THOMAS FREDERICK NEWTON

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Bupropion reduces methamphetamine-induced subjective effects and cue-induced craving
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90024, USA
    Neuropsychopharmacology 31:1537-44. 2006
  2. ncbi request reprint Safety of intravenous methamphetamine administration during treatment with bupropion
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    Psychopharmacology (Berl) 182:426-35. 2005
  3. ncbi request reprint Cocaine and methamphetamine produce different patterns of subjective and cardiovascular effects
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Semel Institute for Neuroscience and Human Behavior, Room A7 372, 740 Westwood Plaza, Los Angeles, CA 90024, USA
    Pharmacol Biochem Behav 82:90-7. 2005
  4. ncbi request reprint A comprehensive assessment of the safety of intravenous methamphetamine administration during treatment with selegiline
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at the University of California at Los Angeles, USA
    Pharmacol Biochem Behav 82:704-11. 2005
  5. doi request reprint Presence and persistence of psychotic symptoms in cocaine- versus methamphetamine-dependent participants
    James J Mahoney
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA
    Am J Addict 17:83-98. 2008
  6. doi request reprint Predictors of cardiovascular response to methamphetamine administration in methamphetamine-dependent individuals
    Gilles Fleury
    Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Am J Addict 17:103-10. 2008
  7. ncbi request reprint Pathological gamblers demonstrate frontal lobe impairment consistent with that of methamphetamine-dependent individuals
    Ari D Kalechstein
    Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA
    J Neuropsychiatry Clin Neurosci 19:298-303. 2007
  8. pmc Evaluation of the cardiovascular and subjective effects of rivastigmine in combination with methamphetamine in methamphetamine-dependent human volunteers
    Richard De La Garza
    David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Int J Neuropsychopharmacol 11:729-41. 2008
  9. ncbi request reprint MDMA use and neurocognition: a meta-analytic review
    Ari D Kalechstein
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at the University of California, Los Angeles, CA 90024, USA
    Psychopharmacology (Berl) 189:531-7. 2007
  10. ncbi request reprint Subjective and cardiovascular effects of cocaine during treatment with amantadine and baclofen in combination
    Erin Rotheram-Fuller
    UCLA Department of Family Medicine, 10880 Wilshire Blvd Suite 1800, Los Angeles, CA 90024, USA
    Psychiatry Res 152:205-10. 2007

Research Grants

Detail Information

Publications19

  1. ncbi request reprint Bupropion reduces methamphetamine-induced subjective effects and cue-induced craving
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90024, USA
    Neuropsychopharmacology 31:1537-44. 2006
    ..Importantly, these data provide a rationale for the evaluation of bupropion in the treatment of methamphetamine dependence...
  2. ncbi request reprint Safety of intravenous methamphetamine administration during treatment with bupropion
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    Psychopharmacology (Berl) 182:426-35. 2005
    ..Methamphetamine dependence is a growing problem for which no medication treatments have proven effective...
  3. ncbi request reprint Cocaine and methamphetamine produce different patterns of subjective and cardiovascular effects
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Semel Institute for Neuroscience and Human Behavior, Room A7 372, 740 Westwood Plaza, Los Angeles, CA 90024, USA
    Pharmacol Biochem Behav 82:90-7. 2005
    ..We predict that these differences may impact drug use and relapse patterns, and may have implications in medications development for these addictive disorders...
  4. ncbi request reprint A comprehensive assessment of the safety of intravenous methamphetamine administration during treatment with selegiline
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at the University of California at Los Angeles, USA
    Pharmacol Biochem Behav 82:704-11. 2005
    ..The available data suggest that selegiline is likely to be safe if used as a pharmacotherapy for methamphetamine dependence...
  5. doi request reprint Presence and persistence of psychotic symptoms in cocaine- versus methamphetamine-dependent participants
    James J Mahoney
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA
    Am J Addict 17:83-98. 2008
    ..Future studies will compare psychotic symptoms reported by non-dependent recreational stimulant users to stimulant-dependent individuals...
  6. doi request reprint Predictors of cardiovascular response to methamphetamine administration in methamphetamine-dependent individuals
    Gilles Fleury
    Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Am J Addict 17:103-10. 2008
    ..Race did not have a significant effect on cardiovascular response. Taken together, these findings may help in the prevention and treatment of cardiovascular events in a population at high risk of premature morbidity and mortality...
  7. ncbi request reprint Pathological gamblers demonstrate frontal lobe impairment consistent with that of methamphetamine-dependent individuals
    Ari D Kalechstein
    Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA
    J Neuropsychiatry Clin Neurosci 19:298-303. 2007
    ..These findings demonstrate that the severity of frontal lobe dysfunction in pathological gambling is similar to that observed in methamphetamine-dependent individuals on frequently used clinical measures...
  8. pmc Evaluation of the cardiovascular and subjective effects of rivastigmine in combination with methamphetamine in methamphetamine-dependent human volunteers
    Richard De La Garza
    David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Int J Neuropsychopharmacol 11:729-41. 2008
    ..05). Taken together, the findings in the current report suggest that pharmacological manipulations that enhance brain ACh warrant continued investigation as potential treatments for Meth addiction...
  9. ncbi request reprint MDMA use and neurocognition: a meta-analytic review
    Ari D Kalechstein
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at the University of California, Los Angeles, CA 90024, USA
    Psychopharmacology (Berl) 189:531-7. 2007
    ..To determine the association between MDMA misuse and neurocognition using meta-analysis...
  10. ncbi request reprint Subjective and cardiovascular effects of cocaine during treatment with amantadine and baclofen in combination
    Erin Rotheram-Fuller
    UCLA Department of Family Medicine, 10880 Wilshire Blvd Suite 1800, Los Angeles, CA 90024, USA
    Psychiatry Res 152:205-10. 2007
    ..Study findings support the safety of the amantadine-baclofen combination treatment for cocaine dependence...
  11. ncbi request reprint Apathy syndrome in cocaine dependence
    Ari D Kalechstein
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, UCLA Neuropsychiatric Institute, 760 Westwood Plaza, A7 372, Los Angeles, CA 90024, USA
    Psychiatry Res 109:97-100. 2002
    ..These data suggest that apathy is present during the initial phases of abstinence for a subset of cocaine-dependent individuals. This group may benefit from targeted pharmacological intervention...
  12. ncbi request reprint Methamphetamine abstinence syndrome: preliminary findings
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA
    Am J Addict 13:248-55. 2004
    ..The abstinence syndrome associated with methamphetamine dependence varied considerably in intensity and duration but generally was mild and resolved quickly for most individuals...
  13. ncbi request reprint Association between quantitative EEG and neurocognition in methamphetamine-dependent volunteers
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, UCLA School of Medicine, Room A7 372, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Clin Neurophysiol 115:194-8. 2004
    ..Exposure to methamphetamine is associated with long-lasting reductions in markers for dopaminergic neurons in preclinical models and in humans. These changes may be associated with alterations in brain electrical activity and in cognition...
  14. ncbi request reprint Irritability following abstinence from cocaine predicts euphoric effects of cocaine administration
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, UCLA School of Medicine, Room A7 372, 760 Westwood Boulevard, Los Angeles, CA 90024, USA
    Addict Behav 28:817-21. 2003
    ..If these findings are replicated in a larger sample, then it may be necessary to reconsider the applicability of the opponent process model to cocaine addiction in humans...
  15. ncbi request reprint Methamphetamine dependence is associated with neurocognitive impairment in the initial phases of abstinence
    Ari D Kalechstein
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, School of Medicine, USA
    J Neuropsychiatry Clin Neurosci 15:215-20. 2003
    ....
  16. ncbi request reprint Quantitative EEG abnormalities in recently abstinent methamphetamine dependent individuals
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA
    Clin Neurophysiol 114:410-5. 2003
    ....
  17. pmc Methamphetamine craving induced in an online virtual reality environment
    Christopher Culbertson
    Department of Psychiatry, UCLA, Los Angeles, CA, USA
    Pharmacol Biochem Behav 96:454-60. 2010
    ....
  18. pmc A qualitative and quantitative review of cocaine-induced craving: the phenomenon of priming
    James J Mahoney
    David Geffen School of Medicine at the University of California Los Angeles, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, United States
    Prog Neuropsychopharmacol Biol Psychiatry 31:593-9. 2007
    ..Clinical experience suggests that acute exposure to cocaine elicits craving (hereafter referred to as "priming"); however, this has received surprisingly little attention in the clinical literature...
  19. ncbi request reprint Apathy predicts hedonic but not craving response to cocaine
    Thomas F Newton
    David Geffen School of Medicine at the University of California Los Angeles, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90024, USA
    Pharmacol Biochem Behav 82:236-40. 2005
    ..The data reveal that cocaine-induced craving is not ubiquitous, and may not play a critical role in the maintenance of cocaine dependence. Overall, the findings suggest that apathy predicts hedonic but not craving response to cocaine...

Research Grants5

  1. POSTDOCTORAL INTERDISCIPLINARY HIV-AIDS
    Thomas Newton; Fiscal Year: 2003
    ..Each trainee's curriculum is individually designed to meet their needs and the hands-on research experience is tailored to provide experiences needed to develop independent researchers. ..
  2. Perindopril-Methamphetamine Interaction Study
    Thomas Newton; Fiscal Year: 2006
    ..Cardiovascular responses and secondary outcome measures will be evaluated by repeated-measures analysis of variance (ANOVA). ..
  3. Clinical Research Education for Drug Abuse Professionals
    Thomas Newton; Fiscal Year: 2006
    ..abstract_text> ..
  4. Assess of Stress Effects in Methamphetamine Dependence
    Thomas Newton; Fiscal Year: 2007
    ..A more complete understanding of stress-related aspects of addiction will facilitate the development of treatments for stimulant dependence. ..
  5. Laboratory Models of Cocaine Self-Administration
    Thomas Newton; Fiscal Year: 2007
    ..abstract_text> ..