- Modeling and simulation of procoagulant circulating tumor cells in flowAngela M Lee
Department of Aerospace and Mechanical Engineering, Viterbi School of Engineering, University of Southern California Los Angeles, CA, USA
Front Oncol 2:108. 2012..Therefore, our model highlights the potential to determine patient-specific risks for CTC-induced hypercoagulability as a function of CTC number and individual patient concentration of coagulation factors...
- Spreaders and sponges define metastasis in lung cancer: a Markov chain Monte Carlo mathematical modelPaul K Newton
Department of Aerospace and Mechanical Engineering, Viterbi School of Engineering, University of Southern California, Los Angles 90089, USA
Cancer Res 73:2760-9. 2013..The model shows that the combined characteristics of the primary and the first metastatic site to which it spreads largely determine the future pathways and timescales of systemic disease...
- A stochastic Markov chain model to describe lung cancer growth and metastasisPaul K Newton
Department of Aerospace and Mechanical Engineering and Department of Mathematics, University of Southern California, Los Angeles, California, United States of America
PLoS ONE 7:e34637. 2012..The model allows us to simulate and quantify disease progression pathways and timescales of progression from the lung position to other sites and we highlight several key findings based on the model...