Andrew Newberg

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Dopamine transporter density may be associated with the depressed affect in healthy subjects
    Andrew Newberg
    Department of Radiology, Division of Nuclear Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Nucl Med Commun 28:3-6. 2007
  2. ncbi request reprint Dopamine transporter binding in smokers and nonsmokers
    Andrew Newberg
    Division of Nuclear Medicine, Department of Radiology, University of Pennsylvania Health System, Philadelphia, PA, USA
    Clin Nucl Med 32:452-5. 2007
  3. doi request reprint Cerebral blood flow differences between long-term meditators and non-meditators
    Andrew B Newberg
    Division of Nuclear Medicine, Department of Radiology, University of Pennsylvania Medical Center, USA
    Conscious Cogn 19:899-905. 2010
  4. ncbi request reprint Concurrent CBF and CMRGlc changes during human brain activation by combined fMRI-PET scanning
    Andrew B Newberg
    Department of Radiology, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Neuroimage 28:500-6. 2005
  5. ncbi request reprint Safety, biodistribution, and dosimetry of 123I-IMPY: a novel amyloid plaque-imaging agent for the diagnosis of Alzheimer's disease
    Andrew B Newberg
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Nucl Med 47:748-54. 2006
  6. ncbi request reprint Meditation effects on cognitive function and cerebral blood flow in subjects with memory loss: a preliminary study
    Andrew B Newberg
    Division of Nuclear Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Alzheimers Dis 20:517-26. 2010
  7. pmc μ-Opioid receptor availability in the amygdala is associated with smoking for negative affect relief
    Mary Falcone
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 222:701-8. 2012
  8. ncbi request reprint Greater availability of brain dopamine transporters in major depression shown by [99m Tc]TRODAT-1 SPECT imaging
    David J Brunswick
    Depression Research Unit, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Am J Psychiatry 160:1836-41. 2003
  9. pmc Dopamine transporter levels in cocaine dependent subjects
    Paul Crits-Christoph
    Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Suite 650, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 98:70-6. 2008
  10. ncbi request reprint Artificial neural network classifier for the diagnosis of Parkinson's disease using [99mTc]TRODAT-1 and SPECT
    Paul D Acton
    Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Phys Med Biol 51:3057-66. 2006

Research Grants

Detail Information

Publications44

  1. ncbi request reprint Dopamine transporter density may be associated with the depressed affect in healthy subjects
    Andrew Newberg
    Department of Radiology, Division of Nuclear Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Nucl Med Commun 28:3-6. 2007
    ..We used the selective DAT radiopharmaceutical Tc-TRODAT-1 and SPECT brain imaging, to examine differences in DAT levels in healthy subjects with and without depressive affect...
  2. ncbi request reprint Dopamine transporter binding in smokers and nonsmokers
    Andrew Newberg
    Division of Nuclear Medicine, Department of Radiology, University of Pennsylvania Health System, Philadelphia, PA, USA
    Clin Nucl Med 32:452-5. 2007
    ..This study determined whether healthy current smokers and nonsmokers exhibit differences in dopamine transporter (DAT) binding measured by Tc-99m TRODAT SPECT...
  3. doi request reprint Cerebral blood flow differences between long-term meditators and non-meditators
    Andrew B Newberg
    Division of Nuclear Medicine, Department of Radiology, University of Pennsylvania Medical Center, USA
    Conscious Cogn 19:899-905. 2010
    ..The observed changes associated with long-term meditation appear in structures that underlie the attention network and also those that relate to emotion and autonomic function...
  4. ncbi request reprint Concurrent CBF and CMRGlc changes during human brain activation by combined fMRI-PET scanning
    Andrew B Newberg
    Department of Radiology, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Neuroimage 28:500-6. 2005
    ..Although initially validated using a brief, non-quantitative protocol, this approach can provide quantitative CBF and CMRGlc, with a broad range of potential applications in functional physiology and pathophysiology...
  5. ncbi request reprint Safety, biodistribution, and dosimetry of 123I-IMPY: a novel amyloid plaque-imaging agent for the diagnosis of Alzheimer's disease
    Andrew B Newberg
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Nucl Med 47:748-54. 2006
    ..The pharmacologic safety profile of the compound was simultaneously assessed...
  6. ncbi request reprint Meditation effects on cognitive function and cerebral blood flow in subjects with memory loss: a preliminary study
    Andrew B Newberg
    Division of Nuclear Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Alzheimers Dis 20:517-26. 2010
    ..While the findings are encouraging, there are a number of limitations that can be addressed in future studies with more participants and more detailed analyses...
  7. pmc μ-Opioid receptor availability in the amygdala is associated with smoking for negative affect relief
    Mary Falcone
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 222:701-8. 2012
    ..The perception that smoking relieves negative affect contributes to smoking persistence. Endogenous opioid neurotransmission, and the μ-opioid receptor (MOR) in particular, plays a role in affective regulation and is modulated by nicotine...
  8. ncbi request reprint Greater availability of brain dopamine transporters in major depression shown by [99m Tc]TRODAT-1 SPECT imaging
    David J Brunswick
    Depression Research Unit, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Am J Psychiatry 160:1836-41. 2003
    ..The present study was an examination of the availability of brain dopamine transporter sites in patients with major depression and in healthy comparison subjects...
  9. pmc Dopamine transporter levels in cocaine dependent subjects
    Paul Crits-Christoph
    Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Suite 650, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 98:70-6. 2008
    ..DAT levels were unrelated to craving, severity of cocaine use, or duration of cocaine use, but DAT levels in the caudate and anterior putamen were significantly (p<0.05) negatively correlated with days since last use of cocaine...
  10. ncbi request reprint Artificial neural network classifier for the diagnosis of Parkinson's disease using [99mTc]TRODAT-1 and SPECT
    Paul D Acton
    Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Phys Med Biol 51:3057-66. 2006
    ..4% total accuracy, 97.5% specificity and 91.4% sensitivity). However, it should be stressed that, as with all applications of an ANN, it was difficult to interpret precisely what triggers in the images were being detected by the network...
  11. pmc FDG-PET imaging can diagnose periprosthetic infection of the hip
    Timothy Chryssikos
    Department of Nuclear Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Clin Orthop Relat Res 466:1338-42. 2008
    ..The overall accuracy of this novel noninvasive imaging modality reached 0.91 (115 of 127). Based on our results, FDG-PET appears a promising and accurate diagnostic tool for distinguishing septic from aseptic painful hip prostheses...
  12. ncbi request reprint Differences in [99mTc]TRODAT-1 SPECT binding to dopamine transporters in patients with multiple system atrophy and Parkinson's disease
    Randel L Swanson
    Division of Nuclear Medicine, 110 Donner Building, H U P, 3400 Spruce Street, Philadelphia, PA, 19104, USA
    Eur J Nucl Med Mol Imaging 32:302-7. 2005
    ..This study evaluated whether [99mTc]TRODAT-1 binding to the dopamine transporter differentiates MSA from other movement disorders...
  13. ncbi request reprint A metabolic imaging severity rating scale for the assessment of cognitive impairment
    Andrew Newberg
    Division of Nuclear Medicine, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, 19104, USA
    Clin Nucl Med 28:565-70. 2003
    ..This study was designed to validate a simple scoring system for evaluating fluorodeoxyglucose (FDG) positron emission tomographic (PET) scans that can be used routinely in patients undergoing the clinical assessment of cognitive impairment...
  14. ncbi request reprint Comparison of region-of-interest analysis and human observers in the diagnosis of Parkinson's disease using [99mTc]TRODAT-1 and SPECT
    Paul D Acton
    Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Phys Med Biol 51:575-85. 2006
    ..89, best ROI AUC = 0.90). This suggested that the human observers are visually acquiring similar information from the images that are contained in the semi-quantitative striatal uptake...
  15. ncbi request reprint Cerebral blood flow during meditative prayer: preliminary findings and methodological issues
    Andrew Newberg
    Division of Nuclear Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    Percept Mot Skills 97:625-30. 2003
    ....
  16. ncbi request reprint Clinical validation of fully 3-D versus 2.5-D RAMLA reconstruction on the Philips-ADAC CPET PET scanner
    Stephen Chiang
    Department of Radiology, University of Pennsylvania, USA
    Nucl Med Commun 25:1103-7. 2004
    ..The purpose of this study was to investigate if the fully 3-D RAMLA reconstruction software brings an appreciable improvement in clinical image quality and reader confidence...
  17. ncbi request reprint Deep venous thrombosis on F-18 FDG PET/CT imaging
    Brian D Sydow
    Division of Nuclear Medicine, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Nucl Med 31:403-4. 2006
  18. ncbi request reprint A preliminary study of dopamine transporter binding in bipolar and unipolar depressed patients and healthy controls
    Jay D Amsterdam
    Department of Psychiatry, The Depression Research Unit, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuropsychobiology 55:167-70. 2007
    ..We hypothesized that DAT levels might be higher in bipolar versus unipolar patients...
  19. ncbi request reprint Biodistribution and imaging with (123)I-ADAM: a serotonin transporter imaging agent
    Andrew B Newberg
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Nucl Med 45:834-41. 2004
    ..The study was conducted within a regulatory framework that required its pharmacologic safety to be assessed simultaneously...
  20. ncbi request reprint 123I-ADAM binding to serotonin transporters in patients with major depression and healthy controls: a preliminary study
    Andrew B Newberg
    Division of Nuclear Medicine, Department of Radiology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Nucl Med 46:973-7. 2005
    ..We hypothesized that SERT binding activity may be altered in patients with MDD. This study compared SERT binding in patients with MDD with that in healthy controls...
  21. ncbi request reprint Stability of cerebral blood flow measures using a split-dose technique with (99m)Tc-exametazime SPECT
    Andrew B Newberg
    Division of Nuclear Medicine, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Commun 26:475-8. 2005
    ..Such a paradigm is frequently used in the clinical and research setting to assess various brain states...
  22. ncbi request reprint Striatal dopamine transporter imaging correlates with anxiety and depression symptoms in Parkinson's disease
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Nucl Med 46:227-32. 2005
    ..We studied the correlation of striatal dopamine transporter (DAT) imaging with anxiety and depression symptoms in Parkinson's disease (PD)...
  23. ncbi request reprint PET in seizure disorders
    Andrew B Newberg
    Division of Nuclear Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, 110 Donner Building, Philadelphia, PA 19104, USA
    Radiol Clin North Am 43:79-92. 2005
    ..PET will continue to play a major role, not only in the clinical arena, but also in investigating the pathogenesis and treatment of various seizure disorders...
  24. ncbi request reprint Cerebral blood flow effects of pain and acupuncture: a preliminary single-photon emission computed tomography imaging study
    Andrew B Newberg
    Department of Radiology, University of Pennsylvania Health System, Philadelphia, USA
    J Neuroimaging 15:43-9. 2005
    ..The purpose of this study was to investigate the cerebral blood flow changes associated with the analgesic effect of acupuncture in patients with chronic pain...
  25. doi request reprint Dosimetry of 11C-carfentanil, a micro-opioid receptor imaging agent
    Andrew B Newberg
    Department of Radiology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nucl Med Commun 30:314-8. 2009
    ..The study was conducted within a regulatory framework that required its pharmacological safety to be assessed simultaneously...
  26. ncbi request reprint The role of PET imaging in the management of patients with central nervous system disorders
    Andrew B Newberg
    Division of Nuclear Medicine, Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, 110 Donner Building, Philadelphia, PA 19104, USA
    Radiol Clin North Am 43:49-65. 2005
    ..As such applications become more widely tested, their introduction into the clinical arena will further advance the use of PET imaging in the evaluation and management of CNS disorders...
  27. pmc Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers
    Riju Ray
    Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 108:9268-73. 2011
    ..Future translational investigations can elucidate the role of MORs in nicotine addiction, which may lead to development of novel therapeutics...
  28. ncbi request reprint Determination of regional cerebral function with FDG-PET imaging in neuropsychiatric disorders
    Andrew Newberg
    Division of Nuclear Medicine, The Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    Semin Nucl Med 32:13-34. 2002
    ..This article will also explore what FDG-PET imaging has revealed in these neuropsychiatric disorders and how these findings relate to both research and clinical applications...
  29. pmc 123I-ADAM SPECT imaging of serotonin transporter binding in patients with night eating syndrome: a preliminary report
    Jennifer D Lundgren
    Center for Weight and Eating Disorders, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Psychiatry Res 162:214-20. 2008
    ..These findings, in conjunction with the therapeutic response of NES to sertraline, indicate that the serotonin system is involved in the pathophysiology of NES...
  30. pmc Cerebral blood flow effects of yoga training: preliminary evaluation of 4 cases
    Debbie L Cohen
    Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Altern Complement Med 15:9-14. 2009
    ..Experienced practitioners of yoga have been shown to alter brain function, but this case series measured cerebral blood flow before and after a 12-week training program in Iyengar yoga (IY) for naïve subjects...
  31. ncbi request reprint Lifestyle Modification in Blood Pressure Study II (LIMBS): study protocol of a randomized controlled trial assessing the efficacy of a 24 week structured yoga program versus lifestyle modification on blood pressure reduction
    Debbie L Cohen
    Perelman School of Medicine at the University of Pennsylvania, Department of Medicine, Renal, Electrolyte and Hypertension Division, Philadelphia, PA 190104, USA
    Contemp Clin Trials 36:32-40. 2013
    ....
  32. ncbi request reprint FDG-PET findings in patients with suspected encephalitis
    Bruce Y Lee
    Division of Nuclear Medicine, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Nucl Med 29:620-5. 2004
    ..We explore the role of FDG-PET in the diagnostic evaluation of encephalitis...
  33. ncbi request reprint Neuroimaging in patients with head injury
    Andrew B Newberg
    Division of Nuclear Medicine, Philadelphia, PA 19104, USA
    Semin Nucl Med 33:136-47. 2003
    ..This article will review the current uses of neuroimaging techniques in head trauma and delineate future applications...
  34. pmc Neuroimaging during trance state: a contribution to the study of dissociation
    Julio Fernando Peres
    Division of Nuclear Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS ONE 7:e49360. 2012
    ..This finding deserves further investigation both in terms of replication and explanatory hypotheses...
  35. ncbi request reprint (99m)Tc-(V) DMSA uptake in systemic AL amyloidosis and normal bone scintigraphy
    Siamak Moghadam Kia
    Division of Nuclear Medicine, Department of Radiology, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medi cine, Philadelphia, PA, USA
    Hell J Nucl Med 13:69-70. 2010
    ..g. osteomyelitis and hence, increasingly is being used for detecting infection/inflammation in soft tissues...
  36. ncbi request reprint Structural and functional imaging correlates for age-related changes in the brain
    Paul C Tumeh
    Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Semin Nucl Med 37:69-87. 2007
    ..Defining normal alterations in brain function and structure allows early detection of disorders such as Alzheimer's and Parkinson's diseases, which are commonly associated with normal aging...
  37. ncbi request reprint Early uncoupling of cerebral blood flow and metabolism after bilateral thalamic infarction
    Beau M Ances
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    AJNR Am J Neuroradiol 25:1685-7. 2004
    ..We chronicled the evolving relationship of blood flow and metabolism with concomitant single photon emission CT and positron emission tomography from the subacute to chronic phase following bilateral thalamic infarction...
  38. ncbi request reprint 18F FDG uptake in the large arteries: a correlation study with the atherogenic risk factors
    Mijin Yun
    Division of Nuclear Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    Semin Nucl Med 32:70-6. 2002
    ..The positive correlation of arterial FDG uptake with the atherogenic risk factors suggested a promising role for FDG-PET imaging in the diagnosis of atherosclerosis and follow-up after treatment intervention...
  39. pmc Neuroimaging in traumatic brain imaging
    Bruce Lee
    Department of Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvani 19104, USA
    NeuroRx 2:372-83. 2005
    ..Neuroimaging also can be important in the chronic therapy of TBI, identifying chronic sequelae, determining prognosis, and guiding rehabilitation...
  40. ncbi request reprint Visual processing impairments and decrements in regional brain activity in Alzheimer's disease
    Salina J van Rhijn
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Exp Neuropsychol 26:11-23. 2004
    ....
  41. doi request reprint A preliminary study of the acute effects of religious ritual on anxiety
    Matthew W Anastasi
    University of Pennsylvania, Philadelphia, PA 19104, USA
    J Altern Complement Med 14:163-5. 2008
    ..However, many rituals have multiple components that can account for such effects. Few studies have distinguished between the effects of ritual and those related specifically to religious content and teachings...
  42. ncbi request reprint The measurement of regional cerebral blood flow during glossolalia: a preliminary SPECT study
    Andrew B Newberg
    Division of Nuclear Medicine, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Psychiatry Res 148:67-71. 2006
    ..This is the first functional neuroimaging study to demonstrate changes in cerebral activity during glossolalia. The frontal lobes, parietal lobes, and left caudate were most affected...
  43. ncbi request reprint Normal patterns and variants in single-photon emission computed tomography and positron emission tomography brain imaging
    Andrew B Newberg
    Division of Nuclear Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Semin Nucl Med 33:42-55. 2003
    ....
  44. ncbi request reprint Cerebral blood flow changes during retrieval of traumatic memories before and after psychotherapy: a SPECT study
    Julio F P Peres
    Neuroscience and Behavior, Institute of Psychology, Universidade de Sao Paulo, Brazil
    Psychol Med 37:1481-91. 2007
    ..However, few studies have investigated the neural substrates of psychotherapy-related symptom changes...

Research Grants6

  1. STN STIMULATION--DA TRANSPORTERS & OUTCOME IN PARKINSON'
    Andrew Newberg; Fiscal Year: 2002
    ..This study will provide that data while pursuing a long-term goal of developing a more effective and economical method for objectively assessing the outcome of an new treatment. ..
  2. STN STIMULATION--DA TRANSPORTERS & OUTCOME IN PARKINSON'
    Andrew Newberg; Fiscal Year: 2003
    ..This study will provide that data while pursuing a long-term goal of developing a more effective and economical method for objectively assessing the outcome of an new treatment. ..
  3. STN STIMULATION--DA TRANSPORTERS & OUTCOME IN PARKINSON'
    Andrew Newberg; Fiscal Year: 2004
    ..This study will provide that data while pursuing a long-term goal of developing a more effective and economical method for objectively assessing the outcome of an new treatment. ..
  4. Siemens Symbia T SPECT-CT Scanner
    Andrew Newberg; Fiscal Year: 2006
    ..Overall, this scanner will become a major tool for our present and future research programs with a focus on brain SPECT imaging, but also the potential to include many other types of studies. ..
  5. Evaluation of a Novel Amyloid Plaque SPECT Tracer for Diagnosing AD
    Andrew Newberg; Fiscal Year: 2009
    ....