Affiliation: University of Washington
- Regional variation in out-of-hospital cardiac arrest incidence and outcomeGraham Nichol
Department of Biostatistics, University of Washington Clinical Trial Center, Seattle, WA, USA
JAMA 300:1423-31. 2008..The health and policy implications of regional variation in incidence and outcome of out-of-hospital cardiac arrest remain to be determined...
- Advanced cardiac life support in out-of-hospital cardiac arrestIan G Stiell
Department of Emergency Medicine, Ottawa Health Research Institute, University of Ottawa, Ottawa Ont, Canada
N Engl J Med 351:647-56. 2004..The Ontario Prehospital Advanced Life Support (OPALS) Study tested the incremental effect on the rate of survival after out-of-hospital cardiac arrest of adding a program of advanced life support to a program of rapid defibrillation...
- Does induction of hypothermia improve outcomes after in-hospital cardiac arrest?Graham Nichol
University of Washington Harborview Center for Prehospital Emergency Care, USA
Resuscitation 84:620-5. 2013..Therefore, we evaluated the effect of induced hypothermia in a large cohort of patients with in-hospital cardiac arrest...
- Using and interpreting cost-effectiveness acceptability curves: an example using data from a trial of management strategies for atrial fibrillationElisabeth Fenwick
Public Health and Health Policy, University of Glasgow, Glasgow, UK
BMC Health Serv Res 6:52. 2006..The objective of the paper is to illustrate how to construct and interpret a CEAC...
- Methodological design for economic evaluation in Public Access Defibrillation (PAD) trialGraham Nichol
Harborview Center for Prehospital Research and Training, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
Am Heart J 150:202-8. 2005..Our objective is to describe the rationale and methods for the economic analysis of the PAD trial. The objective of this analysis is to assess whether automated external defibrillators (AEDs) use by lay responders is good value for money...
- Cost-effectiveness of cardiac resynchronization therapy in patients with symptomatic heart failureGraham Nichol
University of Washington Harborview Prehospital Emergency Care Research and Training Center and Harborview Medical Center, Seattle, Washington 98104, USA
Ann Intern Med 141:343-51. 2004..Resynchronization of ventricular contraction in patients with heart failure improves ejection fraction. The long-term morbidity and costs associated with such cardiac resynchronization therapy remain unclear...
- Impact of informed consent requirements on cardiac arrest research in the United States: exception from consent or from research?G Nichol
Clinical Epidemiology Program and Department of Medicine, University of Ottawa, ON, Canada
Resuscitation 62:3-23. 2004..We systematically reviewed randomized trials over a 10-year period to assess the impact of these regulations...
- Systematic review of percutaneous cardiopulmonary bypass for cardiac arrest or cardiogenic shock statesGraham Nichol
University of Washington, Harborview Center for Prehospital Emergency Care, Box 359727, 325 Ninth Ave, Seattle, WA 98104, USA
Resuscitation 70:381-94. 2006..Therefore, we have reviewed systematically the published experience with percutaneous bypass in patients with cardiogenic shock or cardiac arrest...
- Design and implementation of resuscitation research: special challenges and potential solutionsGraham Nichol
University of Washington, Harborview Center for Prehospital Emergency Care, Box 359727, 325 Ninth Avenue, Seattle, WA 98104, USA
Resuscitation 73:337-46. 2007..Rigorous statistical methods can be used to analyze multiple data without an excessive increase in the chance of a false-positive result...
- International Resuscitation Network Registry: design, rationale and preliminary resultsG Nichol
University of Washington, Seattle, WA 98104, USA
Resuscitation 65:265-77. 2005..Therefore, it is feasible to conduct adequately powered randomized trials of resuscitation therapies in international settings...
- On coenrollment in clinical resuscitation studies: review and experience from randomized trialsG Nichol
University of Washington Harborview Center for Prehospital Emergency Care, Department of Medicine and University of Washington Clinical Trial Center, Department of Biostatistics, University of Washington, Seattle, WA 98104, USA
Resuscitation 81:792-5. 2010..Patients with acute life-threatening illness are candidates for enrollment in multiple trials. Whether patients are enrolled in multiple trials has implications for patient safety, trial enrollment duration, and study validity...
- Consent in resuscitation trials: benefit or harm for patients and society?Graham Nichol
University of Washington Clinical Trial Center, Seattle, WA, USA
Resuscitation 70:360-8. 2006..Such research can be conducted without prior consent if specific criteria are met. However consent is sometimes required for continued participation and may bias the results of the study...
- Cost-effectiveness of lay responder defibrillation for out-of-hospital cardiac arrestGraham Nichol
University of Washington, Seattle, WA, USA
Ann Emerg Med 54:226-35.e1-2. 2009....
- Regional cardiac resuscitation systems of careGraham Nichol
University of Washington Harborview Center for Prehospital Emergency Care, Seattle, Washington, USA
Curr Opin Crit Care 16:223-30. 2010..We review evidence of the effectiveness of regional cardiac resuscitation systems and describe preliminary recommended elements of such systems...
- What is the quality of life for survivors of cardiac arrest? A prospective studyG Nichol
Clinical Epidemiology Unit, Loeb Research Institute, University of Ottawa, Ontario, Canada
Acad Emerg Med 6:95-102. 1999..To evaluate the quality of life of survivors of in-hospital and out-of-hospital cardiac arrest, and to correlate quality of life with clinically important parameters...
- Survival increases with CPR by Emergency Medical Services before defibrillation of out-of-hospital ventricular fibrillation or ventricular tachycardia: observations from the Resuscitation Outcomes ConsortiumSteven M Bradley
University of Washington Harborview Center for Prehospital Emergency Care, Department of Medicine, University of Washington, Seattle, WA, USA
Resuscitation 81:155-62. 2010..We examined the effect of the duration of Emergency Medical Services (EMS) cardiopulmonary resuscitation (CPR) prior to first defibrillation on survival in patients with out-of-hospital VF/VT...
- Predicting survival after out-of-hospital cardiac arrest: role of the Utstein data elementsThomas D Rea
Department of Medicine, University of Washington, 401 5th Avenue, Seattle, WA, USA
Ann Emerg Med 55:249-57. 2010..The Utstein elements are designed to assess these links and provide the basis for comparing outcomes within and across communities. We assess whether these measures sufficiently predict survival and explain outcome differences...
- Transthoracic incremental monophasic versus biphasic defibrillation by emergency responders (TIMBER): a randomized comparison of monophasic with biphasic waveform ascending energy defibrillation for the resuscitation of out-of-hospital cardiac arrest due Peter J Kudenchuk
Department of Medicine, University of Washington, Seattle, WA, USA
Circulation 114:2010-8. 2006..Although biphasic, as compared with monophasic, waveform defibrillation for cardiac arrest is increasing in use and popularity, whether it is truly a more lifesaving waveform is unproven...
- Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trialEileen M Bulger
Department of Surgery, University of Washington, Seattle, USA
JAMA 304:1455-64. 2010..Hypertonic fluids restore cerebral perfusion with reduced cerebral edema and modulate inflammatory response to reduce subsequent neuronal injury and thus have potential benefit in resuscitation of patients with traumatic brain injury (TBI)...
- Out-of-hospital hypertonic resuscitation after traumatic hypovolemic shock: a randomized, placebo controlled trialEileen M Bulger
Department of Surgery, University of Washington, Seattle, WA
Ann Surg 253:431-41. 2011..To determine whether out-of-hospital administration of hypertonic fluids would improve survival after severe injury with hemorrhagic shock...
- The use of pre-hospital mild hypothermia after resuscitation from out-of-hospital cardiac arrestFrancis Kim
Department of Medicine and Neurology, University of Washington, Seattle, Washington 98104, USA
J Neurotrauma 26:359-63. 2009..Whether field cooling will improve survival and neurologic outcome remains an important unanswered clinical question...
- Choosing antithrombotic therapy for elderly patients with atrial fibrillation who are at risk for fallsM Man-Son-Hing
Department of Medicine, University of Ottawa, Ontario, Canada
Arch Intern Med 159:677-85. 1999..To determine whether the risk of falling (with a possible increased chance of subdural hematoma) should influence the choice of antithrombotic therapy in elderly patients with atrial fibrillation...
- Comparison of the Cerebral Performance Category score and the Health Utilities Index for survivors of cardiac arrestIan G Stiell
Department of Emergency Medicine, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
Ann Emerg Med 53:241-248. 2009..We evaluate the comparability of results from the Cerebral Performance Category scale versus those of the validated but more complex Health Utilities Index scale for health-related quality of life...
- Two simple questions to assess neurologic outcomes at 3 months after out-of-hospital cardiac arrest: experience from the public access defibrillation trialW T Longstreth
Department of Neurology, School of Medicine, University of Washington, Seattle, WA, USA
Resuscitation 81:530-3. 2010..Two simple questions have been used to classify neurologic outcome in patients with stroke. Could they be similarly applied to patients with cardiac arrest?..
- Dialysis, kidney transplantation, or pancreas transplantation for patients with diabetes mellitus and renal failure: a decision analysis of treatment optionsGreg A Knoll
Division of Nephrology, Department of Medicine, University of Ottawa, Canada
J Am Soc Nephrol 14:500-15. 2003..For patients without a living donor, simultaneous pancreas-kidney transplantation is associated with the greatest life expectancy...
- Essential features of designating out-of-hospital cardiac arrest as a reportable event: a scientific statement from the American Heart Association Emergency Cardiovascular Care Committee; Council on Cardiopulmonary, Perioperative, and Critical Care; CouncGraham Nichol
University of Washington, USA
Circulation 117:2299-308. 2008..Potential barriers to action on cardiac arrest include concerns about privacy, methodological challenges, and costs associated with designating cardiac arrest as a reportable event...
- Active surface cooling protocol to induce mild therapeutic hypothermia after out-of-hospital cardiac arrest: a retrospective before-and-after comparison in a single hospitalCreighton W Don
Departments of Medicine, University of Washington, Seattle, WA, USA
Crit Care Med 37:3062-9. 2009....
- Cardiac arrest and cardiopulmonary resuscitation outcome reports: update and simplification of the Utstein templates for resuscitation registries. A statement for healthcare professionals from a task force of the international liaison committee on resusciIan Jacobs
Pediatric Critical Care Fellowship, Children s Hospital of Philadelphia, Department of Anesthesia and Critical Care, 34th St and Civic Center Blvd Sixth Floor, Room 6120C, Philadelphia, PA 19104 4309, USA
Resuscitation 63:233-49. 2004..Uniform collection and tracking of registry data should enable better continuous quality improvement within every hospital, EMS system, and community...
- Reducing barriers for implementation of bystander-initiated cardiopulmonary resuscitation: a scientific statement from the American Heart Association for healthcare providers, policymakers, and community leaders regarding the effectiveness of cardiopulmonBenjamin S Abella
University of Pennsylvania, USA
Circulation 117:704-9. 2008
- Delayed time to defibrillation after in-hospital cardiac arrestPaul S Chan
Saint Luke s Mid America Heart Institute, Kansas City, MO 64111, USA
N Engl J Med 358:9-17. 2008..However, empirical data on the prevalence of delayed defibrillation in the United States and its effect on survival are limited...
- Recommended guidelines for monitoring, reporting, and conducting research on medical emergency team, outreach, and rapid response systems: an Utstein-style scientific statement: a scientific statement from the International Liaison Committee on ResuscitatMary Ann Peberdy
Virginia Commonwealth University, USA
Circulation 116:2481-500. 2007
- Hospitalization costs of primary stenting versus thrombolysis in acute myocardial infarction: cost analysis of the Canadian STAT StudyMichel R Le May
Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Canada
Circulation 108:2624-30. 2003..This study looks at the hospitalization costs of primary stenting compared with accelerated tPA...
- The Resuscitation Outcomes Consortium Epistry-Trauma: design, development, and implementation of a North American epidemiologic prehospital trauma registryCraig D Newgard
Center for Policy and Research in Emergency Medicine, Department of Emergency Medicine, Oregon Health and Science University, Portland, OR 97239 3098, United States
Resuscitation 78:170-8. 2008..This data registry samples patients from 264 EMS agencies transporting to 287 acute care hospitals in both the United States and Canada...
- Resuscitation Outcomes Consortium (ROC) PRIMED cardiac arrest trial methods part 1: rationale and methodology for the impedance threshold device (ITD) protocolTom P Aufderheide
Milwaukee, WI, USA
Resuscitation 78:179-85. 2008..Secondary aims are to compare functional status and depression at discharge and at 3 and 6 months post-discharge in survivors...
- Health-related quality of life is better for cardiac arrest survivors who received citizen cardiopulmonary resuscitationIan Stiell
Clinical Epidemiology Unit, Office F657, Ottawa Health Research Institute, 1053 Carling Ave, Ottawa, Ontario K1Y 4E9, Canada
Circulation 108:1939-44. 2003..This study evaluated the prehospital factors associated with better health-related quality of life for survivors of out-of-hospital cardiac arrest...
- The Public Access Defibrillation (PAD) trial: study design and rationaleJoseph P Ornato
Department of Emergency Medicine, Medical College of Virginia, Virginia Commonwealth University Health Center, 401 North 12th Street, Box 525, Room G 248, Richmond, VA 23298 0525, USA
Resuscitation 56:135-47. 2003..Secondary endpoints include neurological status, health-related quality of life (HRQL), cost, and cost-effectiveness. Data collection will last approximately 15 months and is expected to be completed in September 2003...
- Cardiopulmonary resuscitation of adults in the hospital: a report of 14720 cardiac arrests from the National Registry of Cardiopulmonary ResuscitationMary Ann Peberdy
Virginia Commonwealth University s Health System, West Hospital, Richmond, VA 23298, USA
Resuscitation 58:297-308. 2003..Neurological outcome in discharged survivors was generally good. Eighty-six percent of patients with Cerebral Performance Category-1 (CPC-1) at the time of hospital admission had a postarrest CPC-1 at the time of hospital discharge...
- The PULSE initiative: scientific priorities and strategic planning for resuscitation research and life saving therapiesLance B Becker
Department of Medicine, University of Chicago, Chicago, IL 60637, USA
Circulation 105:2562-70. 2002
- Scientific knowledge gaps and clinical research priorities for cardiopulmonary resuscitation and emergency cardiovascular care identified during the 2005 International Consensus Conference on ECC [corrected] and CPR science with treatment recommendations:Raúl J Gazmuri
North Chicago VA and Rosalind Franklin University of Medicine and Science, USA
Circulation 116:2501-12. 2007
- Recommended guidelines for monitoring, reporting, and conducting research on medical emergency team, outreach, and rapid response systems: an Utstein-style scientific statement. A Scientific Statement from the International Liaison Committee on ResuscitatMary Ann Peberdy
Resuscitation 75:412-33. 2007
- Cardiac arrest and cardiopulmonary resuscitation outcome reports: update and simplification of the Utstein templates for resuscitation registries: a statement for healthcare professionals from a task force of the International Liaison Committee on ResusciIan Jacobs
Circulation 110:3385-97. 2004..Uniform collection and tracking of registry data should enable better continuous quality improvement within every hospital, emergency medical services system, and community...
- Cost-effectiveness of rhythm versus rate control in atrial fibrillationDeborah A Marshall
Center for Evaluation of Medicine, McMaster University and St Joseph s Hospital, Hamilton, Ontario, Canada
Ann Intern Med 141:653-61. 2004..Consequently, economic factors often play a role in guiding treatment selection...
- First documented rhythm and clinical outcome from in-hospital cardiac arrest among children and adultsVinay M Nadkarni
Departments of Anesthesia, Critical Care, and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia 19104 4399, USA
JAMA 295:50-7. 2006..Cardiac arrests in children are typically asystole or PEA...
- Community lay rescuer automated external defibrillation programs: key state legislative components and implementation strategies: a summary of a decade of experience for healthcare providers, policymakers, legislators, employers, and community leaders froTom Aufderheide
Circulation 113:1260-70. 2006..This statement will not address legislation to support home AED programs. Such recommendations may be made after the conclusion of a large study of home AED use...
- Use of implantable cardioverter defibrillators after out-of-hospital cardiac arrest: a prospective follow-up studyRatika Parkash
Ottawa Health Research Institute
CMAJ 171:1053-6. 2004..We sought to determine the ICD insertion rate among survivors of out-of-hospital cardiac arrest and to determine factors associated with ICD implantation...
- Economic value of out-of-hospital emergency care: a structured literature reviewE Brooke Lerner
Department of Emergency Medicine, University of Rochester, Rochester, NY 14642, USA
Ann Emerg Med 47:515-24. 2006..The objective of this study is to conduct a structured review of published economic evaluations of out-of-hospital emergency care to assess its economic value...
- Response to cardiac arrest and selected life-threatening medical emergencies: the medical emergency response plan for schools--a statement for healthcare providers, policymakers, school administrators, and community leadersMary Fran Hazinski
Ann Emerg Med 43:83-99. 2004
- Response to cardiac arrest and selected life-threatening medical emergencies: the medical emergency response plan for schools: A statement for healthcare providers, policymakers, school administrators, and community leadersMary Fran Hazinski
Circulation 109:278-91. 2004
- Rationale, development and implementation of the Resuscitation Outcomes Consortium Epistry-Cardiac ArrestLaurie J Morrison
Prehospital and Transport Medicine Research Program, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Suite C753, Toronto, Ontario, Canada M4N 3M5
Resuscitation 78:161-9. 2008..To describe the development, design and consequent scientific implications of the Resuscitation Outcomes Consortium (ROC) population-based registry; ROC Epistry-Cardiac Arrest...
- Response to cardiac arrest and selected life-threatening medical emergencies: the medical emergency response plan for schools. A statement for healthcare providers, policymakers, school administrators, and community leadersMary Fran Hazinski
Pediatrics 113:155-68. 2004
- A comprehensive framework for determining the cost of an emergency medical services systemE Brooke Lerner
Department of Emergency Medicine, University of Rochester, Rochester, NY, USA
Ann Emerg Med 49:304-13. 2007..This framework can be used to standardize the calculation of EMS system costs to a community. Standardizing the calculation of EMS cost will allow for comparisons of costs between studies, communities, and interventions...
- Evaluation of outcome and cost-effectiveness using an FDG PET-guided approach to management of patients with coronary disease and severe left ventricular dysfunction (PARR-2): rationale, design, and methodsRob Beanlands
Cardiac PET Center, Divisions of Cardiology and Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Control Clin Trials 24:776-94. 2003..If so, thousands of such patients can be risk-stratified to select who is likely to benefit from revascularization...
- Scientific knowledge gaps and clinical research priorities for cardiopulmonary resuscitation and emergency cardiovascular care identified during the 2005 International Consensus Conference on ECC and CPR Science with Treatment Recommendations. A consensusRaúl J Gazmuri
Rosalind Franklin University of Medicine and Science, North Chicago Medical Center, Chicago, USA
Resuscitation 75:400-11. 2007
- Assessment of BLS skills: optimizing use of instructor and manikin measuresBonnie Lynch
University of Dundee School of Medicine, Dundee, Tayside Centre for General Practice, Mackenzie Building, Kirsty Semple Way, Dundee DD2 4BF, United Kingdom
Resuscitation 76:233-43. 2008..Comparisons of instructors' subjective assessments with objective data from recording manikins provide one means of understanding the magnitude and type of instructor errors in assessment...
- Recommendations for implementation of community consultation and public disclosure under the Food and Drug Administration's "Exception from informed consent requirements for emergency research": a special report from the American Heart AssociatiHenry Halperin
Johns Hopkins University
Circulation 116:1855-63. 2007
- Cancer screening and life expectancy of Canadian patients with kidney failureSahar Kajbaf
Division of Nephrology, Department of Medicine, Loeb Research Institute, Ottawa, Ontario, Canada
Nephrol Dial Transplant 17:1786-9. 2002..The purpose of this study was to determine if patients with ESRD benefit, in terms of life expectancy, by screening for breast and cervical cancer...
- Positron emission tomography and recovery following revascularization (PARR-1): the importance of scar and the development of a prediction rule for the degree of recovery of left ventricular functionRob S B Beanlands
Cardiac PET Centre, Divisions of Cardiology and Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada
J Am Coll Cardiol 40:1735-43. 2002....
- Effectiveness of a 30-min CPR self-instruction program for lay responders: a controlled randomized studyBonnie Lynch
RMC Research Corporation, 522 SW Fifth Avenue, Suite 1407, Portland, OR 97204, USA
Resuscitation 67:31-43. 2005..The hypotheses were that VSI results in performance of basic CPR skills superior to that of untrained learners and similar to that of learners in Heartsaver classes...
- Retention of CPR skills learned in a traditional AHA Heartsaver course versus 30-min video self-training: a controlled randomized studyEric L Einspruch
RMC Research Corporation, 111 SW Columbia Street, Suite 1200, Portland, OR 97201, United States
Resuscitation 74:476-86. 2007....
- Review of economic evaluations of radiofrequency catheter ablation for cardiac arrhythmiasDeborah A Marshall
Department of Clinical Epidemiology and Biostatistics, McMaster University and Centre for Evaluation of Medicines, St Joseph s Hospital, Hamilton, Canada
Can J Cardiol 19:1285-304. 2003....