The first nonsulfated sulfakinin activity reported suggests nsDSK acts in gut biology
    R Nichols
    Biological Chemistry Department, The University of Michigan Medical School, 3220B Medical Science Research Building III, Ann Arbor, MI 48109 0606, USA
    Peptides 28:767-73. 2007
    ..Sulfakinin activities, spatial and temporal distribution, and homology to CCK and gastrin suggest sulfated and nonsulfated DSK peptides act in diverse roles in the neural and gastrointestinal systems including gut emptying and satiety...
  12. ncbi Multiple antigenic peptides designed to structurally related Drosophila peptides
    R Nichols
    Depart of Biological Chemistry, University of Michigan, Ann Arbor 48109 1048, USA
    Peptides 18:41-5. 1997
    ....
  13. pmc Human RFamide-related peptide-1 diminishes cellular and integrated cardiac contractile performance
    R Nichols
    Department of Biological Chemistry, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Peptides 31:2067-74. 2010
    ..Elucidation of mechanisms involved in hRFRP-1 synthesis, release, and signaling may aid the development of strategies to prevent or attenuate cardiac dysfunction...
  14. ncbi Dromyosuppressin and drosulfakinin, two structurally related Drosophila neuropeptides, are uniquely expressed in the adult central nervous system
    R Nichols
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 1048, USA
    Ann N Y Acad Sci 814:315-8. 1997
    ..Our data indicate that DMS and DSK staining patterns in the adult central nervous system are unique and nonoverlapping...
  15. ncbi Regulating the activity of a cardioacceleratory peptide
    R Nichols
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 1048, USA
    Peptides 20:1153-8. 1999
    ..The effects observed in the animal and tissue and in larvae, pupae, and adults suggest that Drosophila crustacean cardioactive peptide cardiac signaling is modulated and developmentally regulated...
  16. ncbi The effects of three Drosophila melanogaster myotropins on the frequency of foregut contractions differ
    Susan Kaminski
    Undergraduate Research Opportunity Program, University of Michigan, Ann Arbor, MI 48109, USA
    J Neurogenet 16:125-34. 2002
    ....
  17. ncbi The drosulfakinin 0 (DSK 0) peptide encoded in the conserved Dsk gene affects adult Drosophila melanogaster crop contractions
    Gregory C Palmer
    Biological Chemistry Department, University of Michigan Medical School, Medical Science Research Building III, Ann Arbor, MI 48109 0606, USA
    J Insect Physiol 53:1125-33. 2007
    ..Peptide and genomic conservation, activity, and spatial and temporal distribution support the conclusion that DSK 0 plays diverse biological roles in drosopholids including regulating gut muscle contraction...
  18. ncbi A nonpeptide provides insight into mechanisms that regulate Drosophila melanogaster heart contractions
    Melissa Mispelon
    Undergraduate Cell and Molecular Biology Program, Biological Chemistry Department, University of Michigan Medical School, 4444 Medical Sciences Building I, Ann Arbor, MI 48109 0606, USA
    Peptides 24:1599-605. 2003
    ..These findings are consistent with the presence of tissue-specific myosuppressin receptors or mechanisms...
  19. ncbi Cellular expression of the Drosophila melanogaster FMRFamide neuropeptide gene product DPKQDFMRFamide. Evidence for differential processing of the FMRFamide polypeptide precursor
    R Nichols
    Department of Biological Chemistry, University of Michigan, Ann Arbor, USA
    J Mol Neurosci 6:1-10. 1995
    ..These data suggest that the Drosophila FMRFamide polypeptide precursor undergoes differential processing to produce DPKQDFMRFamide immunoreactive material in a limited number of cells expressing the FMRFamide precursor...
  20. ncbi Regulation of Drosophila FMRFamide neuropeptide gene expression
    R Nichols
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 1048, USA
    J Neurobiol 39:347-58. 1999
    ..Taken together, these data support the conclusion that TPAEDFMRFamide is differentially processed from the FMRFamide polypeptide protein precursor and may act in both neural and gastrointestinal tissue...
  21. ncbi The structure of the FMRFamide receptor and activity of the cardioexcitatory neuropeptide are conserved in mosquito
    Amanda Duttlinger
    Biological Chemistry Department, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neuropeptides 37:120-6. 2003
    ..These data support the conclusion that the structure of the FMRFamide receptor and activity of the cardioexcitatory FMRFamide neuropeptide are conserved in mosquito...
  22. ncbi Neuropeptide precursor processing detected by triple immunolabeling
    J McCormick
    Biology Department, University of Michigan, Ann Arbor 48109 1048, USA
    Cell Tissue Res 297:197-202. 1999
    ..Thus, our data indicate that D. melanogaster contains cell-specific proteolytic enzymes to cleave a polypeptide protein precursor, resulting in unique expression patterns of neuropeptides...
  23. ncbi The different effects of three Drosophila melanogaster dFMRFamide-containing peptides on crop contractions suggest these structurally related peptides do not play redundant functions in gut
    Amanda Duttlinger
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 0606, USA
    Peptides 23:1953-7. 2002
    ....
  24. ncbi Drosophila melanogaster FMRFamide-containing peptides: redundant or diverse functions?
    Janna Merte
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 1048, USA
    Peptides 23:209-20. 2002
    ..melanogaster FMRFamide gene in order to review the data on the expression, regulation, and activity of these peptides as well as acknowledge further endeavors required to elucidate FaRP signaling...
  25. ncbi Spatial and temporal analysis of the Drosophila FMRFamide neuropeptide gene product SDNFMRFamide: evidence for a restricted expression pattern
    R Nichols
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 1048, USA
    Neuropeptides 29:205-13. 1995
    ..This finding suggests that the Drosophila FMRFamide precursor undergoes differential post-translational processing...
  26. ncbi Spatial and temporal immunocytochemical analysis of drosulfakinin (Dsk) gene products in the Drosophila melanogaster central nervous system
    R Nichols
    Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Cell Tissue Res 283:107-16. 1996
    ..The observed expression of DSK-immunoreactive materials throughout development in numerous cells of the central nervous system suggests that DSK peptides may serve as hormones, modulators, or transmitters involved in several functions...
  27. ncbi Drosophila melanogaster myotropins have unique functions and signaling pathways
    J Merte
    Department of Biological Chemistry, University of Michigan, 830 N University Avenue, Ann Arbor, MI 48109 1048, USA
    Peptides 23:757-63. 2002
    ..The structures, expression patterns, and activities of the myotropins suggest they have important but different roles in biology and different signaling pathways...
  28. ncbi Genetic variation affecting heart rate in Drosophila melanogaster
    J Robbins
    Department of Biology, University of Michigan, Ann Arbor 48109 1048, USA
    Genet Res 74:121-8. 1999
    ....
  29. ncbi Isolation and structural characterization of Drosophila TDVDHVFLRFamide and FMRFamide-containing neural peptides
    R Nichols
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 1048
    J Mol Neurosci 3:213-8. 1992
    ..Two Drosophila neural genes, dsk and FMRFamide, are known to encode -ArgPheNH2-containing peptides; however, neither encodes TDVDHVFLRFamide, indicating that Drosophila contains another precursor encoding -ArgPheNH2 peptides...
  30. ncbi DPKQDFMRFamide expression is similar in two distantly related Drosophila species
    J Friedman
    Undergraduate Cell and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109-1048, USA
    Peptides 22:235-9. 2001
    ..Structure identity and similar distribution of DPKQDFMRFamide in D. virilis and D. melanogaster, two distantly related Drosophila species, suggests an important and conserved activity for the peptide...
  31. ncbi PCR amplification using deoxyinosine to replace an entire codon and at ambiguous positions
    H Liu
    University of Michigan, Ann Arbor
    Biotechniques 16:24-6. 1994
  32. pmc Identification in Drosophila melanogaster of the invertebrate G protein-coupled FMRFamide receptor
    Tom Meeusen
    Laboratory of Developmental Physiology and Molecular Biology, Katholieke Universiteit Leuven, Naamsestraat 59, Belgium
    Proc Natl Acad Sci U S A 99:15363-8. 2002
    ..To our knowledge, the cloned DrmFMRFa-R is the first functionally active FMRFamide G protein-coupled receptor described in invertebrates to date...
  33. ncbi Drosophila melanogaster flatline encodes a myotropin orthologue to Manduca sexta allatostatin
    Mitchell D Price
    Department of Biology, Queen s University, K7L 3N6, Kingston, Ontario, Canada
    Peptides 23:787-94. 2002
    ..In situ tissue hybridization further suggests FLT is a novel brain-gut peptide and specifically, the measured activity indicates that it is a potent myotropin. Despite its profound myotropic effect, pupae injected with FLT eclosed...
  34. ncbi Localization of leucomyosuppressin in the brain and circadian clock of the cockroach Leucophaea maderae
    Sandra Söhler
    Department of Biology, Animal Physiology, Philipps University Marburg, Marburg, Germany
    Cell Tissue Res 328:443-52. 2007
    ..Thus, leucomyosuppressin might play a role in the circadian system other than in the control of locomotor activity rhythms...
  35. pmc Evidence dromyosuppressin acts at posterior and anterior pacemakers to decrease the fast and the slow cardiac activity in the blowfly Protophormia terraenovae
    Anna Maria Angioy
    Dipartimento di Biologia Sperimentale, Sezione di Fisiologia Generale, Universita di Cagliari, 09042 Monserrato Cagliari, Italy
    Peptides 28:585-93. 2007
    ....

Research Grants2

  1. Novel Genes Involved in Drug Response
    Ruthann Nichols; Fiscal Year: 2002
    ..Ultimately, our research will determine the role of these gene products in mediating the effect of nicotine in humans. ..