Thomas Neylan

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Suppressed monocyte gene expression profile in men versus women with PTSD
    Thomas C Neylan
    Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Brain Behav Immun 25:524-31. 2011
  2. doi request reprint Prior night sleep duration is associated with psychomotor vigilance in a healthy sample of police academy recruits
    Thomas C Neylan
    Department of Psychiatry, University of California, San Francisco, San Francisco, California, USA
    Chronobiol Int 27:1493-508. 2010
  3. pmc Insomnia severity is associated with a decreased volume of the CA3/dentate gyrus hippocampal subfield
    Thomas C Neylan
    Mental Health Service, DVA Medical Center, San Francisco, California 94121, USA
    Biol Psychiatry 68:494-6. 2010
  4. ncbi request reprint Neuroendocrine regulation of sleep disturbances in PTSD
    Thomas C Neylan
    University of California, San Francisco, San Francisco DVAMC 116P, 4150 Clement Street, San Francisco, CA 94121, USA
    Ann N Y Acad Sci 1071:203-15. 2006
  5. doi request reprint Routine work environment stress and PTSD symptoms in police officers
    Shira Maguen
    San Francisco VA Medical Center, San Francisco, CA, USA
    J Nerv Ment Dis 197:754-60. 2009
  6. ncbi request reprint Hypothalamic-pituitary-adrenal axis activity and sleep in posttraumatic stress disorder
    Christian Otte
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Neuropsychopharmacology 30:1173-80. 2005
  7. pmc Cortisol levels are positively correlated with hippocampal N-acetylaspartate
    Thomas C Neylan
    Mental Health Service, San Francisco Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Biol Psychiatry 54:1118-21. 2003
  8. ncbi request reprint Effects of metyrapone on hypothalamic-pituitary-adrenal axis and sleep in women with post-traumatic stress disorder
    Christian Otte
    Department of Psychiatry, University of California, San Francisco, California, USA
    Biol Psychiatry 61:952-6. 2007
  9. ncbi request reprint Predictors of posttraumatic stress in police and other first responders
    Charles R Marmar
    San Francisco Veterans Affairs Medical Center, 4150 Clement St 116 P, San Francisco, CA 94121, USA
    Ann N Y Acad Sci 1071:1-18. 2006
  10. ncbi request reprint Association between childhood trauma and catecholamine response to psychological stress in police academy recruits
    Christian Otte
    Department of Psychiatry, University of California San Francisco, and Veterans Affairs Medical Center, San Francisco, CA, USA
    Biol Psychiatry 57:27-32. 2005

Research Grants

  1. SLEEP AND AROUSAL DISTURBANCES IN PTSD
    Thomas Neylan; Fiscal Year: 2002
  2. Neuroendocrine Regulation of Sleep in PTSD
    Thomas Neylan; Fiscal Year: 2007

Detail Information

Publications41

  1. pmc Suppressed monocyte gene expression profile in men versus women with PTSD
    Thomas C Neylan
    Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Brain Behav Immun 25:524-31. 2011
    ..Changes in immune cell gene expression may contribute to medical morbidity in PTSD...
  2. doi request reprint Prior night sleep duration is associated with psychomotor vigilance in a healthy sample of police academy recruits
    Thomas C Neylan
    Department of Psychiatry, University of California, San Francisco, San Francisco, California, USA
    Chronobiol Int 27:1493-508. 2010
    ..These findings demonstrate the feasibility of detecting sleep and circadian effects on cognitive performance in large field studies. These findings have implications regarding the daytime functioning of police officers...
  3. pmc Insomnia severity is associated with a decreased volume of the CA3/dentate gyrus hippocampal subfield
    Thomas C Neylan
    Mental Health Service, DVA Medical Center, San Francisco, California 94121, USA
    Biol Psychiatry 68:494-6. 2010
    ..Our objective was to determine whether insomnia severity in a sample of posttraumatic stress disorder (PTSD) patients and control subjects was associated with decreased volume in the CA3/dentate hippocampal subfield...
  4. ncbi request reprint Neuroendocrine regulation of sleep disturbances in PTSD
    Thomas C Neylan
    University of California, San Francisco, San Francisco DVAMC 116P, 4150 Clement Street, San Francisco, CA 94121, USA
    Ann N Y Acad Sci 1071:203-15. 2006
    ....
  5. doi request reprint Routine work environment stress and PTSD symptoms in police officers
    Shira Maguen
    San Francisco VA Medical Center, San Francisco, CA, USA
    J Nerv Ment Dis 197:754-60. 2009
    ..Ensuring that the work environment is functioning optimally protects against the effects of duty-related critical incidents and negative life events outside police service...
  6. ncbi request reprint Hypothalamic-pituitary-adrenal axis activity and sleep in posttraumatic stress disorder
    Christian Otte
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Neuropsychopharmacology 30:1173-80. 2005
    ..Future studies should explore the temporal relationship between HPA activity, sleep disturbances, and psychopathology after a traumatic event...
  7. pmc Cortisol levels are positively correlated with hippocampal N-acetylaspartate
    Thomas C Neylan
    Mental Health Service, San Francisco Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Biol Psychiatry 54:1118-21. 2003
    ..This study examined the relationship of hypothalamic-pituitary-adrenal measures and hippocampal N-acetylaspartate (NAA) in posttraumatic stress disorder (PTSD) patients and control subjects...
  8. ncbi request reprint Effects of metyrapone on hypothalamic-pituitary-adrenal axis and sleep in women with post-traumatic stress disorder
    Christian Otte
    Department of Psychiatry, University of California, San Francisco, California, USA
    Biol Psychiatry 61:952-6. 2007
    ..We previously reported a diminished delta sleep and hypothalamic-pituitary-adrenal (HPA) response to metyrapone in men with post-traumatic stress disorder (PTSD). In this study, we aimed to extend these findings to women...
  9. ncbi request reprint Predictors of posttraumatic stress in police and other first responders
    Charles R Marmar
    San Francisco Veterans Affairs Medical Center, 4150 Clement St 116 P, San Francisco, CA 94121, USA
    Ann N Y Acad Sci 1071:1-18. 2006
    ..Next steps in this line of research will be to test this model prospectively in a sample of 400 police academy recruits assessed during training and currently being followed for the first 2 years of police service...
  10. ncbi request reprint Association between childhood trauma and catecholamine response to psychological stress in police academy recruits
    Christian Otte
    Department of Psychiatry, University of California San Francisco, and Veterans Affairs Medical Center, San Francisco, CA, USA
    Biol Psychiatry 57:27-32. 2005
    ..Childhood trauma is a risk factor for anxiety disorders in adulthood. One possible mechanism for this association is an increased neuroendocrine response to stress in adults with a history of childhood trauma...
  11. doi request reprint Transcriptional control of monocyte gene expression in post-traumatic stress disorder
    Aoife O'Donovan
    Veteran s Affairs Medical Center, San Francisco, CA 94121, USA
    Dis Markers 30:123-32. 2011
    ..Altered transcriptional control of monocyte gene expression could contribute to exaggerated inflammatory activity in PTSD...
  12. ncbi request reprint Association between alexithymia and neuroendocrine response to psychological stress in police academy recruits
    Shannon E McCaslin
    PTSD Research Program, University of California, San Francisco, VAMC 4150 Clement Street 116P, San Francisco, CA 94121, USA
    Ann N Y Acad Sci 1071:425-7. 2006
    ..Alexithymia scores were negatively associated with catecholamine response to the video challenge but no association was found between alexithymia scores and cortisol reactivity...
  13. doi request reprint A prospective study of trait anger and PTSD symptoms in police
    Susan M Meffert
    Department of Psychiatry, University of California, San Francisco, CA 94143, USA
    J Trauma Stress 21:410-6. 2008
    ..Increased anger is important not only because of the impact it has on individual distress and physical health, but also because of its potential public health impact...
  14. doi request reprint Longitudinal effects of PTSD on memory functioning
    Kristin W Samuelson
    Mental Health Service, San Francisco Veteran s Affairs Medical Center, San Francisco, CA 94133, USA
    J Int Neuropsychol Soc 15:853-61. 2009
    ..Compared to veterans without PTSD, veterans with PTSD showed a greater decline in delayed facial recognition only, and this decline was extremely subtle...
  15. ncbi request reprint The mediating effects of sleep in the relationship between traumatic stress and health symptoms in urban police officers
    David Mohr
    University of California, San Francisco, California, USA
    Psychosom Med 65:485-9. 2003
    ..This study explored the hypothesis that the relationship between posttraumatic stress symptoms and health is mediated by sleep problems...
  16. ncbi request reprint No improvement of posttraumatic stress disorder symptoms with guanfacine treatment
    Thomas C Neylan
    Department of Psychiatry, University of California, San Francisco, USA
    Am J Psychiatry 163:2186-8. 2006
    ..The authors report an 8-week, double-blind, randomized controlled trial of guanfacine versus placebo for posttraumatic stress disorder (PTSD)...
  17. pmc Family psychiatric history, peritraumatic reactivity, and posttraumatic stress symptoms: a prospective study of police
    Sabra S Inslicht
    San Francisco VA Medical Center, San Francisco, CA 94121, USA
    J Psychiatr Res 44:22-31. 2010
    ..Family history of psychiatric and substance use disorders has been associated with posttraumatic stress disorder (PTSD) in cross-sectional studies...
  18. pmc Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder
    Norbert Schuff
    Center for Imaging of Neurodegenerative Diseases, DVA Medical Center, San Francisco, CA 94121, USA
    Psychiatry Res 162:147-57. 2008
    ..NAA appears to be a more sensitive marker for neuronal abnormality in PTSD than brain volume. The alteration in the anterior cingulate cortex in PTSD has implications for fear conditioning and extinction...
  19. pmc Patterns of altered cortical perfusion and diminished subcortical integrity in posttraumatic stress disorder: an MRI study
    Norbert Schuff
    Center for Imaging of Neurodegenerative Diseases, DVA Medical Center San Francisco, CA 94121, USA
    Neuroimage 54:S62-8. 2011
    ..Structural, perfusion, and diffusion MRI together may provide a signature for a PTSD marker...
  20. doi request reprint Trait dissociation predicts posttraumatic stress disorder symptoms in a prospective study of urban police officers
    Shannon E McCaslin
    Mental Health Service, San Francisco VA Medical Center, San Francisco, California 94121, USA
    J Nerv Ment Dis 196:912-8. 2008
    ....
  21. pmc Posttraumatic stress disorder and health-related quality of life in patients with coronary heart disease: findings from the Heart and Soul Study
    Beth E Cohen
    Department of Veterans Affairs Medical Center, General Internal Medicine, University of California, San Francisco, CA 94121, USA
    Arch Gen Psychiatry 66:1214-20. 2009
    ..In addition to its tremendous mental health burden, PTSD has been associated with worse physical health status and an increased risk of cardiovascular disease...
  22. pmc Neuropsychological functioning in posttraumatic stress disorder and alcohol abuse
    Kristin W Samuelson
    Mental Health Service, San Francisco Veteran s Affairs Medical Center, San Francisco, CA, USA
    Neuropsychology 20:716-26. 2006
    ..By controlling for alcohol and depression, the authors can more conclusively demonstrate that verbal memory and attention differences are associated with PTSD...
  23. ncbi request reprint Current concepts in pharmacotherapy for posttraumatic stress disorder
    Frank B Schoenfeld
    Department of Veterans Affairs Medical Center in San Francisco, San Francisco, California 94121, USA
    Psychiatr Serv 55:519-31. 2004
    ..Pharmacotherapy for PTSD that is comorbid with other psychiatric disorders is highlighted...
  24. ncbi request reprint The effect of nefazodone on subjective and objective sleep quality in posttraumatic stress disorder
    Thomas C Neylan
    Department of Psychiatry, University of California, and the Psychiatry Service, San Francisco Veterans Affairs Medical Center, 94121, USA
    J Clin Psychiatry 64:445-50. 2003
    ..This study assesses the efficacy of nefazodone treatment (target dose of 400-600 mg/day) on objective and subjective sleep quality in Vietnam combat veterans with chronic DSM-IV posttraumatic stress disorder (PTSD)...
  25. pmc Attention, learning, and memory in posttraumatic stress disorder
    Thomas C Neylan
    Mental Health Service, San Francisco DVA Medical Center, San Francisco, California 94121, USA
    J Trauma Stress 17:41-6. 2004
    ..In this study, reduced hippocampal NAA did not appear to be associated with impaired declarative memory...
  26. ncbi request reprint New directions in the pharmacotherapy of posttraumatic stress disorder
    Charles R Marmar
    Department of Psychiatry, University of California, Department of Veterans Affairs Medical Center, San Francisco, California, USA
    Psychiatr Q 73:259-70. 2002
    ..Recommendations are specified for pharmacotherapy of trauma survivors in the immediate aftermath of traumatic exposure, and for those with acute and chronic posttraumatic stress disorders...
  27. ncbi request reprint PTSD symptoms predict waking salivary cortisol levels in police officers
    Thomas C Neylan
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Psychoneuroendocrinology 30:373-81. 2005
    ....
  28. ncbi request reprint Critical incident exposure and sleep quality in police officers
    Thomas C Neylan
    Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA
    Psychosom Med 64:345-52. 2002
    ..We examined the effects of critical incident exposure (trauma exposure) and routine (nontraumatic) work environment stressors on sleep quality after controlling for the effects of work shift schedule...
  29. ncbi request reprint Increased cortisol in women with intimate partner violence-related posttraumatic stress disorder
    Sabra S Inslicht
    Department of Psychology, University of Pittsburgh Sennott Square, 3rd Floor, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
    Psychoneuroendocrinology 31:825-38. 2006
    ..Alterations of hypothalamic-pituitary-adrenal (HPA) axis function and sympathetic-adrenal activity have been proposed as key factors in biological models of posttraumatic stress disorder (PTSD)...
  30. ncbi request reprint Delta sleep response to metyrapone in post-traumatic stress disorder
    Thomas C Neylan
    Department of Psychiatry, University of California, USA
    Neuropsychopharmacology 28:1666-76. 2003
    ..The results suggest that the delta sleep response to metyrapone is a measure of the brain response to increases in hypothalamic CRF. These data also suggest that the ACTH and sleep EEG response to hypothalamic CRF is decreased in PTSD...
  31. ncbi request reprint Fear-potentiated startle and posttraumatic stress symptoms in urban police officers
    Nnamdi Pole
    Department of Psychiatry, University of California, San Francisco, USA
    J Trauma Stress 16:471-9. 2003
    ..Our results emphasize the importance of contextual threat and suggest that laboratory measures of startle improve upon self-reported exaggerated startle alone in indexing PTSD symptom severity in urban police officers...
  32. pmc Depressive symptoms and 24-hour urinary norepinephrine excretion levels in patients with coronary disease: findings from the Heart and Soul Study
    Christian Otte
    Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Am J Psychiatry 162:2139-45. 2005
    ..Elevated catecholamine levels may contribute to this association, but whether depressive symptoms are associated with catecholamine levels in patients with heart disease is unknown...
  33. pmc Serum brain-derived neurotrophic factor predicts responses to escitalopram in chronic posttraumatic stress disorder
    William Berger
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:1279-84. 2010
    ..Some studies have found that antidepressants increase serum brain-derived neurotrophic factor (BDNF) levels in patients with major depression and the expression of BDNF mRNA in limbic structures of rats...
  34. ncbi request reprint Temporal instability of auditory and visual event-related potentials in posttraumatic stress disorder
    Thomas C Neylan
    Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Biol Psychiatry 53:216-25. 2003
    ....
  35. ncbi request reprint Increased cortisol in women with intimate partner violence-related posttraumatic stress disorder
    Sabra S Inslicht
    Veterans Affairs Medical Center, 4150 Clement Street 116P, San Francisco, CA 94121, USA
    Ann N Y Acad Sci 1071:428-9. 2006
    ..Cortisol was elevated in women with lifetime PTSD compared to controls. No differences were found for platelet catecholamines...
  36. pmc Posttraumatic stress disorder and risk of dementia among US veterans
    Kristine Yaffe
    San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Arch Gen Psychiatry 67:608-13. 2010
    ..Posttraumatic stress disorder (PTSD) is highly prevalent among US veterans because of combat and may impair cognition...
  37. ncbi request reprint A meta-analysis of cortisol response to challenge in human aging: importance of gender
    Christian Otte
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Psychoneuroendocrinology 30:80-91. 2005
    ..Prospective studies should explore whether the higher cortisol response in the elderly is a risk factor for developing neuropsychiatric and medical disorders...
  38. ncbi request reprint Associations between childhood trauma and emotion-modulated psychophysiological responses to startling sounds: a study of police cadets
    Nnamdi Pole
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1043, USA
    J Abnorm Psychol 116:352-61. 2007
    ..Results suggest that childhood trauma may lead to long-lasting alterations in emotional and psychophysiological reactivity even in the absence of current Axis I psychopathology...
  39. ncbi request reprint Distinguishing current from remitted posttraumatic stress disorder
    Steven H Woodward
    Arch Gen Psychiatry 63:940-1; author reply 941-2. 2006
  40. ncbi request reprint Fiftieth anniversary of the discovery of rapid eye movement (REM) sleep
    Thomas C Neylan
    J Neuropsychiatry Clin Neurosci 15:453. 2003
  41. ncbi request reprint Applied neuroscience in the study of delirium: the classic work of Engel and Romano
    Thomas C Neylan
    J Neuropsychiatry Clin Neurosci 16:525. 2004

Research Grants6

  1. SLEEP AND AROUSAL DISTURBANCES IN PTSD
    Thomas Neylan; Fiscal Year: 2002
    ..Finally, the study will validate wrist actigraphy against ambulatory polysomnography and provide data on 24 hour sleep-wake activity levels in PTSD. ..
  2. Neuroendocrine Regulation of Sleep in PTSD
    Thomas Neylan; Fiscal Year: 2007
    ..Finally, the results from the study have implications for the clinical applicability of CRF receptor antagonists, which continue to be developed. ..