Peter E Newburger

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Evaluation and management of patients with isolated neutropenia
    Peter E Newburger
    Departments of Pediatrics and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA
    Semin Hematol 50:198-206. 2013
  2. pmc Cyclic neutropenia and severe congenital neutropenia in patients with a shared ELANE mutation and paternal haplotype: evidence for phenotype determination by modifying genes
    Peter E Newburger
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Pediatr Blood Cancer 55:314-7. 2010
  3. doi request reprint The American Society of Pediatric Hematology/Oncology distinguished career award goes to Laurence A. Boxer, MD
    Peter E Newburger
    Departments of Pediatrics and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Pediatr Blood Cancer 50:1121-2. 2008
  4. ncbi request reprint Global analysis of neutrophil gene expression
    P E Newburger
    Department of Pediatrics and Molecular Genetics Microbiology, University of Massachusetts Medical School, Worchester 01605, USA
    Curr Opin Hematol 7:16-20. 2000
  5. ncbi request reprint Adolescents with cancer: access to clinical trials and age-appropriate care
    Peter E Newburger
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Curr Opin Pediatr 14:1-4. 2002
  6. pmc A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster
    Xueqing Zhang
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Blood 113:2526-34. 2009
  7. ncbi request reprint Mosaic tetraploidy and transient GFI1 mutation in a patient with severe chronic neutropenia
    Jessica C Hochberg
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Pediatr Blood Cancer 50:630-2. 2008
  8. ncbi request reprint Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils
    Evelyn A Kurt-Jones
    Department of Medicine, University of Massachusetts Medical School, Worcester 01605, USA
    Blood 100:1860-8. 2002
  9. doi request reprint Advances in understanding the pathogenesis of HLH
    G Naheed Usmani
    Division of Pediatric Hematology and Oncology, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    Br J Haematol 161:609-22. 2013
  10. ncbi request reprint A molecular classification of congenital neutropenia syndromes
    Laurence A Boxer
    Division of Pediatric Hematology Oncology, Department of Pediatrics, C S Mott Children s Hospital, University of Michigan, Ann Arbor, Michigan, USA
    Pediatr Blood Cancer 49:609-14. 2007

Research Grants

  1. GENE EXPRESSION IN MATURE NEUTROPHILS
    Peter E Newburger; Fiscal Year: 2010
  2. GENE EXPRESSION IN MATURE NEUTROPHILS
    Peter Newburger; Fiscal Year: 2003
  3. HOX cluster intergenic non-coding RNAs in myeloid differentiation and function
    SHERMAN MORTON WEISSMAN; Fiscal Year: 2010

Collaborators

Detail Information

Publications29

  1. pmc Evaluation and management of patients with isolated neutropenia
    Peter E Newburger
    Departments of Pediatrics and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA
    Semin Hematol 50:198-206. 2013
    ..Hematopoietic stem cell transplantation is a curative therapy for congenital neutropenia with MDS/AML or with cytogenetic abnormalities indicating impending conversion. ..
  2. pmc Cyclic neutropenia and severe congenital neutropenia in patients with a shared ELANE mutation and paternal haplotype: evidence for phenotype determination by modifying genes
    Peter E Newburger
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Pediatr Blood Cancer 55:314-7. 2010
    ..Mutations of the ELANE gene (the symbol recently replacing ELA2) are considered largely responsible for most cases of CN and SCN, but specific mutations are typically associated with one or the other...
  3. doi request reprint The American Society of Pediatric Hematology/Oncology distinguished career award goes to Laurence A. Boxer, MD
    Peter E Newburger
    Departments of Pediatrics and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Pediatr Blood Cancer 50:1121-2. 2008
  4. ncbi request reprint Global analysis of neutrophil gene expression
    P E Newburger
    Department of Pediatrics and Molecular Genetics Microbiology, University of Massachusetts Medical School, Worchester 01605, USA
    Curr Opin Hematol 7:16-20. 2000
    ..The data also indicate that activated neutrophils are a source of newly synthesized, physiologically significant, intercellular signaling molecules...
  5. ncbi request reprint Adolescents with cancer: access to clinical trials and age-appropriate care
    Peter E Newburger
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Curr Opin Pediatr 14:1-4. 2002
    ..The challenge before both the medical and pediatric health care communities is to assure adolescent patients the benefits of inclusion in clinical trials and treatment in age-appropriate settings...
  6. pmc A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster
    Xueqing Zhang
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Blood 113:2526-34. 2009
    ..These findings suggest that HOTAIRM1 plays a role in the myelopoiesis through modulation of gene expression in the HOXA cluster...
  7. ncbi request reprint Mosaic tetraploidy and transient GFI1 mutation in a patient with severe chronic neutropenia
    Jessica C Hochberg
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Pediatr Blood Cancer 50:630-2. 2008
    ..We speculate that an underlying genetic defect, inherited in an autosomal dominant pattern, leads to both disordered mitosis and neutropenia in this kindred...
  8. ncbi request reprint Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils
    Evelyn A Kurt-Jones
    Department of Medicine, University of Massachusetts Medical School, Worcester 01605, USA
    Blood 100:1860-8. 2002
    ..Thus, our studies demonstrate that GM-CSF dramatically enhances the functional response of neutrophils to TLR2 ligands, including LPS-associated lipopeptides...
  9. doi request reprint Advances in understanding the pathogenesis of HLH
    G Naheed Usmani
    Division of Pediatric Hematology and Oncology, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    Br J Haematol 161:609-22. 2013
    ..The detection of gene defects has contributed considerably to our understanding of HLH, but the mechanisms leading to acquired HLH have yet to be fully determined...
  10. ncbi request reprint A molecular classification of congenital neutropenia syndromes
    Laurence A Boxer
    Division of Pediatric Hematology Oncology, Department of Pediatrics, C S Mott Children s Hospital, University of Michigan, Ann Arbor, Michigan, USA
    Pediatr Blood Cancer 49:609-14. 2007
    ..This review describes and classifies, on a molecular basis, both primary congenital neutropenia and multifaceted syndromes associated with neutropenia...
  11. ncbi request reprint The role of toll-like receptors in herpes simplex infection in neonates
    Evelyn A Kurt-Jones
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Infect Dis 191:746-8. 2005
    ..This may explain the sepsis syndrome that is seen with HSV (and other virus infections) in neonates...
  12. doi request reprint HOX antisense lincRNA HOXA-AS2 is an apoptosis repressor in all trans retinoic acid treated NB4 promyelocytic leukemia cells
    Hang Zhao
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Cell Biochem 114:2375-83. 2013
    ..HOXA-AS2-mediated negative regulation thus contributes to the fine-tuning of apoptosis during ATRA-induced myeloid differentiation in NB4 cells...
  13. ncbi request reprint Temporal evolution of gene expression in rat carotid artery following balloon angioplasty
    Jian Ming Li
    Department of Surgery, Division of Vascular Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Cell Biochem 101:399-410. 2007
    ..This study highlighted mesenchymal stromal cell cytokines-driven inflammatory extracellular matrix remodeling, as target processes for potential clinical therapeutic intervention...
  14. pmc Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia
    Michael Landowski
    Division of Genetics and Program in Genomics, The Manton Center for Orphan Disease Research, Boston Children s Hospital, Boston, MA, USA
    Hum Genet 132:1265-74. 2013
    ..These data identify RPL15 as a new gene involved in DBA and further support the presence of large deletions in RP genes in DBA patients...
  15. ncbi request reprint Gene expression in mature neutrophils: early responses to inflammatory stimuli
    Xueqing Zhang
    University of Massachusetts Medical School, LRB 404, 364 Plantation Street, Worcester, MA 01655, USA
    J Leukoc Biol 75:358-72. 2004
    ..The present study indicates that combinatorial transcriptional regulation including alterations of chromatin structure may play a role in the rapid changes in gene expression that occur in these terminally differentiated cells...
  16. pmc Toll-like receptor-mediated activation of neutrophils by influenza A virus
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Blood 112:2028-34. 2008
    ..These studies demonstrate neutrophil activation by influenza virus and highlight the importance of TLR7 and TLR8 in that response...
  17. pmc Nuclease sensitive element binding protein 1 gene disruption results in early embryonic lethality
    Lin Fan
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biochem 99:140-5. 2006
    ..In either case, these data indicate the functional importance of the NSEP1 gene in murine early embryonic development...
  18. ncbi request reprint Gene expression in human neutrophils during activation and priming by bacterial lipopolysaccharide
    Yasuhiro Tsukahara
    Department of Genetics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT, USA
    J Cell Biochem 89:848-61. 2003
    ..Supplementary material for this article can be found on the Journal of Cellular Biochemistry website (http://jws-edci.interscience.wiley.com:8998/jpages/0730-2312/suppmat/89/v89.page.html)...
  19. ncbi request reprint Genomic and proteomic analysis of the myeloid differentiation program: global analysis of gene expression during induced differentiation in the MPRO cell line
    Zheng Lian
    Department of Genetics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT, USA
    Blood 100:3209-20. 2002
    ..Data are available online at http://bioinfo.mbb.yale.edu/expression/myelopoiesis...
  20. pmc Essential role of nuclear factor-kappaB for NADPH oxidase activity in normal and anhidrotic ectodermal dysplasia leukocytes
    Marcos Luengo-Blanco
    Department of Pediatrics and Pharmacology, Center for Investigation in Pediatrics, State University of Campinas Medical School, Campinas, SP, Brazil
    Blood 112:1453-60. 2008
    ..These studies show that NF-kappaB is necessary for CYBB and NCF1 gene expression and activation of the phagocyte NADPH oxidase in this model system...
  21. ncbi request reprint Up-regulation of NADPH oxidase components and increased production of interferon-gamma by leukocytes from sickle cell disease patients
    Lívia E Marçal
    Center for Investigation in Pediatrics, Department of Pediatrics, State University of Campinas Medical School, Campinas, Sao Paulo, Brazil
    Am J Hematol 83:41-5. 2008
    ..These findings help to explain our previous observation showing the increased respiratory burst activity of mononuclear leukocytes from SCD patients and may contribute to inflammation and tissue damage in these patients...
  22. pmc RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells
    Hidenori Hattori
    Blood 110:640-50. 2007
    ..Thus, our results highlight the involvement of the ubiquitin-mediated proteolysis pathway in ATRA-induced cell-cycle arrest and provide a novel strategy for modulating ATRA-elicited cellular effects...
  23. ncbi request reprint Hematology and oncology
    Peter E Newburger
    Curr Opin Pediatr 15:1-2. 2003
  24. ncbi request reprint The effect of IFN-gamma and TNF-alpha on the NADPH oxidase system of human colostrum macrophages, blood monocytes, and THP-1 cells
    Ana Carolina Almeida
    Department of Pediatrics and Pharmacology, State University of Campinas Medical School, Brazil
    J Interferon Cytokine Res 25:540-6. 2005
    ..This partial divergence of gp91- phox gene expression, NADPH oxidase activity, and TNF-alpha release is probably a consequence of different events of myeloid cell biology and relates at least in part to cell differentiation state...
  25. ncbi request reprint Chronic granulomatous disease in Latin American patients: clinical spectrum and molecular genetics
    Piedad Agudelo-Florez
    Center for Investigation in Pediatrics and Department of Pediatrics, State University of Campinas Medical School, Campinas, Sao Paulo, Brazil
    Pediatr Blood Cancer 46:243-52. 2006
    ..The aim of this study was to analyze the clinical features and to investigate the molecular genetic defects of Latin American patients with CGD...
  26. ncbi request reprint A panorama of lineage-specific transcription in hematopoiesis
    Yuval Kluger
    Department of Cell Biology, New York University School of Medicine, New York, USA
    Bioessays 26:1276-87. 2004
    ..Understanding the biologic significance, mechanisms and constraints underlying these differences is a challenge for experimentalists and computational biologists alike...
  27. ncbi request reprint The effect of IFN-gamma and TNF-alpha on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells
    Juan A Lopez
    Center for Investigation in Pediatrics and Department of Pharmacology, State University of Campinas Medical School, Campinas SP, Brazil
    J Interferon Cytokine Res 23:737-44. 2003
    ..We conclude that IFN-gamma and TNF-alpha are sufficient to induce the differentiation of HL-60 clone 15 cells to the eosinophilic lineage and to upregulate gp91-phox gene expression and activity of the NADPH oxidase system...
  28. ncbi request reprint Hematology and oncology
    Peter E Newburger
    Curr Opin Pediatr 16:1-2. 2004
  29. ncbi request reprint A limited number of genes are involved in the differentiation of germinal center B cells
    Yasuhiro Nakayama
    Department of Genetics, Yale University School of Medicine, 300 Cedar St, New Haven, Connecticut 06510, USA
    J Cell Biochem 99:1308-25. 2006
    ....

Research Grants12

  1. GENE EXPRESSION IN MATURE NEUTROPHILS
    Peter E Newburger; Fiscal Year: 2010
    ..Identification of novel neutrophil-specific genes and regulatory networks could provide new targets for augmentation of host defense, attenuation of inflammation, and treatments of disorders of myelopoiesis. ..
  2. GENE EXPRESSION IN MATURE NEUTROPHILS
    Peter Newburger; Fiscal Year: 2003
    ..Insight into transcriptional and post-transcriptional mechanisms of gene expression in this system may also be applicable to other, more complex, cell types and tissues. ..
  3. HOX cluster intergenic non-coding RNAs in myeloid differentiation and function
    SHERMAN MORTON WEISSMAN; Fiscal Year: 2010
    ....