Research Topics
Genomes and Genes | Margaret C NevilleSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
Research Grants
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Publications
Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis!Steven M Anderson
Department of Pathology, University of Colorado Health Sciences Center, East 17th Avenue, Aurora, CO 80045, USA
Breast Cancer Res 9:204. 2007....- Gene regulatory networks in lactation: identification of global principles using bioinformaticsDanielle G Lemay
Department of Food Science and Technology, University of California, One Shields Ave, Davis, CA 95616, USA
BMC Syst Biol 1:56. 2007..The molecular events underlying mammary development during pregnancy, lactation, and involution are incompletely understood... 
Regulation of milk lipid secretion and compositionM C Neville
Department of Physiology, University of Colorado Health Science Center, Denver 80262, USA
Annu Rev Nutr 17:159-83. 1997..Evidence is presented that fatty acids may play a major regulatory role in acute changes in de novo mammary fatty acid synthesis, acting primarily on the activity of acetyl coenzyme A carboxylase...- Introduction: secretory activation: from the past to the futureMargaret C Neville
Department of Physiology and Biophysics, University of Colorado, Denver, CO, USA
J Mammary Gland Biol Neoplasia 12:205-10. 2007..We focus specifically on the activation of secretion at parturition, and show that the field is ripe for new investigation... - Hormonal regulation of mammary differentiation and milk secretionMargaret C Neville
Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver 80262, USA
J Mammary Gland Biol Neoplasia 7:49-66. 2002.... - Physiology and endocrine changes underlying human lactogenesis IIM C Neville
Department of Physiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Nutr 131:3005S-8S. 2001..We speculate that this problem may result from accumulation of a substance in the mammary alveolus that inhibits lactogenesis, even in the face of appropriate hormonal changes after parturition... - Lactogenesis. The transition from pregnancy to lactationM C Neville
Department of Physiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
Pediatr Clin North Am 48:35-52. 2001..These fundamental studies must be coupled with good prospective clinical studies if physicians are to obtain a useful, comprehensive understanding of lactogenesis in women... - Anatomy and physiology of lactationM C Neville
Department of Physiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
Pediatr Clin North Am 48:13-34. 2001..Other areas that require attention are the behavior correlates of breastfeeding and the transfer of drugs and toxins into milk. The latter may have a long-term impact on infant health and should receive increased attention... - Physiology of lactationM C Neville
Department of Physiology, University of Colorado Health Sciences Center, Denver, USA
Clin Perinatol 26:251-79, v. 1999..Finally, interactions between lactation and maternal metabolism are briefly described and the interaction of lactation with fertility discussed... - Cytoplasmic lipid droplet accumulation in developing mammary epithelial cells: roles of adipophilin and lipid metabolismTanya D Russell
Graduate Programs in Molecular Biology, Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Aurora, CO, USA
J Lipid Res 48:1463-75. 2007.... - Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epitheliumMichael C Rudolph
1Department of Physiology and Biophysics, University of Colorado Denver, Aurora, CO, USA
Am J Physiol Endocrinol Metab 299:E918-27. 2010.... - Mammary physiology and milk secretionJames L McManaman
Department of Physiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Adv Drug Deliv Rev 55:629-41. 2003..In this article we review our current understanding of the normal solute transport and secretory processes involved in milk production, and discuss potential regulatory mechanisms... - Lipid synthesis in lactation: diet and the fatty acid switchMichael C Rudolph
Department of Pathology, University of Colorado Health Sciences Center, Anschutz Medical Campus, 12801 East 17th Avenue, Mail Stop 8104, P O Box 6511, Aurora, CO 80045, USA
J Mammary Gland Biol Neoplasia 12:269-81. 2007..These regulatory pathways may be critical to the production of milk with a balanced TAG composition to support neonatal development of the newborn... - Metabolic regulation in the lactating mammary gland: a lipid synthesizing machineMichael C Rudolph
Department of Physiology and Biophysics, University of Colorado Health Sciences Center at Fitzsimmons, Aurora, Colorado 80045, USA
Physiol Genomics 28:323-36. 2007..They also implicate the transcription factor SREBP-1c in regulation of part of the pathway... - Analysis of lactation defects in transgenic miceCarol A Palmer
Department of Physiology, University of Colorado Health Sciences Center at Fitzsimmons, Aurora, CO 80045, USA
J Mammary Gland Biol Neoplasia 11:269-82. 2006.... - Regulation of milk lipid formation and secretion in the mouse mammary glandJames L McManaman
Division of Basic Reproductive Science, Department Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Adv Exp Med Biol 554:263-79. 2004..Together these studies provide a molecular and cellular framework for understanding the process of milk lipid formation... - Albumin transcytosis across the epithelium of the lactating mouse mammary glandJenifer Monks
Department of Physiology and Biophysics, Room 2802-2, Box C240, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Physiol 560:267-80. 2004..The possibility that the massive transfer of albumin into mouse milk is mediated by fluid phase transport is considered... - Functional development of the mammary gland: use of expression profiling and trajectory clustering to reveal changes in gene expression during pregnancy, lactation, and involutionMichael C Rudolph
Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Mammary Gland Biol Neoplasia 8:287-307. 2003..With progesterone withdrawal, PRL and IGF-1 signaling are activated, in turn activating Akt/PKB and the SREBPs, leading to increased lipid synthesis... - Disruption of occludin function in polarized epithelial cells activates the extrinsic pathway of apoptosis leading to cell extrusion without loss of transepithelial resistanceNeal E Beeman
Department of Physiology and Biophysics, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
BMC Cell Biol 10:85. 2009..Occludin is a tetraspanin protein normally localized to tight junctions. The protein interacts with a variety of pathogens including viruses and bacteria, an interaction that sometimes leads to its extrajunctional localization... - Estimates of milk constituents from lactating bonnet macaque (Macaca radiata) mothers between two and seven months post-partumMark L Laudenslager
Department of Psychiatry, University of Colorado Denver School of Medicine, Denver, CO 80220, USA
J Med Primatol 39:368-73. 2010..We assayed milk samples from bonnet macaque (Macaca radiata) mothers as part of studies characterizing development of this species... - Complement activation fragment Bb in early pregnancy and spontaneous preterm birthAnne M Lynch
Department of Obstetrics and Gynecology, University of Colorado Denver, Denver, CO 80045, USA
Am J Obstet Gynecol 199:354.e1-8. 2008.... - Alternative complement pathway activation fragment Bb in early pregnancy as a predictor of preeclampsiaAnne M Lynch
Department of Obstetrics and Gynecology, University of Colorado at Denver and Health Sciences Center, Denver, CO, USA
Am J Obstet Gynecol 198:385.e1-9. 2008..The purpose of this study was to determine whether elevated levels of the activation fragment Bb in early pregnancy are predictive of preeclampsia... - A D-peptide analog of the second extracellular loop of claudin-3 and -4 leads to mislocalized claudin and cellular apoptosis in mammary epithelial cellsHeidi K Baumgartner
Department of Physiology and Biophysics, University of Colorado Denver, School of Medicine, 12800 E 19th Ave, Aurora, CO 80045, USA
Chem Biol Drug Des 77:124-36. 2011..In conclusion, both the D- and L-forms of a small peptide that mimics a sequence in the second extracellular loop of claudins can target and disrupt claudin proteins in an epithelial monolayer and initiate apoptosis... - Identifying significant temporal variation in time course microarray data without replicatesStephen C Billups
Department of Mathematical and Statistical Sciences, University of Colorado, Denver, CO, USA
BMC Bioinformatics 10:96. 2009..This paper describes a replicate-free method that was developed as part of a study of the estrous cycle in the rat mammary gland in which no replicate data was collected... - Transduction of the mammary epithelium with adenovirus vectors in vivoTanya D Russell
Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Virol 77:5801-9. 2003..Our results demonstrate that intraductal injection of adenovirus vectors provides a versatile and noninvasive method of investigating genes of interest in mouse mammary epithelial cells... - Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactationKathryn L Schwertfeger
Departments of Pathology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Lipid Res 44:1100-12. 2003.... - Lactation and neonatal nutrition: defining and refining the critical questionsMargaret C Neville
University of Colorado School of Medicine, Aurora, CO 80045, USA
J Mammary Gland Biol Neoplasia 17:167-88. 2012..In sum, we present a roadmap for multidisciplinary research into all aspects of human lactation, milk and its role in infant nutrition for the next decade and beyond... - Claudin 7 expression and localization in the normal murine mammary gland and murine mammary tumorsBrigitte Blackman
University of Colorado Health Sciences Center, Denver, Colorado, USA
Breast Cancer Res 7:R248-55. 2005..To set the stage for functional experiments on this molecule, we examined the developmental expression and localization of claudin 7 in the murine mammary epithelium and in a selection of murine mammary tumors... - The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milkJoshua N VanHouten
Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8020, USA
Endocrinology 148:5943-54. 2007.... - Bovine glucose transporter GLUT8: cloning, expression, and developmental regulation in mammary glandFeng qi Zhao
Lactation and Mammary Gland Biology Group, Department of Animal Science, University of Vermont, Burlington, Vermont 05405, USA
Biochim Biophys Acta 1680:103-13. 2004..These results suggest that GLUT8 expression may be regulated by lactogenic hormones and that GLUT8 may play a role in glucose uptake in the lactating mammary gland... - Impaired tight junction sealing and precocious involution in mammary glands of PKN1 transgenic miceAndreas Fischer
Institute of Pharmacology, Center for Cardiovascular Research, Charite University Medicine, 10115 Berlin, Germany
J Cell Sci 120:2272-83. 2007..Our results provide evidence that PKN1 participates in the regulation of tight junction sealing in the mammary gland by interfering with glucocorticoid signaling... - Calcium secretion into milkMargaret C Neville
University of Colorado Health Sciences Center at Fitzsimmons, Aurora, 80010, USA
J Mammary Gland Biol Neoplasia 10:119-28. 2005..Currently nothing appears to be known about the mechanisms that mediate transport of calcium across the basolateral membrane of the alveolar cell... - Sodium dependence of nitrofurantoin active transport across mammary epithelia and effects of dipyridamole, nucleosides, and nucleobasesPhillip M Gerk
University of Kentucky College of Pharmacy, Division of Pharmaceutical Science Lexington, 40536-0082, USA
Pharm Res 19:299-305. 2002..CONCLUSIONS: Nitrofurantoin active transport was sodium dependent and inhibited by dipyridamole, adenosine, and guanosine, but known sodium dependent nucleoside or nucleobase transporters were not involved... - Breast milk retinol concentrations are not associated with systemic inflammation among breast-feeding women in MalawiBarbara Dancheck
Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD, USA
J Nutr 135:223-6. 2005..22 and P = 0.86, respectively). These findings suggest that breast milk retinol concentrations are not affected by systemic inflammation...
Research Grants
- PHYSIOLOGICAL FACTORS AFFECTING HUMAN LACTATIONMargaret Neville; Fiscal Year: 2002....