Genomes and Genes
Margaret C Neville
Affiliation: University of Colorado Denver
- Lactation and neonatal nutrition: defining and refining the critical questionsMargaret C Neville
University of Colorado School of Medicine, Aurora, CO 80045, USA
J Mammary Gland Biol Neoplasia 17:167-88. 2012..In sum, we present a roadmap for multidisciplinary research into all aspects of human lactation, milk and its role in infant nutrition for the next decade and beyond...
- The bovine lactation genome: insights into the evolution of mammalian milkDanielle G Lemay
Department of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
Genome Biol 10:R43. 2009..The newly assembled Bos taurus genome sequence enables the linkage of bovine milk and lactation data with other mammalian genomes...
- Classic studies of mammary development and milk secretion: 1945 - 1980Margaret C Neville
CU Denver School of Medicine, Aurora, CO 80045, USA
J Mammary Gland Biol Neoplasia 14:193-7. 2009..This knowledge provides the groundwork for our current research into the molecular mechanisms involved in milk secretion and its regulation...
- Prolactin-mediated regulation of lipid biosynthesis genes in vivo in the lactating mammary epithelial cellMichael C Rudolph
Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA
Am J Physiol Endocrinol Metab 300:E1059-68. 2011..These data demonstrate that PRL signaling regulates MEC-specific lipogenic gene expression and that PRL signals coordinate the milk synthesis and mammary epithelial cell survival during lactation in the mouse...
- Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epitheliumMichael C Rudolph
1Department of Physiology and Biophysics, University of Colorado Denver, Aurora, CO, USA
Am J Physiol Endocrinol Metab 299:E918-27. 2010....
- Lipid synthesis in lactation: diet and the fatty acid switchMichael C Rudolph
Department of Pathology, University of Colorado Health Sciences Center, Anschutz Medical Campus, 12801 East 17th Avenue, Mail Stop 8104, P O Box 6511, Aurora, CO 80045, USA
J Mammary Gland Biol Neoplasia 12:269-81. 2007..These regulatory pathways may be critical to the production of milk with a balanced TAG composition to support neonatal development of the newborn...
- Cytoplasmic lipid droplet accumulation in developing mammary epithelial cells: roles of adipophilin and lipid metabolismTanya D Russell
Graduate Programs in Molecular Biology, Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Aurora, CO, USA
J Lipid Res 48:1463-75. 2007....
- The insulin receptor plays an important role in secretory differentiation in the mammary glandMargaret C Neville
Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado
Am J Physiol Endocrinol Metab 305:E1103-14. 2013..We conclude that insulin fosters differentiation and may inhibit cell proliferation in the mammary gland of the midpregnant mouse...
- Analysis of lactation defects in transgenic miceCarol A Palmer
Department of Physiology, University of Colorado Health Sciences Center at Fitzsimmons, Aurora, CO 80045, USA
J Mammary Gland Biol Neoplasia 11:269-82. 2006....
- Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis!Steven M Anderson
Department of Pathology, University of Colorado Health Sciences Center, East 17th Avenue, Aurora, CO 80045, USA
Breast Cancer Res 9:204. 2007....
- Introduction: secretory activation: from the past to the futureMargaret C Neville
Department of Physiology and Biophysics, University of Colorado, Denver, CO, USA
J Mammary Gland Biol Neoplasia 12:205-10. 2007..We focus specifically on the activation of secretion at parturition, and show that the field is ripe for new investigation...
- Metabolic regulation in the lactating mammary gland: a lipid synthesizing machineMichael C Rudolph
Department of Physiology and Biophysics, University of Colorado Health Sciences Center at Fitzsimmons, Aurora, Colorado 80045, USA
Physiol Genomics 28:323-36. 2007..They also implicate the transcription factor SREBP-1c in regulation of part of the pathway...
- A D-peptide analog of the second extracellular loop of claudin-3 and -4 leads to mislocalized claudin and cellular apoptosis in mammary epithelial cellsHeidi K Baumgartner
Department of Physiology and Biophysics, University of Colorado Denver, School of Medicine, 12800 E 19th Ave, Aurora, CO 80045, USA
Chem Biol Drug Des 77:124-36. 2011..In conclusion, both the D- and L-forms of a small peptide that mimics a sequence in the second extracellular loop of claudins can target and disrupt claudin proteins in an epithelial monolayer and initiate apoptosis...
- Disruption of occludin function in polarized epithelial cells activates the extrinsic pathway of apoptosis leading to cell extrusion without loss of transepithelial resistanceNeal E Beeman
Department of Physiology and Biophysics, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
BMC Cell Biol 10:85. 2009..Occludin is a tetraspanin protein normally localized to tight junctions. The protein interacts with a variety of pathogens including viruses and bacteria, an interaction that sometimes leads to its extrajunctional localization...
- Identifying significant temporal variation in time course microarray data without replicatesStephen C Billups
Department of Mathematical and Statistical Sciences, University of Colorado, Denver, CO, USA
BMC Bioinformatics 10:96. 2009..This paper describes a replicate-free method that was developed as part of a study of the estrous cycle in the rat mammary gland in which no replicate data was collected...