Anthony P Nicholas

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Dual immunofluorescence study of citrullinated proteins in Alzheimer diseased frontal cortex
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, AL 35294, USA
    Neurosci Lett 545:107-11. 2013
  2. pmc Local administration of glucocorticoids decreases synovial citrullination in rheumatoid arthritis
    Dimitrios Makrygiannakis
    Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, SE 141 86, Stockholm, Sweden
    Arthritis Res Ther 14:R20. 2012
  3. doi request reprint Dual immunofluorescence study of citrullinated proteins in Parkinson diseased substantia nigra
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham, and the Birmingham Veterans Administration Medical Center, Birmingham, AL 35294, USA
    Neurosci Lett 495:26-9. 2011
  4. doi request reprint Effects of levodopa on striatal monoamines in mice with levodopa-induced hyperactivity
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham, AL 35294, USA
    Neurosci Lett 443:204-8. 2008
  5. doi request reprint Striatal histone modifications in models of levodopa-induced dyskinesia
    Anthony P Nicholas
    Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, AL 35294 0017, USA
    J Neurochem 106:486-94. 2008
  6. ncbi request reprint Levodopa-induced hyperactivity in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, Alabama 35294 0017, USA
    Mov Disord 22:99-104. 2007
  7. ncbi request reprint Expression of citrullinated proteins in murine experimental autoimmune encephalomyelitis
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35249 7340, USA
    J Comp Neurol 486:254-66. 2005
  8. ncbi request reprint Atypical Hallervorden-Spatz disease with preserved cognition and obtrusive obsessions and compulsions
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35249 7340, USA
    Mov Disord 20:880-6. 2005
  9. ncbi request reprint Clinical signs and symptoms in a large hereditary spastic paraparesis pedigree with a novel spastin mutation
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, Alabama 35249 7340, USA
    Mov Disord 19:641-8. 2004
  10. ncbi request reprint Immunohistochemical localization of citrullinated proteins in adult rat brain
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35249 7340, USA
    J Comp Neurol 459:251-66. 2003

Detail Information

Publications22

  1. pmc Dual immunofluorescence study of citrullinated proteins in Alzheimer diseased frontal cortex
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, AL 35294, USA
    Neurosci Lett 545:107-11. 2013
    ..Although the identities of these citrullinated proteins remain largely unknown, the present study adds to the growing number of locations in which deiminated proteins may be found in the brains of patients with AD...
  2. pmc Local administration of glucocorticoids decreases synovial citrullination in rheumatoid arthritis
    Dimitrios Makrygiannakis
    Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, SE 141 86, Stockholm, Sweden
    Arthritis Res Ther 14:R20. 2012
    ..As a result, the present study examined the possibility that effective antirheumatic treatment will decrease the level of synovial citrullination...
  3. doi request reprint Dual immunofluorescence study of citrullinated proteins in Parkinson diseased substantia nigra
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham, and the Birmingham Veterans Administration Medical Center, Birmingham, AL 35294, USA
    Neurosci Lett 495:26-9. 2011
    ....
  4. doi request reprint Effects of levodopa on striatal monoamines in mice with levodopa-induced hyperactivity
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham, AL 35294, USA
    Neurosci Lett 443:204-8. 2008
    ..The results of the present study demonstrate that there is a distinct profile of striatal monoamines conducive to LID that must be considered when trying to explain the effects of anti-LID drugs utilizing monoamine receptors...
  5. doi request reprint Striatal histone modifications in models of levodopa-induced dyskinesia
    Anthony P Nicholas
    Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, AL 35294 0017, USA
    J Neurochem 106:486-94. 2008
    ..However, both models exhibit marked deacetylation of histone H4, suggesting that inhibitors of H4 deacetylation may be useful in preventing or reversing LDID...
  6. ncbi request reprint Levodopa-induced hyperactivity in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, Alabama 35294 0017, USA
    Mov Disord 22:99-104. 2007
    ..These results demonstrate that levodopa can cause reproducible hyperactivity in mice that were previously exposed to MPTP...
  7. ncbi request reprint Expression of citrullinated proteins in murine experimental autoimmune encephalomyelitis
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35249 7340, USA
    J Comp Neurol 486:254-66. 2005
    ..spinal cords. These results raise the possibility that citrullination of both GFAP and MBP may contribute to the pathophysiology of EAE and that the brains of EAE mice may contain more pathology than previously realized...
  8. ncbi request reprint Atypical Hallervorden-Spatz disease with preserved cognition and obtrusive obsessions and compulsions
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35249 7340, USA
    Mov Disord 20:880-6. 2005
    ..This case demonstrates that HSD patients who survive into middle age should not be assumed to have a progressive dementia. In such cases, atypical behavioral problems such as persistent obsessions and compulsions may be present instead...
  9. ncbi request reprint Clinical signs and symptoms in a large hereditary spastic paraparesis pedigree with a novel spastin mutation
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, Alabama 35249 7340, USA
    Mov Disord 19:641-8. 2004
    ..These results suggest that specific clinical signs and symptoms may be of value in differentiating individuals affected with SPG4 from family members with nonspecific neurological findings...
  10. ncbi request reprint Immunohistochemical localization of citrullinated proteins in adult rat brain
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35249 7340, USA
    J Comp Neurol 459:251-66. 2003
    ....
  11. ncbi request reprint Increased citrullinated glial fibrillary acidic protein in secondary progressive multiple sclerosis
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, Alabama 35249 7340, USA
    J Comp Neurol 473:128-36. 2004
    ..These data raise the possibility that citrullination of GFAP contributes to the pathophysiology of MS...
  12. pmc Medical decision-making capacity in cognitively impaired Parkinson's disease patients without dementia
    Roy C Martin
    Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Mov Disord 23:1867-74. 2008
    ..Clinicians and researchers should carefully assess decisional capacity in all patients with PD with cognitive impairment...
  13. pmc Clinical interview assessment of financial capacity in older adults with mild cognitive impairment and Alzheimer's disease
    Daniel C Marson
    Department of Neurology, SC 650, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Am Geriatr Soc 57:806-14. 2009
    ..To investigate financial capacity in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) using a clinician interview approach...
  14. ncbi request reprint Preparation of a monoclonal antibody to citrullinated epitopes: its characterization and some applications to immunohistochemistry in human brain
    Anthony P Nicholas
    Department of Neurology and Center for Neuroimmunology, University of Alabama at Birmingham 35249, USA
    Glia 37:328-36. 2002
    ..These potentially implicate citrullinated proteins, notably in astroglial filaments, in a variety of normal and pathological neurobiological processes...
  15. doi request reprint Relief of acquired stuttering associated with Parkinson's disease by unilateral left subthalamic brain stimulation
    Harrison C Walker
    Department of Neurology, University of Alabama at Birmingham, 1720 7th Avenue, South Birmingham, AL 35212, USA
    J Speech Lang Hear Res 52:1652-7. 2009
    ..In this article, the authors report a case of acquired stuttering associated with Parkinson's disease (PD) that was responsive to unilateral subthalamic nucleus deep-brain stimulation (STN DBS) in the language-dominant hemisphere...
  16. ncbi request reprint Increased peptidylarginine deiminase type II in hypoxic astrocytes
    Thiagarajan Sambandam
    Department of Neurology, University of Alabama at Birmingham, School of Medicine, Birmingham, AL 35294, USA
    Biochem Biophys Res Commun 325:1324-9. 2004
    ..Thus, this is the first report to demonstrate a measurable response in the amounts of PAD 2 mRNA, protein and activity in human astrocytes by prolonged hypoxic exposure...
  17. ncbi request reprint The fate of biodegradable microspheres injected into rat brain
    Anthony P Nicholas
    Department of Neurology, University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, 619 19th Street South, Birmingham, AL 35249 7340, USA
    Neurosci Lett 323:85-8. 2002
    ..5 microm in diameter was primarily by microglia in vivo during the first week post-injection. In contrast, only a small minority of these microspheres appeared to be engulfed by astrocytes...
  18. pmc The contribution of executive control on verbal-learning impairment in patients with Parkinson's disease with dementia and Alzheimer's disease
    Timothy J O'Brien
    Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA
    Arch Clin Neuropsychol 24:237-44. 2009
    ..These findings suggest that deficits in executive functions play a vital role in learning impairments in patients with PDD; however, for AD patients, learning difficulties appear relatively independent of executive dysfunction...
  19. ncbi request reprint Expression pattern of peptidylarginine deiminase in rat and human Schwann cells
    Gerburg Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg, Magdeburg, Germany
    Dev Neurobiol 68:101-14. 2008
    ..These data suggest that, similar to the CNS, citrullination of proteins may also exert a specific role in thecourse of PNS development and repair...
  20. ncbi request reprint Citrullinated proteins in rheumatoid arthritis: crucial...but not sufficient!
    Tineke Cantaert
    University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 54:3381-9. 2006
  21. ncbi request reprint Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity
    Leen De Rycke
    Ghent University Hospital, Belgium
    Arthritis Rheum 52:2323-30. 2005
    ....
  22. ncbi request reprint Evidence for Epstein-Barr virus autoantibodies against human brain in demyelinating encephalitis
    Anthony P Nicholas
    Neuropathol Appl Neurobiol 28:498-501. 2002