Research Topics
Species | Jutamas NgampasutadolSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
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Publications
Molecular characterization of the interaction between sialylated Neisseria gonorrhoeae and factor HJutamas Shaughnessy
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Biol Chem 286:22235-42. 2011..These findings provide further insights into the species specificity of gonococcal infections and proof-of-concept of a novel therapeutic approach against gonorrhea, a disease rapidly becoming resistant to conventional antibiotics...
Human factor H interacts selectively with Neisseria gonorrhoeae and results in species-specific complement evasionJutamas Ngampasutadol
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 180:3426-35. 2008..Our findings may help to improve animal models for gonorrhea while also having implications in the choice of complement sources to evaluate neisserial vaccine candidates...- Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infectionJutamas Ngampasutadol
Section of Infectious Diseases, Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
Proc Natl Acad Sci U S A 102:17142-7. 2005..Our findings may lead to the development of better animal models for gonorrhea and may also have implications in the choice of complement sources to evaluate neisserial vaccine candidates... - Heptose I glycan substitutions on Neisseria gonorrhoeae lipooligosaccharide influence C4b-binding protein binding and serum resistanceSanjay Ram
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building, Room 322, 364 Plantation Street, Worcester, MA 01605, USA
Infect Immun 75:4071-81. 2007..This study provides mechanistic insights into how HepI LOS substitutions affect the serum resistance of N. gonorrhoeae... - Species-specificity of Neisseria gonorrhoeae infection: do human complement regulators contribute?Jutamas Ngampasutadol
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, United States
Vaccine 26:I62-6. 2008..Our findings may help to improve animal models for gonorrhea while also having implications in the choice of complement sources to evaluate neisserial vaccine candidates... - Factor H facilitates adherence of Neisseria gonorrhoeae to complement receptor 3 on eukaryotic cellsSarika Agarwal
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 185:4344-53. 2010..These results indicate adherence between fH-coated gonococci and CR3 and may provide a means for gonococci to gain sanctuary into nonprofessional phagocytes... - The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complementLisa A Lewis
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
PLoS Pathog 6:e1001027. 2010..Collectively, these data identify a key complement evasion mechanism with important implications for ongoing efforts to develop meningococcal vaccines that employ fHbp as one of its components... - Characterization of a peptide vaccine candidate mimicking an oligosaccharide epitope of Neisseria gonorrhoeae and resultant immune responses and functionJutamas Ngampasutadol
Section of Infectious Diseases, Department of Medicine, Evans Biomedical Research Center EBRC, Boston University Medical Center, Boston, MA 02118, USA
Vaccine 24:157-70. 2006..These data indicate that a peptide can mimic an oligosaccharide epitope and may form the basis for the development of a vaccine candidate for human immunization against N. gonorrhoeae... - Clinical and epidemiological correlates of genotypes within the Mycobacterium avium complex defined by restriction and sequence analysis of hsp65Sandra C Smole
Department of Medicine, Boston University School of Medicine, VA Boston Healthcare System, Boston, Massachusetts 02130, USA
J Clin Microbiol 40:3374-80. 2002.... - Factor H binding and function in sialylated pathogenic neisseriae is influenced by gonococcal, but not meningococcal, porinGuillermo Madico
Evans Biomedical Research Center, Boston University Medical Center, Boston, MA 02118, USA
J Immunol 178:4489-97. 2007..Our data highlight the different mechanisms used by these two related species to evade complement... - The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistanceGuillermo Madico
Section of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA
J Immunol 177:501-10. 2006..These data provide further support for inclusion of this molecule in a meningococcal vaccine. To reflect the critical function of this molecule, we suggest calling it fH-binding protein... - Molecular characterization of the interaction between porins of Neisseria gonorrhoeae and C4b-binding proteinHanna Jarva
Department of Laboratory Medicine, Division of Medical Protein Chemistry, University of Lund, Malmo, Sweden
J Immunol 179:540-7. 2007..Only those recombinant mutant C4BPs that bound to bacteria rescued them from 100% killing by rhesus serum, thereby providing a functional correlate for the binding studies and highlighting C4BP function in gonococcal serum resistance...