ALEXANDRA NEWTON

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C
    Jonathan D Violin
    Department of Pharmacology, University of California, San Diego, La Jolla 92093, USA
    J Cell Biol 161:899-909. 2003
  2. pmc Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening
    Emma Sierecki
    Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093
    J Med Chem 53:6899-911. 2010
  3. pmc Turning off AKT: PHLPP as a drug target
    Alexandra C Newton
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 email
    Annu Rev Pharmacol Toxicol 54:537-58. 2014
  4. pmc Shedding light on local kinase activation
    John D Scott
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, 1959 Pacific Ave, NE, Seattle, WA 98195 USA
    BMC Biol 10:61. 2012
  5. pmc PKA, PKC, and AKAP localization in and around the neuromuscular junction
    G A Perkins
    Department of Neurosciences and the National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA 92093 0608, USA
    BMC Neurosci 2:17. 2001
  6. pmc Protein kinase C: poised to signal
    Alexandra C Newton
    Dept of Pharmacology, Univ of California at San Diego, La Jolla, 92093, USA
    Am J Physiol Endocrinol Metab 298:E395-402. 2010
  7. ncbi request reprint Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 - 2007)
    Alexandra C Newton
    Department of Pharmacology, University of California San Diego, La Jolla, California, USA
    IUBMB Life 59:741-3. 2007
  8. pmc Lipid activation of protein kinases
    Alexandra C Newton
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093 0721, USA
    J Lipid Res 50:S266-71. 2009
  9. ncbi request reprint Diacylglycerol's affair with protein kinase C turns 25
    Alexandra C Newton
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093 0640, USA
    Trends Pharmacol Sci 25:175-7. 2004
  10. ncbi request reprint Regulation of protein kinase C
    A C Newton
    Department of Pharmacology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0640, USA
    Curr Opin Cell Biol 9:161-7. 1997

Research Grants

  1. Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase
    Alexandra C Newton; Fiscal Year: 2010
  2. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 2002
  3. Phosphoinositide-dependent Kinase: Molecular mechanisms
    ALEXANDRA NEWTON; Fiscal Year: 2006
  4. Phosphoinositide-dependent Kinase: Molecular mechanisms
    ALEXANDRA NEWTON; Fiscal Year: 2003
  5. STRUCTURE, FUNCTION AND REGULATION OF PROTEIN KINASE C
    ALEXANDRA NEWTON; Fiscal Year: 2002
  6. STRUCTURE, FUNCTION AND REGULATION OF PROTEIN KINASE C
    ALEXANDRA NEWTON; Fiscal Year: 2007
  7. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 2001
  8. Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase
    ALEXANDRA NEWTON; Fiscal Year: 2007
  9. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 2000
  10. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 1999

Collaborators

Detail Information

Publications48

  1. pmc A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C
    Jonathan D Violin
    Department of Pharmacology, University of California, San Diego, La Jolla 92093, USA
    J Cell Biol 161:899-909. 2003
    ..Thus, specificity of PKC signaling depends on the local second messenger-controlled equilibrium between kinase and phosphatase activities to result in strict calcium-controlled temporal regulation of substrate phosphorylation...
  2. pmc Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening
    Emma Sierecki
    Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093
    J Med Chem 53:6899-911. 2010
    ..Thus, chemical and virtual screening has resulted in the identification of small molecules that promote Akt signaling by inhibiting its negative regulator PHLPP...
  3. pmc Turning off AKT: PHLPP as a drug target
    Alexandra C Newton
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 email
    Annu Rev Pharmacol Toxicol 54:537-58. 2014
    ..This review discusses the role of PHLPP in terminating AKT signaling and how pharmacological intervention would impact this pathway...
  4. pmc Shedding light on local kinase activation
    John D Scott
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, 1959 Pacific Ave, NE, Seattle, WA 98195 USA
    BMC Biol 10:61. 2012
    ..We discuss here how biosensors are being used to decode this language, affording an unprecedented glimpse into spatio-temporal patterns of protein phosphorylation events within the cell...
  5. pmc PKA, PKC, and AKAP localization in and around the neuromuscular junction
    G A Perkins
    Department of Neurosciences and the National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA 92093 0608, USA
    BMC Neurosci 2:17. 2001
    ..We found previously that a new class of AKAPs, dual-specific AKAPs, denoted D-AKAP1 and D-AKAP2, bind to RIalpha in addition to the RII subunits...
  6. pmc Protein kinase C: poised to signal
    Alexandra C Newton
    Dept of Pharmacology, Univ of California at San Diego, La Jolla, 92093, USA
    Am J Physiol Endocrinol Metab 298:E395-402. 2010
    ..This review introduces the PKC family and then focuses on recent advances in understanding the cellular regulation of its diacylglycerol-regulated members...
  7. ncbi request reprint Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 - 2007)
    Alexandra C Newton
    Department of Pharmacology, University of California San Diego, La Jolla, California, USA
    IUBMB Life 59:741-3. 2007
  8. pmc Lipid activation of protein kinases
    Alexandra C Newton
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093 0721, USA
    J Lipid Res 50:S266-71. 2009
    ....
  9. ncbi request reprint Diacylglycerol's affair with protein kinase C turns 25
    Alexandra C Newton
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093 0640, USA
    Trends Pharmacol Sci 25:175-7. 2004
    ..This discovery placed the lipid second messenger-protein kinase C signaling pathway center stage alongside the cAMP-protein kinase A pathway, which was already established as a fundamental mechanism for transducing extracellular signals...
  10. ncbi request reprint Regulation of protein kinase C
    A C Newton
    Department of Pharmacology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0640, USA
    Curr Opin Cell Biol 9:161-7. 1997
    ....
  11. pmc Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm
    Alexandra C Newton
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093 0640, USA
    Biochem J 370:361-71. 2003
    ..This review focuses on how phosphorylation at each of these sites regulates the maturation, signalling and down-regulation of PKC as a paradigm for how these sites control the function of the ABC kinases...
  12. pmc Differential spatial and temporal phosphorylation of the visual receptor, rhodopsin, at two primary phosphorylation sites in mice exposed to light
    Ryan A Adams
    Department of Chemistry and Biochemistry, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0640, USA
    Biochem J 374:537-43. 2003
    ..Our results are consistent with light triggering rapid priming phosphorylations of rhodopsin by rhodopsin kinase, followed by a slower phosphorylation on Ser(334), which is regulated by protein kinase C...
  13. pmc Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia
    Qinghao Xu
    Department of Anesthesiology, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 31:2113-24. 2011
    ..Together, these findings reveal that afferent inputs trigged by peripheral inflammation initiate spinal activation of PI3K-Akt-mTOR signaling pathway, a component of which participates in neuronal circuits of facilitated pain processing...
  14. pmc PHLPP-1 negatively regulates Akt activity and survival in the heart
    Shigeki Miyamoto
    Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093 0636, USA
    Circ Res 107:476-84. 2010
    ..The regulatory role of PHLPP-1 in the heart has not been considered...
  15. pmc The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity
    Maya T Kunkel
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0721, USA
    J Biol Chem 284:24653-61. 2009
    ..Thus, live cell imaging of PKD activity demonstrates ultrasensitive control of kinase signaling at the scaffold compared with bulk activity in the cytosol or at the plasma membrane...
  16. ncbi request reprint The phosphatase PHLPP controls the cellular levels of protein kinase C
    Tianyan Gao
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA
    J Biol Chem 283:6300-11. 2008
    ..These data reveal that PHLPP controls the cellular levels of PKC by specifically dephosphorylating the hydrophobic motif, thus destabilizing the enzyme and promoting its degradation...
  17. ncbi request reprint The ins and outs of protein kinase C
    Alexandra C Newton
    Department of Pharmacology, University of California at San Diego, La Jolla, USA
    Methods Mol Biol 233:3-7. 2003
  18. pmc The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail
    Christine M Gould
    Pharmacology Department, University of California, San Diego, La Jolla, California 92039 0721, USA
    J Biol Chem 284:4921-35. 2009
    ....
  19. ncbi request reprint A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production
    Daniel R Dries
    Biomedical Sciences Graduate Program and Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 282:826-30. 2007
    ..The finding that a single residue controls the affinity of the C1 domain for DAG-containing membranes provides a molecular explanation for why 1) DAG alone is sufficient to activate nPKCs but not cPKCs and 2) nPKCs target to the Golgi...
  20. pmc Spatiotemporal dynamics of lipid signaling: protein kinase C as a paradigm
    Lisa L Gallegos
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093 0721, USA
    IUBMB Life 60:782-9. 2008
    ..This review focuses on the spatiotemporal dynamics of PKC activation and how it is controlled by lipid second messengers...
  21. ncbi request reprint Measuring the interaction of protein kinase C with membranes: an introduction
    Alexandra C Newton
    Department of Pharmacology, University of California at San Diego, La Jolla, USA
    Methods Mol Biol 233:89-92. 2003
  22. ncbi request reprint Analyzing protein kinase C activation
    Alexandra C Newton
    Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA
    Methods Enzymol 345:499-506. 2002
  23. pmc Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter
    Maya T Kunkel
    Department of Pharmacology and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093 0721, USA
    J Biol Chem 280:5581-7. 2005
    ..These data reveal spatio-temporal gradients of both signal propagation and signal termination in PKB signaling...
  24. doi request reprint Kinetic analysis of the interaction of the C1 domain of protein kinase C with lipid membranes by stopped-flow spectroscopy
    Daniel R Dries
    Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, CA 92093, USA
    J Biol Chem 283:7885-93. 2008
    ....
  25. ncbi request reprint The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C
    Tianyan Gao
    Department of Pharmacology, University of California, La Jolla, California 92093 0640, USA
    J Biol Chem 277:31585-92. 2002
    ..Disruption of this interaction prevents re-phosphorylation and targets the enzyme for down-regulation...
  26. pmc PHLiPPing the switch on Akt and protein kinase C signaling
    John Brognard
    Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093 0721, USA
    Trends Endocrinol Metab 19:223-30. 2008
    ..This review focuses on the function of PHLPP1 and PHLPP2 in modulating signaling by Akt and PKC...
  27. pmc Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock
    Satoru Masubuchi
    Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 107:1642-7. 2010
    ..Our findings reveal that PHLPP1 exerts a previously unappreciated role in circadian control, governing the consolidation of circadian periodicity after resetting...
  28. pmc Calcium transduces plasma membrane receptor signals to produce diacylglycerol at Golgi membranes
    Maya T Kunkel
    Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:22748-52. 2010
    ..Thus, agonist-evoked increases in intracellular Ca(2+) cause increases in Golgi diacylglycerol, allowing this intracellular membrane to serve as a platform for signaling by protein kinases C and D...
  29. ncbi request reprint PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
    John Brognard
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA
    Mol Cell 25:917-31. 2007
    ..Our data unveil a mechanism to selectively terminate Akt-signaling pathways through the differential inactivation of specific Akt isoforms by specific PHLPP isoforms...
  30. pmc Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter
    Maya T Kunkel
    Department of Pharmacology and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 282:6733-42. 2007
    ..These data reveal that Ca(2+) is a major contributor to the initiation of PKD signaling through positive feedback regulation of diacylglycerol production, unveiling a new mechanism in PKD activation...
  31. ncbi request reprint Pathway illuminated: visualizing protein kinase C signaling
    Jonathan D Violin
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093 0640, USA
    IUBMB Life 55:653-60. 2003
    ..This review discusses how fluorescence imaging studies have illuminated the fidelity with which protein kinase C transduces rapidly changing extracellular information into intracellular phosphorylation signals...
  32. ncbi request reprint Invariant Leu preceding turn motif phosphorylation site controls the interaction of protein kinase C with Hsp70
    Tianyan Gao
    Department of Pharmacology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Biol Chem 281:32461-8. 2006
    ..Thus, Hsp70 binds a hydrophobic residue preceding the turn motif, protecting PKC from down-regulation and sustaining the signaling lifetime of the kinase...
  33. ncbi request reprint Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling
    Lisa L Gallegos
    Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 281:30947-56. 2006
    ..Our data reveal that the magnitude and duration of PKC signaling is location-specific and controlled by the level of phosphatase activity and persistence of DAG at each location...
  34. pmc Interaction with AKAP79 modifies the cellular pharmacology of PKC
    Naoto Hoshi
    Department of Pharmacology, 360 Med Surge II, University of California, Irvine, Irvine, CA 92697, USA
    Mol Cell 37:541-50. 2010
    ..This implies that intracellular binding partners not only couple individual molecular events in a cell signaling process but can also change the pharmacological profile of certain protein kinases...
  35. ncbi request reprint Measuring the binding of protein kinase C to sucrose-loaded vesicles
    Jennifer Giorgione
    Department of Pharmacology, University of California at San Diego, La Jolla, USA
    Methods Mol Biol 233:105-13. 2003
  36. pmc Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C
    John Brognard
    Department of Pharmacology and Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California 92093 0721, USA
    J Biol Chem 284:15215-23. 2009
    ..Thus, we have identified a functional polymorphism that impairs the activity of PHLPP2 and correlates with elevated Akt phosphorylation and increased PKC levels...
  37. ncbi request reprint The life and death of protein kinase C
    Christine M Gould
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093 0721, USA
    Curr Drug Targets 9:614-25. 2008
    ....
  38. ncbi request reprint Protein kinase C translocation by modified phorbol esters with functionalized lipophilic regions
    Thomas M Bertolini
    Departments of Chemistry and Pharmacology, University of California, San Diego, La Jolla, California 92093, USA
    J Org Chem 68:5028-36. 2003
    ..The most promising PKC inhibitors had short carboxylic acids capping their C12 and C13 acyl chains, since these compounds did not recruit PKC to any appreciable extent...
  39. ncbi request reprint Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C
    Jennifer Giorgione
    Department of Pharmacology, University of California at San Diego, La Jolla, California 92093 0640, USA
    Biochemistry 42:11194-202. 2003
    ..Thus, engaging both domains can be forced but is highly unfavored. In summary, our data reveal that both C1 domains are oriented for potential membrane interaction but only one C1 domain binds ligand in a physiological context...
  40. pmc Increased membrane affinity of the C1 domain of protein kinase Cdelta compensates for the lack of involvement of its C2 domain in membrane recruitment
    Jennifer R Giorgione
    Department of Pharmacology, University of California at San Diego, La Jolla, California 92093 0721, USA
    J Biol Chem 281:1660-9. 2006
    ....
  41. ncbi request reprint Centrosomal anchoring of protein kinase C betaII by pericentrin controls microtubule organization, spindle function, and cytokinesis
    Dan Chen
    Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, California 92093 0640, USA
    J Biol Chem 279:4829-39. 2004
    ..These results reveal a novel role for PKC betaII in cytokinesis and indicate that this function is mediated by an interaction with pericentrin at centrosomes...
  42. ncbi request reprint PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
    Tianyan Gao
    Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA
    Mol Cell 18:13-24. 2005
    ..Reintroduction of PHLPP into a glioblastoma cell line causes a dramatic suppression of tumor growth. These data are consistent with PHLPP terminating Akt signaling by directly dephosphorylating and inactivating Akt...
  43. ncbi request reprint The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1
    Charles C King
    Department of Pharmacology, University of California at San Diego, La Jolla, California 92093 0721, USA
    J Biol Chem 279:37518-27. 2004
    ..Thus, Grb14 serves as an adaptor protein to recruit PDK-1 to activated insulin receptor, thus promoting Akt phosphorylation and transduction of the insulin signal...
  44. ncbi request reprint Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase
    Dan Chen
    Department of Pharmacology, Molecular Pathology Graduate Program, University of California at San Diego, La Jolla, California 92093 0721, USA
    J Biol Chem 282:33776-87. 2007
    ..Our data reveal a novel mechanism that provides amplitude control in PKC signaling through ubiquitination catalyzed by RINCK, an E3 ligase that specifically recognizes the C1 domain of PKC isoforms...
  45. pmc Regulation of novel protein kinase C epsilon by phosphorylation
    Vittoria Cenni
    Boston Biomedical Research Institute, Watertown, MA 02472, USA
    Biochem J 363:537-45. 2002
    ..However, the regulation of this phosphorylation is different for novel and conventional PKCs. Specifically, the phosphorylation of novel PKCs is regulated rather than constitutive...
  46. pmc A Ras activation pathway dependent on Syk phosphorylation of protein kinase C
    Yuko Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:9470-5. 2003
    ..By recruiting the Grb-2/Sos complex to the plasma membrane, these conventional PKC isoforms contribute to the full activation of the Ras/extracellular signal-regulated kinase signaling pathway in FcepsilonRI-stimulated mast cells...
  47. ncbi request reprint Use of stopped-flow fluorescence spectroscopy to measure rapid membrane binding by protein kinase C
    Eric A Nalefski
    US Genomics, Woburn, MA, USA
    Methods Mol Biol 233:115-28. 2003
  48. pmc The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
    Valeria Facchinetti
    Department of Immunology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    EMBO J 27:1932-43. 2008
    ..Our studies uncover a novel function of the TOR pathway in regulating protein folding and stability, processes that are most likely linked to the functions of TOR in protein synthesis...

Research Grants28

  1. Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase
    Alexandra C Newton; Fiscal Year: 2010
    ....
  2. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 2002
    ..Specifically, the effect of this phosphorylation on rhodopsin s macromolecular interactions (transducin coupling, arrestin binding) will be explored. ..
  3. Phosphoinositide-dependent Kinase: Molecular mechanisms
    ALEXANDRA NEWTON; Fiscal Year: 2006
    ....
  4. Phosphoinositide-dependent Kinase: Molecular mechanisms
    ALEXANDRA NEWTON; Fiscal Year: 2003
    ....
  5. STRUCTURE, FUNCTION AND REGULATION OF PROTEIN KINASE C
    ALEXANDRA NEWTON; Fiscal Year: 2002
    ....
  6. STRUCTURE, FUNCTION AND REGULATION OF PROTEIN KINASE C
    ALEXANDRA NEWTON; Fiscal Year: 2007
    ..Upregulation of phosphatase activity could account for the pleiotropic effects of PKC activation. ..
  7. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 2001
    ..Specifically, the effect of this phosphorylation on rhodopsin s macromolecular interactions (transducin coupling, arrestin binding) will be explored. ..
  8. Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase
    ALEXANDRA NEWTON; Fiscal Year: 2007
    ....
  9. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 2000
    ..Specifically, the effect of this phosphorylation on rhodopsin s macromolecular interactions (transducin coupling, arrestin binding) will be explored. ..
  10. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 1999
    ..Specifically, the effect of this phosphorylation on rhodopsin s macromolecular interactions (transducin coupling, arrestin binding) will be explored. ..
  11. STRUCTURE, FUNCTION AND REGULATION OF PROTEIN KINASE C
    ALEXANDRA NEWTON; Fiscal Year: 2007
    ..Upregulation of phosphatase activity could account for the pleiotropic effects of PKC activation. ..
  12. Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase
    ALEXANDRA NEWTON; Fiscal Year: 2009
    ....
  13. Phosphoinositide-dependent Kinase: Molecular mechanisms
    ALEXANDRA NEWTON; Fiscal Year: 2005
    ....
  14. Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase
    ALEXANDRA NEWTON; Fiscal Year: 2009
    ....
  15. Phosphoinositide-dependent Kinase: Molecular mechanisms
    ALEXANDRA NEWTON; Fiscal Year: 2004
    ....
  16. STRUCTURE, FUNCTION AND REGULATION OF PROTEIN KINASE C
    ALEXANDRA NEWTON; Fiscal Year: 2001
    ....
  17. STRUCTURE, FUNCTION AND REGULATION OF PROTEIN KINASE C
    ALEXANDRA NEWTON; Fiscal Year: 2000
    ....
  18. STRUCTURE, FUNCTION AND REGULATION OF PROTEIN KINASE C
    ALEXANDRA NEWTON; Fiscal Year: 1999
    ....