Research Topics
| Thomas NeylanSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Suppressed monocyte gene expression profile in men versus women with PTSDThomas C Neylan
Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Brain Behav Immun 25:524-31. 2011..Changes in immune cell gene expression may contribute to medical morbidity in PTSD...
Prior night sleep duration is associated with psychomotor vigilance in a healthy sample of police academy recruitsThomas C Neylan
Department of Psychiatry, University of California, San Francisco, San Francisco, California, USA
Chronobiol Int 27:1493-508. 2010..These findings demonstrate the feasibility of detecting sleep and circadian effects on cognitive performance in large field studies. These findings have implications regarding the daytime functioning of police officers...- Insomnia severity is associated with a decreased volume of the CA3/dentate gyrus hippocampal subfieldThomas C Neylan
Mental Health Service, DVA Medical Center, San Francisco, California 94121, USA
Biol Psychiatry 68:494-6. 2010..Our objective was to determine whether insomnia severity in a sample of posttraumatic stress disorder (PTSD) patients and control subjects was associated with decreased volume in the CA3/dentate hippocampal subfield... 
Neuroendocrine regulation of sleep disturbances in PTSDThomas C Neylan
University of California, San Francisco, San Francisco DVAMC 116P, 4150 Clement Street, San Francisco, CA 94121, USA
Ann N Y Acad Sci 1071:203-15. 2006....- Routine work environment stress and PTSD symptoms in police officersShira Maguen
San Francisco VA Medical Center, San Francisco, CA, USA
J Nerv Ment Dis 197:754-60. 2009..Ensuring that the work environment is functioning optimally protects against the effects of duty-related critical incidents and negative life events outside police service... - Hypothalamic-pituitary-adrenal axis activity and sleep in posttraumatic stress disorderChristian Otte
Department of Psychiatry, University of California, San Francisco, CA, USA
Neuropsychopharmacology 30:1173-80. 2005..Future studies should explore the temporal relationship between HPA activity, sleep disturbances, and psychopathology after a traumatic event... - Cortisol levels are positively correlated with hippocampal N-acetylaspartateThomas C Neylan
Mental Health Service, San Francisco Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
Biol Psychiatry 54:1118-21. 2003..Within the range of values seen in our subjects, cortisol may have a trophic effect on the hippocampus... - Effects of metyrapone on hypothalamic-pituitary-adrenal axis and sleep in women with post-traumatic stress disorderChristian Otte
Department of Psychiatry, University of California, San Francisco, California, USA
Biol Psychiatry 61:952-6. 2007..We previously reported a diminished delta sleep and hypothalamic-pituitary-adrenal (HPA) response to metyrapone in men with post-traumatic stress disorder (PTSD). In this study, we aimed to extend these findings to women... - Predictors of posttraumatic stress in police and other first respondersCharles R Marmar
San Francisco Veterans Affairs Medical Center, 4150 Clement St 116 P, San Francisco, CA 94121, USA
Ann N Y Acad Sci 1071:1-18. 2006..Next steps in this line of research will be to test this model prospectively in a sample of 400 police academy recruits assessed during training and currently being followed for the first 2 years of police service... - Association between childhood trauma and catecholamine response to psychological stress in police academy recruitsChristian Otte
Department of Psychiatry, University of California San Francisco, and Veterans Affairs Medical Center, San Francisco, CA, USA
Biol Psychiatry 57:27-32. 2005..Childhood trauma is a risk factor for anxiety disorders in adulthood. One possible mechanism for this association is an increased neuroendocrine response to stress in adults with a history of childhood trauma... - Transcriptional control of monocyte gene expression in post-traumatic stress disorderAoife O'Donovan
Veteran s Affairs Medical Center, San Francisco, CA 94121, USA
Dis Markers 30:123-32. 2011..Altered transcriptional control of monocyte gene expression could contribute to exaggerated inflammatory activity in PTSD... - Association between alexithymia and neuroendocrine response to psychological stress in police academy recruitsShannon E McCaslin
PTSD Research Program, University of California, San Francisco, VAMC 4150 Clement Street 116P, San Francisco, CA 94121, USA
Ann N Y Acad Sci 1071:425-7. 2006..Alexithymia scores were negatively associated with catecholamine response to the video challenge but no association was found between alexithymia scores and cortisol reactivity... - A prospective study of trait anger and PTSD symptoms in policeSusan M Meffert
Department of Psychiatry, University of California, San Francisco, CA 94143, USA
J Trauma Stress 21:410-6. 2008..Increased anger is important not only because of the impact it has on individual distress and physical health, but also because of its potential public health impact... - Longitudinal effects of PTSD on memory functioningKristin W Samuelson
Mental Health Service, San Francisco Veteran s Affairs Medical Center, San Francisco, CA 94133, USA
J Int Neuropsychol Soc 15:853-61. 2009..Compared to veterans without PTSD, veterans with PTSD showed a greater decline in delayed facial recognition only, and this decline was extremely subtle... - The mediating effects of sleep in the relationship between traumatic stress and health symptoms in urban police officersDavid Mohr
University of California, San Francisco, California, USA
Psychosom Med 65:485-9. 2003..This study explored the hypothesis that the relationship between posttraumatic stress symptoms and health is mediated by sleep problems... - No improvement of posttraumatic stress disorder symptoms with guanfacine treatmentThomas C Neylan
Department of Psychiatry, University of California, San Francisco, USA
Am J Psychiatry 163:2186-8. 2006..The authors report an 8-week, double-blind, randomized controlled trial of guanfacine versus placebo for posttraumatic stress disorder (PTSD)... - Family psychiatric history, peritraumatic reactivity, and posttraumatic stress symptoms: a prospective study of policeSabra S Inslicht
San Francisco VA Medical Center, San Francisco, CA 94121, USA
J Psychiatr Res 44:22-31. 2010..Family history of psychiatric and substance use disorders has been associated with posttraumatic stress disorder (PTSD) in cross-sectional studies... - Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorderNorbert Schuff
Center for Imaging of Neurodegenerative Diseases, DVA Medical Center, San Francisco, CA 94121, USA
Psychiatry Res 162:147-57. 2008..NAA appears to be a more sensitive marker for neuronal abnormality in PTSD than brain volume. The alteration in the anterior cingulate cortex in PTSD has implications for fear conditioning and extinction... - Patterns of altered cortical perfusion and diminished subcortical integrity in posttraumatic stress disorder: an MRI studyNorbert Schuff
Center for Imaging of Neurodegenerative Diseases, DVA Medical Center San Francisco, CA 94121, USA
Neuroimage 54:S62-8. 2011..Structural, perfusion, and diffusion MRI together may provide a signature for a PTSD marker... - Trait dissociation predicts posttraumatic stress disorder symptoms in a prospective study of urban police officersShannon E McCaslin
Mental Health Service, San Francisco VA Medical Center, San Francisco, California 94121, USA
J Nerv Ment Dis 196:912-8. 2008.... - Posttraumatic stress disorder and health-related quality of life in patients with coronary heart disease: findings from the Heart and Soul StudyBeth E Cohen
Department of Veterans Affairs Medical Center, General Internal Medicine, University of California, San Francisco, CA 94121, USA
Arch Gen Psychiatry 66:1214-20. 2009..In addition to its tremendous mental health burden, PTSD has been associated with worse physical health status and an increased risk of cardiovascular disease... - Neuropsychological functioning in posttraumatic stress disorder and alcohol abuseKristin W Samuelson
Mental Health Service, San Francisco Veteran s Affairs Medical Center, San Francisco, CA, USA
Neuropsychology 20:716-26. 2006..By controlling for alcohol and depression, the authors can more conclusively demonstrate that verbal memory and attention differences are associated with PTSD... - Current concepts in pharmacotherapy for posttraumatic stress disorderFrank B Schoenfeld
Department of Veterans Affairs Medical Center in San Francisco, San Francisco, California 94121, USA
Psychiatr Serv 55:519-31. 2004..Pharmacotherapy for PTSD that is comorbid with other psychiatric disorders is highlighted... - The effect of nefazodone on subjective and objective sleep quality in posttraumatic stress disorderThomas C Neylan
Department of Psychiatry, University of California, and the Psychiatry Service, San Francisco Veterans Affairs Medical Center, 94121, USA
J Clin Psychiatry 64:445-50. 2003..This study assesses the efficacy of nefazodone treatment (target dose of 400-600 mg/day) on objective and subjective sleep quality in Vietnam combat veterans with chronic DSM-IV posttraumatic stress disorder (PTSD)... - Attention, learning, and memory in posttraumatic stress disorderThomas C Neylan
Mental Health Service, San Francisco DVA Medical Center, San Francisco, California 94121, USA
J Trauma Stress 17:41-6. 2004..In this study, reduced hippocampal NAA did not appear to be associated with impaired declarative memory... - New directions in the pharmacotherapy of posttraumatic stress disorderCharles R Marmar
Department of Psychiatry, University of California, Department of Veterans Affairs Medical Center, San Francisco, California, USA
Psychiatr Q 73:259-70. 2002..Recommendations are specified for pharmacotherapy of trauma survivors in the immediate aftermath of traumatic exposure, and for those with acute and chronic posttraumatic stress disorders... - PTSD symptoms predict waking salivary cortisol levels in police officersThomas C Neylan
Department of Psychiatry, University of California, San Francisco, CA, USA
Psychoneuroendocrinology 30:373-81. 2005.... - Critical incident exposure and sleep quality in police officersThomas C Neylan
Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA
Psychosom Med 64:345-52. 2002..We examined the effects of critical incident exposure (trauma exposure) and routine (nontraumatic) work environment stressors on sleep quality after controlling for the effects of work shift schedule... - Increased cortisol in women with intimate partner violence-related posttraumatic stress disorderSabra S Inslicht
Department of Psychology, University of Pittsburgh Sennott Square, 3rd Floor, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
Psychoneuroendocrinology 31:825-38. 2006..Alterations of hypothalamic-pituitary-adrenal (HPA) axis function and sympathetic-adrenal activity have been proposed as key factors in biological models of posttraumatic stress disorder (PTSD)... - Delta sleep response to metyrapone in post-traumatic stress disorderThomas C Neylan
Department of Psychiatry, University of California, USA
Neuropsychopharmacology 28:1666-76. 2003..The results suggest that the delta sleep response to metyrapone is a measure of the brain response to increases in hypothalamic CRF. These data also suggest that the ACTH and sleep EEG response to hypothalamic CRF is decreased in PTSD... - Fear-potentiated startle and posttraumatic stress symptoms in urban police officersNnamdi Pole
Department of Psychiatry, University of California, San Francisco, USA
J Trauma Stress 16:471-9. 2003..Our results emphasize the importance of contextual threat and suggest that laboratory measures of startle improve upon self-reported exaggerated startle alone in indexing PTSD symptom severity in urban police officers... - Depressive symptoms and 24-hour urinary norepinephrine excretion levels in patients with coronary disease: findings from the Heart and Soul StudyChristian Otte
Department of Psychiatry, University of California, San Francisco, CA 94121, USA
Am J Psychiatry 162:2139-45. 2005..Future longitudinal studies are needed to determine whether elevations in norepinephrine contribute to adverse cardiac outcomes in patients with depressive symptoms... - Serum brain-derived neurotrophic factor predicts responses to escitalopram in chronic posttraumatic stress disorderWilliam Berger
Department of Psychiatry, University of California, San Francisco, CA, USA
Prog Neuropsychopharmacol Biol Psychiatry 34:1279-84. 2010..Some studies have found that antidepressants increase serum brain-derived neurotrophic factor (BDNF) levels in patients with major depression and the expression of BDNF mRNA in limbic structures of rats... - Temporal instability of auditory and visual event-related potentials in posttraumatic stress disorderThomas C Neylan
Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
Biol Psychiatry 53:216-25. 2003..Measures of variability about the group mean appear to be more informative about the cognitive electrophysiology of PTSD than measures of central tendency... - Increased cortisol in women with intimate partner violence-related posttraumatic stress disorderSabra S Inslicht
Veterans Affairs Medical Center, 4150 Clement Street 116P, San Francisco, CA 94121, USA
Ann N Y Acad Sci 1071:428-9. 2006..Cortisol was elevated in women with lifetime PTSD compared to controls. No differences were found for platelet catecholamines... - Posttraumatic stress disorder and risk of dementia among US veteransKristine Yaffe
San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Arch Gen Psychiatry 67:608-13. 2010..Posttraumatic stress disorder (PTSD) is highly prevalent among US veterans because of combat and may impair cognition... - A meta-analysis of cortisol response to challenge in human aging: importance of genderChristian Otte
Department of Psychiatry, University of California, San Francisco, CA, USA
Psychoneuroendocrinology 30:80-91. 2005..Prospective studies should explore whether the higher cortisol response in the elderly is a risk factor for developing neuropsychiatric and medical disorders... - Associations between childhood trauma and emotion-modulated psychophysiological responses to startling sounds: a study of police cadetsNnamdi Pole
Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1043, USA
J Abnorm Psychol 116:352-61. 2007..Results suggest that childhood trauma may lead to long-lasting alterations in emotional and psychophysiological reactivity even in the absence of current Axis I psychopathology... - Distinguishing current from remitted posttraumatic stress disorderSteven H Woodward
Arch Gen Psychiatry 63:940-1; author reply 941-2. 2006 - Fiftieth anniversary of the discovery of rapid eye movement (REM) sleepThomas C Neylan
J Neuropsychiatry Clin Neurosci 15:453. 2003 - Applied neuroscience in the study of delirium: the classic work of Engel and RomanoThomas C Neylan
J Neuropsychiatry Clin Neurosci 16:525. 2004
Research Grants
- SLEEP AND AROUSAL DISTURBANCES IN PTSDThomas Neylan; Fiscal Year: 2002..Finally, the study will validate wrist actigraphy against ambulatory polysomnography and provide data on 24 hour sleep-wake activity levels in PTSD. ..
- Neuroendocrine Regulation of Sleep in PTSDThomas Neylan; Fiscal Year: 2007..Finally, the results from the study have implications for the clinical applicability of CRF receptor antagonists, which continue to be developed. ..