Research Topics
| Peter E NewburgerSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
Research Grants
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Detail Information
Publications
Global analysis of neutrophil gene expressionP E Newburger
Department of Pediatrics and Molecular Genetics Microbiology, University of Massachusetts Medical School, Worchester 01605, USA
Curr Opin Hematol 7:16-20. 2000..The data also indicate that activated neutrophils are a source of newly synthesized, physiologically significant, intercellular signaling molecules...- The American Society of Pediatric Hematology/Oncology distinguished career award goes to Laurence A. Boxer, MDPeter E Newburger
Departments of Pediatrics and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Pediatr Blood Cancer 50:1121-2. 2008 
Cyclic neutropenia and severe congenital neutropenia in patients with a shared ELANE mutation and paternal haplotype: evidence for phenotype determination by modifying genesPeter E Newburger
Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Pediatr Blood Cancer 55:314-7. 2010..Mutations of the ELANE gene (the symbol recently replacing ELA2) are considered largely responsible for most cases of CN and SCN, but specific mutations are typically associated with one or the other...- Adolescents with cancer: access to clinical trials and age-appropriate carePeter E Newburger
Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Curr Opin Pediatr 14:1-4. 2002..The challenge before both the medical and pediatric health care communities is to assure adolescent patients the benefits of inclusion in clinical trials and treatment in age-appropriate settings... - A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA clusterXueqing Zhang
Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA
Blood 113:2526-34. 2009..These findings suggest that HOTAIRM1 plays a role in the myelopoiesis through modulation of gene expression in the HOXA cluster... - Mosaic tetraploidy and transient GFI1 mutation in a patient with severe chronic neutropeniaJessica C Hochberg
Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Pediatr Blood Cancer 50:630-2. 2008..We speculate that an underlying genetic defect, inherited in an autosomal dominant pattern, leads to both disordered mitosis and neutropenia in this kindred... - Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophilsEvelyn A Kurt-Jones
Department of Medicine, University of Massachusetts Medical School, Worcester 01605, USA
Blood 100:1860-8. 2002..Thus, our studies demonstrate that GM-CSF dramatically enhances the functional response of neutrophils to TLR2 ligands, including LPS-associated lipopeptides... - A molecular classification of congenital neutropenia syndromesLaurence A Boxer
Division of Pediatric Hematology Oncology, Department of Pediatrics, C S Mott Children s Hospital, University of Michigan, Ann Arbor, Michigan, USA
Pediatr Blood Cancer 49:609-14. 2007..This review describes and classifies, on a molecular basis, both primary congenital neutropenia and multifaceted syndromes associated with neutropenia... - The role of toll-like receptors in herpes simplex infection in neonatesEvelyn A Kurt-Jones
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Infect Dis 191:746-8. 2005..This may explain the sepsis syndrome that is seen with HSV (and other virus infections) in neonates... - Temporal evolution of gene expression in rat carotid artery following balloon angioplastyJian Ming Li
Department of Surgery, Division of Vascular Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Cell Biochem 101:399-410. 2007..This study highlighted mesenchymal stromal cell cytokines-driven inflammatory extracellular matrix remodeling, as target processes for potential clinical therapeutic intervention... - Toll-like receptor-mediated activation of neutrophils by influenza A virusJennifer P Wang
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Blood 112:2028-34. 2008..These studies demonstrate neutrophil activation by influenza virus and highlight the importance of TLR7 and TLR8 in that response... - Gene expression in mature neutrophils: early responses to inflammatory stimuliXueqing Zhang
University of Massachusetts Medical School, LRB 404, 364 Plantation Street, Worcester, MA 01655, USA
J Leukoc Biol 75:358-72. 2004..The present study indicates that combinatorial transcriptional regulation including alterations of chromatin structure may play a role in the rapid changes in gene expression that occur in these terminally differentiated cells... - Nuclease sensitive element binding protein 1 gene disruption results in early embryonic lethalityLin Fan
Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Cell Biochem 99:140-5. 2006..In either case, these data indicate the functional importance of the NSEP1 gene in murine early embryonic development... - Gene expression in human neutrophils during activation and priming by bacterial lipopolysaccharideYasuhiro Tsukahara
Department of Genetics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT, USA
J Cell Biochem 89:848-61. 2003..Supplementary material for this article can be found on the Journal of Cellular Biochemistry website (http://jws-edci.interscience.wiley.com:8998/jpages/0730-2312/suppmat/89/v89.page.html)... - Genomic and proteomic analysis of the myeloid differentiation program: global analysis of gene expression during induced differentiation in the MPRO cell lineZheng Lian
Department of Genetics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT, USA
Blood 100:3209-20. 2002..Data are available online at http://bioinfo.mbb.yale.edu/expression/myelopoiesis... - Essential role of nuclear factor-kappaB for NADPH oxidase activity in normal and anhidrotic ectodermal dysplasia leukocytesMarcos Luengo-Blanco
Department of Pediatrics and Pharmacology, Center for Investigation in Pediatrics, State University of Campinas Medical School, Campinas, SP, Brazil
Blood 112:1453-60. 2008..These studies show that NF-kappaB is necessary for CYBB and NCF1 gene expression and activation of the phagocyte NADPH oxidase in this model system... - Up-regulation of NADPH oxidase components and increased production of interferon-gamma by leukocytes from sickle cell disease patientsLívia E Marçal
Center for Investigation in Pediatrics, Department of Pediatrics, State University of Campinas Medical School, Campinas, Sao Paulo, Brazil
Am J Hematol 83:41-5. 2008..These findings help to explain our previous observation showing the increased respiratory burst activity of mononuclear leukocytes from SCD patients and may contribute to inflammation and tissue damage in these patients... - RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cellsHidenori Hattori
Blood 110:640-50. 2007..Thus, our results highlight the involvement of the ubiquitin-mediated proteolysis pathway in ATRA-induced cell-cycle arrest and provide a novel strategy for modulating ATRA-elicited cellular effects... - A limited number of genes are involved in the differentiation of germinal center B cellsYasuhiro Nakayama
Department of Genetics, Yale University School of Medicine, 300 Cedar St, New Haven, Connecticut 06510, USA
J Cell Biochem 99:1308-25. 2006.... - Chronic granulomatous disease in Latin American patients: clinical spectrum and molecular geneticsPiedad Agudelo-Florez
Center for Investigation in Pediatrics and Department of Pediatrics, State University of Campinas Medical School, Campinas, Sao Paulo, Brazil
Pediatr Blood Cancer 46:243-52. 2006..The aim of this study was to analyze the clinical features and to investigate the molecular genetic defects of Latin American patients with CGD... - A panorama of lineage-specific transcription in hematopoiesisYuval Kluger
Department of Cell Biology, New York University School of Medicine, New York, USA
Bioessays 26:1276-87. 2004..Understanding the biologic significance, mechanisms and constraints underlying these differences is a challenge for experimentalists and computational biologists alike... - The effect of IFN-gamma and TNF-alpha on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cellsJuan A Lopez
Center for Investigation in Pediatrics and Department of Pharmacology, State University of Campinas Medical School, Campinas SP, Brazil
J Interferon Cytokine Res 23:737-44. 2003..We conclude that IFN-gamma and TNF-alpha are sufficient to induce the differentiation of HL-60 clone 15 cells to the eosinophilic lineage and to upregulate gp91-phox gene expression and activity of the NADPH oxidase system... - Hematology and oncologyPeter E Newburger
Curr Opin Pediatr 16:1-2. 2004 - Hematology and oncologyPeter E Newburger
Curr Opin Pediatr 15:1-2. 2003 - The effect of IFN-gamma and TNF-alpha on the NADPH oxidase system of human colostrum macrophages, blood monocytes, and THP-1 cellsAna Carolina Almeida
Department of Pediatrics and Pharmacology, State University of Campinas Medical School, Brazil
J Interferon Cytokine Res 25:540-6. 2005..This partial divergence of gp91- phox gene expression, NADPH oxidase activity, and TNF-alpha release is probably a consequence of different events of myeloid cell biology and relates at least in part to cell differentiation state...
Research Grants
- GENE EXPRESSION IN MATURE NEUTROPHILSPeter E Newburger; Fiscal Year: 2010..Identification of novel neutrophil-specific genes and regulatory networks could provide new targets for augmentation of host defense, attenuation of inflammation, and treatments of disorders of myelopoiesis. ..
- GENE EXPRESSION IN MATURE NEUTROPHILSPeter Newburger; Fiscal Year: 2003..Insight into transcriptional and post-transcriptional mechanisms of gene expression in this system may also be applicable to other, more complex, cell types and tissues. ..
- HOX cluster intergenic non-coding RNAs in myeloid differentiation and functionSHERMAN MORTON WEISSMAN; Fiscal Year: 2010....