Anne Newman

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi Heritability of and mortality prediction with a longevity phenotype: the healthy aging index
    Jason L Sanders
    Graduate School of Public Health, University of Pittsburgh, A527 Crabtree Hall, 130 DeSoto Street, Pittsburgh, PA 15261
    J Gerontol A Biol Sci Med Sci 69:479-85. 2014
  2. doi The 10 keys to healthy aging: findings from an innovative prevention program in the community
    Anne B Newman
    University of Pittsburgh, Pennsylvania
    J Aging Health 22:547-66. 2010
  3. ncbi Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort
    Anne B Newman
    University of Pittsburgh, Department of Epidemiology, 130 N Bellefield Avenue, Room 532, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 61:72-7. 2006
  4. ncbi Weight change and the conservation of lean mass in old age: the Health, Aging and Body Composition Study
    Anne B Newman
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Clin Nutr 82:872-8; quiz 915-6. 2005
  5. ncbi Progression and regression of sleep-disordered breathing with changes in weight: the Sleep Heart Health Study
    Anne B Newman
    Department of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Intern Med 165:2408-13. 2005
  6. ncbi Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability
    Anne B Newman
    Department of Epidemiology, Physical Therapy, University of Pittsburgh, Pittsburgh, PA 15213, USA
    JAMA 295:2018-26. 2006
  7. pmc Long-term function in an older cohort--the cardiovascular health study all stars study
    Anne B Newman
    Department ofEpidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Geriatr Soc 57:432-40. 2009
  8. ncbi Walking performance and cardiovascular response: associations with age and morbidity--the Health, Aging and Body Composition Study
    Anne B Newman
    Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    J Gerontol A Biol Sci Med Sci 58:715-20. 2003
  9. ncbi Sarcopenia: alternative definitions and associations with lower extremity function
    Anne B Newman
    Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Geriatr Soc 51:1602-9. 2003
  10. pmc A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
    Anne B Newman
    Department of Epidemiology, Graduate School of Public Health, 130 North Bellefield Avenue, Suite 500, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 65:478-87. 2010

Research Grants

Detail Information

Publications111 found, 100 shown here

  1. doi Heritability of and mortality prediction with a longevity phenotype: the healthy aging index
    Jason L Sanders
    Graduate School of Public Health, University of Pittsburgh, A527 Crabtree Hall, 130 DeSoto Street, Pittsburgh, PA 15261
    J Gerontol A Biol Sci Med Sci 69:479-85. 2014
    ..We investigated the HAI's association with survival in the Cardiovascular Health Study and heritability in the Long Life Family Study...
  2. doi The 10 keys to healthy aging: findings from an innovative prevention program in the community
    Anne B Newman
    University of Pittsburgh, Pennsylvania
    J Aging Health 22:547-66. 2010
    ..To develop and evaluate a novel, comprehensive prevention program for older adults designed to assess and improve adherence to preventive health care goals...
  3. ncbi Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort
    Anne B Newman
    University of Pittsburgh, Department of Epidemiology, 130 N Bellefield Avenue, Room 532, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 61:72-7. 2006
    ..Although muscle strength and mass are highly correlated, the relationship between direct measures of low muscle mass (sarcopenia) and strength in association with mortality has not been examined...
  4. ncbi Weight change and the conservation of lean mass in old age: the Health, Aging and Body Composition Study
    Anne B Newman
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Clin Nutr 82:872-8; quiz 915-6. 2005
    ..Weight loss may contribute to the loss of lean mass with age...
  5. ncbi Progression and regression of sleep-disordered breathing with changes in weight: the Sleep Heart Health Study
    Anne B Newman
    Department of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Intern Med 165:2408-13. 2005
    ..This study aims to determine the relationship between change in weight and progression or remission of SDB by polysomnography...
  6. ncbi Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability
    Anne B Newman
    Department of Epidemiology, Physical Therapy, University of Pittsburgh, Pittsburgh, PA 15213, USA
    JAMA 295:2018-26. 2006
    ..Extended walking tests have been examined as outcome predictors in medically ill populations but not in community-dwelling older adults...
  7. pmc Long-term function in an older cohort--the cardiovascular health study all stars study
    Anne B Newman
    Department ofEpidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Geriatr Soc 57:432-40. 2009
    ..To evaluate shared and unique risk factors for maintaining physical and cognitive function into the ninth decade and beyond...
  8. ncbi Walking performance and cardiovascular response: associations with age and morbidity--the Health, Aging and Body Composition Study
    Anne B Newman
    Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    J Gerontol A Biol Sci Med Sci 58:715-20. 2003
    ..The long-distance corridor walk is a timed 400-meter walk test used to assess walking endurance in well-functioning men and women aged 70-79 in the Health, Aging and Body Composition Study...
  9. ncbi Sarcopenia: alternative definitions and associations with lower extremity function
    Anne B Newman
    Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Geriatr Soc 51:1602-9. 2003
    ....
  10. pmc A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
    Anne B Newman
    Department of Epidemiology, Graduate School of Public Health, 130 North Bellefield Avenue, Suite 500, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 65:478-87. 2010
    ..Genome-wide association studies (GWAS) may yield insights into longevity...
  11. pmc An overview of the design, implementation, and analyses of longitudinal studies on aging
    Anne B Newman
    Center for Aging and Population Health, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Geriatr Soc 58:S287-91. 2010
    ..Analysis of longitudinal data requires approaches that account for inevitable missing data. New studies should take advantage of the experience obtained from longitudinal studies on aging already conducted...
  12. pmc A physiologic index of comorbidity: relationship to mortality and disability
    Anne B Newman
    Center for Aging and Population Health, University of Pittsburgh, Graduate School of Public Health, 130 N Bellefield Ave Room 532, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 63:603-9. 2008
    ..We developed a simple physiologic index of comorbidity by scoring five noninvasive tests across the full range of values. We examined the predictive validity of this index for mortality and disability...
  13. pmc Health and function of participants in the Long Life Family Study: A comparison with other cohorts
    Anne B Newman
    University of Pittsburgh, Graduate School of Public Health, Department of Epidemiology, Center for Aging and Population Health, PA 15213, USA
    Aging (Albany NY) 3:63-76. 2011
    ..These findings suggest several priority phenotypes for inclusion in future genetic analysis to identify loci contributing to exceptional survival...
  14. pmc Coronary artery calcium, carotid artery wall thickness, and cardiovascular disease outcomes in adults 70 to 99 years old
    Anne B Newman
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Cardiol 101:186-92. 2008
    ..The CCA-IMT was more strongly related to stroke than CAC, but CAC was also a predictor of stroke...
  15. pmc Total and cause-specific mortality in the cardiovascular health study
    Anne B Newman
    Departments of Epidemiology and Medicine, University of Pittsburgh, 130 North Bellefield Avenue Room 532, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 64:1251-61. 2009
    ..Shared risk factors could be targeted for prevention of premature death and the study of longevity...
  16. pmc Self-reported napping and duration and quality of sleep in the lifestyle interventions and independence for elders pilot study
    Jennifer L Picarsic
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Geriatr Soc 56:1674-80. 2008
    ..To determine the prevalence of self-reported napping and its association with subjective nighttime sleep duration and quality, as measured according to sleep-onset latency and sleep efficiency...
  17. pmc Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health study
    Anne R Cappola
    SCM, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, 764 CRB, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    J Gerontol A Biol Sci Med Sci 64:1268-74. 2009
    ..Assessment of an individual's ability to maintain a DHEAS set point, through examination of multiple DHEAS levels over time, may provide insight into biologic aging...
  18. ncbi Neck and shoulder pain in 70- to 79-year-old men and women: findings from the Health, Aging and Body Composition Study
    Molly T Vogt
    Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Spine J 3:435-41. 2003
    ..Musculoskeletal pain in the cervicobrachial region is considered a major health problem among adults of working age, but little is known about the impact of this pain in the elderly...
  19. pmc Change in circulating adiponectin in advanced old age: determinants and impact on physical function and mortality. The Cardiovascular Health Study All Stars Study
    Jorge R Kizer
    Department of Medicine, Weill Cornell Medical College, New York, USA
    J Gerontol A Biol Sci Med Sci 65:1208-14. 2010
    ....
  20. ncbi Kidney function as a predictor of noncardiovascular mortality
    Linda F Fried
    VA Pittsburgh Healthcare System and Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15240, USA
    J Am Soc Nephrol 16:3728-35. 2005
    ..Kidney function predicts noncardiovascular mortality from multiple causes in the elderly. Further research is needed to understand the mechanisms and evaluate interventions to reduce the high mortality rate in chronic kidney disease...
  21. ncbi How does low back pain impact physical function in independent, well-functioning older adults? Evidence from the Health ABC Cohort and implications for the future
    Debra K Weiner
    Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15206, USA
    Pain Med 4:311-20. 2003
    ..To determine the relationships between low back pain (LBP) frequency and intensity and self-reported and performance-based physical function in a large cohort of well-functioning older adults...
  22. pmc Poor sleep is associated with poorer physical performance and greater functional limitations in older women
    Suzanne E Goldman
    Department of Epidemiology, University ofPittsburgh, Pittsburgh, PA, USA
    Sleep 30:1317-24. 2007
    ..This study examined the association between disturbed sleep and poorer daytime function in older women...
  23. ncbi Weight change, weight change intention, and the incidence of mobility limitation in well-functioning community-dwelling older adults
    Jung Sun Lee
    Healthy Aging Research Program, Department of Epidemiology, University of Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 60:1007-12. 2005
    ..The aim of this study was to determine whether weight, weight change, and weight change intention are associated with risk for mobility limitation in elderly persons...
  24. pmc Sleep-disordered breathing and frailty in the Cardiovascular Health Study Cohort
    Yohannes W Endeshaw
    Division of Geriatrics and Gerontology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    Am J Epidemiol 170:193-202. 2009
    ..The finding of an independent association between SDB and frailty indicator variables among older women could have important implications in interventions aimed at preventing or delaying the progression of frailty...
  25. ncbi A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: the Cardiovascular Health Study
    Neil A Zakai
    Department of Medicine, University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, USA
    Arch Intern Med 165:2214-20. 2005
    ..Anemia is viewed as a negative prognostic factor in the elderly population; its independent impact on survival is unclear...
  26. pmc Sleep-disordered breathing in the National Football League
    Thomas B Rice
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Sleep 33:819-24. 2010
    ..NFL players have a higher prevalence of hypertension, and we sought to determine the prevalence of SDB among players the NFL and the associations of SDB with anthropometric measures and cardiovascular risk factors...
  27. pmc Central nervous system medication use and incident mobility limitation in community elders: the Health, Aging, and Body Composition study
    Robert M Boudreau
    Department of Epidemiology, University of Pittsburgh, PA 15213, USA
    Pharmacoepidemiol Drug Saf 18:916-22. 2009
    ..To evaluate whether CNS medication use in older adults was associated with a higher risk of future incident mobility limitation...
  28. pmc Validation of the health ABC heart failure model for incident heart failure risk prediction: the Cardiovascular Health Study
    Andreas Kalogeropoulos
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA 30322, USA
    Circ Heart Fail 3:495-502. 2010
    ..The recently developed and internally validated Health ABC HF model uses 9 routinely available clinical variables to determine incident heart failure risk. In this study, we sought to externally validate the Health ABC HF model...
  29. ncbi Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults
    Kim Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Circulation 111:3384-90. 2005
    ..The objective of this investigation was to determine whether aPWV is associated with total and cardiovascular (CV) mortality and CV events in a community-dwelling sample of older adults...
  30. ncbi Factors associated with incidence and persistence of symptoms of disturbed sleep in an elderly cohort: the Cardiovascular Health Study
    Stuart F Quan
    Department of Medicine, Sleep and Arizona Respiratory Centers, University of Arizona College of Medicine, Tucson, Arizona 85724, USA
    Am J Med Sci 329:163-72. 2005
    ..Factors influencing these rates were assessed as well...
  31. ncbi The clock drawing test is an independent predictor of incident use of 24-hour care in a retirement community
    Laurie L Lavery
    Division of Geriatric Medicine, University of Pittsburgh, 3471 Fifth Ave, Suite 500, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 60:928-32. 2005
    ..We examined the relationship between executive function, measured with a clock drawing protocol (CLOX1) designed to capture executive impairment, and incident need for increased level of care and total mortality...
  32. ncbi Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Intern Med 165:1612-7. 2005
    ..Diabetes mellitus (DM) and related complications may increase clinical fracture risk in older adults...
  33. pmc Changes in cognitive function in a randomized trial of physical activity: results of the lifestyle interventions and independence for elders pilot study
    Jeff D Williamson
    Roena Kulynych Center for Memory and Cognition Research, Department of Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina 27151, USA
    J Gerontol A Biol Sci Med Sci 64:688-94. 2009
    ....
  34. ncbi Kidney function predicts the rate of bone loss in older individuals: the Cardiovascular Health Study
    Linda F Fried
    VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
    J Gerontol A Biol Sci Med Sci 61:743-8. 2006
    ....
  35. ncbi Diabetes, inflammation, and functional decline in older adults: findings from the Health, Aging and Body Composition (ABC) study
    M Kathleen Figaro
    Department of Medicine, Vanderbilt University Medical Center GRECC, 1310 24th Ave South, Room 4B111, Nashville, TN 37212, USA
    Diabetes Care 29:2039-45. 2006
    ..We examined the effect of C-reactive protein (CRP) and interleukin-6 (IL-6) on the incident mobility limitation in older adults with and without diabetes...
  36. ncbi Limited literacy in older people and disparities in health and healthcare access
    Rebecca L Sudore
    Department of Medicine, Division of Geriatrics, University of California San Francisco, San Francisco, CA, USA
    J Am Geriatr Soc 54:770-6. 2006
    ..To determine the relationship between health literacy, demographics, and access to health care...
  37. pmc Renin angiotensin system gene polymorphisms modify angiotensin-converting enzyme inhibitors' effect on cognitive function: the health, aging and body composition study
    Ihab Hajjar
    Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02131, USA
    J Am Geriatr Soc 58:1035-42. 2010
    ....
  38. pmc Serum insulin-like growth factor-1 binding proteins 1 and 2 and mortality in older adults: the Health, Aging, and Body Composition Study
    Donglei Hu
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Am Geriatr Soc 57:1213-8. 2009
    ..To evaluate the relationship between serum insulin-like growth factor 1 (IGF-1), IGF-1 binding protein 1 (IGFBP-1), and IGF-1 binding protein 2 (IGFBP-2) and fasting insulin, fasting glucose, adiposity, and mortality in older adults...
  39. ncbi Skeletal muscle fatigue, strength, and quality in the elderly: the Health ABC Study
    Andreas Katsiaras
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    J Appl Physiol (1985) 99:210-6. 2005
    ..In conclusion, older men were more fatigue resistant than women, although in both men and women greater fatigue was not related to muscle weakness...
  40. ncbi Short-term weight changes in community-dwelling older adults: the Health, Aging, and Body Composition Weight Change Substudy
    Jung Sun Lee
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Clin Nutr 82:644-50. 2005
    ..The frequency and short-term natural history of weight loss in community-dwelling older adults have not been described. Unintentional weight loss may be more likely to continue than intentional weight loss...
  41. ncbi Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: the cardiovascular health study
    Alexander P Reiner
    Department of Epidemiology, University of Washington, Seattle, WA 98101, USA
    Atherosclerosis 181:175-83. 2005
    ..These findings suggest that modulators of fibrinolytic activity may have a generalized influence on aging, and merit further investigation in studies of genetic determinants of human longevity...
  42. pmc Total and regional adiposity and cognitive change in older adults: The Health, Aging and Body Composition (ABC) study
    Alka M Kanaya
    Department of Medicine, University of California San Francisco, 94115, USA
    Arch Neurol 66:329-35. 2009
    ....
  43. ncbi Risk factors for dementia in the cardiovascular health cognition study
    Lewis H Kuller
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, PA 15261, USA
    Neuroepidemiology 22:13-22. 2003
    ..The Cardiovascular Health Cognition Study has evaluated the determinants of dementia among 3,608 participants that had a magnetic resonance imaging (MRI) of the brain in 1991 and were followed to 1998-1999...
  44. ncbi Diabetes is associated independently of body composition with BMD and bone volume in older white and black men and women: The Health, Aging, and Body Composition Study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Bone Miner Res 19:1084-91. 2004
    ..Diabetes predicted higher hip, whole body, and volumetric spine BMD, and lower spine bone volume, independent of body composition and fasting insulin...
  45. pmc Change in cardiovascular risk factors with progression of kidney disease
    Linda F Fried
    Renal Section, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
    Am J Nephrol 29:334-41. 2009
    ..We evaluated the change in lipids, inflammatory and procoagulant biomarkers with decline in kidney function in a nested case-cohort study in the Cardiovascular Health Study, a community-based study of adults aged >65 years...
  46. pmc Fetuin-A and incident diabetes mellitus in older persons
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, and San Diego Veterans Affairs Healthcare System, 3350 La Jolla Village Dr, Mail Code 111 H, San Diego, CA 92161, USA
    JAMA 300:182-8. 2008
    ..In prior cross-sectional studies in humans, higher fetuin-A levels were associated with insulin resistance. However, the longitudinal association of fetuin-A with incident type 2 diabetes mellitus is unknown...
  47. pmc 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia
    Sachin Yende
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 176:1129-37. 2007
    ..Whether variation within the PAI-1 gene is associated with increased susceptibility to infection is unknown...
  48. ncbi Mortality and cardiovascular risk across the ankle-arm index spectrum: results from the Cardiovascular Health Study
    ANN M O'HARE
    Nephrology Division, Department of Medicine, VA Medical Center San Francisco, University of California, San Francisco, CA, USA
    Circulation 113:388-93. 2006
    ..A high AAI also appears to be associated with higher mortality risk in select populations. However, mortality and cardiovascular risk across the AAI spectrum have not been described in a more broadly defined population...
  49. pmc CRP gene variation and risk of community-acquired pneumonia
    Kenneth J Mukamal
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Respirology 15:160-4. 2010
    ..Whether this variation influences risk of infection, and hence whether CRP has anti-infective activity in humans, is uncertain...
  50. ncbi The relationship between chronically disrupted sleep and healthcare use
    Vishesh K Kapur
    Department of Medicine, University of Washington, Seattle 98104, USA
    Sleep 25:289-96. 2002
    ..To determine whether chronic sleep deprivation, sleep disruption, sleepiness, insomnia, and OSA are associated with increased healthcare use in a community-based population...
  51. pmc Event-related functional magnetic resonance imaging investigation of executive control in very old individuals with mild cognitive impairment
    Caterina Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 57:761-7. 2005
    ....
  52. ncbi Chronic kidney disease and functional limitation in older people: health, aging and body composition study
    Linda F Fried
    Department of Veterans Affairs Pittsburgh Healthcare System, University Drive, Pittsburgh, PA 15240, USA
    J Am Geriatr Soc 54:750-6. 2006
    ..To assess whether chronic kidney disease (CKD) is independently associated with incident physical-function limitation...
  53. pmc Obstructive sleep apnea among obese patients with type 2 diabetes
    Gary D Foster
    Temple University, Philadelphia, Pennsylvania, USA
    Diabetes Care 32:1017-9. 2009
    ..To assess the risk factors for the presence and severity of obstructive sleep apnea (OSA) among obese patients with type 2 diabetes...
  54. pmc The burden of cardiovascular disease in the elderly: morbidity, mortality, and costs
    Ali Yazdanyar
    Center for Aging and Population Health, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 North Bellefield Avenue, Pittsburgh, PA 15213, USA
    Clin Geriatr Med 25:563-77, vii. 2009
    ..This article provides an overview of the epidemiology of CVD in older adults, including an assessment of the impact of CVD on mortality, morbidity, and health care costs...
  55. ncbi Cystatin C and incident peripheral arterial disease events in the elderly: results from the Cardiovascular Health Study
    ANN M O'HARE
    Nephrology Division, Department of Medicine, and General Internal Medicine Section, Veterans Affairs Medical Center San Francisco, 4150 Clement Street, San Faancisco, CA 94121, USA
    Arch Intern Med 165:2666-70. 2005
    ..The association of cystatin C, a novel marker of renal function, with risk for developing complications related to peripheral arterial disease (PAD) has not been examined...
  56. pmc Parity and cardiovascular disease risk among older women: how do pregnancy complications mediate the association?
    Janet M Catov
    University of Pittsburgh, Department of Obstetrics, Gynecology and Reproductive Sciences, Pittsburgh PA 15213, USA
    Ann Epidemiol 18:873-9. 2008
    ..To determine whether parity is associated with increased risk of cardiovascular disease (CVD) after accounting for perinatal complications...
  57. pmc Caregiving, mortality, and mobility decline: the Health, Aging, and Body Composition (Health ABC) Study
    Lisa Fredman
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    Arch Intern Med 168:2154-62. 2008
    ..We hypothesized that caregivers may be more physically active than noncaregivers, which may protect them from health decline...
  58. ncbi Extent of cardiovascular risk reduction associated with treatment of isolated systolic hypertension
    Kim Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Arch Intern Med 163:2728-31. 2003
    ..However, nearly 20% of older adults remain at high risk of heart disease and stroke from untreated ISH...
  59. ncbi Inflammatory and prothrombotic markers and the progression of renal disease in elderly individuals
    Linda Fried
    Renal Section, VA Pittsburgh Healthcare System, University Drive C, Mailstop 111F U, Pittsburgh, PA 15240, USA
    J Am Soc Nephrol 15:3184-91. 2004
    ..Inflammatory and prothrombotic markers are predictors for a change in kidney function in elderly individuals. Interventions that reduce inflammation might confer significant cardiovascular and renal benefits...
  60. pmc Leukocyte Telomere Length Is Not Associated With BMD, Osteoporosis, or Fracture in Older Adults: Results From the Health, Aging and Body Composition Study
    Jason L Sanders
    Medical Scientist Training Program, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Bone Miner Res 24:1531-6. 2009
    ..TL is not associated with BMD, osteoporosis, or fracture in older men or women in this sample...
  61. ncbi Physical activity and functional status in community-dwelling older women: a 14-year prospective study
    Jennifer S Brach
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, 6035 Forbes Tower, Pittsburgh, PA 15260, USA
    Arch Intern Med 163:2565-71. 2003
    ..Short-term prospective studies have shown physical activity to be related to functional status. To our knowledge, the association between physical activity levels and functional status over a longer period has not been established...
  62. pmc Special article: gait measures indicate underlying focal gray matter atrophy in the brain of older adults
    Caterina Rosano
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    J Gerontol A Biol Sci Med Sci 63:1380-8. 2008
    ..Our objective was to identify the spatial distribution of focal atrophy within mobility-related brain regions in relationship with quantitative gait characteristics...
  63. pmc Cardiovascular disease is associated with greater incident dehydroepiandrosterone sulfate decline in the oldest old: the cardiovascular health study all stars study
    Jason L Sanders
    Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Am Geriatr Soc 58:421-6. 2010
    ..To describe cross-sectional and longitudinal associations with dehydroepiandrosterone sulfate (DHEAS) and change in DHEAS with age...
  64. pmc Diabetes mellitus and gait dysfunction: possible explanatory factors
    Jennifer S Brach
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, 6035 Forbes Tower, Pittsburgh, PA 15260, USA
    Phys Ther 88:1365-74. 2008
    ..Limited information regarding potential explanatory factors for this association exists. This study examined the association between diabetes and gait characteristics in older adults and explored potential explanatory factors...
  65. ncbi Focal atrophy and cerebrovascular disease increase dementia risk among cognitively normal older adults
    Caterina Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, Pennysylvania, USA
    J Neuroimaging 17:148-55. 2007
    ....
  66. ncbi Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study
    Jane A Cauley
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 22:1088-95. 2007
    ..We tested this hypothesis in relationship to fractures in 2985 men and women enrolled in the Health ABC study. Results showed that subjects with the greatest number of inflammatory markers have the highest risk of fracture...
  67. ncbi Multitasking: association between poorer performance and a history of recurrent falls
    Kimberly A Faulkner
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 55:570-6. 2007
    ..To examine the association between poorer performance on concurrent walking and reaction time and recurrent falls...
  68. ncbi Geographic variations in stroke incidence and mortality among older populations in four US communities
    Aiman El-Saed
    Department of Epidemiology, University of Pittsburgh, 130 N Bellefield Ave, Rm 405, Pittsburgh, PA 15213, USA
    Stroke 37:1975-9. 2006
    ..The purpose of this study was to compare stroke incidence and mortality rates in 4 US communities...
  69. ncbi Strength and muscle quality in a well-functioning cohort of older adults: the Health, Aging and Body Composition Study
    Anne B Newman
    Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh School of Medicine, 3520 5th Avenue, Suite 300, Pittsburgh, PA 15213, USA
    J Am Geriatr Soc 51:323-30. 2003
    ..To determine whether lower lean mass and higher fat mass have independent effects on the loss of strength and muscle quality in older adults and might explain part of the effect of age...
  70. ncbi Influence of marital status on physical activity levels among older adults
    Kelley K Pettee
    University of Pittsburgh, Pittsburgh, PA, USA
    Med Sci Sports Exerc 38:541-6. 2006
    ....
  71. ncbi Subclinical atherosclerosis in multiple vascular beds: an index of atherosclerotic burden evaluated in postmenopausal women
    Kim Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Atherosclerosis 160:407-16. 2002
    ..Women with lower premenopausal risk factors did not develop high levels of subclinical atherosclerosis, suggesting that atherosclerosis is a preventable disease in women...
  72. ncbi Hearing sensitivity and the risk of incident falls and fracture in older women: the study of osteoporotic fractures
    Elizabeth L Purchase-Helzner
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Epidemiol 14:311-8. 2004
    ..We further hypothesized that decreased bone mineral density would be associated with hearing loss...
  73. pmc Black and white differences in cognitive function test scores: what explains the difference?
    Kala M Mehta
    Division of Geriatrics, University of California at San Francisco, 94121, USA
    J Am Geriatr Soc 52:2120-7. 2004
    ..This study evaluates whether differences in health and socioeconomic indicators, including literacy level, can explain differences in cognitive function test scores between older black and white adults...
  74. ncbi Predicting the development of diabetes in older adults: the derivation and validation of a prediction rule
    Alka M Kanaya
    Department of Medicine and Epidemiology and Biostatics, University of California, San Francisco, California 94115, USA
    Diabetes Care 28:404-8. 2005
    ..We created a prediction rule in one sample and prospectively validated it for incident diabetes in a separate cohort...
  75. ncbi Is there a biomedical explanation for socioeconomic differences in incident mobility limitation?
    Annemarie Koster
    Department of Health Care Studies, Section Medical Sociology, Universiteit Maastricht, Maastricht, The Netherlands
    J Gerontol A Biol Sci Med Sci 60:1022-7. 2005
    ..This study examines the association between socioeconomic status and incident mobility limitation in well-functioning older adults, and seeks to determine whether this link could be explained by biomedical factors...
  76. ncbi Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons
    Marjolein Visser
    Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 60:324-33. 2005
    ..This study aims to investigate whether low muscle mass, low muscle strength, and greater fat infiltration into the muscle predict incident mobility limitation...
  77. ncbi Prognostic value of usual gait speed in well-functioning older people--results from the Health, Aging and Body Composition Study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, Florida 32608, USA
    J Am Geriatr Soc 53:1675-80. 2005
    ..To define clinically relevant cutpoints for usual gait speed and to investigate their predictive value for health-related events in older persons...
  78. ncbi Cross-sectional associations between trunk muscle composition, back pain, and physical function in the health, aging and body composition study
    Gregory E Hicks
    Clinical Research Branch, National Institute on Aging, Baltimore, MD 21201, USA
    J Gerontol A Biol Sci Med Sci 60:882-7. 2005
    ..We hypothesized that lower trunk muscle area and attenuation (higher fat infiltration) are associated with decreased functional capacity...
  79. ncbi Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Epidemiol 160:741-9. 2004
    ..79, 95% confidence interval: 1.24, 2.58 per standard-deviation increase; p < 0.01). The amount of adipose tissue stored in the intraabdominal cavity is an important, independent risk factor for MI in well-functioning, elderly women...
  80. ncbi The association between lipid levels and the risks of incident myocardial infarction, stroke, and total mortality: The Cardiovascular Health Study
    Bruce M Psaty
    Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington 98101, USA
    J Am Geriatr Soc 52:1639-47. 2004
    ..To assess the association between lipid levels and cardiovascular events in older adults...
  81. ncbi Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study
    Marjolein Visser
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 57:M326-32. 2002
    ....
  82. ncbi Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study
    Marjolein Visser
    Institute for Research in Extramural Medicine, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    J Am Geriatr Soc 50:897-904. 2002
    ..Our aim was to determine whether low leg muscle mass and greater fat infiltration in the muscle were associated with poor lower extremity performance (LEP)...
  83. ncbi The 6-min walk test: a quick measure of functional status in elderly adults
    Paul L Enright
    University of Arizona, USA
    Chest 123:387-98. 2003
    ..To determine the correlates of the total 6-min walk distance (6MWD) in a population sample of adults > or = 68 years old...
  84. ncbi One- and two-year change in body composition as measured by DXA in a population-based cohort of older men and women
    Marjolein Visser
    Institute for Research in Extramural Medicine, Vrije University Medical Center, 1081 BT Amsterdam, The Netherlands
    J Appl Physiol 94:2368-74. 2003
    ..Loss of ALST was greater in men compared with women, and greater in blacks compared with whites, suggesting that men and blacks may be more prone to muscle loss...
  85. ncbi Association of high coronary heart disease risk status with circulating oxidized LDL in the well-functioning elderly: findings from the Health, Aging, and Body Composition study
    Paul Holvoet
    Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 23:1444-8. 2003
    ..Therefore, we studied the association between high, predicted CHD risk and oxLDL in the Health ABC cohort...
  86. ncbi Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study)
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Am J Cardiol 92:522-8. 2003
    ..Thus, our findings suggest an important role for IL-6 and TNF-alpha in clinical as well as subclinical cardiovascular disease. In this study, CRP had a weaker association with cardiovascular disease than the cytokines...
  87. ncbi Inflammatory markers and onset of cardiovascular events: results from the Health ABC study
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Circulation 108:2317-22. 2003
    ..Inflammation plays an important role in cardiovascular disease. The aim of this study is to investigate the predictive value of several inflammatory markers on the incidence of cardiovascular events in well-functioning older persons...
  88. ncbi Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study
    Lisa H Colbert
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    J Am Geriatr Soc 52:1098-104. 2004
    ..To examine the association between physical activity and inflammatory markers, with consideration for body fatness and antioxidant use...
  89. ncbi Inflammatory markers and incident mobility limitation in the elderly
    Brenda W J H Penninx
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 52:1105-13. 2004
    ..To examine the relationship between indicators of inflammation and the incidence of mobility limitation in older persons...
  90. ncbi Lipoprotein peroxidation and mobility limitation: results from the Health, Aging, and Body Composition Study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville 32608, USA
    Arch Intern Med 165:2148-54. 2005
    ..The aim of this study was to assess the predictive value of a lipoprotein peroxidation marker, oxidized low-density lipoprotein (oxLDL) for incident mobility limitation (ML)...
  91. ncbi Cystatin C and mortality risk in the elderly: the health, aging, and body composition study
    Michael G Shlipak
    University of San Francisco, General Internal Medicine Section, VA Medical Center 111A1, 4150 Clement Street, San Francisco, CA 94121, USA
    J Am Soc Nephrol 17:254-61. 2006
    ..39], 0.95 [0.68 to 1.32], 1.11 [0.79 to 1.57], 1.16 [0.86 to 1.58]). Cystatin C is a strong, independent risk factor for mortality in the elderly. Future studies should investigate whether cystatin C has a role in clinical medicine...
  92. ncbi Association of usual sleep duration with hypertension: the Sleep Heart Health Study
    Daniel J Gottlieb
    The Pulmonary Center, Boston University School of Medicine, 715 Albany Street, R 304, Boston, MA 02118 2394, USA
    Sleep 29:1009-14. 2006
    ..This study assesses the relationship between usual sleep duration and hypertension in a community-based cohort...
  93. ncbi Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study
    Denise K Houston
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157 1207, USA
    Am J Clin Nutr 87:150-5. 2008
    ..Dietary surveys suggest that many older, community-dwelling adults consume insufficient dietary protein, which may contribute to the age-related loss of lean mass (LM)...
  94. ncbi Kidney dysfunction and fatal cardiovascular disease--an association independent of atherosclerotic events: results from the Health, Aging, and Body Composition (Health ABC) study
    Rajat Deo
    Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD, USA
    Am Heart J 155:62-8. 2008
    ..We evaluated whether impaired kidney function predicted risk of fatal cardiovascular disease independent of prevalent and incident cardiovascular events...
  95. pmc Anxiety symptoms and decline in physical function over 5 years in the health, aging and body composition study
    Kala M Mehta
    Division of Geriatrics, Department of Psychiatry, University of California at San Francisco, San Francisco, California, USA
    J Am Geriatr Soc 55:265-70. 2007
    ..To examine the relationship between anxiety and functional decline...
  96. ncbi Kidney function as a predictor of loss of lean mass in older adults: health, aging and body composition study
    Linda F Fried
    Renal Section, Veterans Affairs Pittsburgh Healthcare System Pittsburgh, Pennsylvania 15240, USA
    J Am Geriatr Soc 55:1578-84. 2007
    ..To assess the association between kidney function and change in body composition in older individuals...
  97. ncbi Factors associated with impaired appetite in well-functioning community-dwelling older adults
    Jung Sun Lee
    Department of Foods and Nutrition, University of Georgia, Athens, GA 30602, USA
    J Nutr Elder 26:27-43. 2006
    ..5 (1.6- 4.1)), poor self-reported health (2.4 (1.7-3.2)), current smoking, chewing problems, reported visual impairment, weight loss since age 50, and log (TNF-alpha) were significantly related to impaired appetite...
  98. ncbi Knee extension strength cutpoints for maintaining mobility
    Todd M Manini
    Institute on Aging, Department of Aging and Geriatric Research, Amsterdam, The Netherlands
    J Am Geriatr Soc 55:451-7. 2007
    ..To identify levels of knee extensor strength that are associated with high and low risk of incident severe mobility limitation (SML) in initially well-functioning older adults...
  99. ncbi Cognitive function, gait speed decline, and comorbidities: the health, aging and body composition study
    Hal H Atkinson
    Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Claude D Pepper Older Americans Independence Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol A Biol Sci Med Sci 62:844-50. 2007
    ..This study examines the relationship between cognitive function and subsequent gait speed decline among high-functioning older adults...
  100. doi Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study
    Fumiko Irie
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Bethesda, MD, USA
    Arch Neurol 65:89-93. 2008
    ..Diabetes and the apolipoprotein E epsilon4 allele (APOE epsilon4) increase the risk for Alzheimer disease (AD). We hypothesize that APOE epsilon4 may modify the risk for AD in individuals with diabetes...
  101. doi Lifestyle factors and incident mobility limitation in obese and non-obese older adults
    Annemarie Koster
    Department of Health Care Studies, Medical Sociology Section, Universiteit Maastricht, Maastricht, The Netherlands
    Obesity (Silver Spring) 15:3122-32. 2007
    ..This study examines the association between incident mobility limitation and 4 lifestyle factors: smoking, alcohol intake, physical activity, and diet in well-functioning obese (n = 667) and non-obese (n = 2027) older adults...

Research Grants15

  1. Exceptional aging: 12 year trajectories to function
    Anne Newman; Fiscal Year: 2007
    ..This study is a critical step towards the identification of the targets and the time points for intervention to preserve function in old age. ..
  2. THE SLEEP HEART HEALTH STUDY
    Anne Newman; Fiscal Year: 2007
    ..Accomplishing these goals will provide important information concerning the public health impact of SDB. ..
  3. Families of cohort survivors over 90 - Study Center
    Anne Newman; Fiscal Year: 2007
    ....
  4. EPIDEMIOLOGY OF CORONARY CALCIFICATION IN THE ELDERLY
    Anne Newman; Fiscal Year: 2005
    ..abstract_text> ..