Cuong Quoc Nguyen
Affiliation: University of Florida
Nguyen C, Peck A. Unraveling the pathophysiology of Sjogren syndrome-associated dry eye disease. Ocul Surf. 2009;7:11-27 pubmed
..Current studies using appropriate animal models in parallel with studies of human subjects are rapidly establishing a foundation for new intervention strategies that go beyond merely treating symptoms. ..
Nguyen C, Sharma A, Lee B, She J, McIndoe R, Peck A. Differential gene expression in the salivary gland during development and onset of xerostomia in Sjögren's syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse. Arthritis Res Ther. 2009;11:R56 pubmed publisher
Nguyen C, Gao J, Kim H, Saban D, Cornelius J, Peck A. IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren's syndrome-like disease of the nonobese diabetic mouse. J Immunol. 2007;179:382-90 pubmed
..These data imply a requirement for the IL-4/STAT6-pathway for onset of the clinical phase of SjS-like disease in the NOD mouse model. ..
Nguyen C, Kim H, Cornelius J, Peck A. Development of Sjogren's syndrome in nonobese diabetic-derived autoimmune-prone C57BL/6.NOD-Aec1Aec2 mice is dependent on complement component-3. J Immunol. 2007;179:2318-29 pubmed
Nguyen C, Hu M, Li Y, Stewart C, Peck A. Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjögren's syndrome: findings in humans and mice. Arthritis Rheum. 2008;58:734-43 pubmed publisher
..NOD-Aec1Aec2 mice and SS patients at the time of disease. A correlation between up-regulated IL-17/IL-23 expression and specific clinical manifestations of SS has yet to be identified. ..
Nguyen C, Cornelius J, Cooper L, Neff J, Tao J, Lee B, et al
. Identification of possible candidate genes regulating Sjögren's syndrome-associated autoimmunity: a potential role for TNFSF4 in autoimmune exocrinopathy. Arthritis Res Ther. 2008;10:R137 pubmed publisher
..Identification of possible candidate genes permits construction of models describing underlying molecular pathogenic mechanisms in this model of SjS and establishes a basis for construction of specific gene knockout mice. ..
Nguyen C, Sharma A, She J, McIndoe R, Peck A. Differential gene expressions in the lacrimal gland during development and onset of keratoconjunctivitis sicca in Sjögren's syndrome (SJS)-like disease of the C57BL/6.NOD-Aec1Aec2 mouse. Exp Eye Res. 2009;88:398-409 pubmed publisher
Nguyen C, Yin H, Lee B, Chiorini J, Peck A. IL17: potential therapeutic target in Sjögren's syndrome using adenovirus-mediated gene transfer. Lab Invest. 2011;91:54-62 pubmed publisher
..Thus, therapeutic approach targeting IL17 may be effective in preventing glandular dysfunction. ..
Nguyen C, Yin H, Lee B, Carcamo W, Chiorini J, Peck A. Pathogenic effect of interleukin-17A in induction of Sjögren's syndrome-like disease using adenovirus-mediated gene transfer. Arthritis Res Ther. 2010;12:R220 pubmed publisher
..Thus, localized anti-IL17 therapy may be effective in preventing glandular dysfunction. ..