Margaret C Neville

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Lactation and neonatal nutrition: defining and refining the critical questions
    Margaret C Neville
    University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 17:167-88. 2012
  2. pmc The bovine lactation genome: insights into the evolution of mammalian milk
    Danielle G Lemay
    Department of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Genome Biol 10:R43. 2009
  3. doi request reprint Classic studies of mammary development and milk secretion: 1945 - 1980
    Margaret C Neville
    CU Denver School of Medicine, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 14:193-7. 2009
  4. pmc Prolactin-mediated regulation of lipid biosynthesis genes in vivo in the lactating mammary epithelial cell
    Michael C Rudolph
    Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 300:E1059-68. 2011
  5. pmc Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium
    Michael C Rudolph
    1Department of Physiology and Biophysics, University of Colorado Denver, Aurora, CO, USA
    Am J Physiol Endocrinol Metab 299:E918-27. 2010
  6. ncbi request reprint Lipid synthesis in lactation: diet and the fatty acid switch
    Michael C Rudolph
    Department of Pathology, University of Colorado Health Sciences Center, Anschutz Medical Campus, 12801 East 17th Avenue, Mail Stop 8104, P O Box 6511, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 12:269-81. 2007
  7. ncbi request reprint Cytoplasmic lipid droplet accumulation in developing mammary epithelial cells: roles of adipophilin and lipid metabolism
    Tanya D Russell
    Graduate Programs in Molecular Biology, Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Aurora, CO, USA
    J Lipid Res 48:1463-75. 2007
  8. pmc The insulin receptor plays an important role in secretory differentiation in the mammary gland
    Margaret C Neville
    Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado
    Am J Physiol Endocrinol Metab 305:E1103-14. 2013
  9. ncbi request reprint Analysis of lactation defects in transgenic mice
    Carol A Palmer
    Department of Physiology, University of Colorado Health Sciences Center at Fitzsimmons, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 11:269-82. 2006
  10. pmc Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis!
    Steven M Anderson
    Department of Pathology, University of Colorado Health Sciences Center, East 17th Avenue, Aurora, CO 80045, USA
    Breast Cancer Res 9:204. 2007

Detail Information

Publications15

  1. pmc Lactation and neonatal nutrition: defining and refining the critical questions
    Margaret C Neville
    University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 17:167-88. 2012
    ..In sum, we present a roadmap for multidisciplinary research into all aspects of human lactation, milk and its role in infant nutrition for the next decade and beyond...
  2. pmc The bovine lactation genome: insights into the evolution of mammalian milk
    Danielle G Lemay
    Department of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Genome Biol 10:R43. 2009
    ..The newly assembled Bos taurus genome sequence enables the linkage of bovine milk and lactation data with other mammalian genomes...
  3. doi request reprint Classic studies of mammary development and milk secretion: 1945 - 1980
    Margaret C Neville
    CU Denver School of Medicine, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 14:193-7. 2009
    ..This knowledge provides the groundwork for our current research into the molecular mechanisms involved in milk secretion and its regulation...
  4. pmc Prolactin-mediated regulation of lipid biosynthesis genes in vivo in the lactating mammary epithelial cell
    Michael C Rudolph
    Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 300:E1059-68. 2011
    ..These data demonstrate that PRL signaling regulates MEC-specific lipogenic gene expression and that PRL signals coordinate the milk synthesis and mammary epithelial cell survival during lactation in the mouse...
  5. pmc Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium
    Michael C Rudolph
    1Department of Physiology and Biophysics, University of Colorado Denver, Aurora, CO, USA
    Am J Physiol Endocrinol Metab 299:E918-27. 2010
    ....
  6. ncbi request reprint Lipid synthesis in lactation: diet and the fatty acid switch
    Michael C Rudolph
    Department of Pathology, University of Colorado Health Sciences Center, Anschutz Medical Campus, 12801 East 17th Avenue, Mail Stop 8104, P O Box 6511, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 12:269-81. 2007
    ..These regulatory pathways may be critical to the production of milk with a balanced TAG composition to support neonatal development of the newborn...
  7. ncbi request reprint Cytoplasmic lipid droplet accumulation in developing mammary epithelial cells: roles of adipophilin and lipid metabolism
    Tanya D Russell
    Graduate Programs in Molecular Biology, Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Aurora, CO, USA
    J Lipid Res 48:1463-75. 2007
    ....
  8. pmc The insulin receptor plays an important role in secretory differentiation in the mammary gland
    Margaret C Neville
    Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado
    Am J Physiol Endocrinol Metab 305:E1103-14. 2013
    ..We conclude that insulin fosters differentiation and may inhibit cell proliferation in the mammary gland of the midpregnant mouse...
  9. ncbi request reprint Analysis of lactation defects in transgenic mice
    Carol A Palmer
    Department of Physiology, University of Colorado Health Sciences Center at Fitzsimmons, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 11:269-82. 2006
    ....
  10. pmc Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis!
    Steven M Anderson
    Department of Pathology, University of Colorado Health Sciences Center, East 17th Avenue, Aurora, CO 80045, USA
    Breast Cancer Res 9:204. 2007
    ....
  11. ncbi request reprint Introduction: secretory activation: from the past to the future
    Margaret C Neville
    Department of Physiology and Biophysics, University of Colorado, Denver, CO, USA
    J Mammary Gland Biol Neoplasia 12:205-10. 2007
    ..We focus specifically on the activation of secretion at parturition, and show that the field is ripe for new investigation...
  12. ncbi request reprint Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine
    Michael C Rudolph
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center at Fitzsimmons, Aurora, Colorado 80045, USA
    Physiol Genomics 28:323-36. 2007
    ..They also implicate the transcription factor SREBP-1c in regulation of part of the pathway...
  13. pmc A D-peptide analog of the second extracellular loop of claudin-3 and -4 leads to mislocalized claudin and cellular apoptosis in mammary epithelial cells
    Heidi K Baumgartner
    Department of Physiology and Biophysics, University of Colorado Denver, School of Medicine, 12800 E 19th Ave, Aurora, CO 80045, USA
    Chem Biol Drug Des 77:124-36. 2011
    ..In conclusion, both the D- and L-forms of a small peptide that mimics a sequence in the second extracellular loop of claudins can target and disrupt claudin proteins in an epithelial monolayer and initiate apoptosis...
  14. pmc Disruption of occludin function in polarized epithelial cells activates the extrinsic pathway of apoptosis leading to cell extrusion without loss of transepithelial resistance
    Neal E Beeman
    Department of Physiology and Biophysics, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    BMC Cell Biol 10:85. 2009
    ..Occludin is a tetraspanin protein normally localized to tight junctions. The protein interacts with a variety of pathogens including viruses and bacteria, an interaction that sometimes leads to its extrajunctional localization...
  15. pmc Identifying significant temporal variation in time course microarray data without replicates
    Stephen C Billups
    Department of Mathematical and Statistical Sciences, University of Colorado, Denver, CO, USA
    BMC Bioinformatics 10:96. 2009
    ..This paper describes a replicate-free method that was developed as part of a study of the estrous cycle in the rat mammary gland in which no replicate data was collected...