R W Neumar

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Molecular mechanisms of ischemic neuronal injury
    R W Neumar
    Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19107 4283, USA
    Ann Emerg Med 36:483-506. 2000
  2. ncbi request reprint Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis
    Robert W Neumar
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Biol Chem 278:14162-7. 2003
  3. ncbi request reprint Calpain activity in the rat brain after transient forebrain ischemia
    R W Neumar
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA
    Exp Neurol 170:27-35. 2001
  4. ncbi request reprint Developmental status of neurons selectively vulnerable to rapidly triggered post-ischemic caspase activation
    Zhaoming Chen
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Neurosci Lett 376:166-70. 2005
  5. doi request reprint Inter-hospital variability in post-cardiac arrest mortality
    Brendan G Carr
    The Robert Wood Johnson Clinical Scholars Program, University of Pennsylvania School of Medicine UPENN SOM, USA
    Resuscitation 80:30-4. 2009
  6. pmc Cardiac catheterization is underutilized after in-hospital cardiac arrest
    Raina M Merchant
    The Robert Wood Johnson Clinical Scholars Program, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, United States
    Resuscitation 79:398-403. 2008
  7. doi request reprint A national analysis of the relationship between hospital factors and post-cardiac arrest mortality
    Brendan G Carr
    The Robert Wood Johnson Clinical Scholars Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Intensive Care Med 35:505-11. 2009
  8. ncbi request reprint Novel surrogate markers for acute brain damage: cerebrospinal fluid levels corrrelate with severity of ischemic neurodegeneration in the rat
    Robert Siman
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
    J Cereb Blood Flow Metab 25:1433-44. 2005
  9. doi request reprint Early goal-directed hemodynamic optimization combined with therapeutic hypothermia in comatose survivors of out-of-hospital cardiac arrest
    David F Gaieski
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Resuscitation 80:418-24. 2009
  10. ncbi request reprint Proteins released from degenerating neurons are surrogate markers for acute brain damage
    Robert Siman
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    Neurobiol Dis 16:311-20. 2004

Research Grants

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Molecular mechanisms of ischemic neuronal injury
    R W Neumar
    Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19107 4283, USA
    Ann Emerg Med 36:483-506. 2000
    ..The primary goal of this review is to provide an overview of molecular injury mechanisms currently believed to be involved in postischemic neuronal death specifically highlighting their time course and potential interactions...
  2. ncbi request reprint Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis
    Robert W Neumar
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Biol Chem 278:14162-7. 2003
    ..Subsequent calpain activity, facilitated by caspase-mediated degradation of calpastatin, contributes to plasma membrane disruption and secondary necrosis...
  3. ncbi request reprint Calpain activity in the rat brain after transient forebrain ischemia
    R W Neumar
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA
    Exp Neurol 170:27-35. 2001
    ....
  4. ncbi request reprint Developmental status of neurons selectively vulnerable to rapidly triggered post-ischemic caspase activation
    Zhaoming Chen
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Neurosci Lett 376:166-70. 2005
    ..These results indicate that the phenomenon of rapidly triggered caspase activation in the adult rat brain after transient forebrain ischemia is specific to mature neurons and does not occur in neuroprogenitor cells or immature neurons...
  5. doi request reprint Inter-hospital variability in post-cardiac arrest mortality
    Brendan G Carr
    The Robert Wood Johnson Clinical Scholars Program, University of Pennsylvania School of Medicine UPENN SOM, USA
    Resuscitation 80:30-4. 2009
    ..We examined hospital-level variation in mortality of patients admitted to United States intensive care units (ICUs) with a diagnosis of cardiac arrest...
  6. pmc Cardiac catheterization is underutilized after in-hospital cardiac arrest
    Raina M Merchant
    The Robert Wood Johnson Clinical Scholars Program, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, United States
    Resuscitation 79:398-403. 2008
    ..We sought to evaluate rates of early catheterization after in-hospital ventricular fibrillation (VF) arrest and the association with survival...
  7. doi request reprint A national analysis of the relationship between hospital factors and post-cardiac arrest mortality
    Brendan G Carr
    The Robert Wood Johnson Clinical Scholars Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Intensive Care Med 35:505-11. 2009
    ..We sought to generate national estimates for post-cardiac arrest mortality, to assess trends, and to identify hospital factors associated with survival...
  8. ncbi request reprint Novel surrogate markers for acute brain damage: cerebrospinal fluid levels corrrelate with severity of ischemic neurodegeneration in the rat
    Robert Siman
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
    J Cereb Blood Flow Metab 25:1433-44. 2005
    ..Measurement of 14-3-3beta and calpain-cleaved tau may be useful for the minimally invasive diagnosis, prognosis, and therapeutic evaluation of acute brain damage...
  9. doi request reprint Early goal-directed hemodynamic optimization combined with therapeutic hypothermia in comatose survivors of out-of-hospital cardiac arrest
    David F Gaieski
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Resuscitation 80:418-24. 2009
    ..Due to the similarities between the post-cardiac arrest state and severe sepsis, it has been postulated that early goal-directed hemodyamic optimization (EGDHO) combined with TH would improve outcome of comatose cardiac arrest survivors...
  10. ncbi request reprint Proteins released from degenerating neurons are surrogate markers for acute brain damage
    Robert Siman
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    Neurobiol Dis 16:311-20. 2004
    ....
  11. ncbi request reprint Selective activation induced cleavage of the NR2B subunit by calpain
    Kelly L Simpkins
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4306, USA
    J Neurosci 23:11322-31. 2003
    ..Such forms could contribute to excitotoxicity and synaptic remodeling...
  12. ncbi request reprint Structural and functional damage sustained by mitochondria after traumatic brain injury in the rat: evidence for differentially sensitive populations in the cortex and hippocampus
    Jonathan Lifshitz
    Head Injury Center, Department of Neurosurgery, University of Pensylvania, Philadelphia, Pensylvania 19104 6316, USA
    J Cereb Blood Flow Metab 23:219-31. 2003
    ..The heterogeneous mitochondrial response to TBI may underlie posttraumatic metabolic dysfunction and contribute to the pathophysiology of TBI...
  13. pmc RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemia
    Matthew B Bevers
    Center for Resuscitation Science, Department of Emergency Medicine, University of Pennsylvania School of Medicine, Ground Ravdin, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Exp Neurol 224:170-7. 2010
    ..These findings represent the first in vivo evidence that reducing expression of an individual calpain isoform can decrease post-ischemic neuronal death and preserve hippocampal function...
  14. pmc Immediate short-duration hypothermia provides long-term protection in an in vivo model of traumatic axonal injury
    Marek Ma
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Neurol 215:119-27. 2009
    ..027). There was no differential protection based on axon size. These results support further clinical investigation of temporally optimized therapeutic hypothermia after traumatic brain injury...
  15. ncbi request reprint Brain ischemia and reperfusion: molecular mechanisms of neuronal injury
    B C White
    Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA
    J Neurol Sci 179:1-33. 2000
    ..Examination of such protocols will require not only characterization of functional and histopathologic outcome, but also study of biochemical markers of the injury processes to establish the role of each drug...
  16. ncbi request reprint Comparison of calpain and caspase activities in the adult rat brain after transient forebrain ischemia
    Chen Zhang
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Neurobiol Dis 10:289-05. 2002
    ....
  17. pmc Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity
    Matthew B Bevers
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Neurochem 108:1237-50. 2009
    ..These findings provide insight into potential mechanisms of calpain-mediated neurodegeneration and have important implications for the development of isoform-specific calpain inhibitor therapy...
  18. ncbi request reprint Endoplasmic reticulum stress-induced cysteine protease activation in cortical neurons: effect of an Alzheimer's disease-linked presenilin-1 knock-in mutation
    R Siman
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:44736-43. 2001
    ....
  19. ncbi request reprint Mechanistic role of calpains in postischemic neurodegeneration
    Matthew B Bevers
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    J Cereb Blood Flow Metab 28:655-73. 2008
    ....
  20. ncbi request reprint Neuroprotection with delayed initiation of prolonged hypothermia after in vitro transient global brain ischemia
    Eric J Lawrence
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Resuscitation 64:383-8. 2005
    ..These results suggest the need for further in vivo studies to define the therapeutic window within which prolonged hypothermia is optimally neuroprotective after cardiac arrest...
  21. pmc Calpain mediates proteolysis of the voltage-gated sodium channel alpha-subunit
    Catherine R von Reyn
    Departments of Bioengineering, Pharmacology, Neurosurgery, Emergency Medicine, and Neuroscience, University of Pennsylvania, Philadelphia, PA 19104 6321, USA
    J Neurosci 29:10350-6. 2009
    ....
  22. doi request reprint NIH Roundtable on Opportunities to Advance Research on Neurologic and Psychiatric Emergencies
    GAIL D'ONOFRIO
    Department of Emergency Medicine, 464 Congress Ave, Ste 260, New Haven, CT 06519, USA
    Ann Emerg Med 56:551-64. 2010
    ..We identify key research questions essential to advancing the science of emergency care and discuss the barriers and strategies to advance research by exploring the collaboration between NIH and the emergency care community...
  23. ncbi request reprint Rule out TBI? Serum markers for traumatic brain injury
    Robert W Neumar
    Ann Emerg Med 39:342-3. 2002

Research Grants2

  1. Optimizing therapeutic hypothermia after cardiac arrest
    ROBERT NEUMAR; Fiscal Year: 2007
    ..In addition, this translational paradigm will be available to efficiently evaluate and optimize therapies that might be compared to or used in combination with therapeutic hypothermia. ..