Paul A Newhouse

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. ncbi Nicotine and nicotinic receptor involvement in neuropsychiatric disorders
    Paul Newhouse
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, 1 South Prospect St, Burlington, VT 05401, USA
    Curr Top Med Chem 4:267-82. 2004
  2. ncbi Sex differences in visual-spatial learning using a virtual water maze in pre-pubertal children
    Paul Newhouse
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, 1 South Prospect St, Burlington, VT, United States
    Behav Brain Res 183:1-7. 2007
  3. ncbi Estrogen administration negatively alters mood following monoaminergic depletion and psychosocial stress in postmenopausal women
    Paul A Newhouse
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT 05401, USA
    Neuropsychopharmacology 33:1514-27. 2008
  4. ncbi Estrogen treatment impairs cognitive performance after psychosocial stress and monoamine depletion in postmenopausal women
    Paul A Newhouse
    Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA
    Menopause 17:860-73. 2010
  5. ncbi Functional brain imaging of nicotinic effects on higher cognitive processes
    Paul A Newhouse
    Clinical Neuroscience Research Unit and Brain Imaging Program, Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT 05401, USA
    Biochem Pharmacol 82:943-51. 2011
  6. ncbi Effects of nicotinic stimulation on cognitive performance
    Paul A Newhouse
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, 1 South Prospect St, Burlington, VT 05403, USA
    Curr Opin Pharmacol 4:36-46. 2004
  7. ncbi Cholinergic modulation of hippocampal activity during episodic memory encoding in postmenopausal women: a pilot study
    Julie A Dumas
    Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA
    Menopause 17:852-9. 2010
  8. ncbi Effects of acute ultra-low dose mecamylamine on cognition in adult attention-deficit/hyperactivity disorder (ADHD)
    Alexandra S Potter
    Clinical Neuroscience Research Unit, Department of Psychiatry, College of Medicine, University of Vermont, Burlington, Vermont 05401, USA
    Hum Psychopharmacol 24:309-17. 2009
  9. ncbi Acute nicotine improves cognitive deficits in young adults with attention-deficit/hyperactivity disorder
    Alexandra S Potter
    Clinical Neuroscience Research Unit, Department of Psychiatry, College of Medicine, University of Vermont, Burlington, VT 05401, United States
    Pharmacol Biochem Behav 88:407-17. 2008
  10. ncbi The effects of age and estrogen on stress responsivity in older women
    Julie A Dumas
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA
    Am J Geriatr Psychiatry 20:734-43. 2012

Research Grants

  1. Estrogen Effects on Cholinergic Function in Older Women
    Paul Newhouse; Fiscal Year: 2007
  2. Transdermal Nicotine Treatment of MCI
    Paul Newhouse; Fiscal Year: 2006
  3. Transdermal Nicotine Treatment of MCI
    Paul Newhouse; Fiscal Year: 2007
  4. Estrogen Effects on Cholinergic Function in Older Women
    Paul A Newhouse; Fiscal Year: 2010

Detail Information

Publications23

  1. ncbi Nicotine and nicotinic receptor involvement in neuropsychiatric disorders
    Paul Newhouse
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, 1 South Prospect St, Burlington, VT 05401, USA
    Curr Top Med Chem 4:267-82. 2004
    ....
  2. ncbi Sex differences in visual-spatial learning using a virtual water maze in pre-pubertal children
    Paul Newhouse
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, 1 South Prospect St, Burlington, VT, United States
    Behav Brain Res 183:1-7. 2007
    ..Rather, these differences may reflect early-life hormonal effects on hippocampal-dependent processes and may suggest different preferential learning strategies by boys and girls...
  3. ncbi Estrogen administration negatively alters mood following monoaminergic depletion and psychosocial stress in postmenopausal women
    Paul A Newhouse
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT 05401, USA
    Neuropsychopharmacology 33:1514-27. 2008
    ..This modulation appears to be independent of alterations in monoaminergic neurotransmission. The dose of estrogen used after menopause may be important in determining the effects of gonadal steroids on emotional regulation...
  4. ncbi Estrogen treatment impairs cognitive performance after psychosocial stress and monoamine depletion in postmenopausal women
    Paul A Newhouse
    Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA
    Menopause 17:860-73. 2010
    ..This study examined whether estradiol (E2) administration can modify cognitive performance after exposure to psychological stress and monoamine depletion...
  5. ncbi Functional brain imaging of nicotinic effects on higher cognitive processes
    Paul A Newhouse
    Clinical Neuroscience Research Unit and Brain Imaging Program, Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT 05401, USA
    Biochem Pharmacol 82:943-51. 2011
    ..The use of functional brain imaging will be a key tool for probing pathologic changes related to brain illness and for nicotinic drug development...
  6. ncbi Effects of nicotinic stimulation on cognitive performance
    Paul A Newhouse
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, 1 South Prospect St, Burlington, VT 05403, USA
    Curr Opin Pharmacol 4:36-46. 2004
    ..Attentional function/dysfunction may serve as an endophenotypic therapeutic target for nicotinic drug development...
  7. ncbi Cholinergic modulation of hippocampal activity during episodic memory encoding in postmenopausal women: a pilot study
    Julie A Dumas
    Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA
    Menopause 17:852-9. 2010
    ....
  8. ncbi Effects of acute ultra-low dose mecamylamine on cognition in adult attention-deficit/hyperactivity disorder (ADHD)
    Alexandra S Potter
    Clinical Neuroscience Research Unit, Department of Psychiatry, College of Medicine, University of Vermont, Burlington, Vermont 05401, USA
    Hum Psychopharmacol 24:309-17. 2009
    ..Comparable studies in humans have not been conducted. The aim of this study was to determine the effects of acute ultra-low doses of mecamylamine on cognition in adult ADHD...
  9. ncbi Acute nicotine improves cognitive deficits in young adults with attention-deficit/hyperactivity disorder
    Alexandra S Potter
    Clinical Neuroscience Research Unit, Department of Psychiatry, College of Medicine, University of Vermont, Burlington, VT 05401, United States
    Pharmacol Biochem Behav 88:407-17. 2008
    ..This study examined acute nicotine in young adults with ADHD-Combined type on cognitive domains including behavioral inhibition, delay aversion, and recognition memory...
  10. ncbi The effects of age and estrogen on stress responsivity in older women
    Julie A Dumas
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA
    Am J Geriatr Psychiatry 20:734-43. 2012
    ..The current study examined whether age after menopause impacted the effect of estradiol (E2) on mood after a psychosocial stress manipulation...
  11. ncbi Manipulation of nicotinic acetylcholine receptors differentially affects behavioral inhibition in human subjects with and without disordered baseline impulsivity
    Alexandra S Potter
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont, 1 South Prospect Street, Burlington, VT 05401, USA
    Psychopharmacology (Berl) 220:331-40. 2012
    ..The specificity of this effect to those with ADHD, the component processes of the SST affected by nicotine, and the effects of nicotinic antagonism are yet unknown...
  12. ncbi Estradiol treatment altered anticholinergic-related brain activation during working memory in postmenopausal women
    Julie A Dumas
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, 1 South Prospect St, Burlington, VT 05401, USA
    Neuroimage 60:1394-403. 2012
    ..These data are the first to show that estradiol modulated antimuscarinic- and anitnicotinic-induced brain activity and suggest that estradiol affected cholinergic system regulation of cognition-related brain activation in humans...
  13. ncbi The Stroop effect in kana and kanji scripts in native Japanese speakers: an fMRI study
    Emily L Coderre
    Department of Psychiatry, University of Vermont College of Medicine, 1 South Prospect Street, Burlington, VT 05401, USA
    Brain Lang 107:124-32. 2008
    ..The results of the present study suggest that the Stroop task in Japanese kana and kanji elicits differential activation in brain regions involved in conflict detection and resolution for syllabic and logographic writing systems...
  14. ncbi Increased working memory-related brain activity in middle-aged women with cognitive complaints
    Julie A Dumas
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA Electronic address
    Neurobiol Aging 34:1145-7. 2013
    ..These findings suggest that subjective cognitive complaints in postmenopausal women might be associated with increased cortical activity during effort-demanding cognitive tasks...
  15. ncbi Central nicotinic cholinergic systems: a role in the cognitive dysfunction in attention-deficit/hyperactivity disorder?
    Alexandra S Potter
    Clinical Neuroscience Research Unit, Department of Psychiatry, College of Medicine, University of Vermont, 1 South Prospect Street, Burlington, VT 05401, United States
    Behav Brain Res 175:201-11. 2006
    ..Finally, we identify specific paradigms and models to guide future investigations into the specific involvement of nicotinic cholinergic systems in ADHD, possibly leading to the development of more effective pharmacotherapies for ADHD...
  16. ncbi Nicotinic versus muscarinic blockade alters verbal working memory-related brain activity in older women
    Julie A Dumas
    Department of Psychiatry, Clinical Neuroscience Research Unit, University of Vermont College of Medicine, Burlington, VT 05401, USA
    Am J Geriatr Psychiatry 16:272-82. 2008
    ..This approach simulates the effects of age- or disease-related neuroreceptor or neuronal loss by temporarily blocking pre- and postsynaptic muscarinic and nicotinic cholinergic receptors...
  17. ncbi Increased memory load-related frontal activation after estradiol treatment in postmenopausal women
    Julie A Dumas
    Clinical Neuroscience Research Unit and Brain Imaging Program, Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT 05401, USA
    Horm Behav 58:929-35. 2010
    ..These data suggest that estradiol treatment effects on cognition may be in part produced through modulation of frontal lobe functioning under difficult task conditions...
  18. ncbi The cholinergic hypothesis of cognitive aging revisited again: cholinergic functional compensation
    Julie A Dumas
    Clinical Neuroscience Research Unit and Brain Imaging Program, Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT 05401, USA
    Pharmacol Biochem Behav 99:254-61. 2011
    ..Future directions for testing hypotheses generated from this model are presented...
  19. ncbi Effects of acute nicotine administration on behavioral inhibition in adolescents with attention-deficit/hyperactivity disorder
    Alexandra S Potter
    Clinical Neuroscience Research Unit, Department of Psychiatry, College of Medicine, University of Vermont, 1 South Prospect Street, Burlington, VT 05401, USA
    Psychopharmacology (Berl) 176:182-94. 2004
    ..The size of the effect is at least comparable to methylphenidate. Positive effects of nicotine on inhibitional performance may contribute to higher rates of cigarette use in adolescents with ADHD...
  20. ncbi Nicotinic acetylcholine receptor system and neuropsychiatric disorders
    Abhay Singh
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, 1 South Prospect Street, Burlington, VT 05401, USA
    IDrugs 7:1096-103. 2004
    ..This review attempts to outline evidence pertaining to the role of the nicotinic receptor system in various neuropsychiatric disorders in the context of understanding appropriate targets for therapeutic drug development...
  21. ncbi Ichi, Ni, 3, 4: neural representation of kana, kanji, and Arabic numbers in native Japanese speakers
    Emily L Coderre
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, 1 South Prospect St, Burlington, VT 05401, USA
    Brain Cogn 70:289-96. 2009
    ..Overall, the data suggest that number reading is processed differently in these three notations...
  22. ncbi Summary of the National Institute on Aging-sponsored conference on depressive symptoms and cognitive complaints in the menopausal transition
    Pauline M Maki
    Department of Psychiatry, University of Illinois, Chicago, IL, USA
    Menopause 17:815-22. 2010
    ....
  23. ncbi Estrogen treatment effects on anticholinergic-induced cognitive dysfunction in normal postmenopausal women
    Julie Dumas
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT 05401, USA
    Neuropsychopharmacology 31:2065-78. 2006
    ..The results suggest that estrogen status may affect cholinergic system tone and may be important for cholinergic system integrity...

Research Grants14

  1. Estrogen Effects on Cholinergic Function in Older Women
    Paul Newhouse; Fiscal Year: 2007
    ....
  2. Transdermal Nicotine Treatment of MCI
    Paul Newhouse; Fiscal Year: 2006
    ..If nicotine proves successful in alleviating cognitive symptoms and in improving global outcomes along with reasonable safety, we will propose a large multicenter clinical trial. ..
  3. Transdermal Nicotine Treatment of MCI
    Paul Newhouse; Fiscal Year: 2007
    ..If nicotine proves successful in alleviating cognitive symptoms and in improving global outcomes along with reasonable safety, we will propose a large multicenter clinical trial. ..
  4. Estrogen Effects on Cholinergic Function in Older Women
    Paul A Newhouse; Fiscal Year: 2010
    ..g. neuroimaging). The over arching goal is to develop information to allow the development of models to potentially predict which women may benefit from the cognitive effects of estradiol after menopause. ..