Research Topics
| Anthony P NicholasSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Detail Information
Publications
Local administration of glucocorticoids decreases synovial citrullination in rheumatoid arthritisDimitrios Makrygiannakis
Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, SE 141 86, Stockholm, Sweden
Arthritis Res Ther 14:R20. 2012..As a result, the present study examined the possibility that effective antirheumatic treatment will decrease the level of synovial citrullination...- Striatal histone modifications in models of levodopa-induced dyskinesiaAnthony P Nicholas
Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, AL 35294 0017, USA
J Neurochem 106:486-94. 2008..However, both models exhibit marked deacetylation of histone H4, suggesting that inhibitors of H4 deacetylation may be useful in preventing or reversing LDID... - Effects of levodopa on striatal monoamines in mice with levodopa-induced hyperactivityAnthony P Nicholas
Department of Neurology, University of Alabama at Birmingham, AL 35294, USA
Neurosci Lett 443:204-8. 2008..The results of the present study demonstrate that there is a distinct profile of striatal monoamines conducive to LID that must be considered when trying to explain the effects of anti-LID drugs utilizing monoamine receptors... - Expression of citrullinated proteins in murine experimental autoimmune encephalomyelitisAnthony P Nicholas
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35249 7340, USA
J Comp Neurol 486:254-66. 2005..spinal cords. These results raise the possibility that citrullination of both GFAP and MBP may contribute to the pathophysiology of EAE and that the brains of EAE mice may contain more pathology than previously realized... - Atypical Hallervorden-Spatz disease with preserved cognition and obtrusive obsessions and compulsionsAnthony P Nicholas
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35249 7340, USA
Mov Disord 20:880-6. 2005..This case demonstrates that HSD patients who survive into middle age should not be assumed to have a progressive dementia. In such cases, atypical behavioral problems such as persistent obsessions and compulsions may be present instead... - Levodopa-induced hyperactivity in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnthony P Nicholas
Department of Neurology, University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, Alabama 35294 0017, USA
Mov Disord 22:99-104. 2007..These results demonstrate that levodopa can cause reproducible hyperactivity in mice that were previously exposed to MPTP... - Clinical signs and symptoms in a large hereditary spastic paraparesis pedigree with a novel spastin mutationAnthony P Nicholas
Department of Neurology, University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, Alabama 35249 7340, USA
Mov Disord 19:641-8. 2004..These results suggest that specific clinical signs and symptoms may be of value in differentiating individuals affected with SPG4 from family members with nonspecific neurological findings... - Increased citrullinated glial fibrillary acidic protein in secondary progressive multiple sclerosisAnthony P Nicholas
Department of Neurology, University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, Alabama 35249 7340, USA
J Comp Neurol 473:128-36. 2004..These data raise the possibility that citrullination of GFAP contributes to the pathophysiology of MS... - Immunohistochemical localization of citrullinated proteins in adult rat brainAnthony P Nicholas
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35249 7340, USA
J Comp Neurol 459:251-66. 2003.... - Dual immunofluorescence study of citrullinated proteins in Parkinson diseased substantia nigraAnthony P Nicholas
Department of Neurology, University of Alabama at Birmingham, and the Birmingham Veterans Administration Medical Center, Birmingham, AL 35294, USA
Neurosci Lett 495:26-9. 2011.... - Medical decision-making capacity in cognitively impaired Parkinson's disease patients without dementiaRoy C Martin
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
Mov Disord 23:1867-74. 2008..Clinicians and researchers should carefully assess decisional capacity in all patients with PD with cognitive impairment... - Clinical interview assessment of financial capacity in older adults with mild cognitive impairment and Alzheimer's diseaseDaniel C Marson
Department of Neurology, SC 650, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Am Geriatr Soc 57:806-14. 2009..To investigate financial capacity in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) using a clinician interview approach... - Preparation of a monoclonal antibody to citrullinated epitopes: its characterization and some applications to immunohistochemistry in human brainAnthony P Nicholas
Department of Neurology and Center for Neuroimmunology, University of Alabama at Birmingham 35249, USA
Glia 37:328-36. 2002..These potentially implicate citrullinated proteins, notably in astroglial filaments, in a variety of normal and pathological neurobiological processes... - Increased peptidylarginine deiminase type II in hypoxic astrocytesThiagarajan Sambandam
Department of Neurology, University of Alabama at Birmingham, School of Medicine, Birmingham, AL 35294, USA
Biochem Biophys Res Commun 325:1324-9. 2004..Thus, this is the first report to demonstrate a measurable response in the amounts of PAD 2 mRNA, protein and activity in human astrocytes by prolonged hypoxic exposure... - Relief of acquired stuttering associated with Parkinson's disease by unilateral left subthalamic brain stimulationHarrison C Walker
Department of Neurology, University of Alabama at Birmingham, 1720 7th Avenue, South Birmingham, AL 35212, USA
J Speech Lang Hear Res 52:1652-7. 2009..In this article, the authors report a case of acquired stuttering associated with Parkinson's disease (PD) that was responsive to unilateral subthalamic nucleus deep-brain stimulation (STN DBS) in the language-dominant hemisphere... - The fate of biodegradable microspheres injected into rat brainAnthony P Nicholas
Department of Neurology, University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, 619 19th Street South, Birmingham, AL 35249 7340, USA
Neurosci Lett 323:85-8. 2002..5 microm in diameter was primarily by microglia in vivo during the first week post-injection. In contrast, only a small minority of these microspheres appeared to be engulfed by astrocytes... - The contribution of executive control on verbal-learning impairment in patients with Parkinson's disease with dementia and Alzheimer's diseaseTimothy J O'Brien
Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA
Arch Clin Neuropsychol 24:237-44. 2009..These findings suggest that deficits in executive functions play a vital role in learning impairments in patients with PDD; however, for AD patients, learning difficulties appear relatively independent of executive dysfunction... - Expression pattern of peptidylarginine deiminase in rat and human Schwann cellsGerburg Keilhoff
Institute of Medical Neurobiology, University of Magdeburg, Magdeburg, Germany
Dev Neurobiol 68:101-14. 2008..These data suggest that, similar to the CNS, citrullination of proteins may also exert a specific role in thecourse of PNS development and repair... - Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunityLeen De Rycke
Ghent University Hospital, Belgium
Arthritis Rheum 52:2323-30. 2005..The link with PAD-2 and local and systemic ACPA levels emphasizes their pathophysiologic relevance for RA-specific humoral autoimmunity... - Evidence for Epstein-Barr virus autoantibodies against human brain in demyelinating encephalitisAnthony P Nicholas
Neuropathol Appl Neurobiol 28:498-501. 2002 - Citrullinated proteins in rheumatoid arthritis: crucial...but not sufficient!Tineke Cantaert
University of Amsterdam, Amsterdam, The Netherlands
Arthritis Rheum 54:3381-9. 2006