Cuong Quoc Nguyen

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Local delivery of AAV2-CTLA4IgG decreases sialadenitis and improves gland function in the C57BL/6.NOD-Aec1Aec2 mouse model of Sjögren's syndrome
    Hongen Yin
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Cranial Research, National Institutes of Health, 10 Center Drive, MSC1190, Bethesda, MD 20892, USA
    Arthritis Res Ther 14:R40. 2012
  2. pmc Sjögren's syndrome: studying the disease in mice
    Nicolas Delaleu
    Broegelmann Research Laboratory, The Gade Institute, University of Bergen, New Laboratory Building, 5th Floor, 5305, 5021 Bergen, Norway
    Arthritis Res Ther 13:217. 2011
  3. pmc Pathogenic effect of interleukin-17A in induction of Sjögren's syndrome-like disease using adenovirus-mediated gene transfer
    Cuong Q Nguyen
    Eli and Edythe L, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA
    Arthritis Res Ther 12:R220. 2010
  4. pmc IL17: potential therapeutic target in Sjögren's syndrome using adenovirus-mediated gene transfer
    Cuong Q Nguyen
    Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL 32610, USA
    Lab Invest 91:54-62. 2011
  5. pmc Differential gene expression in the salivary gland during development and onset of xerostomia in Sjögren's syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse
    Cuong Q Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Arthritis Res Ther 11:R56. 2009
  6. pmc Unraveling the pathophysiology of Sjogren syndrome-associated dry eye disease
    Cuong Q Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida 32610, USA
    Ocul Surf 7:11-27. 2009
  7. pmc Differential gene expressions in the lacrimal gland during development and onset of keratoconjunctivitis sicca in Sjögren's syndrome (SJS)-like disease of the C57BL/6.NOD-Aec1Aec2 mouse
    Cuong Q Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Exp Eye Res 88:398-409. 2009
  8. pmc Identification of possible candidate genes regulating Sjögren's syndrome-associated autoimmunity: a potential role for TNFSF4 in autoimmune exocrinopathy
    Cuong Q Nguyen
    Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
    Arthritis Res Ther 10:R137. 2008
  9. pmc Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjögren's syndrome: findings in humans and mice
    Cuong Q Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Arthritis Rheum 58:734-43. 2008
  10. pmc Development of Sjogren's syndrome in nonobese diabetic-derived autoimmune-prone C57BL/6.NOD-Aec1Aec2 mice is dependent on complement component-3
    Cuong Q Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    J Immunol 179:2318-29. 2007

Collaborators

Detail Information

Publications16

  1. pmc Local delivery of AAV2-CTLA4IgG decreases sialadenitis and improves gland function in the C57BL/6.NOD-Aec1Aec2 mouse model of Sjögren's syndrome
    Hongen Yin
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Cranial Research, National Institutes of Health, 10 Center Drive, MSC1190, Bethesda, MD 20892, USA
    Arthritis Res Ther 14:R40. 2012
    ..NOD-Aec1Aec2 mice, an animal model of pSS...
  2. pmc Sjögren's syndrome: studying the disease in mice
    Nicolas Delaleu
    Broegelmann Research Laboratory, The Gade Institute, University of Bergen, New Laboratory Building, 5th Floor, 5305, 5021 Bergen, Norway
    Arthritis Res Ther 13:217. 2011
    ..The present review summarizes current literature pertaining to both spontaneous and extrinsic-factor induced SS-like diseases in mouse models, discussing advantages and disadvantages related to the use of murine models in SS research...
  3. pmc Pathogenic effect of interleukin-17A in induction of Sjögren's syndrome-like disease using adenovirus-mediated gene transfer
    Cuong Q Nguyen
    Eli and Edythe L, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA
    Arthritis Res Ther 12:R220. 2010
    ..In the present study, we investigated the function of IL-17A on the development and onset of SS...
  4. pmc IL17: potential therapeutic target in Sjögren's syndrome using adenovirus-mediated gene transfer
    Cuong Q Nguyen
    Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL 32610, USA
    Lab Invest 91:54-62. 2011
    ..Thus, therapeutic approach targeting IL17 may be effective in preventing glandular dysfunction...
  5. pmc Differential gene expression in the salivary gland during development and onset of xerostomia in Sjögren's syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse
    Cuong Q Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Arthritis Res Ther 11:R56. 2009
    ..In an attempt to define the molecular bases underlying the onset of stomatitis sicca (xerostomia) in this C57BL/6.NOD-Aec1Aec2 mouse model, we have carried out a study using genomic microarray technology...
  6. pmc Unraveling the pathophysiology of Sjogren syndrome-associated dry eye disease
    Cuong Q Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida 32610, USA
    Ocul Surf 7:11-27. 2009
    ..Current studies using appropriate animal models in parallel with studies of human subjects are rapidly establishing a foundation for new intervention strategies that go beyond merely treating symptoms...
  7. pmc Differential gene expressions in the lacrimal gland during development and onset of keratoconjunctivitis sicca in Sjögren's syndrome (SJS)-like disease of the C57BL/6.NOD-Aec1Aec2 mouse
    Cuong Q Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Exp Eye Res 88:398-409. 2009
    ....
  8. pmc Identification of possible candidate genes regulating Sjögren's syndrome-associated autoimmunity: a potential role for TNFSF4 in autoimmune exocrinopathy
    Cuong Q Nguyen
    Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
    Arthritis Res Ther 10:R137. 2008
    ....
  9. pmc Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjögren's syndrome: findings in humans and mice
    Cuong Q Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Arthritis Rheum 58:734-43. 2008
    ..Importantly, Th17 cells appear to be intimately involved in autoimmunity. We undertook the present study to investigate whether the Th17/IL-23 system is up-regulated in Sjögren's syndrome (SS)...
  10. pmc Development of Sjogren's syndrome in nonobese diabetic-derived autoimmune-prone C57BL/6.NOD-Aec1Aec2 mice is dependent on complement component-3
    Cuong Q Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    J Immunol 179:2318-29. 2007
    ..C3(-/-) mice, apparently a direct consequence of C3 deficiency, supports a much more important role for complement in the adaptive autoimmune response than previously recognized, possibly implicating an essential role for innate immunity...
  11. pmc IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren's syndrome-like disease of the nonobese diabetic mouse
    Cuong Q Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    J Immunol 179:382-90. 2007
    ..These data imply a requirement for the IL-4/STAT6-pathway for onset of the clinical phase of SjS-like disease in the NOD mouse model...
  12. ncbi request reprint Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies
    Cuong Quoc Nguyen
    University of Florida, College of Dentistry, Department of Oral Biology, PO Box 100424, Gainesville, FL 32610, USA
    Front Biosci 12:1767-89. 2007
    ..Not surprising, the B cell is taking center stage. Here, we present an in-depth discussion of how B cell populations may be involved in orchestrating or determining exocrine gland dysfunction...
  13. pmc Sjögren's syndrome: an old tale with a new twist
    Byung Ha Lee
    Department of Oral Biology, College of Dentistry, University of Florida, PO Box 100424, Gainesville, FL 32610, USA
    Arch Immunol Ther Exp (Warsz) 57:57-66. 2009
    ....
  14. ncbi request reprint Early pathogenic events associated with Sjögren's syndrome (SjS)-like disease of the NOD mouse using microarray analysis
    Smruti J Killedar
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Lab Invest 86:1243-60. 2006
    ..The importance of NF-kappaB as a critical signal transduction pathway is also suggested but its link is not yet clear...
  15. pmc Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition
    Maire E Doyle
    Department of Oral Biology, College of Medicine, University of Florida, Gainesville, Florida, USA
    Am J Pathol 171:1224-36. 2007
    ..Thus, using this model we can identify potentially important pathophysiological mechanisms of the autoimmune attack and possible diagnostic markers for development of SjS-associated dacryoadenitis...
  16. pmc Characterization of intraocular immunopathology following intracameral inoculation with alloantigen
    Daniel R Saban
    Department of Pathology, University of Florida, Gainesville, FL, USA
    Mol Vis 14:615-24. 2008
    ..Thus, the current study was undertaken to detect and characterize potential pathological effects on intraocular tissues following intracameral inoculation with alloantigen...