K L Nichol
Affiliation: University of Minnesota
- The efficacy, effectiveness and cost-effectiveness of inactivated influenza virus vaccinesKristin L Nichol
VA Medical Center and University of Minnesota, VA Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
Vaccine 21:1769-75. 2003..Additional health economic studies from developing countries and from tropical/subtropical regions will be vitally important for better understanding of the global burden of influenza and potential benefits of vaccination...
- Live attenuated influenza virus vaccines: new options for the prevention of influenzaK L Nichol
Medicine Service 111, VA Medical Center, University of Minnesota Medical School, One Veterans Drive, Minneapolis, MN 55417, USA
Vaccine 19:4373-7. 2001..LAIV vaccines will be an important addition to the armamentarium for fighting influenza...
- Cost-benefit analysis of a strategy to vaccinate healthy working adults against influenzaK L Nichol
Medicine Service 111, Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
Arch Intern Med 161:749-59. 2001..This group is not included among the traditional priority groups for annual vaccination. Immunization rates remain low...
- Cost effectiveness of influenza vaccination for healthy persons between ages 65 and 74 yearsKristin L Nichol
VA Medical Center, Medicine Service 111, One Veterans Drive, Minneapolis, MN 55417, USA
Vaccine 20:S21-4. 2002..The findings of this study again affirm the value of an age-based strategy for routine influenza vaccination of all elderly persons including healthy elderly persons between 65 and 74 years...
- The health and economic benefits associated with pneumococcal vaccination of elderly persons with chronic lung diseaseK L Nichol
Veterans Affairs Medical Center and the University of Minnesota Medical School, Minneapolis, USA
Arch Intern Med 159:2437-42. 1999..More than 50% of the elderly population has not received pneumococcal vaccination. Uncertainty regarding the benefits of immunization, particularly for noninvasive disease, may contribute to the underuse of pneumococcal vaccine...
- The health and economic benefits of influenza vaccination for healthy and at-risk persons aged 65 to 74 yearsK L Nichol
University of Minnesota, Minneapolis, USA
Pharmacoeconomics 16:63-71. 1999..The objective of this study was to assess the health and economic benefits of influenza vaccination in both healthy and at-risk seniors aged 65 to 74 years...
- Effectiveness of live, attenuated intranasal influenza virus vaccine in healthy, working adults: a randomized controlled trialK L Nichol
Medicine Service, VA Medical Center, and the University of Minnesota, Minneapolis 55417, USA
JAMA 282:137-44. 1999..Influenza virus is a major cause of illness, disruption to daily life, and increased use of health care in all age groups...
- Influence of clinical case definitions with differing levels of sensitivity and specificity on estimates of the relative and absolute health benefits of influenza vaccination among healthy working adults and implications for economic analysesKristin L Nichol
Minneapolis VA Medical Center and University of Minnesota, Medicine Service 111, 1 Veterans Drive, Minneapolis, MN 55417, USA
Virus Res 103:3-8. 2004..The definitions of clinical influenza illness and outcome periods should be selected to match the study question...
- Cost benefit of influenza vaccination in healthy, working adults: an economic analysis based on the results of a clinical trial of trivalent live attenuated influenza virus vaccineKristin L Nichol
VA Medical Center, Medicine Service 111, One Veterans Drive, Minneapolis, MN 55417, USA
Vaccine 21:2207-17. 2003..We therefore conducted a cost benefit analysis of influenza vaccination of healthy working adults utilizing clinical outcome data from a trial of LAIV in healthy working adults...
- Generalist and subspecialist physicians' knowledge, attitudes, and practices regarding influenza and pneumococcal vaccinations for elderly and other high-risk patients: a nationwide surveyK L Nichol
Center for Chronic Disease Outcomes Research, VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
Arch Intern Med 161:2702-8. 2001..Influenza and pneumococcal vaccination rates remain too low. This survey assessed generalist and subspecialist physicians' knowledge, attitudes, and practices regarding influenza and pneumococcal vaccinations for high-risk patients...
- Influenza vaccine effectiveness in preventing hospitalizations and deaths in persons 65 years or older in Minnesota, New York, and Oregon: data from 3 health plansJ Nordin
HealthPartners Research Foundation, Minneapolis, MN 55440-1524, USA
J Infect Dis 184:665-70. 2001..These results show that all elderly persons should be immunized annually for influenza. The methods used in this study are an efficient cost-effective way to study vaccine impact and similar questions...
- Side effects associated with pneumococcal vaccinationK L Nichol
Medical Service, VA Medical Center, Minneapolis, MN 55417, USA
Am J Infect Control 25:223-8. 1997..These findings should help health care providers and their patients address an important barrier to pneumococcal immunization...
- Health-related quality of life predicts future health care utilization and mortality in veterans with self-reported physician-diagnosed arthritis: the veterans arthritis quality of life studyJasvinder A Singh
Rheumatology Section, Medicine Service, VA Medical Center, Minneapolis, MN 55417, USA
Semin Arthritis Rheum 34:755-65. 2005..To investigate whether health-related quality of life (HRQOL) measures predict health care utilization and mortality in a cohort of veterans with self-reported physician-diagnosed arthritis...
- Colds and influenza-like illnesses in university students: impact on health, academic and work performance, and health care useKristin L Nichol
Medicine Service, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
Clin Infect Dis 40:1263-70. 2005..We sought to assess the impact of URIs (colds and influenza-like illnesses [ILIs]) on the health, academic and work performance, and health care use of university students...
- The Veterans Short Form 36 questionnaire is predictive of mortality and health-care utilization in a population of veterans with a self-reported diagnosis of asthma or COPDMark D Sprenkle
Division of Pulmonary and Critical Care Medicine, Hennepin County Medical Center, Minneapolis, MN 55415, USA
Chest 126:81-9. 2004..However, as their predictive capacity for mortality or medical utilization is less well defined, we sought to examine the relationship of a general measure of HRQL and outcomes in persons with obstructive lung disease...
- Heterogeneity of influenza case definitions and implications for interpreting and comparing study resultsKristin L Nichol
University of Minnesota, Medicine Service 111, Minneapolis Veterans Affairs Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
Vaccine 24:6726-8. 2006....
- Modeling seasonal influenza outbreak in a closed college campus: impact of pre-season vaccination, in-season vaccination and holidays/breaksKristin L Nichol
Research Service, Veterans Affairs Medical Center, Minneapolis, Minnesota, United States of America
PLoS ONE 5:e9548. 2010..We conducted the present study to assess the impact of various vaccination strategies including delayed (i.e., in-season) vaccination on influenza outbreaks on a college campus...
- Improving influenza vaccination rates among adultsKristin L Nichol
University of Minnesota, USA
Cleve Clin J Med 73:1009-15. 2006..We should also consider alternative paradigms for vaccine delivery, and be sure to be vaccinated ourselves...
- Influenza vaccination in the elderly: impact on hospitalisation and mortalityKristin L Nichol
Minneapolis Veterans Affairs Medical Center, University of Minnesota, Minneapolis, Minnesota 55417, USA
Drugs Aging 22:495-515. 2005..Enhancing vaccine delivery to elderly persons would represent important progress toward that goal...
- Vaccines for seasonal and pandemic influenzaKristin L Nichol
University of Minnesota and Minneapolis VA Medical Center, Minneapolis, MN, USA
J Infect Dis 194:S111-8. 2006..Additional experimental approaches are required to achieve the ultimate goal for seasonal and pandemic influenza prevention--namely, the ability to generate broadly cross-reactive and durable protection in humans...
- Influenza vaccination and reduction in hospitalizations for cardiac disease and stroke among the elderlyKristin L Nichol
Veterans Affairs Medical Center and the University of Minnesota, Minneapolis 55417, USA
N Engl J Med 348:1322-32. 2003..During two influenza seasons, we assessed the influence of vaccination against influenza on the risk of hospitalization for heart disease and stroke, hospitalization for pneumonia and influenza, and death from all causes...
- Effectiveness of influenza vaccine in the community-dwelling elderlyKristin L Nichol
Medicine Service and Center for Chronic Disease Outcomes Research, Minneapolis Veterans Affairs Medical Center and University of Minnesota, Minneapolis 55417, USA
N Engl J Med 357:1373-81. 2007..This study examined the effectiveness of influenza vaccine in seniors over the long term while addressing potential bias and residual confounding in the results...
- Rapid diagnosis of influenza infection in older adults: influence on clinical care in a routine clinical settingSarah J D'Heilly
VA Medical Center, Minneapolis, MN, USA
J Clin Virol 42:124-8. 2008..Laboratory diagnosis of influenza has previously relied on viral isolation in culture. Rapid antigen tests (RATs) are now available but few studies have examined their use in older adults under routine clinical conditions...
- Influenza vaccination among college and university students: impact on influenzalike illness, health care use, and impaired school performanceKristin L Nichol
VA Medical Center, Minneapolis, MN 55417, USA
Arch Pediatr Adolesc Med 162:1113-8. 2008..To assess influenza vaccine effectiveness against influenzalike illness (ILI) and ILI impact on health care use and school performance among college and university students...
- Burden of influenza-like illness and effectiveness of influenza vaccination among working adults aged 50-64 yearsKristin L Nichol
Research Service, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
Clin Infect Dis 48:292-8. 2009..Uncertainties regarding influenza disease impact and benefits of vaccination may contribute to low vaccination rates among adults aged 50-64 years...
- Challenges in evaluating influenza vaccine effectiveness and the mortality benefits controversyKristin L Nichol
Research Service 151, VA Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
Vaccine 27:6305-11. 2009..At present, even after taking into account the potential for residual bias and confounding, most studies confirm the benefits of vaccination among the elderly for reducing hospitalization and death...
- Factors associated with influenza and pneumococcal vaccination behavior among high-risk adultsK L Nichol
Medical Service, Minneapolis Veterans Affairs Medical Center, MN 55417, USA
J Gen Intern Med 11:673-7. 1996..CONCLUSIONS: Emphasis on provider recommendations and the knowledge and attitudes of patients may enhance influenza and pneumococcal vaccination rates, even in the context of organized vaccination programs...
- Influence of clinical outcome and outcome period definitions on estimates of absolute clinical and economic benefits of influenza vaccination in community dwelling elderly personsK L Nichol
VA Medical Center, Minneapolis, MN 55417, USA
Vaccine 24:1562-8. 2006..They also highlight how different outcome definitions can influence the results of health economic analyses...
- Long-term success with the national health objective for influenza vaccination: an institution-wide modelK L Nichol
Section of General Internal Medicine, VA Medical Center, Minneapolis, MN 55417
J Gen Intern Med 7:595-600. 1992..CONCLUSION: This highly successful institution-wide influenza vaccination program can be sustained long-term. Elements of this program may help others take advantage of opportunities for influenza prevention...
- Burden of upper respiratory illnesses among college and university students: 2002-2003 and 2003-2004 cohortsK L Nichol
Medicine Service 111, Minneapolis VA Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
Vaccine 24:6724-5. 2006..Efforts to prevent upper respiratory illnesses among college and university students could improve their health and reduce health care utilization during the winter months...
- Health-related quality of life, functional impairment, and healthcare utilization by veterans: veterans' quality of life studyJasvinder A Singh
Medicine Service, Center for Chronic Disease Outcomes Research, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
J Am Geriatr Soc 53:108-13. 2005..To describe the health status of veterans receiving care in a veterans integrated service network (VISN)...
- Work-site-based influenza vaccination in healthcare and non-healthcare settingsSarah J D'Heilly
Medicine Service and Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minnesota 55417, USA
Infect Control Hosp Epidemiol 25:941-5. 2004..To better understand work-site-based programs for influenza vaccination...
- Immune function and vaccine responses in healthy advanced elderly patientsP J Carson
Infectious Disease Section Campus Box 111F, Veterans Affairs Medical Center, 1 Veterans Dr, Minneapolis, MN 55417, USA
Arch Intern Med 160:2017-24. 2000..However, to our knowledge, few studies have specifically characterized the rapidly expanding advanced elderly population or controlled adequately for concurrent diseases...
- Safety and acceptability of pneumococcal vaccinations administered in nontraditional settingsSarah D'Heilly
Medicine Service and Center for Chronic Disease Outcomes Research, VA Medical Center and Department of Medicine, University of Minnesota, Minneapolis 55417, USA
Am J Infect Control 30:261-8. 2002..Concerns about the safety and acceptability of vaccine administration in nontraditional settings might leave patients and their providers reluctant to take advantage of nontraditional settings for immunizations...
- Adherence of mass vaccinators to timing guidelines for influenza vaccinationSarah J D'Heilly
Medicine Service and Center for Chronic Disease Outcomes Research, Veterans Administration Medical Center, Minneapolis, Minnesota, USA
Am J Prev Med 26:46-50. 2004..This cross-sectional survey of persons vaccinated in nontraditional settings (NTS) by mass vaccinators was conducted to assess how effectively the mass vaccinators were able to implement these vaccination-timing guidelines...
- Safety of influenza vaccinations administered in nontraditional settingsSarah J D'Heilly
The Medicine Service 111, VA Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
Vaccine 24:4024-7. 2006..No deaths were reported. We conclude that influenza vaccine administration in mass vaccination clinics is safe and adverse events after influenza vaccination in NTS are extremely low...
- Efficacy and effectiveness of influenza vaccinationKristin L Nichol
VA Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
Vaccine 26:D17-22. 2008..Published by Elsevier Ltd...
- Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: a VA cooperative studyGeoffrey J Gorse
Department of Veterans Affairs, Medical Center, Saint Louis University, St Louis, MO, USA
Vaccine 21:2133-44. 2003..17, 0.53), and -0.05 for type B virus (95% CL: -1.13, 0.48). However, there was a possible advantage for TC over TP in reducing respiratory consequences of an influenza season measured by pulmonary function and symptoms at end of study...
- Cost-effectiveness of live attenuated influenza vaccine versus inactivated influenza vaccine among children aged 24-59 months in the United StatesBryan R Luce
United BioSource Corporation, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA
Vaccine 26:2841-8. 2008....
- Recognizing influenza in older patients with chronic obstructive pulmonary disease who have received influenza vaccineKathleen M Neuzil
Department of Veterans Affairs Puget Sound Health Care System and University of Washington School of Medicine, Seattle, Washington 98108, USA
Clin Infect Dis 36:169-74. 2003..Additional studies are warranted to define optimal methods for the diagnosis of influenza among older persons with chronic obstructive pulmonary disease...
- Impact of a winter respiratory virus season on patients with COPD and association with influenza vaccinationGeoffrey J Gorse
Division of Infectious Diseases and Immunology, Saint Louis University Health Sciences Center, 3635 Vista Ave FDT 8N, St Louis, MO 63110, USA
Chest 130:1109-16. 2006....
- Development and validation of a clinical prediction rule for hospitalization due to pneumonia or influenza or death during influenza epidemics among community-dwelling elderly personsEelko Hak
Julius Center for General Practice and Patient Oriented Research, University Medical Center, Utrecht, The Netherlands
J Infect Dis 189:450-8. 2004....
- Influence of high-risk medical conditions on the effectiveness of influenza vaccination among elderly members of 3 large managed-care organizationsEelko Hak
HealthPartners Research Foundation, Bloomington, IN, USA
Clin Infect Dis 35:370-7. 2002..4- to 4.7-fold higher among high-risk than among healthy elderly persons. All elderly individuals may substantially benefit from vaccination. However, the impact of influenza is greater in persons with high-risk medical conditions...
- Immunization for seniorsDale W Bratzler
Oklahoma Foundation for Medical Quality, Inc, Oklahoma City, Oklahoma, USA
J Law Med Ethics 30:128-34. 2002..Despite state efforts to improve vaccination rates of seniors, efforts that have included regulatory and educational approaches, significant challenges remain in designing immunization programs for seniors that are universally effective...
- Guidelines for quality standards for immunizationPierce Gardner
Department of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
Clin Infect Dis 35:503-11. 2002
- Barriers to adult immunizationDavid R Johnson
Scientific and Medical Affairs, Sanofi Pasteur Inc, Swiftwater, Pennsylvania 18017, USA
Am J Med 121:S28-35. 2008..We conclude that a better understanding of why adults do not get vaccinated is important for efforts to increase immunization rates in this broad age group...
- Non-traditional settings for influenza vaccination of adults: costs and cost effectivenessLisa A Prosser
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
Pharmacoeconomics 26:163-78. 2008..All analyses are from the US societal perspective...
- Safety, efficacy, and effectiveness of live, attenuated, cold-adapted influenza vaccine in an indicated population aged 5-49 yearsRobert B Belshe
Center for Vaccine Development, Saint Louis University School of Medicine, St Louis, MO 63110, USA
Clin Infect Dis 39:920-7. 2004....
- First do no harm: ensuring that healthcare workers vaccinate and are vaccinatedKristin L Nichol
Infect Control Hosp Epidemiol 24:799-800. 2003
- Clinical effectiveness of first and repeat influenza vaccination in adult and elderly diabetic patientsIngrid Looijmans-Van den Akker
Julius Center for Health Sciences and Primary Health Care, University Medical Center, Utrecht, The Netherlands
Diabetes Care 29:1771-6. 2006..We assessed the clinical effectiveness of influenza vaccination in adults with diabetes and specifically examined potential modification of effect by age and prior influenza vaccine uptake...
- Benefits of influenza vaccine in US elderly--appreciating issues of confounding bias and precisionEelko Hak
Int J Epidemiol 35:800-2; author reply 799-800. 2006
- Where adults reported receiving influenza vaccination in the United StatesJames A Singleton
National Immunization Program, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Am J Infect Control 33:563-70. 2005..This study assessed locations at which US adults receive influenza (flu) vaccinations and the relative roles that traditional and nontraditional vaccination settings play in influenza vaccine delivery...
- Influenza vaccination: policy versus evidence: no gap between policy and evidenceDavid S Fedson
BMJ 333:1020. 2006