C B Newgard

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1
    C B Newgard
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Diabetes 49:1967-77. 2000
  2. pmc Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen
    R M O'Doherty
    Gifford Laboratories for Diabetes Research, Marjorie Touchstone Diabetes Center, Department of Biochemistry, Dallas, Texas, USA
    J Clin Invest 105:479-88. 2000
  3. pmc Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production
    C Wu
    Department of Biochemistry, Molecular Biology and Biophysics, Medical School, University of Minnesota, Minneapolis, Minnesota, USA
    J Clin Invest 107:91-8. 2001
  4. ncbi request reprint Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia
    R M O'Doherty
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9040, USA
    Diabetes 48:2022-7. 1999
  5. ncbi request reprint Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition
    R M O'Doherty
    Gifford Laboratories for Diabetes Research and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    Am J Physiol 277:E544-50. 1999
  6. ncbi request reprint Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells
    H Mulder
    Touchstone Center for Diabetes Research and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 276:6479-84. 2001
  7. ncbi request reprint Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines
    G Chen
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 276:766-72. 2001
  8. ncbi request reprint Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats
    K Y Trinh
    Gifford Laboratories for Diabetes Research and Departments of Biochemistry and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 273:31615-20. 1998
  9. ncbi request reprint Overexpression of the P46 (T1) translocase component of the glucose-6-phosphatase complex in hepatocytes impairs glycogen accumulation via hydrolysis of glucose 1-phosphate
    J An
    Departments of Biochemistry and Internal Medicine and Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 276:10722-9. 2001

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1
    C B Newgard
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Diabetes 49:1967-77. 2000
    ....
  2. pmc Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen
    R M O'Doherty
    Gifford Laboratories for Diabetes Research, Marjorie Touchstone Diabetes Center, Department of Biochemistry, Dallas, Texas, USA
    J Clin Invest 105:479-88. 2000
    ..Because of its ability to enhance glucose storage without affecting other metabolic indicators, the glycogen-targeting subunit may prove valuable in controlling blood glucose levels in diabetes...
  3. pmc Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production
    C Wu
    Department of Biochemistry, Molecular Biology and Biophysics, Medical School, University of Minnesota, Minneapolis, Minnesota, USA
    J Clin Invest 107:91-8. 2001
    ..Our findings underscore the critical role played by hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in control of fuel homeostasis and suggest that this enzyme may be considered as a therapeutic target in diabetes...
  4. ncbi request reprint Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia
    R M O'Doherty
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9040, USA
    Diabetes 48:2022-7. 1999
    ....
  5. ncbi request reprint Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition
    R M O'Doherty
    Gifford Laboratories for Diabetes Research and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    Am J Physiol 277:E544-50. 1999
    ..We conclude that moderate increases in plasma leptin levels decrease liver glycogen degradation during the fed-to-fasted transition...
  6. ncbi request reprint Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells
    H Mulder
    Touchstone Center for Diabetes Research and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 276:6479-84. 2001
    ..These findings extend our previous observations and are not consistent with the LC-CoA hypothesis as originally set forth...
  7. ncbi request reprint Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines
    G Chen
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 276:766-72. 2001
    ....
  8. ncbi request reprint Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats
    K Y Trinh
    Gifford Laboratories for Diabetes Research and Departments of Biochemistry and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 273:31615-20. 1998
    ..Our studies show that overexpression of G6Pase in liver is sufficient to perturb whole animal glucose and lipid homeostasis, possibly contributing to the development of metabolic abnormalities associated with diabetes...
  9. ncbi request reprint Overexpression of the P46 (T1) translocase component of the glucose-6-phosphatase complex in hepatocytes impairs glycogen accumulation via hydrolysis of glucose 1-phosphate
    J An
    Departments of Biochemistry and Internal Medicine and Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 276:10722-9. 2001
    ..Finally, P46 overexpression enhanced glucose 1-phosphate but not fructose 6-phosphate hydrolysis in intact microsomes, providing a mechanism by which P46 overexpression may exert its preferential effects on glycogen metabolism...