Margaret C Neville

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Anatomy and physiology of lactation
    M C Neville
    Department of Physiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Pediatr Clin North Am 48:13-34. 2001
  2. pmc Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis!
    Steven M Anderson
    Department of Pathology, University of Colorado Health Sciences Center, East 17th Avenue, Aurora, CO 80045, USA
    Breast Cancer Res 9:204. 2007
  3. pmc Gene regulatory networks in lactation: identification of global principles using bioinformatics
    Danielle G Lemay
    Department of Food Science and Technology, University of California, One Shields Ave, Davis, CA 95616, USA
    BMC Syst Biol 1:56. 2007
  4. ncbi Regulation of milk lipid secretion and composition
    M C Neville
    Department of Physiology, University of Colorado Health Science Center, Denver 80262, USA
    Annu Rev Nutr 17:159-83. 1997
  5. ncbi Introduction: secretory activation: from the past to the future
    Margaret C Neville
    Department of Physiology and Biophysics, University of Colorado, Denver, CO, USA
    J Mammary Gland Biol Neoplasia 12:205-10. 2007
  6. ncbi Hormonal regulation of mammary differentiation and milk secretion
    Margaret C Neville
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver 80262, USA
    J Mammary Gland Biol Neoplasia 7:49-66. 2002
  7. ncbi Physiology and endocrine changes underlying human lactogenesis II
    M C Neville
    Department of Physiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Nutr 131:3005S-8S. 2001
  8. ncbi Lactogenesis. The transition from pregnancy to lactation
    M C Neville
    Department of Physiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Pediatr Clin North Am 48:35-52. 2001
  9. ncbi Physiology of lactation
    M C Neville
    Department of Physiology, University of Colorado Health Sciences Center, Denver, USA
    Clin Perinatol 26:251-79, v. 1999
  10. ncbi Cytoplasmic lipid droplet accumulation in developing mammary epithelial cells: roles of adipophilin and lipid metabolism
    Tanya D Russell
    Graduate Programs in Molecular Biology, Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Aurora, CO, USA
    J Lipid Res 48:1463-75. 2007

Research Grants

  1. PHYSIOLOGICAL FACTORS AFFECTING HUMAN LACTATION
    Margaret Neville; Fiscal Year: 2002

Detail Information

Publications35

  1. ncbi Anatomy and physiology of lactation
    M C Neville
    Department of Physiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Pediatr Clin North Am 48:13-34. 2001
    ..Other areas that require attention are the behavior correlates of breastfeeding and the transfer of drugs and toxins into milk. The latter may have a long-term impact on infant health and should receive increased attention...
  2. pmc Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis!
    Steven M Anderson
    Department of Pathology, University of Colorado Health Sciences Center, East 17th Avenue, Aurora, CO 80045, USA
    Breast Cancer Res 9:204. 2007
    ....
  3. pmc Gene regulatory networks in lactation: identification of global principles using bioinformatics
    Danielle G Lemay
    Department of Food Science and Technology, University of California, One Shields Ave, Davis, CA 95616, USA
    BMC Syst Biol 1:56. 2007
    ..The molecular events underlying mammary development during pregnancy, lactation, and involution are incompletely understood...
  4. ncbi Regulation of milk lipid secretion and composition
    M C Neville
    Department of Physiology, University of Colorado Health Science Center, Denver 80262, USA
    Annu Rev Nutr 17:159-83. 1997
    ..Evidence is presented that fatty acids may play a major regulatory role in acute changes in de novo mammary fatty acid synthesis, acting primarily on the activity of acetyl coenzyme A carboxylase...
  5. ncbi Introduction: secretory activation: from the past to the future
    Margaret C Neville
    Department of Physiology and Biophysics, University of Colorado, Denver, CO, USA
    J Mammary Gland Biol Neoplasia 12:205-10. 2007
    ..We focus specifically on the activation of secretion at parturition, and show that the field is ripe for new investigation...
  6. ncbi Hormonal regulation of mammary differentiation and milk secretion
    Margaret C Neville
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver 80262, USA
    J Mammary Gland Biol Neoplasia 7:49-66. 2002
    ....
  7. ncbi Physiology and endocrine changes underlying human lactogenesis II
    M C Neville
    Department of Physiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Nutr 131:3005S-8S. 2001
    ..We speculate that this problem may result from accumulation of a substance in the mammary alveolus that inhibits lactogenesis, even in the face of appropriate hormonal changes after parturition...
  8. ncbi Lactogenesis. The transition from pregnancy to lactation
    M C Neville
    Department of Physiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Pediatr Clin North Am 48:35-52. 2001
    ..These fundamental studies must be coupled with good prospective clinical studies if physicians are to obtain a useful, comprehensive understanding of lactogenesis in women...
  9. ncbi Physiology of lactation
    M C Neville
    Department of Physiology, University of Colorado Health Sciences Center, Denver, USA
    Clin Perinatol 26:251-79, v. 1999
    ..Finally, interactions between lactation and maternal metabolism are briefly described and the interaction of lactation with fertility discussed...
  10. ncbi Cytoplasmic lipid droplet accumulation in developing mammary epithelial cells: roles of adipophilin and lipid metabolism
    Tanya D Russell
    Graduate Programs in Molecular Biology, Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Aurora, CO, USA
    J Lipid Res 48:1463-75. 2007
    ....
  11. pmc Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium
    Michael C Rudolph
    1Department of Physiology and Biophysics, University of Colorado Denver, Aurora, CO, USA
    Am J Physiol Endocrinol Metab 299:E918-27. 2010
    ....
  12. ncbi Mammary physiology and milk secretion
    James L McManaman
    Department of Physiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Adv Drug Deliv Rev 55:629-41. 2003
    ..In this article we review our current understanding of the normal solute transport and secretory processes involved in milk production, and discuss potential regulatory mechanisms...
  13. ncbi Lipid synthesis in lactation: diet and the fatty acid switch
    Michael C Rudolph
    Department of Pathology, University of Colorado Health Sciences Center, Anschutz Medical Campus, 12801 East 17th Avenue, Mail Stop 8104, P O Box 6511, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 12:269-81. 2007
    ..These regulatory pathways may be critical to the production of milk with a balanced TAG composition to support neonatal development of the newborn...
  14. ncbi Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine
    Michael C Rudolph
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center at Fitzsimmons, Aurora, Colorado 80045, USA
    Physiol Genomics 28:323-36. 2007
    ..They also implicate the transcription factor SREBP-1c in regulation of part of the pathway...
  15. ncbi Analysis of lactation defects in transgenic mice
    Carol A Palmer
    Department of Physiology, University of Colorado Health Sciences Center at Fitzsimmons, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 11:269-82. 2006
    ....
  16. ncbi Regulation of milk lipid formation and secretion in the mouse mammary gland
    James L McManaman
    Division of Basic Reproductive Science, Department Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Adv Exp Med Biol 554:263-79. 2004
    ..Together these studies provide a molecular and cellular framework for understanding the process of milk lipid formation...
  17. pmc Albumin transcytosis across the epithelium of the lactating mouse mammary gland
    Jenifer Monks
    Department of Physiology and Biophysics, Room 2802 2, Box C240, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Physiol 560:267-80. 2004
    ..The possibility that the massive transfer of albumin into mouse milk is mediated by fluid phase transport is considered...
  18. pmc The insulin receptor plays an important role in secretory differentiation in the mammary gland
    Margaret C Neville
    Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado
    Am J Physiol Endocrinol Metab 305:E1103-14. 2013
    ..We conclude that insulin fosters differentiation and may inhibit cell proliferation in the mammary gland of the midpregnant mouse...
  19. pmc Disruption of occludin function in polarized epithelial cells activates the extrinsic pathway of apoptosis leading to cell extrusion without loss of transepithelial resistance
    Neal E Beeman
    Department of Physiology and Biophysics, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    BMC Cell Biol 10:85. 2009
    ..Occludin is a tetraspanin protein normally localized to tight junctions. The protein interacts with a variety of pathogens including viruses and bacteria, an interaction that sometimes leads to its extrajunctional localization...
  20. pmc Estimates of milk constituents from lactating bonnet macaque (Macaca radiata) mothers between two and seven months post-partum
    Mark L Laudenslager
    Department of Psychiatry, University of Colorado Denver School of Medicine, Denver, CO 80220, USA
    J Med Primatol 39:368-73. 2010
    ..We assayed milk samples from bonnet macaque (Macaca radiata) mothers as part of studies characterizing development of this species...
  21. ncbi Functional development of the mammary gland: use of expression profiling and trajectory clustering to reveal changes in gene expression during pregnancy, lactation, and involution
    Michael C Rudolph
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Mammary Gland Biol Neoplasia 8:287-307. 2003
    ..With progesterone withdrawal, PRL and IGF-1 signaling are activated, in turn activating Akt/PKB and the SREBPs, leading to increased lipid synthesis...
  22. pmc Complement activation fragment Bb in early pregnancy and spontaneous preterm birth
    Anne M Lynch
    Department of Obstetrics and Gynecology, University of Colorado Denver, Denver, CO 80045, USA
    Am J Obstet Gynecol 199:354.e1-8. 2008
    ....
  23. pmc Alternative complement pathway activation fragment Bb in early pregnancy as a predictor of preeclampsia
    Anne M Lynch
    Department of Obstetrics and Gynecology, University of Colorado at Denver and Health Sciences Center, Denver, CO, USA
    Am J Obstet Gynecol 198:385.e1-9. 2008
    ..The purpose of this study was to determine whether elevated levels of the activation fragment Bb in early pregnancy are predictive of preeclampsia...
  24. pmc A D-peptide analog of the second extracellular loop of claudin-3 and -4 leads to mislocalized claudin and cellular apoptosis in mammary epithelial cells
    Heidi K Baumgartner
    Department of Physiology and Biophysics, University of Colorado Denver, School of Medicine, 12800 E 19th Ave, Aurora, CO 80045, USA
    Chem Biol Drug Des 77:124-36. 2011
    ..In conclusion, both the D- and L-forms of a small peptide that mimics a sequence in the second extracellular loop of claudins can target and disrupt claudin proteins in an epithelial monolayer and initiate apoptosis...
  25. pmc Identifying significant temporal variation in time course microarray data without replicates
    Stephen C Billups
    Department of Mathematical and Statistical Sciences, University of Colorado, Denver, CO, USA
    BMC Bioinformatics 10:96. 2009
    ..This paper describes a replicate-free method that was developed as part of a study of the estrous cycle in the rat mammary gland in which no replicate data was collected...
  26. ncbi Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation
    Kathryn L Schwertfeger
    Departments of Pathology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Lipid Res 44:1100-12. 2003
    ....
  27. pmc Transduction of the mammary epithelium with adenovirus vectors in vivo
    Tanya D Russell
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Virol 77:5801-9. 2003
    ..Our results demonstrate that intraductal injection of adenovirus vectors provides a versatile and noninvasive method of investigating genes of interest in mouse mammary epithelial cells...
  28. pmc Lactation and neonatal nutrition: defining and refining the critical questions
    Margaret C Neville
    University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 17:167-88. 2012
    ..In sum, we present a roadmap for multidisciplinary research into all aspects of human lactation, milk and its role in infant nutrition for the next decade and beyond...
  29. pmc Claudin 7 expression and localization in the normal murine mammary gland and murine mammary tumors
    Brigitte Blackman
    University of Colorado Health Sciences Center, Denver, Colorado, USA
    Breast Cancer Res 7:R248-55. 2005
    ..To set the stage for functional experiments on this molecule, we examined the developmental expression and localization of claudin 7 in the murine mammary epithelium and in a selection of murine mammary tumors...
  30. ncbi The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk
    Joshua N VanHouten
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8020, USA
    Endocrinology 148:5943-54. 2007
    ....
  31. ncbi Bovine glucose transporter GLUT8: cloning, expression, and developmental regulation in mammary gland
    Feng qi Zhao
    Lactation and Mammary Gland Biology Group, Department of Animal Science, University of Vermont, Burlington, Vermont 05405, USA
    Biochim Biophys Acta 1680:103-13. 2004
    ..These results suggest that GLUT8 expression may be regulated by lactogenic hormones and that GLUT8 may play a role in glucose uptake in the lactating mammary gland...
  32. ncbi Impaired tight junction sealing and precocious involution in mammary glands of PKN1 transgenic mice
    Andreas Fischer
    Institute of Pharmacology, Center for Cardiovascular Research, Charite University Medicine, 10115 Berlin, Germany
    J Cell Sci 120:2272-83. 2007
    ..Our results provide evidence that PKN1 participates in the regulation of tight junction sealing in the mammary gland by interfering with glucocorticoid signaling...
  33. ncbi Calcium secretion into milk
    Margaret C Neville
    University of Colorado Health Sciences Center at Fitzsimmons, Aurora, 80010, USA
    J Mammary Gland Biol Neoplasia 10:119-28. 2005
    ..Currently nothing appears to be known about the mechanisms that mediate transport of calcium across the basolateral membrane of the alveolar cell...
  34. ncbi Sodium dependence of nitrofurantoin active transport across mammary epithelia and effects of dipyridamole, nucleosides, and nucleobases
    Phillip M Gerk
    University of Kentucky College of Pharmacy, Division of Pharmaceutical Science Lexington, 40536 0082, USA
    Pharm Res 19:299-305. 2002
    ..The sodium dependence and effects of nucleoside and nucleobase transport inhibitors were determined to ascertain the role of sodium dependent nucleoside or nucleobase transporters in nitrofurantoin active transport across mammary epithelia...
  35. ncbi Breast milk retinol concentrations are not associated with systemic inflammation among breast-feeding women in Malawi
    Barbara Dancheck
    Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Nutr 135:223-6. 2005
    ..22 and P = 0.86, respectively). These findings suggest that breast milk retinol concentrations are not affected by systemic inflammation...

Research Grants2

  1. PHYSIOLOGICAL FACTORS AFFECTING HUMAN LACTATION
    Margaret Neville; Fiscal Year: 2002
    ....