A B Newman

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc The effect of different public health interventions on longevity, morbidity, and years of healthy life
    Paula Diehr
    Departments of Biostatistics, University of Washington, Seattle, WA, USA
    BMC Public Health 7:52. 2007
  2. ncbi request reprint Relationship between coronary artery calcification and other measures of subclinical cardiovascular disease in older adults
    Anne B Newman
    Division of Geriatric Medicine, University of Pittsburgh, PA 15213, USA
    Arterioscler Thromb Vasc Biol 22:1674-9. 2002
  3. ncbi request reprint Commentary on "Embracing complexity: A consideration of hypertension in the very old"
    Anne B Newman
    University of Pittsburgh School of Medicine, Pennsylvania, 15213, USA
    J Gerontol A Biol Sci Med Sci 58:666-7; discussion 669-70. 2003
  4. ncbi request reprint "Successful aging": effect of subclinical cardiovascular disease
    Anne B Newman
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Intern Med 163:2315-22. 2003
  5. ncbi request reprint The role of comorbidity in the assessment of intermittent claudication in older adults
    A B Newman
    Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh School of Medicine, Keystone Blds, Suite 300, 3529 First Avenue, Pittsburgh, PA 15213 3313, USA
    J Clin Epidemiol 54:294-300. 2001
  6. ncbi request reprint Cardiovascular disease and mortality in older adults with small abdominal aortic aneurysms detected by ultrasonography: the cardiovascular health study
    A B Newman
    Division of Geriatric Medicine, University of Pittsburgh School of Medicine, 3520 Fifth Avenue, Suite 300, Pittsburgh, PA 15213, USA
    Ann Intern Med 134:182-90. 2001
  7. ncbi request reprint Racial differences in coronary artery calcification in older adults
    Anne B Newman
    Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh VA Healthcare System, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arterioscler Thromb Vasc Biol 22:424-30. 2002
  8. ncbi request reprint Strength and muscle quality in a well-functioning cohort of older adults: the Health, Aging and Body Composition Study
    Anne B Newman
    Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh School of Medicine, 3520 5th Avenue, Suite 300, Pittsburgh, PA 15213, USA
    J Am Geriatr Soc 51:323-30. 2003
  9. ncbi request reprint Coronary artery calcification in older adults to age 99: prevalence and risk factors
    A B Newman
    Division of Geriatric Medicine, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    Circulation 104:2679-84. 2001
  10. ncbi request reprint The association of bone mineral density measures with incident cardiovascular disease in older adults
    G N Farhat
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15232, USA
    Osteoporos Int 18:999-1008. 2007

Collaborators

Detail Information

Publications91

  1. pmc The effect of different public health interventions on longevity, morbidity, and years of healthy life
    Paula Diehr
    Departments of Biostatistics, University of Washington, Seattle, WA, USA
    BMC Public Health 7:52. 2007
    ..Here, we compare the benefits of such types of public health interventions...
  2. ncbi request reprint Relationship between coronary artery calcification and other measures of subclinical cardiovascular disease in older adults
    Anne B Newman
    Division of Geriatric Medicine, University of Pittsburgh, PA 15213, USA
    Arterioscler Thromb Vasc Biol 22:1674-9. 2002
    ..In the Cardiovascular Health Study, subclinical cardiovascular disease (CVD) predicted CVD events in older adults. The extent to which this measure or its components reflect calcified coronary disease is unknown...
  3. ncbi request reprint Commentary on "Embracing complexity: A consideration of hypertension in the very old"
    Anne B Newman
    University of Pittsburgh School of Medicine, Pennsylvania, 15213, USA
    J Gerontol A Biol Sci Med Sci 58:666-7; discussion 669-70. 2003
  4. ncbi request reprint "Successful aging": effect of subclinical cardiovascular disease
    Anne B Newman
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Intern Med 163:2315-22. 2003
    ..Among those without clinical disease, high levels of subclinical disease are associated with poor survival. The effect of the extent of subclinical cardiovascular disease on the quality of the remaining years has not been defined...
  5. ncbi request reprint The role of comorbidity in the assessment of intermittent claudication in older adults
    A B Newman
    Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh School of Medicine, Keystone Blds, Suite 300, 3529 First Avenue, Pittsburgh, PA 15213 3313, USA
    J Clin Epidemiol 54:294-300. 2001
    ..The Rose Questionnaire for IC is specific for PAD, but a negative questionnaire does not indicate a lack of symptoms, rather the presence of PAD along with other conditions that can cause pain...
  6. ncbi request reprint Cardiovascular disease and mortality in older adults with small abdominal aortic aneurysms detected by ultrasonography: the cardiovascular health study
    A B Newman
    Division of Geriatric Medicine, University of Pittsburgh School of Medicine, 3520 Fifth Avenue, Suite 300, Pittsburgh, PA 15213, USA
    Ann Intern Med 134:182-90. 2001
    ..It is unknown whether these factors explain the high mortality rate associated with abdominal aortic aneurysm...
  7. ncbi request reprint Racial differences in coronary artery calcification in older adults
    Anne B Newman
    Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh VA Healthcare System, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arterioscler Thromb Vasc Biol 22:424-30. 2002
    ..The lower CAC scores in blacks compared with whites observed in this study is consistent with either a lower prevalence of coronary artery disease or a lower extent of calcification of coronary artery disease...
  8. ncbi request reprint Strength and muscle quality in a well-functioning cohort of older adults: the Health, Aging and Body Composition Study
    Anne B Newman
    Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh School of Medicine, 3520 5th Avenue, Suite 300, Pittsburgh, PA 15213, USA
    J Am Geriatr Soc 51:323-30. 2003
    ..To determine whether lower lean mass and higher fat mass have independent effects on the loss of strength and muscle quality in older adults and might explain part of the effect of age...
  9. ncbi request reprint Coronary artery calcification in older adults to age 99: prevalence and risk factors
    A B Newman
    Division of Geriatric Medicine, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    Circulation 104:2679-84. 2001
    ..However, the prevalence and risk factors for coronary artery calcification in populations >65 years have not been well studied...
  10. ncbi request reprint The association of bone mineral density measures with incident cardiovascular disease in older adults
    G N Farhat
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15232, USA
    Osteoporos Int 18:999-1008. 2007
    ..BMD measures were inversely related to CVD in women and white men, independent of age and shared risk factors for osteoporosis and CVD...
  11. ncbi request reprint Ankle-arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study. The Cardiovascular Health Study Group
    A B Newman
    University of Pittsburgh, Pittsburgh, PA, USA
    Arterioscler Thromb Vasc Biol 19:538-45. 1999
    ..1 decrement in the AAI. An AAI of <0.9 is an independent risk factor for incident CVD, recurrent CVD, and mortality in this group of older adults in the Cardiovascular Health Study...
  12. ncbi request reprint Prevalence and risk factors for abdominal aortic aneurysms in older adults with and without isolated systolic hypertension
    B L Naydeck
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Cardiol 83:759-64. 1999
    ..Patients with AAA also had greater wall thickness and greater diameter of the iliac arteries, which are probably associated with the underlying disease process...
  13. pmc Concurrent change in dehydroepiandrosterone sulfate and functional performance in the oldest old: results from the Cardiovascular Health Study All Stars study
    J L Sanders
    Medical Scientist Training Program, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    J Gerontol A Biol Sci Med Sci 65:976-81. 2010
    ..We evaluated concurrent DHEAS and functional decline in a very old cohort to test if DHEAS change tracks with functional change during aging...
  14. pmc Executive function, memory, and gait speed decline in well-functioning older adults
    N L Watson
    Department of Epidemiology, University of Pittsburgh, Pennsylvania, Pittsburgh, PA 15213 3545, USA
    J Gerontol A Biol Sci Med Sci 65:1093-100. 2010
    ..In community-dwelling older adults, global cognitive function predicts longitudinal gait speed decline. Few prospective studies have evaluated whether specific executive cognitive deficits in aging may account for gait slowing over time...
  15. ncbi request reprint Volumetric and areal bone mineral density measures are associated with cardiovascular disease in older men and women: the health, aging, and body composition study
    G N Farhat
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, 127 Parran Hall, PA 15261, USA
    Calcif Tissue Int 79:102-11. 2006
    ..In conclusion, our results provide further evidence for an inverse association between BMD and CVD in men and women. Future research should investigate common pathophysiological links for osteoporosis and CVD...
  16. pmc Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study
    K I Erickson
    Department of Psychology, University of Pittsburgh, PA, USA
    Neurology 75:1415-22. 2010
    ....
  17. ncbi request reprint Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study
    B H Goodpaster
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Appl Physiol (1985) 90:2157-65. 2001
    ..These results demonstrate that the attenuation values of muscle on computed tomography in older persons can account for differences in muscle strength not attributed to muscle quantity...
  18. ncbi request reprint Kidney function and markers of inflammation in elderly persons without chronic kidney disease: the health, aging, and body composition study
    C R Keller
    Department of Medicine, University of California, San Francisco, California, USA
    Kidney Int 71:239-44. 2007
    ..05). Cystatin C has a linear association with inflammatory biomarkers in an ambulatory elderly cohort with estimated glomerular filtration rates >or=60; associations are particularly strong with TNF-alpha and the STNF-R...
  19. ncbi request reprint Weight change in old age and its association with mortality
    A B Newman
    Division of Geriatric Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    J Am Geriatr Soc 49:1309-18. 2001
    ..CONCLUSIONS: This study confirms that even modest decline in body weight is an important and independent marker of risk of mortality in older adults...
  20. ncbi request reprint Hormone replacement therapy is associated with higher FEV1 in elderly women
    C L Carlson
    Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Respir Crit Care Med 163:423-8. 2001
    ..67 [95% CI 0.48, 0.95]). We conclude that postmenopausal women who use HRT have higher levels of FEV1 and less obstruction, which could not be explained by their lower rates of smoking and other health factors associated with HRT use...
  21. ncbi request reprint Associations of subclinical cardiovascular disease with frailty
    A B Newman
    The University of Pittsburgh, Pennsylvania, USA
    J Gerontol A Biol Sci Med Sci 56:M158-66. 2001
    ..Little work has been done to define frailty and describe the underlying pathophysiology...
  22. pmc The risk of Parkinson disease associated with urate in a community-based cohort of older adults
    S Jain
    Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15213 3232, USA
    Neuroepidemiology 36:223-9. 2011
    ..Studies suggest an inverse association between urate concentration and the risk of Parkinson disease (PD). We investigated this in the Cardiovascular Health Study in an elderly community-based cohort of adults...
  23. pmc Shorter telomeres are associated with obesity and weight gain in the elderly
    O T Njajou
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0794, USA
    Int J Obes (Lond) 36:1176-9. 2012
    ..Therefore, we set out to test the hypothesis that TL may be a risk factor for increased adiposity using data from a large population-based cohort study...
  24. pmc Genetic analysis of serum osteocalcin and bone mineral in multigenerational Afro-Caribbean families
    A L Kuipers
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Osteoporos Int 23:1521-31. 2012
    ..Osteocalcin is a major component of bone matrix. Concentrations of total, carboxylated, and uncarboxylated osteocalcin, are highly heritable and genetically correlated with bone mineral content (BMC) within African ancestry families...
  25. ncbi request reprint Temporal trends in the use of anticoagulants among older adults with atrial fibrillation
    N L Smith
    Department of Medicine, University of Washington, Seattle, USA
    Arch Intern Med 159:1574-8. 1999
    ..Insufficient documentation exists on the extent to which the use of these therapies following trial publications has continued to increase in the elderly with atrial fibrillation...
  26. ncbi request reprint Relation of sleep-disordered breathing to cardiovascular disease risk factors: the Sleep Heart Health Study
    A B Newman
    University of Pittsburgh, 3520 Fifth Avenue, Suite 300, Pittsburgh, PA 15213, USA
    Am J Epidemiol 154:50-9. 2001
    ..If sleep-disordered breathing is shown in future follow-up to increase the risk for incident CVD events, part of the risk is likely to be due to the higher cardiovascular risk factors in those with higher RDI...
  27. ncbi request reprint Genetic markers for ancestry are correlated with body composition traits in older African Americans
    J R Shaffer
    Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Osteoporos Int 18:733-41. 2007
    ..We found significant correlations between proportion of European ancestry and several musculoskeletal traits, indicating that admixture mapping may be a useful strategy for locating genes affecting these traits...
  28. ncbi request reprint A new approach of measuring muscle impairment during a functional task: quadriceps muscle activity recorded during chair stand
    J S Brach
    Department of Physical Therapy, University of Pittsburgh, Pennsylvania 15260, USA
    J Gerontol A Biol Sci Med Sci 56:M767-70. 2001
    ..The purpose of this study was to describe a new approach of measuring muscle impairment during a functional task...
  29. pmc Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjects
    S Yende
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, PA 15238, USA
    Thorax 61:10-6. 2006
    ..Inflammatory markers are increased in chronic obstructive pulmonary disease (COPD) and are hypothesised to play an important part in muscle dysfunction and exercise intolerance...
  30. ncbi request reprint Preclinical Alzheimer disease: neuropsychological test performance 1.5 to 8 years prior to onset
    J Saxton
    University of Pittsburgh, Oxford Building, Room 738, Pittsburgh, PA 15213, USA
    Neurology 63:2341-7. 2004
    ..To determine if individuals ultimately diagnosed with Alzheimer disease (AD) exhibited evidence of cognitive impairment on neuropsychological tests administered between 1.5 years and 8.1 years before dementia onset...
  31. pmc The association of osteoarthritis risk factors with localized, regional and diffuse knee pain
    L R Thompson
    Department of Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, PA, United States
    Osteoarthritis Cartilage 18:1244-9. 2010
    ..To identify determinants of different patterns of knee pain with a focus on risk factors for knee osteoarthritis (OA)...
  32. ncbi request reprint Gait variability in community-dwelling older adults
    J S Brach
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Am Geriatr Soc 49:1646-50. 2001
    ..Improvement in step-length and step-width variability with attempted acceleration might be a key factor to examine in future studies of disability risk and therapeutic interventions...
  33. ncbi request reprint Functional neuroimaging indicators of successful executive control in the oldest old
    C Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, PA 15260, USA
    Neuroimage 28:881-9. 2005
    ..Older adults who are able to perform executive control tasks as well as young adults, also seem to implement speed-accuracy trade-off strategies which may rely on increased parietal activation...
  34. ncbi request reprint Higher 1,25-dihydroxyvitamin D3 concentrations associated with lower fall rates in older community-dwelling women
    K A Faulkner
    University of Pittsburgh, 130 DeSoto Street, Parran 509, Pittsburgh, PA 15261, USA
    Osteoporos Int 17:1318-28. 2006
    ..The purpose of this study was to examine the relationships of vitamin D supplementation and serum concentrations of vitamin D metabolites and parathyroid hormone (PTH) with neuromuscular function and falls in older community-dwelling women...
  35. pmc Anxiety symptoms and decline in physical function over 5 years in the health, aging and body composition study
    Kala M Mehta
    Division of Geriatrics, Department of Psychiatry, University of California at San Francisco, San Francisco, California, USA
    J Am Geriatr Soc 55:265-70. 2007
    ..To examine the relationship between anxiety and functional decline...
  36. pmc Poor sleep is associated with poorer physical performance and greater functional limitations in older women
    Suzanne E Goldman
    Department of Epidemiology, University ofPittsburgh, Pittsburgh, PA, USA
    Sleep 30:1317-24. 2007
    ..This study examined the association between disturbed sleep and poorer daytime function in older women...
  37. ncbi request reprint Kidney function as a predictor of loss of lean mass in older adults: health, aging and body composition study
    Linda F Fried
    Renal Section, Veterans Affairs Pittsburgh Healthcare System Pittsburgh, Pennsylvania 15240, USA
    J Am Geriatr Soc 55:1578-84. 2007
    ..To assess the association between kidney function and change in body composition in older individuals...
  38. ncbi request reprint Factors associated with impaired appetite in well-functioning community-dwelling older adults
    Jung Sun Lee
    Department of Foods and Nutrition, University of Georgia, Athens, GA 30602, USA
    J Nutr Elder 26:27-43. 2006
    ..5 (1.6- 4.1)), poor self-reported health (2.4 (1.7-3.2)), current smoking, chewing problems, reported visual impairment, weight loss since age 50, and log (TNF-alpha) were significantly related to impaired appetite...
  39. ncbi request reprint Cognitive function, gait speed decline, and comorbidities: the health, aging and body composition study
    Hal H Atkinson
    Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Claude D Pepper Older Americans Independence Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol A Biol Sci Med Sci 62:844-50. 2007
    ..This study examines the relationship between cognitive function and subsequent gait speed decline among high-functioning older adults...
  40. ncbi request reprint Psychosocial risk factors and the metabolic syndrome in elderly persons: findings from the Health, Aging and Body Composition study
    Nicole Vogelzangs
    Department of Psychiatry and Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:563-9. 2007
    ..This study investigated the cross-sectional relationship between psychosocial risk factors and the metabolic syndrome in a community-based sample of older persons...
  41. ncbi request reprint Inflammatory markers and onset of cardiovascular events: results from the Health ABC study
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Circulation 108:2317-22. 2003
    ..Inflammation plays an important role in cardiovascular disease. The aim of this study is to investigate the predictive value of several inflammatory markers on the incidence of cardiovascular events in well-functioning older persons...
  42. ncbi request reprint Knee extension strength cutpoints for maintaining mobility
    Todd M Manini
    Institute on Aging, Department of Aging and Geriatric Research, Amsterdam, The Netherlands
    J Am Geriatr Soc 55:451-7. 2007
    ..To identify levels of knee extensor strength that are associated with high and low risk of incident severe mobility limitation (SML) in initially well-functioning older adults...
  43. ncbi request reprint Neck and shoulder pain in 70- to 79-year-old men and women: findings from the Health, Aging and Body Composition Study
    Molly T Vogt
    Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Spine J 3:435-41. 2003
    ..Musculoskeletal pain in the cervicobrachial region is considered a major health problem among adults of working age, but little is known about the impact of this pain in the elderly...
  44. ncbi request reprint Diabetes is associated independently of body composition with BMD and bone volume in older white and black men and women: The Health, Aging, and Body Composition Study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Bone Miner Res 19:1084-91. 2004
    ..Diabetes predicted higher hip, whole body, and volumetric spine BMD, and lower spine bone volume, independent of body composition and fasting insulin...
  45. ncbi request reprint Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study
    Lisa H Colbert
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    J Am Geriatr Soc 52:1098-104. 2004
    ..To examine the association between physical activity and inflammatory markers, with consideration for body fatness and antioxidant use...
  46. ncbi request reprint Inflammatory markers and incident mobility limitation in the elderly
    Brenda W J H Penninx
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 52:1105-13. 2004
    ..To examine the relationship between indicators of inflammation and the incidence of mobility limitation in older persons...
  47. ncbi request reprint Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study
    Marco Pahor
    Department of Aging and Geriatric Research, College of Medicine, University of Florida, 1329 SW 16th St, Rm 5161, Gainesville, FL 32608, USA
    J Gerontol A Biol Sci Med Sci 61:1157-65. 2006
    ..Our objective was to assess the effect of a comprehensive physical activity (PA) intervention on the SPPB and other physical performance measures...
  48. ncbi request reprint Kidney dysfunction and fatal cardiovascular disease--an association independent of atherosclerotic events: results from the Health, Aging, and Body Composition (Health ABC) study
    Rajat Deo
    Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD, USA
    Am Heart J 155:62-8. 2008
    ..We evaluated whether impaired kidney function predicted risk of fatal cardiovascular disease independent of prevalent and incident cardiovascular events...
  49. ncbi request reprint Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study
    Denise K Houston
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157 1207, USA
    Am J Clin Nutr 87:150-5. 2008
    ..Dietary surveys suggest that many older, community-dwelling adults consume insufficient dietary protein, which may contribute to the age-related loss of lean mass (LM)...
  50. ncbi request reprint Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study
    Marjolein Visser
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 57:M326-32. 2002
    ....
  51. ncbi request reprint Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study
    Marjolein Visser
    Institute for Research in Extramural Medicine, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    J Am Geriatr Soc 50:897-904. 2002
    ..Our aim was to determine whether low leg muscle mass and greater fat infiltration in the muscle were associated with poor lower extremity performance (LEP)...
  52. ncbi request reprint The 6-min walk test: a quick measure of functional status in elderly adults
    Paul L Enright
    University of Arizona, USA
    Chest 123:387-98. 2003
    ..To determine the correlates of the total 6-min walk distance (6MWD) in a population sample of adults > or = 68 years old...
  53. ncbi request reprint One- and two-year change in body composition as measured by DXA in a population-based cohort of older men and women
    Marjolein Visser
    Institute for Research in Extramural Medicine, Vrije University Medical Center, 1081 BT Amsterdam, The Netherlands
    J Appl Physiol 94:2368-74. 2003
    ..Loss of ALST was greater in men compared with women, and greater in blacks compared with whites, suggesting that men and blacks may be more prone to muscle loss...
  54. ncbi request reprint Association of high coronary heart disease risk status with circulating oxidized LDL in the well-functioning elderly: findings from the Health, Aging, and Body Composition study
    Paul Holvoet
    Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 23:1444-8. 2003
    ..Therefore, we studied the association between high, predicted CHD risk and oxLDL in the Health ABC cohort...
  55. ncbi request reprint Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study)
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Am J Cardiol 92:522-8. 2003
    ..Thus, our findings suggest an important role for IL-6 and TNF-alpha in clinical as well as subclinical cardiovascular disease. In this study, CRP had a weaker association with cardiovascular disease than the cytokines...
  56. pmc Fetuin-A and incident diabetes mellitus in older persons
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, and San Diego Veterans Affairs Healthcare System, 3350 La Jolla Village Dr, Mail Code 111 H, San Diego, CA 92161, USA
    JAMA 300:182-8. 2008
    ..In prior cross-sectional studies in humans, higher fetuin-A levels were associated with insulin resistance. However, the longitudinal association of fetuin-A with incident type 2 diabetes mellitus is unknown...
  57. pmc Association between nighttime sleep and napping in older adults
    Suzanne E Goldman
    Department of Neurology, Sleep Disorders Program, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Sleep 31:733-40. 2008
    ..Napping might indicate deficiencies in nighttime sleep, but the relationship is not well defined. We assessed the association of nighttime sleep duration and fragmentation with subsequent daytime sleep...
  58. ncbi request reprint Physical activity in prefrail older adults: confidence and satisfaction related to physical function
    W Jack Rejeski
    Department of Health and Exercise Science, Box 7868, Wake Forest University, Winston Salem, NC 27109, USA
    J Gerontol B Psychol Sci Soc Sci 63:P19-26. 2008
    ..This is an important finding in light of the importance of these process variables in behavior change and quality of life...
  59. doi request reprint Total insulinlike growth factor 1 and insulinlike growth factor binding protein levels, functional status, and mortality in older adults
    Robert C Kaplan
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Am Geriatr Soc 56:652-60. 2008
    ..To assess the association between total insulinlike growth factor (IGF)-1, IGF binding protein-1 (IGFBP-1), and IGFBP-3 levels and functioning and mortality in older adults...
  60. doi request reprint Lifestyle factors and incident mobility limitation in obese and non-obese older adults
    Annemarie Koster
    Department of Health Care Studies, Medical Sociology Section, Universiteit Maastricht, Maastricht, The Netherlands
    Obesity (Silver Spring) 15:3122-32. 2007
    ..This study examines the association between incident mobility limitation and 4 lifestyle factors: smoking, alcohol intake, physical activity, and diet in well-functioning obese (n = 667) and non-obese (n = 2027) older adults...
  61. doi request reprint Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study
    Fumiko Irie
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Bethesda, MD, USA
    Arch Neurol 65:89-93. 2008
    ..Diabetes and the apolipoprotein E epsilon4 allele (APOE epsilon4) increase the risk for Alzheimer disease (AD). We hypothesize that APOE epsilon4 may modify the risk for AD in individuals with diabetes...
  62. ncbi request reprint Association of usual sleep duration with hypertension: the Sleep Heart Health Study
    Daniel J Gottlieb
    The Pulmonary Center, Boston University School of Medicine, 715 Albany Street, R 304, Boston, MA 02118 2394, USA
    Sleep 29:1009-14. 2006
    ..This study assesses the relationship between usual sleep duration and hypertension in a community-based cohort...
  63. ncbi request reprint Diabetes, inflammation, and functional decline in older adults: findings from the Health, Aging and Body Composition (ABC) study
    M Kathleen Figaro
    Department of Medicine, Vanderbilt University Medical Center GRECC, 1310 24th Ave South, Room 4B111, Nashville, TN 37212, USA
    Diabetes Care 29:2039-45. 2006
    ..We examined the effect of C-reactive protein (CRP) and interleukin-6 (IL-6) on the incident mobility limitation in older adults with and without diabetes...
  64. ncbi request reprint The association between lipid levels and the risks of incident myocardial infarction, stroke, and total mortality: The Cardiovascular Health Study
    Bruce M Psaty
    Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington 98101, USA
    J Am Geriatr Soc 52:1639-47. 2004
    ..To assess the association between lipid levels and cardiovascular events in older adults...
  65. ncbi request reprint A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: the Cardiovascular Health Study
    Neil A Zakai
    Department of Medicine, University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, USA
    Arch Intern Med 165:2214-20. 2005
    ..Anemia is viewed as a negative prognostic factor in the elderly population; its independent impact on survival is unclear...
  66. pmc Black and white differences in cognitive function test scores: what explains the difference?
    Kala M Mehta
    Division of Geriatrics, University of California at San Francisco, 94121, USA
    J Am Geriatr Soc 52:2120-7. 2004
    ..This study evaluates whether differences in health and socioeconomic indicators, including literacy level, can explain differences in cognitive function test scores between older black and white adults...
  67. ncbi request reprint Lipoprotein peroxidation and mobility limitation: results from the Health, Aging, and Body Composition Study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville 32608, USA
    Arch Intern Med 165:2148-54. 2005
    ..The aim of this study was to assess the predictive value of a lipoprotein peroxidation marker, oxidized low-density lipoprotein (oxLDL) for incident mobility limitation (ML)...
  68. ncbi request reprint Prognostic value of usual gait speed in well-functioning older people--results from the Health, Aging and Body Composition Study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, Florida 32608, USA
    J Am Geriatr Soc 53:1675-80. 2005
    ..To define clinically relevant cutpoints for usual gait speed and to investigate their predictive value for health-related events in older persons...
  69. ncbi request reprint Short-term weight changes in community-dwelling older adults: the Health, Aging, and Body Composition Weight Change Substudy
    Jung Sun Lee
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Clin Nutr 82:644-50. 2005
    ..The frequency and short-term natural history of weight loss in community-dwelling older adults have not been described. Unintentional weight loss may be more likely to continue than intentional weight loss...
  70. ncbi request reprint Lower serum albumin concentration and change in muscle mass: the Health, Aging and Body Composition Study
    Marjolein Visser
    Institute of Health Sciences, Faculty of Earth and Life Sciences, Vrije Universiteit, Amsterdam, The Netherlands
    Am J Clin Nutr 82:531-7. 2005
    ..Low albumin concentrations in older persons increase the risk of poor health outcomes, including functional decline...
  71. ncbi request reprint Is there a biomedical explanation for socioeconomic differences in incident mobility limitation?
    Annemarie Koster
    Department of Health Care Studies, Section Medical Sociology, Universiteit Maastricht, Maastricht, The Netherlands
    J Gerontol A Biol Sci Med Sci 60:1022-7. 2005
    ..This study examines the association between socioeconomic status and incident mobility limitation in well-functioning older adults, and seeks to determine whether this link could be explained by biomedical factors...
  72. ncbi request reprint Weight change, weight change intention, and the incidence of mobility limitation in well-functioning community-dwelling older adults
    Jung Sun Lee
    Healthy Aging Research Program, Department of Epidemiology, University of Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 60:1007-12. 2005
    ..The aim of this study was to determine whether weight, weight change, and weight change intention are associated with risk for mobility limitation in elderly persons...
  73. ncbi request reprint The clock drawing test is an independent predictor of incident use of 24-hour care in a retirement community
    Laurie L Lavery
    Division of Geriatric Medicine, University of Pittsburgh, 3471 Fifth Ave, Suite 500, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 60:928-32. 2005
    ..We examined the relationship between executive function, measured with a clock drawing protocol (CLOX1) designed to capture executive impairment, and incident need for increased level of care and total mortality...
  74. ncbi request reprint Cross-sectional associations between trunk muscle composition, back pain, and physical function in the health, aging and body composition study
    Gregory E Hicks
    Clinical Research Branch, National Institute on Aging, Baltimore, MD 21201, USA
    J Gerontol A Biol Sci Med Sci 60:882-7. 2005
    ..We hypothesized that lower trunk muscle area and attenuation (higher fat infiltration) are associated with decreased functional capacity...
  75. ncbi request reprint Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Intern Med 165:1612-7. 2005
    ..Diabetes mellitus (DM) and related complications may increase clinical fracture risk in older adults...
  76. ncbi request reprint Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons
    Marjolein Visser
    Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 60:324-33. 2005
    ..This study aims to investigate whether low muscle mass, low muscle strength, and greater fat infiltration into the muscle predict incident mobility limitation...
  77. ncbi request reprint Kidney function as a predictor of noncardiovascular mortality
    Linda F Fried
    VA Pittsburgh Healthcare System and Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15240, USA
    J Am Soc Nephrol 16:3728-35. 2005
    ..Kidney function predicts noncardiovascular mortality from multiple causes in the elderly. Further research is needed to understand the mechanisms and evaluate interventions to reduce the high mortality rate in chronic kidney disease...
  78. ncbi request reprint Cystatin C and mortality risk in the elderly: the health, aging, and body composition study
    Michael G Shlipak
    University of San Francisco, General Internal Medicine Section, VA Medical Center 111A1, 4150 Clement Street, San Francisco, CA 94121, USA
    J Am Soc Nephrol 17:254-61. 2006
    ..39], 0.95 [0.68 to 1.32], 1.11 [0.79 to 1.57], 1.16 [0.86 to 1.58]). Cystatin C is a strong, independent risk factor for mortality in the elderly. Future studies should investigate whether cystatin C has a role in clinical medicine...
  79. pmc Limited literacy and mortality in the elderly: the health, aging, and body composition study
    Rebecca L Sudore
    University of California, San Francisco, CA 94121, USA
    J Gen Intern Med 21:806-12. 2006
    ..While limited literacy is common and its prevalence increases with age, no prospective study has assessed whether limited literacy is associated with mortality in older adults...
  80. ncbi request reprint Kidney function predicts the rate of bone loss in older individuals: the Cardiovascular Health Study
    Linda F Fried
    VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
    J Gerontol A Biol Sci Med Sci 61:743-8. 2006
    ....
  81. ncbi request reprint Impact of inflammation on the relationship among alcohol consumption, mortality, and cardiac events: the health, aging, and body composition study
    Cinzia Maraldi
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, 1329 SW 16th St, Gainesville, FL 32608, USA
    Arch Intern Med 166:1490-7. 2006
    ..We investigated the relationship of alcohol intake with all-cause mortality and cardiac events and evaluated whether this relationship is mediated or modified by inflammatory markers...
  82. ncbi request reprint Renal function and heart failure risk in older black and white individuals: the Health, Aging, and Body Composition Study
    Kirsten Bibbins-Domingo
    Division of General Internal Medicine, San Francisco General Hospital, CA 94143 1364, USA
    Arch Intern Med 166:1396-402. 2006
    ..Our objective was to determine whether the association of chronic kidney disease with incident heart failure differs between blacks and whites...
  83. ncbi request reprint Skeletal muscle fatigue, strength, and quality in the elderly: the Health ABC Study
    Andreas Katsiaras
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    J Appl Physiol (1985) 99:210-6. 2005
    ..In conclusion, older men were more fatigue resistant than women, although in both men and women greater fatigue was not related to muscle weakness...
  84. ncbi request reprint Concordance and discordance between two measures of lower extremity function: 400 meter self-paced walk and SPPB
    Stephen P Sayers
    Human Physiology Laboratory, Department of Health Sciences, Sargent College of Rehabilitation Sciences, Boston University, USA
    Aging Clin Exp Res 18:100-6. 2006
    ..A secondary purpose was to determine whether the 400-m W could better discriminate physical performance among high functioning older adults by examining the distribution of 400-m W scores...
  85. ncbi request reprint Limited literacy in older people and disparities in health and healthcare access
    Rebecca L Sudore
    Department of Medicine, Division of Geriatrics, University of California San Francisco, San Francisco, CA, USA
    J Am Geriatr Soc 54:770-6. 2006
    ..To determine the relationship between health literacy, demographics, and access to health care...
  86. ncbi request reprint Metabolic syndrome and the risk of cardiovascular disease in older adults
    Javed Butler
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Am Coll Cardiol 47:1595-602. 2006
    ..The purpose of this study was to assess whether metabolic syndrome (MetSyn) predicts a higher risk for cardiovascular events in older adults...
  87. ncbi request reprint Association of inflammatory markers with socioeconomic status
    Annemarie Koster
    Department of Health Care Studies, Section of Medical Sociology, Universiteit Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Gerontol A Biol Sci Med Sci 61:284-90. 2006
    ....
  88. ncbi request reprint Mortality and cardiovascular risk across the ankle-arm index spectrum: results from the Cardiovascular Health Study
    ANN M O'HARE
    Nephrology Division, Department of Medicine, VA Medical Center San Francisco, University of California, San Francisco, CA, USA
    Circulation 113:388-93. 2006
    ..A high AAI also appears to be associated with higher mortality risk in select populations. However, mortality and cardiovascular risk across the AAI spectrum have not been described in a more broadly defined population...
  89. ncbi request reprint Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Epidemiol 160:741-9. 2004
    ..79, 95% confidence interval: 1.24, 2.58 per standard-deviation increase; p < 0.01). The amount of adipose tissue stored in the intraabdominal cavity is an important, independent risk factor for MI in well-functioning, elderly women...
  90. ncbi request reprint Aspirin use for the primary prevention of coronary heart disease in older adults
    Nicolas Rodondi
    Department of Epidemiology and Biostatistics, University of California, San Francisco, Calif, USA
    Am J Med 118:1288. 2005
    ..We determined the prevalence of aspirin use in relation to coronary heart disease risk and changes over time...
  91. ncbi request reprint Predicting the development of diabetes in older adults: the derivation and validation of a prediction rule
    Alka M Kanaya
    Department of Medicine and Epidemiology and Biostatics, University of California, San Francisco, California 94115, USA
    Diabetes Care 28:404-8. 2005
    ..We created a prediction rule in one sample and prospectively validated it for incident diabetes in a separate cohort...